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#cell cycle stages
microscopiaiwm · 4 months
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MITOSIS- its Occurrence, Stages and Significance.
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                                        INTRODUCTION: Mitosis is a type of cell division that takes place in living organisms and it is commonly defined as the process of duplication of chromosomes in eukaryotic cells and distributed during cell division.  The process where a single cell divides resulting in two identical cells, each resulted cell contains the same number of chromosomes and…
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ihateitheretaylor · 3 months
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My legs felt like jelly after i rode bicycle for like 20-25 mins, and then my periods arrived. WHY DO PERIODS EVEN EXIST, i know its important , but the first day of mensuration is fricking fricking painful. ugh anyways, pls tell me i should be motivated enough, for my 5'1 52 kg body to continue cycling🙂
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mayuris-posts · 2 years
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#In fact#the success and Cost of the IVF cycle depends upon this.#Congratulations are due as you have crossed the 1st milestone - the fertilization or fusion of healthy eggs harvested from the woman with s#In the course of the natural fertilization process#when the embryo is formed within the body#changes occur inside the uterus as it prepares itself to accept the embryo and subsequently offer it nutrition. This seemingly simple proce#During the IVF cycle#this complex process is carried out by the embryologist in the IVF laboratory. This entire process needs to be monitored while creating co#Between 24 and 30 hours after fertilization (Day 1)#the embryo gets divided into 2 cells. By Day 2 the embryo is 4 cells and by the third day#the embryo is a 6-8 celled structure.#On the 4th day#the embryo cells are now fused#within 16-32 cell structures. This structure is now called a morula#which is a fast developing stage.#On day 5 of the embryo#the cells are specialized and carry out necessary functioning. The outer surface of the morula is the placenta in making & fluid secretions#Now#the real challenge is surviving and growing during the next 48 hrs. (day 3 to 5). The not-so-competent embryos will not survive this stage#implantation will occur only if the embryo reaches the day 5 stage.#The IVF center has the option of transferring on Day 3#hoping that the natural environment within the womb will take it to day 5 and enable implantation to occur.#However#this is taking a risk at the patient's expense. If#after a day 3 transfer an innately deficient embryo does not survive to grow to day 5#the transfer is bound to fail.#At Pearl Women’s Hospital#we do only day 5 transfers. In short#we transfer only when we are confident that the embryo is good enough to have grown up to day 5#increasing the chances of successful implantation.
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animalshowdown · 1 month
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Phylum Round 3
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Annelida: Segmented Worms. This group includes earthworms, leeches, and many classes under the umbrella of “polychaete”. This diverse phylum encompasses deposit feeders (eating dirt), detritivores, scavengers, deadly ambush predators, filter feeders, parasites, herbivores, and more. They are broadly defined by their repeating body segments and parapodia, which are nubby appendages used for both movement and breathing. Some have curved jaws for catching prey or scraping detritus off of rocks, while others have wide, elaborate, brightly colored feather-like fans for filter feeding. While able to crawl freely, a majority of marine Annelids spend most of their time in self-built tubes or burrows. Among their many important functions, they play a key role in mixing soil/sediment, breaking down decaying organic matter, and providing a key food source to countless other animals.
Cnidaria: Jellyfish, anemones, corals, box jellies, and hydroids. They have a gelatinous body with radial symmetry, a decentralized nervous system, and tentacles surrounding a simple mouth. The defining feature of this phylum are their cnidocytes, or stinging cells. There are two different body plans of the Cnidaria; an immobile “polyp” attached to a surface, or a free-living “medusa” which can swim or drift in the water column. Many polyp Cnidarians, such as corals, live in colonies. Some corals build reefs which serve as habitat for other animals. Free-living medusa Cnidarians must return to the seafloor in a polyp-like stage as a part of their life cycle.
