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l0v3tast3 · 1 year

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✎ hmm trying somethin new ,,,,

tags: smut mdni!!, rough sex, dirty talk, pet names, afab!reader, fav x reader type thing

word count: 480ish

he has your hair bunched into a messy ponytail, gripped tightly in his hand while the other lays flat on your upper back, pushing your upper body further into the bed. your neck strains with how your head is pulled back, just enough so you don't suffocate in the damp, wrinkled sheets.

your breaths are so shallow in between the moans and the babbling that spills from your drool-covered lips. it's just so hard to breath when his cock is bullying into you so hard and fast, when he just doesn't stop fucking you like a machine.

"aren't ya gonna thank me, baby?" he spits; his voice is gravelly and out-of-breath, but he's so invested in how your swollen cunt has his dick in a death grip that he doesn't even notice he's tired.

you barely can even register his words, your muddled brain having already been fucked empty hours ago.

after a few seconds of him impatiently waiting for a response, he turns your head and pushes it down, laying across your back and bringing his face down to yours. he had only paused for a few seconds but you were already whining, mumbling for him not to stop.

you were just so cute that he had to start fucking you again. deep, sharp thrusts pushed you further up the bed and caused you to cry out, your hands flying back to try to tell him to slow down.

"i said, you should really thank me, princess, for fuckin' you so damn good," he hissed in your ear, easily taking your hands and pinning them down on either side of your head. "you asked me for this, didn't you? fuckin' whined and begged until i stuck my dick in you."

"yes- yes! thank you! thank you, thank you-" you repeat it over and over like you're praying to him and he soaks it up with a grin. once your mantra dies down back into mindless moaning, he lets go of one hand to pet your hair, rubbing his thumb over your tear and mascara-stained cheek comfortingly.

"see, sweetheart, that wasn't so hard, was it?" his hips finally slow down, moving more fluidly, going from punishing to loving in seconds.

your body finally relaxes a bit, so wound from the overstimulation and the feeling of his cock trying to fuck into your cervix. your hope that he's finally giving you a break is soon squashed, though.

after a few tender moments he's flipping you over onto your back and gathering your legs in his arms to press them up by your head. all you can muster is a whimper when he easily slides his dick back into you, both of you covered in both of your cum.

"don't worry, baby, i'm rewarding you. you're just such a good girl for me," he coos, a patronizing smile plastered on his face as he resumes his cruel pace.

ghost , price // eren , levi , jean // toji , satoru , nanami , suguru

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rphunter · 14 hours

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hellooo there, you can call me hoax!! i'm a 21 yo writer searching for 18+ roleplay partners!

i write in past tense third person and try my best to match my partners' response lengths, though i can usually churn out anywhere between one and ten paragraphs! as for characters + pairings, i can write both original + canon characters, though when it comes to pairings, i usually prefer writing ocxoc or ccxcc. i'm not entirely opposed to ocxcc, but it's definitely a case-by-case basis for me. feel free to ask nonetheless! on a similar note, i tend to write mxm pairings more than anything, but i'm also not super strict about that! i may write mxf or fxf, but once again, on a case-by-case basis. that being said, the only specifications i'm somewhat strict with are my muses -- find a list of them below, but please don't ask me to play any unlisted characters! as a side note, i'm a BIG multishipper, so i'll write for a lot! even if we don't share a fandom, please feel free to ask about my original characters + plots!

if you'd like to write together, feel free to reach out to me via discord or tumblr @ ghostyhoax -- i'm not the best at keeping track of likes n such, but i'll try my best to reach out to those who interact as well!

hetalia – alfred f jones, matthew williams, arthur kirkland, francis bonnefoy, ivan braginsky, yao wang, ludwig bielschmidt, kiku honda, roderich edelstein, tolys laurinaitis, feliks łukasiewicz, tino väinämöinen, antonio fernández carriedo, natalya arlovskaya

homestuck – john egbert, dave strider, rose lalonde, jade harley, tavros nitram, sollux captor, vriska serket, eridan ampora, feferi peixes, dirk strider

sally face – travis phelps

south park – stan marsh, kyle broflovski, tweek tweak, butters stotch

the goldfinch – theo decker

it (2017 + 2019) – eddie kaspbrak, stanley uris

the outsiders – ponyboy curtis, johnny cade

the breakfast club – brian johnson, john bender

my hero academia – yuga aoyama, tenya iida, ochako uraraka, denki kaminari, shoto todoroki, katsuki bakugou, izuku midoriya, neito monoma, shota aizawa, hizashi yamada, tomura shigaraki

attack on titan – armin arlert, jean kirschstein, marco bodt, sasha braus, connie springer, levi ackerman, erwin smith, hange zoë

