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reasonsforhope · 8 months

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Story from the Washington Post here, non-paywall version here.

Washington Post stop blocking linksharing and shit challenge.

"The young woman was catatonic, stuck at the nurses’ station — unmoving, unblinking and unknowing of where or who she was.

Her name was April Burrell.

Before she became a patient, April had been an outgoing, straight-A student majoring in accounting at the University of Maryland Eastern Shore. But after a traumatic event when she was 21, April suddenly developed psychosis and became lost in a constant state of visual and auditory hallucinations. The former high school valedictorian could no longer communicate, bathe or take care of herself.

April was diagnosed with a severe form of schizophrenia, an often devastating mental illness that affects approximately 1 percent of the global population and can drastically impair how patients behave and perceive reality.

“She was the first person I ever saw as a patient,” said Sander Markx, director of precision psychiatry at Columbia University, who was still a medical student in 2000 when he first encountered April. “She is, to this day, the sickest patient I’ve ever seen.” ...

It would be nearly two decades before their paths crossed again. But in 2018, another chance encounter led to several medical discoveries...

Markx and his colleagues discovered that although April’s illness was clinically indistinguishable from schizophrenia, she also had lupus, an underlying and treatable autoimmune condition that was attacking her brain.

After months of targeted treatments [for lupus] — and more than two decades trapped in her mind — April woke up.

The awakening of April — and the successful treatment of other people with similar conditions — now stand to transform care for some of psychiatry’s sickest patients, many of whom are languishing in mental institutions.

Researchers working with the New York state mental health-care system have identified about 200 patients with autoimmune diseases, some institutionalized for years, who may be helped by the discovery.

And scientists around the world, including Germany and Britain, are conducting similar research, finding that underlying autoimmune and inflammatory processes may be more common in patients with a variety of psychiatric syndromes than previously believed.

Although the current research probably will help only a small subset of patients, the impact of the work is already beginning to reshape the practice of psychiatry and the way many cases of mental illness are diagnosed and treated.

“These are the forgotten souls,” said Markx. “We’re not just improving the lives of these people, but we’re bringing them back from a place that I didn’t think they could come back from.” ...

Waking up after two decades

The medical team set to work counteracting April’s rampaging immune system and started April on an intensive immunotherapy treatment for neuropsychiatric lupus...

The regimen is grueling, requiring a month-long break between each of the six rounds to allow the immune system to recover. But April started showing signs of improvement almost immediately...

A joyful reunion

“I’ve always wanted my sister to get back to who she was,” Guy Burrell said.

In 2020, April was deemed mentally competent to discharge herself from the psychiatric hospital where she had lived for nearly two decades, and she moved to a rehabilitation center...

Because of visiting restrictions related to covid, the family’s face-to-face reunion with April was delayed until last year. April’s brother, sister-in-law and their kids were finally able to visit her at a rehabilitation center, and the occasion was tearful and joyous.

“When she came in there, you would’ve thought she was a brand-new person,” Guy Burrell said. “She knew all of us, remembered different stuff from back when she was a child.” ...

The family felt as if they’d witnessed a miracle.

“She was hugging me, she was holding my hand,” Guy Burrell said. “You might as well have thrown a parade because we were so happy, because we hadn’t seen her like that in, like, forever.”

“It was like she came home,” Markx said. “We never thought that was possible.”

...After April’s unexpected recovery, the medical team put out an alert to the hospital system to identify any patients with antibody markers for autoimmune disease. A few months later, Anca Askanase, a rheumatologist and director of the Columbia Lupus Center,who had been on April’s treatment team, approached Markx. “I think we found our girl,” she said.

Bringing back Devine

When Devine Cruz was 9, she began to hear voices. At first, the voices fought with one another. But as she grew older, the voices would talk about her, [and over the years, things got worse].

For more than a decade, the young woman moved in and out of hospitals for treatment. Her symptoms included visual and auditory hallucinations, as well as delusions that prevented her from living a normal life.

Devine was eventually diagnosed with schizoaffective disorder, which can result in symptoms of both schizophrenia and bipolar disorder. She also was diagnosed with intellectual disability.

She was on a laundry list of drugs — two antipsychotic medications, lithium, clonazepam, Ativan and benztropine — that came with a litany of side effects but didn’t resolve all her symptoms...