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gayconstruct · 3 months
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Humans are Weird — Fever
We literally heat up to cook our bodies when we can't ward off things with our immune cells, and there's a VERY slim margin for what's healthy vs what's not. If you'd like to skip the context portion scroll down to the second set of emdashes
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For some quick context, I use some consistent concepts and variations of time words under the impression there's a unified, simplified time scale in an intergalactic universal community
Shifts are 10 hours with hour lunches
There's 3 parts to every species day — Work, Relax, and Sleep — all 10 hours
Diurnal aliens including most humans are working in the mornings, relaxing in the evenings, and sleeping at night
Crepuscular aliens are working in the evenings, relaxing at night, sleeping in the morning
And Nocturnal aliens are working at night, relaxing in the morning, and sleeping in the evening
The clock is from 01:00 — 30:00 (simple 30 hour days for an even number and more leisure time) and rolls over to 01:00 from 30:59 with 01:00 being the roll over from night to morning
Time Increments
Seconds = Instants
Minutes = Moments
Hours = Periods
Days = Cycles
Weeks = Phases
Months = Stages
and Years = Terms
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Temperature Rising
Diverse biomes and work sectors began to stir to life, as the many species stationed upon the Integrated Vessel Ro’Vanna responded to the coming shift change. The Universal Timepiece, standard across the known universe, finally struck 0100 Cycles, the nocturnal species like the Umborra and Nostro eager to spend their recreational hours peacefully, while Diurnal species like the Shal’Dorei and newly integrated Humans were waking to begin another productive morning. 
Qin, the most well known Troqir aboard and one of its select Charters, rushed to his station in the hub of the Astrometry Center, cranial crests flaring with an eagerness that to most of his crewmates would otherwise go unnoticed. Ready to start his shift as soon as his posterior hit the chair, the rather tall and muscular humanoid gracelessly plopped down, emitting quite the noise as he got started. Other species present had their full attention focused on their tasking at hand, not a single thought or care thrown to his quite hasty entrance to his station. Several crystalline scales in the crook of his neck iridesced at the thought of his companion joining him soon, his thoughts anywhere but the latest mapping data coming up on his Virtual HUD. Time passed quickly at first, the sturdy man pointing metallic fingers to different notifications that needed immediate attention, adjusting calculations to chart the next few thousand Cargo routes as he went. After roughly 14.5 moments, though, he turned to search for his oddly quiet coworker to notice that the Human had made no attempt to join him this morning, the thought causing a darker color to glisten across his crystal scaling.
He’s late.
Why is he late?
He specifically stated last night he’d “see me soon.”
He’s never this late.
For the first time in his life, Qin was completely out of focus. Several happy-go-lucky phases — human parlance, not his own — had enveloped him, exchanging his stark Troqir logicality for Human whimsy and curiosity. His work tempo was slower and uncoordinated, an unfamiliar feeling coalescing into the turbulent color shifts across his luminescent scales. Every instant that passed on the cargo vessel's timekeeper seemed to lurch at an uneven pace, a deepening pit forming at the base of his abdomen. For four and a half painstaking periods, Qin swallowed his personal thoughts to gain some form of traction on his workload, swallowing emotion as all of his people were taught and opting for diligent productivity, until - finally - the release of his allotted Nutrition Period arrived. There was no moment spared as his dense footfalls rushed towards his companions quarters, his focus unbroken as the ceiling dropped from 4 meters to a much tighter 2.4m. Qin, at just under 2.2 meters, absentmindedly ducked to overcompensate, having quickly become accustomed to this section and its many distinctions after quite a few visits. 
There at last, the tall, silvery man reached what was worth looking for, a door which read in standard human language,
Room 152
Aspen Wright
With the slightest shake in his hand, Qin formed his digits into a fist to knock. 
Knocking… he thought, quite the odd custom, but like many human practices, this was the most respectful of his companion’s personal space and time. For several instants, the silence in the Human Sector’s Hall allowed him no sweet mercy, the lone alien man uncertain what to do as his weight shifted back and forth between his feet, a metal clang ringing out with each motion. Thankfully, a digital projection finally slid across the width of the door, Entry Permitted, displayed in large English typeface.
Thank the Fathers and Mothers for universal translation.
With the invitation obvious and a rather low duck through the smaller door, Qin entered into the darkened room — the simulated window turned off, the curtains drawn, clothes strewn across the floor, and strange devices and pill capsules laid upon the table — not even the so-called “fairy lights” lit the quarters he had become so accustomed to. The Troqirian’s own voice came quieter than he expected, as he rasped out, “Aspen? Are you there?” A strange groan followed, then silence, then- a weary voice.