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f4nrir · 1 year

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WRITELIST .. 📁

MARVEL / MCU

steven grant, marc spector, jake lockley, steve rogers, bucky barnes, tony stark, peter parker, eddie brock/venom, wade wilson, matt murdock.

SPIDERVERSE

peter b. parker, the spot, spider noir.

CALL OF DUTY: MODERN WARFARE II

simon “ghost” riley, alejandro vargas, john "soap" mactavish, john price, kyle "gaz" garrick, könig.

jason todd, dick grayson, constantine, bruce wayne (the batman 2022).

UNCHARTED (STRICTLY THE VIDEO GAME)

nathan drake, samuel drake, rafe adler.

SCREAM

billy loomis, stu macher, chad meeks-martin, ethan landry.

ATTACK ON TITAN

reiner braun, bertholdt hoover, jean kirschstein, porco galliard, zeke yeager, erwin smith, levi ackerman.

MISC. .

lucifer morningstar (lucifer) , joel miller (tv show & game; specify), edward cullen (twilight), poe dameron (star wars).

[ more characters may be added ]

#˚◞ ✦ . navigation #— zeppelin’s files 📁

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thearoace · 4 years

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AND HIS NAME IS JEAN CENA!

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papijean · 3 years

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I just realized you're a jean girl

papijean fucking duh

I think you'll appreciate what I found 🤤😩

Please my panties can only handle so much 💦💦🥵 JEAN AHHHHHH

#lay it on them papa john #jean kirschstein

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white-cat-of-doom · 3 years

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the Rum Tum Tugger is beef

He sure is!

(Nico Kirschstein Smith, Physio Therapist for the UK International Tour 2018, as half way between Chorus Tugger and full Tugger, with a very starstruck Dane Quixall out of costume.)

But then the question becomes, what kind of beef do you prefer?

Maybe a nice Italian Steak (my personal favourite)?

(Riccardo Sinisi, cover in Vienna 2019)

How about some Waygu?

(Tokyo 2018)

Or just the classic striploin?

(John Partridge, CATS 1998)

There are no wrong choices!

#CATS Musical #CATS the Musical #Rum Tum Tugger #Dane Quixall #Nico Kirschstein #CATS UK Tour 2018 #CATS Tokyo 2018 #CATS 1998 #John Partridge #CATS Vienna 2019 #Riccardo Sinisi #More power to you Anon #Unless you want to eat him #We do not do that here sorry #All kitties are for looking and not for eating

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magicmiss · 3 years

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The Candy Curtis case // Part 64

Aka ,,Lady Doctor’’

Oh god oh fuck oh no !

Time’s up ! Ymir has a choice and it’s easy made, isn’t ? Isn’t ?

This one is a bit short (or actually the only one that fit the normal format but whatever) but next will be 9 pages long !! So brace yourself people cuz the show is just starting...

Reblog, share and comment ! The Patreon ! 🚬❄️ 💋

#snk #aot #mikasa ackerman #jeankasa #reiner braun #jean kirschstein #John kirschtein* sorry ehe #1950 jeankasa au #historia reiss #snk ymir #ymir x historia #the case candy curtis #John was into something when he thought about Reiner sadly he didn’t acted on it #what will Ymir choose btw ? what do you guys think ?

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brandnewwingz · 5 years

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Attack On Titan characters as John Mulaney quotes

Keith Shadis:

Armin:

Levi:

Eren:

Erwin:

Hange:

Hannes:

Annie:

Mikasa:

Jean:

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reinerbraunprotectionsquad · 6 years

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*Jean and Eren get into another fight during their trainee years*

Jean: At least I'm not some suicidal bastard!