She also had lupus, which she had been diagnosed with when she was about 14, although doctors had never made a connection between the disease and her mental health...

Last August, the medical team prescribed monthly immunosuppressive infusions of corticosteroids and chemotherapy drugs, a regime similar to what April had been given a few years prior. By October, there were already dramatic signs of improvement.

“She was like ‘Yeah, I gotta go,’” Markx said. “‘Like, I’ve been missing out.’”

After several treatments, Devine began developing awareness that the voices in her head were different from real voices, a sign that she was reconnecting with reality. She finished her sixth and final round of infusions in January.

In March, she was well enough to meet with a reporter. “I feel like I’m already better,” Devine said during a conversation in Markx’s office at the New York State Psychiatric Institute, where she was treated. “I feel myself being a person that I was supposed to be my whole entire life.” ...

Her recovery is remarkable for several reasons, her doctors said. The voices and visions have stopped. And she no longer meets the diagnostic criteria for either schizoaffective disorder or intellectual disability, Markx said...

Today, Devine lives with her mother and is leading a more active and engaged life. She helps her mother cook, goes to the grocery store and navigates public transportation to keep her appointments. She is even babysitting her siblings’ young children — listening to music, taking them to the park or watching “Frozen 2” — responsibilities her family never would have entrusted her with before her recovery.

Expanding the search for more patients

While it is likely that only a subset of people diagnosed with schizophrenia and psychotic disorders have an underlying autoimmune condition, Markx and other doctors believe there are probably many more patients whose psychiatric conditions are caused or exacerbated by autoimmune issues...

The cases of April and Devine also helped inspire the development of the SNF Center for Precision Psychiatry and Mental Health at Columbia, which was named for the Stavros Niarchos Foundation, which awarded it a $75 million grant in April. The goal of the center is to develop new treatments based on specific genetic and autoimmune causes of psychiatric illness, said Joseph Gogos, co-director of the SNF Center.

Markx said he has begun care and treatment on about 40 patients since the SNF Center opened. The SNF Center is working with the New York State Office of Mental Health, which oversees one of the largest public mental health systems in America, to conduct whole genome sequencing and autoimmunity screening on inpatients at long-term facilities.

For “the most disabled, the sickest of the sick, even if we can help just a small fraction of them, by doing these detailed analyses, that’s worth something,�� said Thomas Smith, chief medical officer for the New York State Office of Mental Health. “You’re helping save someone’s life, get them out of the hospital, have them live in the community, go home.”

Discussions are underway to extend the search to the 20,000 outpatients in the New York state system as well. Serious psychiatric disorders, like schizophrenia, are more likely to be undertreated in underprivileged groups. And autoimmune disorders like lupus disproportionately affect women and people of color with more severity.

Changing psychiatric care

How many people ultimately will be helped by the research remains a subject of debate in the scientific community. But the research has spurred excitement about the potential to better understand what is going on in the brain during serious mental illness...

Emerging research has implicated inflammation and immunological dysfunction as potential players in a variety of neuropsychiatric conditions, including schizophrenia, depression and autism.

“It opens new treatment possibilities to patients that used to be treated very differently,” said Ludger Tebartz van Elst, a professor of psychiatry and psychotherapy at University Medical Clinic Freiburg in Germany.

In one study, published last year in Molecular Psychiatry, Tebartz van Elst and his colleagues identified 91 psychiatric patients with suspected autoimmune diseases, and reported that immunotherapies benefited the majority of them.

Belinda Lennox, head of the psychiatry department at the University of Oxford, is enrolling patients in clinical trials to test the effectiveness of immunotherapy for autoimmune psychosis patients.

As a result of the research, screenings for immunological markers in psychotic patients are already routine in Germany, where psychiatrists regularly collect samples from cerebrospinal fluid.

Markx is also doing similar screening with his patients. He believes highly sensitive and inexpensive blood tests to detect different antibodies should become part of the standard screening protocol for psychosis.

Also on the horizon: more targeted immunotherapy rather than current “sledgehammer approaches” that suppress the immune system on a broad level, said George Yancopoulos, the co-founder and president of the pharmaceutical company Regeneron.

“I think we’re at the dawn of a new era. This is just the beginning,” said Yancopoulos."