“Q-,” a cough, “Qin?”
“Y-yes… it is I, I am present,” a facepalm.
“Oh, this is a-” more coughing, “a surprise. Aren’t you on Lunch Break sweetie?”
For a moment, the light from Qin’s Luminescent Scales - ones at his nape, a few at his crests, even the ones on his exposed digits - shined brighter than before, a rainbow of colors flowing across their surface at the thought of being a “sweetie”, before taking a dim, solemn purple. “I- yes, but when you did not show up promptly 15 moments late after last night's recreation I- I began to worry. Lateness? Normal to an extent. Absence??? Abnormal, even for you… Did I… do something wrong? Did our meetings and leisure time make work uncomfortable for you?”
For his first time that entire cycle, Aspen bolted upright with a purpose, but immediately regretted it as a wave of dizziness caused the room to spin around him before he fell the wrong direction, right out of his bed into the floor.
The sight startled Qin, having no frame of reference where the human man was until now, “Fathers and Mothers! Aspen, are you injured!?”
With a weak chuckle and the groan of even more pain, he responded in turn, “I’m fine, I’m fine… I’m sorry to worry you, you never make me uncomfortable dear, I’m just a bit [under the weather] today.” Another small laugh came, and then he continued, “I was trying to tell you that, and I- I must’ve moved too fast… everything is- ugh everything is spinning. Could you help me back into bed?”
Frantic to assist, Qin’s larger form - clumsy in the smaller space, helped lie the smaller, lighter human in his nest, placing his head upon the pillow. Once situated, he covered the small man, as many human’s liked, and noticed his skin far hotter to the touch than normal, homeostatic balance oddly off. “Damn translator…” a joyous light crossing his scales as he used the human swear as he’d been taught, “for whatever reason the English to Troqirian dictionary hasn’t found a suitable translation for your imprecise speech… Could you please explain?”
“Ah, thank you for the lift, love.” Settling for an instant, eyes closed and his head on the pillow, Aspen pondered with a clouded, slow mind, trying to search for the words as his body ached and caught a chill. “... uh- an English idiom of common use in my native tongue… it’s like… to feel sick, to be unwell. I didn’t go to my work shift today because I’m too sick to go… I’m- I’m sorry I didn’t contact you to say something, this fever is really kicking my ass.”
Fever? What in the Cradles was a Fever? 
“Ah… Fever- yes. Hmm, and that is… The translator states you have an elevated temperature? You were hot to the touch, hot because you’re currently ill, or ‘under the weather’ as it were?” Pondering his line of thinking, Qin couldn’t help but attempt to puzzle it together, his evolved logic center placing presented data together to reach understanding. 
Why is his temperature so elevated? He… he’s too hot… His temperature felt at least 311.8°K through my temperature cells… Humans are on average 310.2°K and their species exhibits signs of death at temperatures of 315°K or more… Fathers and Mothers that’s far too close. That is far too close.
Startling Aspen’s tired eyes open, the large metallic man started in with question after question, “How are you okay? You were perfectly normal yesterday. You’re temperature is far too elevated! Are you dying? Do you need emergency services? I can call the Human Physician on board! I can, I can, I-”
“Stop. It is gonna be okay. This- uh this is a normal human response to various pathogens our immune system is unable to combat with its defense cells, so we get hotter and hotter to try to kill the invader before it can do too much damage. I’ve already spoken to the captain and the doctor and I was given some things to bolster my strength while I attempt to naturally ride out my fever. It’s gonna be okay Qin, I’m gonna be okay. The fever just has to kill the pathogen and it’ll break on its own.”
For several quiet moments Qin sat in disbelief at such a process. Actively breaking their delicate homeostasis for an illness? Their specialized cells unable to do it on their own??? He found himself running his digits through his smaller companions' hair as he pondered. He looked so weak, so small, so… precious. 
Breaking the deathly silence with a few coughs, Aspen shuddered from his fever chills, squinting to the light of Qin’s scales before smiling to himself, “I can see your scared glow through my eyelids, Qin, I promise I’m okay… though the comforting touch is nice.”