Eren:

#I crack myself up #eren jaeger #jean kirschstein #jean kirshtein #jean kirstein #snk #aot #shingeki no kyojin #attack on titan #104th trainees squad #john mulaney #my post

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witchyleaf · 7 years

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I'm officially working on my snk/Treasure Planet AU for a fic, and as I'm writing Jean as John Silver I wanted to do some 'concept art' for my own fic because I'm OBSESSED

#my art #jean kirschstein #John silver #treasure planet #I'm doing all this on my iPad with just my finger and I'm so PLEASED #Llawlietamane art #fanart #snk #aot #au #jeanmarco #wote

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despairsfavoritebear · 7 years

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Welp.... I guess I’m doing this.

BCTagged by @4361726f6c696e65 (THANKS!)

Rules: Answer the questions and tag 20 blogs you want to get to know better

Nicknames: I’m going to be honest.... I don’t have any.

Star sign: Aries

Height: 5′5.5, 5′6

Time right now: 2:44 PM

Last thing you googled: Titanic Decks

Song stuck in my head: Uh, I don’t have one for once

Last movie I watched: Deadpool???? I think?

Last TV show I watched: Dragon Ball Super????

What I’m wearing right now: Blush pink kimono with orange roses, a dusty rose blouse, dark wash jeans, and blush pink flats

When I created this blog: Uh..... 2 years ago? Maybe 3? I have no idea. I forget.

What kind of stuff I post: Danganronpa fanart and Danganronpa memes. Occasionally, I will write stupid things for DR

Do I get asks regularly?: LOL NO

Why did I choose my url: I was trying to come up with a clever username.... this is what I came up with

Gender?: I am a female.

Favorite color: Green

Average hours of sleep: HAHAHAHA like 4 to 6 hours maybe?

Lucky number: I’m probably the unluckiest person you will never meet so... I don’t have one

Favorite characters: Oh... Oh dear. This is going to be a long one. OKIE DOKIE.... Monokuma, Monomi, Chihiro Fujisaki, Toko Fukawa, Sakura Ogami, Hajime Hinata, Chiaki Nanami, Fuyuhiko Kuzuryu, Sonia Nevermind, Peko Pekoyama, Mikan Tsumiki, Gundham Tanaka, Kotoko Utsugi, Nagisa Shingetsu, Shirokuma, Kurokuma, Chisa Yukizome, Seiko Kimura, Big Daddy, Little Sister, Sherlock Holmes, John Watson, Jim Moriarty, Yuuri Katsuki, Victor Nikiforov, Yuri, Plisetsky, Otabek Altin, Phichit Chylanont, Christophe Giacometti, Deadpool (Wade Wilson), Peter Parker (Spiderman), Professor X, Magneto, Wolverine, Psychlock, Emma Frost, Rouge, Tony Stark, Steve Rogers, Sam Wilson, Natasha Romanov, Clint Barton, Selina Kyle, Pamela Ivy, Harleen Quinzell, Jason Todd, The Joker, Raven, Beast Boy, Sansa Stark, Jon Snow, Arya Stark, Tyrion Lannister, Daenerys Targaryen, Widowmaker, Gabriel Reyes, Jack Morrison, Hanzo Shimada, Genji Shimada, Reinhardt, Jesse McCree, Angela Ziegler, Zenyatta, Jamison Fawkes, Hana “D.Va” Song, Jonas Wagner (from Long Exposure), Mitch Muller (from Long Exposure), Zelda, Link, Marshall Lee, Prince Gumball, Marceline, Princess Bubblegum, Greece, Prussia, Norway, Denmark, England, America, Kaneki Ken, Hideyoshi Nagachika, Touka Kirishima, Jean Kirschstein, Marco Bott, Levi Ackerman, Miles Edgeworth, Franskia von Karma, Rey (from Stark Wars), Life (from MOLAD), Death (from MOLAD), MIMIKYU, Jack Zimmermann, Eric “Bitty” Bittle, Shitty Knight, Larissa “Lardo” Duan, Chris “Chowder” Chow, Adam “Holster” Birkholtz, Justin “Ransom” Oluransi, William “Dex” Poindexter, Derek “Nursey” Nurse, Kent Parson, Noctis Caelum, Ignis Scientia, Gladiolus Amicitia, Prompto Argentum, Cidney and many, MANY more. Oh my god....