-via The Washington Post, June 1, 2023

#mental illness #schizophrenia #schizoaffective #psychotic disorders #psychology #neurology #autoimmune #autoimmine disease #neuroscience #medical news #medical research #catatonia #immunotherapy #immune system #clinical trials #good news #hope

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ccrpsorg · 1 year

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Most Common Clinical Trial Therapy Areas

2023 Top Clinical Trial Areas

Clinical trials are a fundamental part of the medical research process. They help determine the safety and effectiveness of new treatment approaches, contributing to advancements in the medical field. With an ever-growing number of clinical trials conducted worldwide each year, it's essential to identify the most impactful and relevant therapy areas being researched. This article will discuss the top five clinical trial areas that have taken center stage in 2023. We will cover the prevalence of these clinical trials, funding, and expected outcomes for each therapy area, as well as the future of clinical trials in 2023.

1. Oncology: Leading the Charge in Clinical Trials

Cancer is among the leading causes of death globally, and the need for innovative therapies has never been higher. In 2023, the oncology domain is still the most common area in clinical trial research, representing nearly 50% of clinical trials worldwide. The United States bears the majority of these trials, boasting over 25,000 active studies in oncology alone. Europe is a close second, with multiple countries working together to fund and conduct innovative cancer research.

Government agencies, pharmaceutical companies, and non-profit organizations have invested billions of dollars into cancer research. In 2023, the National Cancer Institute (NCI) in the United States received more than $6.5 billion in funding for cancer research. Many prominent clinical trials this year target hard-to-treat cancers, such as lung, breast, and pancreatic cancer, with a focus on immunotherapy, targeted therapies, and cellular therapies. The future of oncology research is bright, as advancements in technology and global collaboration continue to push the boundaries of cancer treatment.

2. Neurology: Addressing the Growing Burden of Neurological Disorders

Neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, affect millions of people worldwide. With the growing prevalence of these disorders, neurology has emerged as a leading area in clinical trial research. The United States leads the world in neurological clinical trials, followed closely by Europe and Asia.

Global funding for neurological clinical trials reached new heights in 2023, with a focus on addressing neurodegenerative conditions like Alzheimer's and Parkinson's. Public and private sectors invested heavily in this research, with organizations like the National Institutes of Health (NIH) allocating over $3 billion to neurological clinical trials in 2023. The outcomes of these trials aim to slow down, prevent, or cure neurological diseases, and hope to improve overall quality of life for affected individuals.

3. Infectious Diseases: Tackling Emerging and Reemerging Pathogens

The COVID-19 pandemic has underscored the importance of research and preparedness in combating infectious diseases. In response to this global challenge, the field has seen significant growth in clinical trials focused on infectious diseases. Research funding for these trials has boasted increased support worldwide, with both public and private sectors contributing to the development of novel vaccines and treatments.

In 2023, clinical trials in infectious diseases tackled novel pathogens, as well as reemerged diseases like tuberculosis and malaria. The World Health Organization (WHO) played a significant role in funding and initiating these trials, collaborating with governments and pharmaceutical companies to ensure rapid response and treatment development. The outcomes of these trials will contribute to global health security and preparedness for future pandemics and disease outbreaks.

4. Cardiology: Addressing the Global Burden of Cardiovascular Disease

Cardiovascular disease (CVD) is a leading cause of death worldwide, with almost 18 million annual fatalities. In 2023, cardiology clinical trials aimed to improve prevention, diagnosis, and treatment of CVD, encompassing areas such as heart failure, coronary artery disease, and hypertension.

Globally, funding for cardiology research came from government agencies, non-profit organizations, and pharmaceutical companies. The United States, Europe, and several Asian countries allocated substantial resources to support these clinical trials. The anticipated outcomes of these trials will emphasize personalized and precision medicine approaches in cardiovascular healthcare and ultimately reduce the burden of CVD around the world.

5. Rare Diseases: Advancing Treatment for Orphan Disorders

In recent years, the focus on rare diseases has grown significantly, resulting in more clinical trials aimed at developing treatments for orphan disorders affecting less than 200,000 individuals in the United States. Developing therapies for rare diseases is often financially challenging due to the small patient populations. However, regulatory incentives and growing public awareness have resulted in an increase in funding and clinical trials in this area.