“Well your eyelids are thin layers containing Keratin and Collagen, it's a miracle your species is alive…”
A laugh, somewhat stronger this time, escaped Aspen’s lips as he smiled again, “And yours have thick metallic plates and the most beautiful glowing scales I’ve ever seen. What about it?”
A hot reddish-pink overtook the Troqir’s luminescent features as he realized what power the smaller man held over him. The power to care. The power to worry. The power to be emotionally honest, something found few and far between his own people. 
The power to be bold.
“Th-they’re beautiful, you… are beautiful, Aspen… I’m sorry I haven’t said it sooner. You always try to make advances on me, and I always try to deflect them with feigned ignorance.”
Slowly, the small human man scooted to leave some room next to himself in the bed, the blanket moving and leaving him even colder than he already was, “Please… could you stay with me a while longer… could you… could you cuddle me to keep me warm?”
The pink glow wouldn’t cease for some time, as the giant of a man laid down on the small bed and wrapped his warm silvery arms around his companion, a small humming noise coming from deep in his throat like a pur. Aspen snuggled close to stifle his chills, overjoyed to know his feelings were reciprocated. Feeling the radiant heat from his alien partner, he drifted into peaceful sleep for the first time that awful sick day.
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dougdimmadodo · 4 months
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Lion's Mane Jellyfish (Cyanea capillata)
Family: Cyaneid Jellyfish Family (Cyaneidae)
IUCN Conservation Status: Unassessed
Named for its frilly "mane" made up of over 1,200 long, stinging tentacles, the Lion's Mane Jellyfish is among the largest known jellyfish species; while this viral image showing a diver next to a Lion's Mane Jellyfish has been edited to make the jellyfish appear far larger than it actually is, members of this species still dwarf most of their relatives, with a bell ("main body") diameter of over 2.4 meters (7.89 feet) and a tentacle length of as much as 30 meters (98.4 feet), making it one the longest animals on earth. Typically found near the surface in the Arctic, northern Atlantic and northern Pacific Ocean regions, Lion's Mane Jellyfishes, like all jellyfishes, lack brains, eyes, hearts or respiratory organs (instead exchanging gasses directly between the water around them and their extremely thin tissues,) and rely heavily on waves and ocean tides to travel, but are able to slowly propel themselves in a given direction by expanding the 8 bag-like lobes of their bodies to take in water and then forcing it out again to push themselves along (although they can also to some extent detect and react to their orientation and surroundings owing to a series of frilly sensory structures located around their body's rim, know as rhopalia.) Like most jellyfishes the long, trailing tentacles of a Lion's Mane Jellyfish are lined with touch-sensitive, harpoon-like cells called cnidocytes that fire venomous barbs into any animal that touches them, and after a tentacle has stung and ensnared suitable prey (mainly fish, large plankton and smaller jellyfishes) it is pulled back towards the body where the prey is passed through a mouth-like opening on the jellyfish's underside and into a simple body cavity where it is digested, with any indigestible matter, such as shells or bones, later being ejected from the body through the same opening it entered through. The life cycle of the Lion's Mane Jellyfish, like that of most jellyfishes, takes place in 4 distinct stages and seems highly elaborate compared to that of most animals; the bag-like adults that we typically think of as jellyfishes, known as medusas, are either male or female and reproduce sexually by releasing gametes into the water around them, and should these gametes meet they fuse and develop into tiny larvae. The larvae then settle onto a solid surface and develop into polyps (a second, immobile life stage resembling a sea anemone,) and each polyp then asexually reproduces several times, with genetically identical, slow-swimming young splitting off of its body as buds. Each of these asexually-produced individuals will then develop into a medusa, continuing the cycle and meaning that each single instance of sexual reproduction in Lion's Mane Jellyfishes produces multiple asexually-produced offspring. Despite their massive size medusas of this species only live for around a year, although their polyps, which only reproduce under ideal environmental conditions, may remain dormant for longer than this.
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bethanythebogwitch · 9 months
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The modern world is nice, but sometimes you just get the urge to go primitive. Because I'm a complete wimp who would die within a day of giving up the internet, I'm going to deal with that urge by talking about primitive animals. It's Wet Beast Wednesday and I'm talking about lancelets.