Dream job: Dude. History Professor OR Managing a museum. That would be sick (working on it) but I guess you want a DREAM, DREAM job, it would have to be probably an author or editor.

Number of blankets I sleep with: Depends. If it’s cold, 4; If it’s warm, one to two.

I tag: @just-a-weeb, @ultra-who-even-cares, @otakushifter, @primus-is-king-8413, @3dglassesandgemshards, @towaciity, @danganronparuinedmylife, @faith-and-fandom, @shsl-gamer-rper

#UGH #I fall too fast for characters #this is a fucking lot #jesus christ #if you guys have any favorites in my list let me know #that would be cool to meet someone else that loves these things too #yeah #tagged #dr

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dorcasrempel · 6 years

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Restricting a key cellular nutrient could slow tumor growth

Remove tumor cells from a living organism and place them in a dish, and they will multiply even faster than before. The mystery of why this is has long stumped cancer researchers, though many have simply focused on the mutations and chains of molecular reactions that could prompt such a disparity. Now, a group of MIT researchers suggests that the growth limitations in live organisms may stem from a different source: the cell’s environment. More specifically, they found that the amino acid aspartate serves as a key nutrient needed for the “proliferation” or rapid duplication of cancer cells when oxygen is not freely available.

The biologists took cancer cells from various tissue types and engineered them to convert another, more abundant substrate into aspartate using the gene encoding an enzyme from guinea pigs. This had no effect on the cells sitting in a dish, but the same cells implanted into mice engendered tumors that grew faster than ever before. The researchers had increased the cells’ aspartate supply, and in doing so successfully sped up proliferation in a living entity.

“There hasn’t been a lot of thought into what slows tumor growth in terms of the cellular environment, including the sort of food cancer cells need,” says Matthew Vander Heiden, associate professor of biology, associate director of the Koch Institute for Integrative Cancer Research, and senior author of the study. “For instance, if you’re trying to get to a given destination and I want to slow you down, my best bet is to set up a roadblock at a place on your route where you’d experience a slow-down anyways, like a long traffic light. That’s essentially what we’re interested in here — understanding what nutrients the cell is already lacking that put the brakes on proliferation, and then further limiting those nutrients to inhibit growth even more.”

Lucas Sullivan, a postdoc in Vander Heiden’s lab, is the lead author of the study, which appeared in Nature Cell Biology on June 25.

Building the case for aspartate

Isolating a single factor that could impact tumor growth within an organism is tricky business. One potential candidate came to Sullivan via a paper he co-authored with graduate student Dan Gui in 2015, which asked a somewhat controversial question: Why is it that cells need to consume oxygen through cellular respiration in order to proliferate?

It’s a rather counter-intuitive question, because some scientific literature suggests just the opposite: Cancer cells in an organism (“in vivo”) do not enjoy the same access to oxygen as they would in a dish, and therefore don’t depend on oxygen to produce enough energy to divide. Instead, they switch to a different process, fermentation, that doesn’t require oxygen. But Sullivan and Gui noted that cancer cells do rely on oxygen for another reason: to produce aspartate as a byproduct.

Aspartate, they soon confirmed, does, in fact, play a crucial role in controlling the rate of cancer cell proliferation. In another study one year later, Sullivan and Gui noted that the antidiabetic drug metformin, known to inhibit mitochondria, slowed tumor growth and decreased aspartate levels in cells in vivo. Since mitochondria are key to cellular respiration, Sullivan reasoned that blocking their function in an already oxygen-constrained environment (the tumor) might make cancer cells vulnerable to further suppression of respiration — and aspartate — explaining why metformin seems to have such a strong effect on tumor growth.

Despite being potentially required for certain amino acids and the synthesis of all four DNA nucleotides, aspartate is already hard to come by, even in oxygen-rich environments. It’s among the lowest concentration amino acids in our blood, and has no way to enter our cells unless a rare protein transporter is present. Precisely why aspartate import is so inefficient remains an evolutionary mystery; one possibility is that its scarcity serves as a “failsafe,” preventing cells from multiplying until they have all the resources to properly do so.