Rare disease clinical trials are prevalent in both the United States and Europe, with a focus on gene therapy, enzyme replacement therapy, and targeted treatments. Public health agencies

Oncology: One of the most common clinical trials by therapy area is oncology, which involves testing medications and treatments with the goal of helping to improve patient outcomes when dealing with various types of cancer. Examples of these clinical trials include those that seek to determine the efficacy of new drugs in treating particular forms of cancer, or researching novel therapeutic approaches such as immunotherapy.

Cardiovascular Disease: Clinical trials related to cardiovascular disease are also quite common. These tests may involve assessing the effectiveness of new medications that can help lower blood pressure or improve cardiac function, as well as examining lifestyle interventions such as diet and exercise for their potential to reduce risk factors associated with heart disease.

Diabetes: Clinical trials related to diabetes are also a frequent occurrence due to its prevalence in many parts of the world. These studies often aim to understand how better management strategies for diabetes can improve quality of life for patients and reduce long-term complications associated with this condition.

Neurology: Clinical trials pertaining to neurology are commonplace in research settings because there is still much unknown about how the brain and nervous system work, as well as treatment effectiveness for conditions like epilepsy, Parkinson’s disease, multiple sclerosis, and stroke recovery.

Mental Health: Mental health-related clinical trials are becoming increasingly more common as researchers continue to investigate and develop better treatments for depression, anxiety disorders, bipolar disorder, schizophrenia, PTSD, addiction and other issues related to mental health and wellbeing.

Respiratory Disease: Clinical trials involving respiratory diseases, such as asthma or chronic obstructive pulmonary disease (COPD), have become more commonplace in recent years due to their rising prevalence throughout the world; they typically involve testing new medications or therapies that can help manage symptoms and reduce exacerbations associated with these conditions.

Immunology: Immunology-focused clinical research has become more popular over recent years due to its potential implications for developing treatments for autoimmune diseases like rheumatoid arthritis or lupus; these clinical trials often involve testing existing medications or creating new ones from scratch in order to achieve desired results regarding immune system regulation within individuals living with autoimmune conditions .

Gastroenterology: Gastroenterological clinical research is commonplace due primarily to its relevance within digestive disorders such as Crohn’s Disease or Irritable Bowel Syndrome (IBS). Research conducted in this area generally seeks to gain an understanding into how certain dietary changes or drug treatments might be effective at managing symptoms associated with gastrointestinal problems while reducing side effects associated with traditional pharmacological approaches .

Endocrinology: Endocrinological clinical research is yet another form of study found in medical circles due primarily via its relevance within hormone-related issues such as diabetes mellitus type 1 & 2; this type of study typically involves testing ways in which different hormones might interact differently between individuals who have similar conditions but don't respond positively/negatively the same way when it comes to traditional forms of treatment .

Ophthalmology: Last but not least is ophthalmology which looks at vision disorders like glaucoma and age related macular degeneration (AMD); here researchers test existing medications/treatments looking for improvement when it comes both short term relief from eye pain/blurring but also long term protection against further loss/damage occurring over time via regular monitoring sessions

Learn more about clinical trials and become involved in management of clinical trials through further training with CCRPS.

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eretzyisrael · 5 months

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Good News From Israel

Israel's Good News Newsletter to 17th Dec 23

In the 17th Dec 23 edition of Israel’s good news, the highlights include:

Two emotional family reunions during the war.

Two breakthroughs that help us understand how our brains work.

The world’s first approved laser cure for glaucoma.

Two typical examples of the IDF showing compassion, even in war.

Israelis are making the world’s most powerful telescope and miniature cameras.

Two private initiatives to regenerate Gaza border agricultural communities.

A national Torah scroll is being written to immortalize victims of Oct 7.