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(image: a lancelet. Not much to look at, are they?)
Lancelets, or amphioxi, are highly basal (close to the ancestral form) chordates that are vaguely similar to fish, but are vastly more primitive. They have all the characteristics of chordates, the key one being a notochord, a flexible rodlike structure that goes down the body. The majority of chordates that are still alive are vertebrates, who have incorporated the notochord into the spinal column. The other groups of surviving chordates are the tunicates (who I'll get to eventually) and the lancelets. Because lancelets are so primitive, they are used at model organisms representing an early stage of vertebrate evolution. It was originally thought that lancelets are remnants of an early lineage that eventually evolved into vertebrates. Genetic studies later showed that tunicates are actually more closely related to modern vertebrates than lancelets. They are still used as a model organism as they are a fantastic representation of early chordates. The similarity of lancelets to the 530 million year old Pikaia gracilens, one of the earliest known chordates, is one of the reasons they are such a useful model organism.
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(image: a diagram of lancelet anatomy by Wikipedia user Systematicist)
Lancelets can be found all over the world, living in temperate to tropical shallow seas. The only known exception is Asymmetron inferum, which has been found around whale falls at 225 m (738 ft) deep. They are small animals, reaching around 8 cm at their largest. An amphioxus looks pretty worm-like, with a simple mouth at one end and a pointed tail at the other. The name amphioxus means "both (ends) pointed" which is a pretty appropriate description. The mouth is lined with tentacle-like threads called oral cilli, which are used for feeding. Lancelets are filter-feeders that use the cirri to filter plankton, microbes, and organic detritus. Water and food pass into the pharynx (back of the mouth), which is line with gill slits. This is where it gets weird. The gill slits aren't used for respiration, but for feeding. Mucus gets pushed through the gill slits by cilia, trapping the food and moving it deeper into the digestive tract. Not only to lancelets not use their gill slits to respirate, they actually don't have a respiratory system at all. Instead, they just absorb dissolved oxygen through their thin and simple layer of skin. Their circulatory system doesn't move oxygen around either as there is no heart or hemoglobin present. For what it's worth, they don't have a proper live either. When you look at a lancelet's anatomy, you can see similarities to fish anatomy, just much more primitive and with some parts missing.
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(image: the head of a lancelet, with mouth and cilli visible)
Lancelets have 4 different systems used for vision. Two, the Joseph cells and Hesse organs, are simple photoreceptors that are on the notochord and detect light along the back of the animal. Imagine having a bunch of very simple yes on your spinal cord that can see through your skin. There is also a simple photoreceptor called the lamellar body (which confusingly is also the name of a type of lipid) and a single simple eye on the head. Speaking of light, lancelets are florescent, producing green light when exposed to blue to ultraviolet light. In all species, the proteins responsible for this are found around the cilii and eye, but some species also have them in the gonads and tail. The purpose for this florescence isn't exactly known, but a common hypothesis is that it helps attract plankton toward their mouths.
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(image: an extreme close-up of a lancelet's cilli fluorescing)
Lancelets have seasonal reproduction cycles that occur in summer. Females release their eggs first, followed my males releasing sperm to fertilize them. Depending on species, spawning can either occur at specific times, or gradually throughout breeding season. Development occurs in several stages. In the frist stage, they live in the substrate, but they will quickly move into the water column to become swimmers. These swimming larvae practice diel vertical migration, traveling to the surface at night and returning to the seafloor in the day. While larvae can swim, they are still subject to the current and can be carried long distances. Adults retain their ability to swim, which is done by wriggling like an eel and in some cases, spinning around in a spiral fashion while moving forward. Unlike the larvae, adults spend most of their time buried in the substrate with only their heads exposed. They typically only emerge when mating or if disturbed.
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(image: a diagram of the lancelet life cycle. source)
Because of their use as model organisms, humans have developed methods to keep and breed lancelets in captivity. The majority of research has been done on Branchiostoma lanceolatum, but several other species have been studied. Multiple species are endangered due to pollution and global warming. Several species are edible and can either be eaten whole or used as a food additive. In spring, when their gonads begin to develop for breeding season, they develop a bad flavor.