Regardless, the easiest way for cells to get aspartate is not to import it from outside, but rather to make it directly inside, breaking down another amino acid called asparagine to generate it. However, there are very few known mammals that have an enzyme capable of producing aspartate from asparagine — among them, the guinea pig.

Channeling the guinea pig

In the 1950s, a researcher named John Kidd made an accidental discovery. He injected cancer-ridden rats with sera from various animals — rabbits, horses, guinea pigs, and the like — and discovered that guinea pig serum alone shrunk the rats’ tumors. It wasn’t until years later that scientists learned it was an enzyme in the guinea pig blood called guinea pig asparaginase 1 (gpASNase1) that was responsible for this antitumorigenic effect. Today, we know about a host of simpler organisms with similar enzymes, including bacteria and zebrafish. In fact, bacterial asparaginase is approved as a medicine to treat acute lymphocytic leukemia.

Because guinea pigs are mammals and thus have similar metabolisms to our own, the MIT researchers decided to use gpASNase1 to increase aspartate levels in tumors in four different tumor types and ask whether the tumors would grow faster. This was the case for three of the four types: The colon cancer cells, osteosarcoma cells, and mouse pancreatic cancer cells divided more rapidly than before, but the human pancreatic cancer cells continued to proliferate at their normal pace.

“This is a relatively small sample, but you could take this to mean that not every cell in the body is as sensitive to loss of aspartate production as others,” Sullivan says. “Acquiring aspartate may be a metabolic limitation for only a subset of cancers, since aspartate can be produced via a number of different pathways, not just through asparagine conversion.”

When the researchers tried to slow tumor growth using the antidiabetic metformin, the cells expressing gpASNase1 remained unaffected — confirming Sullivan’s prior suspicion that metformin slows tumor growth specifically by impeding cellular respiration and suppressing aspartate production.

“Our initial finding connecting metformin and proliferation was very serendipitous,” he says, “but these most recent results are a clear proof of concept. They show that decreasing aspartate levels also decreases tumor growth, at least in some tumors. The next step is to determine if there are other ways to more intentionally target aspartate synthesis in certain tissues and improve our current therapeutic approaches.”

Although the efficacy of using metformin to treat cancer remains controversial, these findings indicate that one means to target tumors would be to prevent them from accessing or producing nutrients like aspartate to make new cells.

“Although there are many limitations to cancer cell proliferation, which metabolites become limiting for tumor growth has been poorly understood,” says Kivanc Birsoy, the Chapman-Perelman Assistant Professor at Rockefeller University. “This study identifies aspartate as one such limiting metabolite, and suggests that its availability could be targeted for anti-cancer therapies.”

Birsoy is a former postdoc in professor of biology David Sabatini’s lab, who authored a paper published in the same issue of Nature Cell Biology, identifying aspartate as a major growth limitation in oxygen-deprived tumors.

“These companion papers demonstrate that some tumors in vivo are really limited by the chemical processes that require oxygen to get the aspartate they need to grow, which can affect their sensitivity to drugs like metformin,” Vander Heiden says. “We’re beginning to realize that understanding which cancer patients will respond to which treatments may be determined by factors besides genetic mutations. To really get the full picture, we need to take into account where the tumor is located, its nutrient availability, and the environment in which it lives.”

The research was funded by an NIH Pathway to Independence Award, the American Cancer Society, Ludwig Center for Molecular Oncology Fund, the National Science Foundation, a National Institutes of Health Ruth Kirschstein Fellowship, Alex’s Lemonade Stand Undergraduate Research Fellowship, Damon Runyon Cancer Research Foundation, Howard Hughes Medical Institute Faculty Scholar Award, Stand Up to Cancer, Lustgarten Foundation, Ludwig Center at MIT, the National Institutes of Health, and MIT’s Center for Precision Cancer Medicine.

Restricting a key cellular nutrient could slow tumor growth syndicated from https://osmowaterfilters.blogspot.com/

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