So many positive news articles last week focused on regenerating life for individuals, communities and in other areas. Medical regeneration involved rehabilitating wounded IDF personnel; reuniting separated families; two Israeli therapies for regenerating the lives of traumatized children, and another that generates companionship for the elderly. Israelis are able to generate thousands of clinical trial simulations, regenerate eye functionality in glaucoma patients, and can show how dormant bacteria regenerates. An Israeli female Israeli professor is responsible for generating three startups including one that regenerates spinal cords. And an Israeli IDF reservist donated her bone marrow to regenerate a patient's immune system. Read about the The volunteers and organizations that have been regenerating neglected farms in Israel's south; and the food rescue startup that has been regenerated after shutdown during the Covid pandemic. Israel is 3rd in the world for Generative AI startups (see newsletter for details) and one startup even generates responses to hate speech. Other Israeli startups regenerate machinery at risk of breaking down and recharge electric buses wirelessly. Many startups have relocated to safer areas in Israel and begun regenerating their businesses with increased productivity. Finally, a combined religious and secular project to write Torah scrolls is regenerating the spiritual unity of the Jewish State. The photo is of Hanukkah celebrations in Herzliya, which regenerated a much needed happy diversion among children and adults alike.

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voiceactresskurutta · 13 days

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me: hi i need a good referral to some sort of mental health specialist to get proper diagnoses for these specific potential issues. i've put this off for a long time because i have a hard time making decisions, struggle with communication/contacting professionals, and have a hard time trusting medical personnel without a good reference my pcp: here's a list of several dozen providers i printed out that include a lot of ones you don't quality for and don't specialize in what you asked about, it's just a massive print out of all our resources me: wow this is worthless to me

#this was several weeks ago and i have not worked up the courage to call any of them #personal #venting #i got a pcp awhile back because i desperately needed med refills #and the free clinic won't see me anymore since i got medicaid #the people in my city were all either not taking new patients or booked out for months #the lady i saw though had so many red flags i really don't want to see her again #but since it's medicaid every time i switch a pcp i need to call them and have it officially changed #and they have to send me a new card #it's such a hassle #it's so hard to go through the trial and error process of finding a good provider #genuinely had a terrible time talking to that woman and want to avoid her like the plague #i miss my old provider in my old state even though i never liked living in that state

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bgniusnews · 2 years

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#cancer medicine #Cancer Drug Trial #cancer clinical trials #health #awareness week #tumblr #tumblog #latest news #skin care tips #drug cure news 2022 #bgnius news

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airxiem · 8 days

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As if I had enough of a reason to have to frequently check information about what kind of PTSD I have.

Post pandemic stress disorder is still a thing at least online and there's dissociative PTSD. I'm just in a triangle of checking in and out against my will and sometimes I feel like I'm just as 2 dimensional as a piece of paper. Then, I can't remember hardly anything about my personality before covid. I can't even connect with the memories. I mean, if there were like studies being done on this stuff I wouldn't be sitting here annoyed. I looked and there's like 2 in United States. I can't even go sit somewhere and let them pome at me and get paid for it.

#ptsd #cptsd #dissociative ptsd #pist pandemic stress disorder #ppsd #just give me a new brain #idgaf #clinical trials #studies

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chemxpert · 1 month

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Essence of Drug Master Files (DMF) in Pharmaceutical Industry

In the vast realm of pharmaceuticals, ensuring safety, efficacy, and compliance is paramount. Among the many regulatory requirements, the drug master file (DMF) stands as a cornerstone for facilitating the smooth approval process of pharmaceutical products. This comprehensive guide delves into the intricacies of DMFs, exploring their significance, types, and relevance in the pharmaceutical landscape.

#new rules for clinical trials in India #top 10 pharmaceutical companies #biggest pharmaceutical companies #types of data in pharmaceutical industry #pharmaceutical company datasets #pharmaceutical product development

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marketresercher · 2 months

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Clinical Trial Management System (CTMS) Market Share, Size 2024 Movements by Analysis, Progression Status, Revenue Expectation to 2030

****Everything You Need to Know About Clinical Trial Management System (CTMS) everything is Here....!

The Comprehensive study on Clinical Trial Management System (CTMS) Market includes historical data as well as share, size, and projection information for the major players, geographies, applications, and product categories for the years 2024 to 2030. The Market study includes comprehensive insights on the competitive environment, description, broad product portfolio of key players, SWOT analysis, and significant business strategy implemented by rivals, revenue, Porters Five Forces Analysis, and sales projections. The report also features an impact analysis of the market dynamics, highlighting the factors currently driving and limiting market growth, and the impact they could have on the short, medium, and long-term outlook. The main goal of the paper is to further illustrate how the latest scenario, the economic slowdown, and war events affect the market for Clinical Trial Management System (CTMS).