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Mom: "we have garden eels at home". Garden eels at home:
(image: three lancelets sticking their heads out of the sediment)
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a-edgar-allan-hoe · 11 months
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Fade Into You
ResidentEvil4Remake!Leon Kennedy x FemScientist/Pathologist/!Reader
Resident Evil x The Last of Us crossover
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A/N: Just a little idea I had lying around. The timelines are a bit jumbled up since the Last of Us and Resident Evil take place in different eras so I made this story takes place in modern time so bear with me here. I hope y'all like it and let me know what you think! 💜
Summary: Imagine being a scientist set with the task of finding a cure for everything that has happened, assigned to return the world to how it once was only to become an assignment for someone else, an agent named Leon S. Kennedy tasked with making sure you are transported safely to your destination.
Warnings: language, some potential suggestive content, blood and gore and violence.
Notes: angst, some comfort and fluff and Leon’s terrible dad jokes and some trauma sprinkled in there.
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Time. Time is a strange thing. Nonphysical and always there, always changing, from beginning to end. At the same time, it comes in cycles, repetitions and patterns. A metaphysical figment of creation, a concept constructed and molded to the understanding of the human species. An entity bigger than ourselves, spanning across millions of galaxies, and yet can fit within the palm of our hands. What is time, other than of what we know of it. Often times you found yourself wondering the same thing.
You don't know how long it has been since the outbreak, since the virus that started to plague the earth was first heard on the news, since well..........everything. So much has happened since, you had trouble remembering a lot of it, or any of it for that matter.
You used to work for the CDC, you still do, or what’s left of it, before you were taken against your will................there's not much left of anything anymore. Back then, you were the leading scientist in the department of Cancer Prevention and Control. 'New and upcoming young scientist leads the fight against cancer', titled the articles that were written about you, some of them far too promising and others harshly criticizing and objectifying. You're pretty sure you still have those articles stashed away somewhere, the good, the bad, and the ugly. What for? You’re not sure. Motivation perhaps, if there was any still left in you.
You were the best at your field, nearing a breakthrough for finding the ultimate cure for cancer that targeted the cells at the earliest and even latest stage, diminishing the illness completely as if it had never even existed in the host. You had even been featured on the cover of Life Magazine and the Smithsonian magazine for your work, the photos taken of you wearing your lab coat and standing over your microscope or interacting with your team and your patients. Boy was your father proud, his little girl on the verge of revolutionizing the medical world, he almost always had a hard time believing it, still picturing the day he held you bundled in his arms when you were first born. You were still ever his little girl to him. You could still remember the look on his face, the way he beamed when he found out, buying a copy of both those magazines just to frame it up on the wall as if there wasn’t already enough pictures of you and your little sister throughout your years.
You almost accomplished your mission, almost. You were close, so close. And then the virus took over, the Plagas and then the Cordyceps brain infection. Cancer became the least of worries.
Since the epidemic, you tried to save as much of your family photos as you could. After all, they were the only things left as a reminder of the past, of how things were. It's been so long the pictures almost don't seem real, like something created out of the mind of a delusionist, taken from of the pages of a science fiction novel, an imitation of an alternate reality. Never in you right mind did you think all those flesh-eating zombie movies you snuck out to watch with your sister at the local theater as a teen would feel more true to life than the actual past, the history of the human race.
Every night before you went to sleep, you'd pull out the storage box from under your bed, the one containing your family's photo albums, flipping through each page and staring at the photos of your parents and little sister as a way of forcing your brain to remember them. You believed this was your way of keeping them in your memory, recollecting the moment behind when each photograph was taken as if they were pieces of a broken vase meant to hold all that was you, pieces that sliced at you whenever you tried to put them back together. Truth was, you were afraid, desperate to cling on to the echo of their existence. And so you looked at those photos in a ritualistic manner, each and every night before bed. Truth is, you were starting to forget their faces, their voices, and you knew it.
In the beginning there were many; scientists, doctors, or pathologists or whatever you wanna call them, working on the task that was given to you by the government, each and every one of them fighting for a life of their own and the lives of many. Now they were just names on the diplomas that hung in their offices, names printed under an achievement of the institution they attended, just pieces of paper left to gather dust and be forgotten. Sometimes you wondered if you were the only one left; in your state, your country, the world? Who knows. In the building you worked, there used to be seven, then there were six, then five, then four…………….now there was only you.
