#triple-negative

[medicomunicare]

TRPS1 as possible unique biomarker for triple-negative? Investigations on cellular biology and mechanisms

The mammary gland is a complex tissue comprising a variety of cell types. Their proper functioning is crucial for the health of the breast. Breast cancer is the widest condition affecting breast health and can be categorized as estrogen receptor (ER)/progesterone receptor (PR)-positive luminal, human epidermal growth factor receptor 2 (HER2)-positive, or triple-negative breast cancer (TNBC) types…

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#breast cancer #cell proliferation #cellular signaling #estrogen receptor #luminal progenitor cells #signaling pathway #transcription factor #triple-negative

[eewtp]

Chalice of the Gods, Wrath of the Triple Goddess…

Nico and Will I’m sorry you two go stuck with the title that you ended up with

#I’m so negative today but 😐 sometimes I can’t stand the name tsats #especially when all the PJO books are titled very nicely #and this tsats business was not it and so very obviously an outlier 😭 #I can’t do better don’t even ask because I am struggling to name the rewrite I’m working on #pjo #nico di angelo #will solace #solangelo #solangelo book #the sun and the star #tsats #chalice of the gods #wrath of the triple goddess #pjo fandom

[the-patrex]

Hey question! Does anyone know how to stop being a shut in that only talks to one person?

#shut up patrex #my skills in social interactions were always borderline bad #bbut after pandemic and now fully work remotely my skills have reached triple negative numbers

[m4rs-ex3]

people: it's so unfair to dog pile on gwen for all her "numerous mistakes" !!!

me: yeah !!

people: she's a traumatized kid, and either way her downfalls were nothing compared to a bunch of other people in that movie !!!

me: YEAH !!!

people: i mean what about peter b

me: uh yeah!

people: he did so many shitty things !!!!!

me: yea

me: *sobs in corner*

#he did all of it but i don't care #tbh that's like a triple standard bc he's a traumatized child #i don't give a mayday shit if he's a wisecracking man child #let's all come together as a community #and not jump to conclusions #and not hate #and not spread negativity #and agree that every bad character move ever is miguel's fault #ty 🫶🫶🫶🫶🫶🫶 #spiderverse #atsv #across the spiderverse #across the spider verse #gwen stacy #peter b parker

[lalunebleue]

Goodbye, 2023, you can go f-yourself!

I know that I've been off most of last year and I wanted to give a little explanation.

TLDR for people who don't want to read my many paragraphs - My mom had cancer but is in full recovery now. Please get your regular mammograms and do your breast exams!

Anyways, at the end of February, my mom found out that she had stage two triple-negative breast cancer that was in one breast and in one lymph node. For those that don't know triple-negative is super aggressive and once it gets into the lymph node, it can be very bad because it can travel anywhere in the body so they must treat it like it's everywhere. It's also not hormone driven, so there aren't a lot of options for treatment.

The doctors immediately started chemo every week through July. They broke it up into two cycles. The first cycle was rough, but she got through it with minimal side effects. The second cycle was awful. She wanted to quit after the first round, but she gathered up the courage to keep going back for the next three treatments. It was really hard watching her have to go through all of that.

After she recovered from the chemo for a few weeks in August, she had a double mastectomy. They had offered to just take out what was left of the lump and the lymph node, but my mom said that she'd had no use for them anymore at 70-something and would rather not have the worry of the cancer coming back. I really can't blame her. It had been year after year of worry until it finally happened.

Finally in the beginning of September, we had gotten the amazing news that the chemo treatments with the double mastectomy had gotten all the cancer, even the lymph nodes came back clear. She completed 5 weeks of daily radiation in October and now she only has two more treatments of Keytruda before she'll be given a clean bill of health.

The only reason that she's had such a positive outcome is because they caught it so early. She always gets her yearly mammogram and quite frequently had to go back for a second look after. Please, everyone make sure that you get yours done regularly.

#nonsims #cancer awareness #triple negative breast cancer

[cellberry]

Did you guys hear that c!Mumza canonically managed to save the souls of the Triple Ts when the nuke went off? She brought c!Tommy and c!Tubbo to meet c!Ranboo and Michael B in the nether-looking area and c!Jack to the End to meet the remaining Syndicate members. They can travel between the realms at any time ofc.

#the tommy and tubbo you saw at the end of their respective finales have no memories because they are unrelated doppelgangers #fake lore #c!tommy #c!tubbo #c!jack #c!kristin #c!ranboo #michael beloved #c!benchtrio #dream smp finale #syndicate finale #dream smp #dsmp neg #dream smp lore #dsmp finale discussion #dsmp lore spoilers #dsmp lore #dsmp finale #dsmp #spoilers #triple ts #the syndicate #bench trio #mumza #tommyinnit #tubbo #ranboo #jack manifold #tw unreality #my posts

[silverstars87]

So I finished all 16 rounds of chemo and now I’m first case on Monday 12/4 for bilateral nipple sparking mastectomies, right port removal, and bilateral expander placement with a cellular dermis.