Clinical Trial Management System (CTMS) Market is growing at a +14.7% CAGR during the forecast period 2024-2030. The increasing interest of the individuals in this industry is that the major reason for the expansion of this market.

The Top Key Players profiled in the report:

Oracle, Medidata Solutions, Parexel International Corporation, IBM, Bioclinica, Bio-Optronics, Datatrak International, Veeva Systems, Mastercontrol, DSG, ERT, Advarra Technology Solutions, Mednet Solutions, Arisglobal, DZS Clinical Services (WDB Holdings Co. Ltd) and others.

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Clinical Trial Management System (CTMS) Market Segmentation:

Clinical Trial Management System Market by Product, 2020-2029, (USD Million)

Software

Services

Clinical Trial Management System Market by Delivery, 2020-2029, (USD Million)

Web-Based (On-Demand)

Licensed Enterprise (On-Premises)

Cloud-Based (SAAS)

Clinical Trial Management System Market by Deployment, 2020-2029, (USD Million)

Enterprise-Wide CTMS

On-Site CTMS

Clinical Trial Management System Market by End User, 2020-2029, (USD Million)

Large Pharma-Biotech Companies

CROS

Medical Device Manufacturers

Small & Mid-Sized Pharma-Biotech Companies

Other End Users

Based on geography, the global market for Clinical Trial Management System (CTMS) and Disruptions has been segmented as follows:

North America (United States, Canada, Mexico)

South America (Brazil, Argentina, Ecuador, Chile)

Asia Pacific (China, Japan, India, Korea)

Europe (Germany, UK, France, Italy)

Middle East Africa (Egypt, Turkey, Saudi Arabia, Iran) and more.

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To study and analyze the global market size (value & volume) by company, key regions/countries, products and application, history data, and forecast to 2030.

To understand the structure of market by identifying its various sub segments.

To share detailed information about the key factors influencing the growth of the market (growth potential, opportunities, drivers, industry-specific challenges and risks).

Focuses on the key global manufacturers, to define, describe and analyze the sales volume, value, market share, market competition landscape, SWOT analysis and development plans in next few years.

To analyze the growth trends, future prospects, and their contribution to the total market.

To project the value and volume of submarkets, with respect to key regions (along with their respective key countries).

To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market.

To strategically profile the key players and comprehensively analyze their growth strategies.

The report provides insights on the following pointers:

Market Penetration: Comprehensive information on the product portfolios of the top players in the Clinical Trial Management System (CTMS)

Product Development/Innovation: Detailed insights on the upcoming technologies, R&D activities, and product launches in the market.

Competitive Assessment: In-depth assessment of the Clinical Trial Management System (CTMS) market strategies, geographic and business segments of the leading players in the market.

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Market Diversification: Exhaustive information about new products, untapped geographies, recent developments, and investments in the Clinical Trial Management System (CTMS)

Take a look at the full report with detailed TOC here:

Some of the key questions scrutinized in the study are:

Which companies are expanding litanies of products with the aim to diversify product portfolio?

Which companies have drifted away from their core competencies and how have those impacted the strategic landscape of the Clinical Trial Management System (CTMS) market?

Which companies have expanded their horizons by engaging in long-term societal considerations?

Which firms have bucked the pandemic trend and what frameworks they adopted to stay resilient?

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louderfade · 5 months

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PAY NO ATTENTION TO THE FINE PRINT THAT'S ACTUALLY JUST FOR DECORATION AND IT'S ALL REALLY BORING WE SWEAR

is your job performance suffering due to a persistent desire to lead a fulfilling life? the friendly pharmaceutical companies have developed a solution which they have generously made available for purchase. here watch this drug advertisement we worked so hard on. it shows people free of pain enjoying their day at the office. these are actual patients we cured, not paid actors. questioning this or any statement indicates affiliation with political extremism on both sides and means you're probably a terrorist. maybe even a double terrorist. besides, knowledge is a burden, wouldn't you rather just trust us, the way you do with your health? you should ask your doctor if workmoronal is right for you. workmoronal treats all symptoms related to resistance and/or defense of personal freedoms and can reduce your sense of having a soul in under two weeks. get back to being a productive employee with workmoronal from johnson and johnson. a family company. but not your family. you don't really see them anymore. and you're fine with that. really. by now you're generally ok with whatever the boss decides. another full recovery made possible by workmoronal.