I Wish this wasn’t happening.

I cry a lot. And my husband won’t even speak to me for the past 5 months.

#nursing #nurblr #nurse practitioner #registered nurse #aprn #triple negative breast cancer #breast cancer #brca1

[jaythelay]

I don't mind Lethal Company's dev taking a break, bro this game's fine as is, needs some work, but otherwise this game's simply good, which is genuinely impressive in modern times.

My biggest fear is the seemingly unknown wider problem, a two-fer, Modding and Desync.

See, presently there's like 3 "Bigger Lobby" mods, all 3 incompatible with each other. This makes playing with randoms a mere possible chance. But it gets worse. You can get more mods than just that, like the Skinwalker mod, or a TV mod, or poster mods.

Not every mod requires everyone to have it, but even then, if your files are a single byte off, that can utterly desync you, or put you in the wall.

What Lethal Company Truly Needs is this:

Mod Support in the form of file sharing like in Gmod servers. You join, you download the mods for that game, ya leave and they disable or delete themselves.

I want to join random lobbies that are modded to hell and back. The game's fine on it's own, yes, but you can get an avalanche of content from it simply by adding a few QoL mods that clearly were intentional design that I simply don't vibe with.

For example, 4 players is clearly the intended design, and that's perfectly fine, but I'm in a server with like at least 10 people, we all wanna play LC together. Or the radio mod that lets you speak while at a terminal, or the mod that removes the mask from the model of a fake player (genuinely should've been base game)

Lemme put it to you this way if it still doesn't click: You open the game, open the server browser, and if the host labels their server, it'll tell you what biggerlobby mod they're using. If they didn't, you have absolutely no clue what mod(s) they're using. This means scrolling a poorly made server list, clicking every server, being told you can't join due to different files between host and client, or joining, but being stuck inside a wall. That's what finding a random lobby is like now, and it could be fixed via downloading the mods when you join

Problem here is that, I dunno how the hell you safely do that. Ya can't make it so people download files directly from the client's harddrive because you could easily sneak files in there, and not to be rude but I don't think a game like this would handle such a concept well. Which is why I say just add Steam Workshop as a middleground, then work on the server browser, make it so knowing what mods isn't as important as joining the game.

Does the game need more features, levels, enemies, and items? Sure, to some degree, but what it needs is to ensure the community doesn't splinter as soon as possible, is a mod synchronisation of some kind. Otherwise this game will run into some large, unfixable problems.

If ya'll played Arma 2's Day-Z mod, you know exactly what I'm talking about, just to a far, far smaller degree:

Right now, no one has attachment to either of the 3 bigger lobby mods, but only one is used more than the other 2. If that mod adds a feature, say, cosmetics, and adds another feature ontop of that, and another, and none of those are in the other 2 mods, or base game, then an attachment will be made, and any changes to the game feels like forced downgrades to that mod, you'll constantly be fighting to make the game be like the modded experiences of the biggest modding base, and that can make people bitter from all angles, it removes the personal touch of the game as well, which is why I still think having bigger lobbies and a normal difficulty mode by default is best in this case, get the intended experience and the fun additions.

Mod Sync. Seriously think it worth being the very next update. Otherwise this game's future is already in jeopardy and every update increases the problems by outdating mods, seemingly for no good reason to some. While the one dev takes a perfectly fine break, hundreds of mod creators are steadily at work to immedietely outdate the game for most people. Just...put the plug on that and fix it before it floods.

Seriously though there needs to be some cohesion, and the dumbshit "thunderstore" has got to GO. Who the hell has a modding website that doesn't have pictures of said mod? A website that wants you to install it's mod installer to collect data on you.

Heavily suggest using Steam Workshop so people can download the most popular collections, it's the simplest band-aid solution to a long-term currently bubbling problem. Really just don't want to see this fanbase splinter off and make the random lobby problem even worse where some mod devs make certain mods "incompatible" due to a feud they had that's uninvolved with everything.

#Lethal Company #it's already impossible to play a bigger lobby with people unless you got one of the 3 #and it's not exactly labeled or navigatable #none of this is to be negative #just seen this bit before and it always sucks when shit hits the fan #normally I reccomend AGAINST adding Steam Workshop for your E.A. game #because that's when the developer just abandons the project #looking at you ultimate epic battle simulator 1 and 2 #but in this case the game just needs some rounding out and it's fine #like sure more enemies items and moons #that's cool #but honestly unnecessary #ya did good man #round it out #add workshop #make more art #ya did it #ya did more than any triple a dev in decades #ya made a good game that's only mildly buggy

[kremlin]

real post: are any of the freeware locally-run ocr libraries any good yet? i have pdfs that i want to derasterize but not unless the error rate isn’t nearly nonzero