it's really wonderful the way science is helping people lead better lives every day. not people like you though. people like the guy who owns johnson and johnson. who remembers what his family looks like. but he worked hard. he earned what he has. his collection of bank notes proves that he's a better person than you, and this moral superiority has kept him healthy. he didn't need a doctor's help to be a Valuable and Productive Employee. you, however, require a treatment regimen of workmoronal. also you've been asking too many questions and the doctor has diagnosed you with chronic curiosity, which, without treatment, can be fatal (for someone much more important than you). so you've been prescribed two capsules of acceptall, to be taken with booze. this should help slow down your higher brain and reduce symptoms of critical thinking. you may return to work tomorrow. in fact you have to or you'll starve in the street. if you would prefer to use a suicide booth at this time, please see the reception staff to schedule an appointment. patients who miss their appointments will be charged a fee they can't afford. this reflects a society that values keeping one's word. otherwise people might find you unreliable. and that doesn't look very good on a resume.

it would seem that the severity of your case demands a higher level of care. may we suggest our outpatient treatment program to correct confusion surrounding life's purpose? it's the doctor's opinion that you're a good candidate for priority readjustment therapy. this is highly effective and a great opportunity for you. well, no it won't bring you any peace or reduce the psychic impact of the horrors, and it doesn't actually help you feel better in any noticeable way. but we're healthcare providers. that's not what we do here. we are however proud to offer a wide array of pill-shaped solutions to problems. well, not your problems. once again, we refer to the problems of the johnson and johnson guy who gets to see his family. and one of his problems is you. specifically what remains of your humanity and the stubborn way in which you cling to it. workmoronal will make you forget about all that. we have pills that can gut you from the inside and lobotomize you irrevocably until you no longer suffer or despair. you will no longer know love or joy either, but it won't take you long to be desperate enough not to care. they'll make real life so miserable you'll line up to have the spark of your spirit chemically extinguished. you might even be grateful for it. almost everyone is eventually grateful for it. but don't be too hard on yourself. you're only the picked-clean ghostbones of a human, after all. you were such a cooperative patient that even the scavengers got their fill. and everyone has already eaten by the time you realize they never set a place for you at their table. for those born to your station, there are only two options at every meal: you're either the servant or you're what's being served.

#cue greater omaha by desaparecidos lol but no really do it that song rocks #workmoronal is my new favorite joke #i'm finding every opportunity to use it irl and now my friends are saying it #in a clinical trial workmoronal produced a 20 percent increase in willingness to remain a slave #and showed a marked increase in indifference toward trading one's single life on earth away to benefit rich strangers #this unsavory advertisement has been brought to you by the company that owns all the drug companies #(makers of workmoronal: the only cure for creeping feelings that there must be more to life than this dear god please let there be more)#late stage capitalism #take your productivity pills and charge your surveillance state cell phone #the future is worse #text

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reasonsforhope · 1 year

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“British scientists have grown human red blood cells in a lab for the first time, and conducted a clinical trial to give it to patients.

The blood is grown by encouraging stem cells found in a blood donor’s sample to become new red blood cells, and opens the door to transfusion treatments for those with ultra-rare blood types.

For the near total majority of blood transfusions, British hospitals will still rely on people rolling up their sleeves and donating. This is, and will remain the case for, A, B, O, and AB blood types.

But what if a patient needs a blood transfusion of the “Bombay” blood group? It’s a tough call, as the British NIH knows of three people in the whole of the UK with this ultra-rare blood type.

Certain diseases, such as sickle-cell anemia, require regular blood transfusions, and if this patient were to also have the Bombay blood type, or “Jka-b-” or “Rh-null” also called “golden blood,” or “SARA” type after the first person it was discovered in, they are in serious danger...