#elusive triple negative

[hello-god-its-me-sara]

Jonathan Crane and his southern grammar (or lack there of if you ask Alfred probably)

#y'all vs all y'all #yes there is a difference #southern grammar #double negatives #double contractions #triple contractions #contractions all the way down #the infamous ain't #jonathan crane #southern jonathan crane giving aneurysms to everyone around him #southern jonathan crane

[medicomunicare]

Il ruolo degli ormoni sessuali nel controllo e nella responsività biologica dei diversi tipi di tumore mammario

Gli ormoni sessuali sono una parte importante sia della patogenesi che nella progressione del carcinoma mammario. Ognuni di essi ha le sue azioni molecolari sulle cellule tumorali, mediate dalla loro interazione con i recettori nucleari che ahnno funzione di fattori di trascrizione. Regolarmente il carcinoma mammario è molto responsivo agli estrogeni, eccetto la forma triplo-negativa che non…

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#androgeni #aromatasi #biomarkers #carcinoma mammario #cellular signaling #enzalutamide #espressione genica #estradiolo #estrogeni #letrozolo #medicina personalizzata #oncogenesi #precision medicine #progesterone #recettore #replicazione cellulare #triple-negative #tumore al seno

[drugstorecowboi]

End of an era. Thanks for everything AHC. It’s been a wild ride these last few years🫡

#americas hardcore fest #triple b records #slapshot #mindforce #negative approach #gridiron #fury #shipwreck #bitter end is the TBA #spy #colin of arabia #restraining order #buried alive #clear #demolition #burning lord #best wishes #adrienne #day by day #grand scheme #diztort #hard stripes #never again #missing link #wild side #result of choice #scarab #wise #wreckage #live it down

[dysaniadisorder]

i am so sick of all in-community homophobia & transphobia being blamed on teenagers shut the fuck up i was raised by a butch woman do u know the amount of 25-year-olds who have claimed to be elders and told me not to use neos or say the word queer. a lot ok

#the sheer amount of queer teens in shit households. who do not believe they'll live to thirty. #years pass and one thing stays consistent adults are fffucking assholes #like. yeah. even the theater kid who's annoying about the terms twink and bear is still misgendered every minute of every day #like do u know how little we are even encouraged to know... i dont even see ppl having hope for us at this point #somewhere it went from 'queer kids; read queer books!!' #to 'gay babies are all sooo homophobic and they don't even know it' #shut up shut up i hate you. you cannot blame the entire communities problems on someone who's writing an essay on the pearl #shout out to my cw teacher who reccomended me a book; told me the main character was gay in the 1920's and winked at me #triple negative shout out to the 20-smth lesbian who tried making casual conversation w me about how she knows all her bi friends #are either special straight women or lesbians in denial. and i went ahaha. mhm. im gonna go #u guys are losing fucking sight................. anyways #just a rant ignore this

[alsoyooraiyah]

Ugh aventurine….

#ive never been so terribly fascinated and drawn in by character yet have negative interest to ever play the game theyre in #maybe ill watch full story once its out i just wanna know what his deal is #i keep seeing the fucker compared to kaeya and kaveh and ajax like HELLO WHAT DO YOU MEAN W ALL THREE???????? #triple whammy my god i need to know more

[beautifulstorms]

so I caught covid from canadian nationals and did in fact have the 40 degree fever + cough of death response for a couple days :( the fever is gone but the cough is not and i can barely get through workday afternoons without falling asleep

#it's rlly horrifying that i had such a severe response #i thought i was dying but i also tested false negative three times #so i also thought i had the flu but no! it actually is covid for real #i am triple vaxxed and actually had my booster booked for the tuesday after but. oh well #i just want to get better so i can go back to doing things in person :(

[bpod-bpod]

Pollen-powered Delivery

Spring is a beautiful time of year as flowers start to bloom again. But for some, it spells trouble as hay fever goes into overdrive. While pesky pollen may be irritating for some, now it could be lifesaving for others – specifically those with a certain type of breast cancer. Triple-negative breast cancer makes up around 10–15% of all breast cancer cases and is difficult to treat as it’s missing three receptors that cancer therapeutics usually target. Studies suggest that the best way to treat this type of breast cancer is through chemotherapy, but combining that with the delivery of oxygen. This is where pollen (pictured) comes in as researchers showed it could be a useful way to deliver both chemotherapy with its spiky exterior, and oxygen due to its hollow centre – which can be released in a controlled manner using ultrasound – to the cancer cells simultaneously and help the treatments work better.

Written by Sophie Arthur

Image from work by Baojie Wen and colleagues

Department of Ultrasound, Institute of Translational Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medicine School, Nanjing University, Nanjing, China

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Advanced Science, May 2023

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#science #biomedicine #triple-negative breast cancer #breast cancer #cancer #chemotherapy #pollen #oxygen #immunofluorescence