“This world-leading research lays the groundwork for the manufacture of red blood cells that can safely be used to transfuse people with disorders like sickle cell,” said Dr. Farrukh Shah, the medical director of transfusion at NHS Blood and Transplant.” -via Good News Network, 11/16/22

#blood #medical research #medical science #blood type #sickle cell disease #good news #hope #clinical trials

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dueranconsultancy · 7 months

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Licence For Fixed Dose Combination- Dueranconsultancy

If you are planning to obtain an FDC licence for your fixed dose combination drug in India, Dueran Consultancy is the best choice to help you succeed. Contact us today

#Investigational new drugs #New Drugs Clinical Trials #drug license certificate #central drugs standard control organization #subsequent new drug license

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headlinehorizon · 8 months

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Revolutionary AI-Designed Drug Enters Clinical Trials: Latest News

A groundbreaking new AI-designed drug for COVID-19 has entered Phase I clinical trials, offering hope for an effective treatment against the disease. Stay updated with the latest news on headline horizon.

#headline horizon #news #latest news #AI-designed drug #COVID-19 treatment #clinical trials

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afeelgoodblog · 4 months

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The Best News of Last Year - 2023 Edition

Welcome to our special edition newsletter recapping the best news from the past year. I've picked one highlight from each month to give you a snapshot of 2023. No frills, just straightforward news that mattered. Let's relive the good stuff that made our year shine.

January - London: Girl with incurable cancer recovers after pioneering treatment

A girl’s incurable cancer has been cleared from her body after what scientists have described as the most sophisticated cell engineering to date.

2. February - Utah legislature unanimously passes ban on LGBTQ conversion therapy

The Utah State Legislature has unanimously approved a bill that enshrines into law a ban on LGBTQ conversion therapy.

3. March - First vaccine for honeybees could save billions

The United States Department of Agriculture (USDA) has approved the world’s first-ever vaccine intended to address the global decline of honeybees. It will help protect honeybees from American foulbrood, a contagious bacterial disease which can destroy entire colonies.

4. April - Fungi discovered that can eat plastic in just 140 days

Australian scientists have successfully used backyard mould to break down one of the world's most stubborn plastics — a discovery they hope could ease the burden of the global recycling crisis within years. 

5. May - Ocean Cleanup removes 200,000th kilogram of plastic from the Pacific Ocean

The Dutch offshore restoration project, Ocean Cleanup, says it has reached a milestone. The organization's plastic catching efforts have now fished more than 200,000 kilograms of plastic out of the Pacific Ocean, Ocean Cleanup said on Twitter.

6. June - U.S. judge blocks Florida ban on care for trans minors in narrow ruling, says ‘gender identity is real’

A federal judge temporarily blocked portions of a new Florida law that bans transgender minors from receiving puberty blockers, ruling Tuesday that the state has no rational basis for denying patients treatment.

7. July - World’s largest Phosphate deposit discovered in Norway

A massive underground deposit of high-grade phosphate rock in Norway, pitched as the world’s largest, is big enough to satisfy world demand for fertilisers, solar panels and electric car batteries over the next 50 years, according to the company exploiting the resource.

8. August - Successful room temperature ambient-pressure magnetic levitation of LK-99

If the claim by Sukbae Lee and Ji-Hoon Kim of South Korea’s Quantum Energy Research Centre holds up, the material could usher in all sorts of technological marvels, such as levitating vehicles and perfectly efficient electrical grids.

9. September - World’s 1st drug to regrow teeth enters clinical trials

The ability to regrow your own teeth could be just around the corner. A team of scientists, led by a Japanese pharmaceutical startup, are getting set to start human trials on a new drug that has successfully grown new teeth in animal test subjects.

10. October - Nobel Prize goes to scientists behind mRNA Covid vaccines

The Nobel Prize in Physiology or Medicine has been awarded to a pair of scientists who developed the technology that led to the mRNA Covid vaccines. Professors Katalin Kariko and Drew Weissman will share the prize.

11. November - No cases of cancer caused by HPV in Norwegian 25-year olds, the first cohort to be mass vaccinated for HPV.

Last year there were zero cases of cervical cancer in the group that was vaccinated in 2009 against the HPV virus, which can cause the cancer in women.

12. December - President Biden announces he’s pardoning all convictions of federal marijuana possession

President Joe Biden announced Friday he's issuing a federal pardon to every American who has used marijuana in the past, including those who were never arrested or prosecuted.

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And there you have it – a year's worth of uplifting news! I hope these positive stories brought a bit of joy to your inbox. As I wrap up this special edition, I want to thank all my supporters!

Buy me a coffee ❤️

Merry Christmas and Happy New Year!

#best news of last week

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