Time seems to be nonexistent to you. The clocks on your walls meant nothing, nothing more than some numbers and a bunch of little gears that turn the hands to display the hour. A symbol of endless nothingness. The white walls of the building you worked in were just a place that they happened to hang on. And god you hated those white walls. You’ve lost count of the days you spent locked up within them, with nothing to keep you company except for the lab rats and your own thoughts. It's a wonder you didn't lose your sanity. A time came when you’d question if you’d ever see another human again. It seems as if your prayers were answered.
You were currently sat on the makeshift bed of a small base hideout, staring ahead at the fabric of the military tent that blew slightly against the wind, the makeshift tent that you stayed in after you were rescued, if you would call it that. Being the only woman at a base full of military men had its own fears, and you'd almost rather be out with the infected than here. You don’t know what it’s like anymore, being free I mean, you only remember being held hostage, held in one place to work for the government only to be taken away to work for another before being taken again for your so-called expertise, like an almost endless cycle, as if you were some goods that needed to be traded off and transported from one destination to another until you could no longer be of use.
You couldn't remember much after you were taken by the cult in an attempt to bring back Umbrella Corp or whatever they wished to call themselves, the memory of it all was still as fuzzy as when you first arrived under their "management". Now what would you even call your current circumstance? A formal and civil hostage situation under the label of U.S. personnel? You were only being held for the time being before being sent back to the states to work for whatever was left of the government. And as much as you wanted to go back home, or what's left of it if we're being honest, you've only heard of how worse it has gotten since you left.
“Y/l/n.” One of the soldiers called for you as he opened the flap entrance to your tent, his form casting a shadow across the floor in front of you. “It’s time.”
You gave the soldier a quick nod, grabbing your backpack from the floor and the small pocket knife that you kept under your pillow, stuffing the folded blade in the back pocket of your jeans as you got up and walked out of your tent. You followed the soldier as he led you through the open area where other soldiers were gathered, some of them standing guard, some eating their meals and others standing around leisurely as they conversed with each other. You could feel their eyes on you, watching you tag behind the soldier that was in front of you as he led you to the bigger tent on the other side of the field, the tent where the officers and higher ups held their meetings to discuss important matters.
You heard some voices coming out from inside the tent, two to be exact, discussing something important apparently. It’s all they ever did around here. And as you stepped in after the soldier, you saw the colonel speaking to a man you had never seen before. Tall, blond hair, wearing civilian yet practical clothes with tactical gear over it, unlike everyone else here who donned the military uniforms. He's definitely not military-
“Sir-“ the soldier that led you spoke, alerting the colonel of your presence.
“Ah. There you are.” The colonel turned towards you with a smile, the corners of his eyes crinkling from his old age as he gestured you over to where he stood at the table that was stationed dead center of the larger tent. “Was beginning to think you wouldn’t show.”
You looked between the two men across from you in the tent once the soldier that was by you had left, allowing you a better view as you only watched with slight uncertainty before approaching the officer. The man whom you did not recognize had looked your way as well, his face not showing a single shift in emotion upon your arrival, but you had managed to notice the slight curious quirk of his brow at seeing you. Who the hell was he?
“Say hello to your assignment,” the colonel gestured towards you as he spoke to the blond man. God you hated being called that, assignment. “Dr. y/n y/l/n."
“Leon S. Kennedy.” The man outstretched his hand, to which you stared at with the blankest look possible.
"............Pleasure." You gave the man a short smile, completely disregarding his offer for a handshake before turning to the older officer and pulling him aside as if the young man wasn’t even present in the first place, watching from the side of your eye as he awkwardly pulled his hand back, a look of hidden puzzlement on his face. You didn't want to seem rude but this was not what you had signed up for, being alone for who knows how long with a man you absolutely did not know.
“Agent Kennedy here is to ensure that you are transported and arrived safely to your destination.” The colonel answered after seeing the silent but scrutinizing look on your face.
So an agent huh. He’s probably as stuck up as the rest of those shit heads you've had to come across. Agent or not, who's to say he isn't like the others.
“What does that have to do with me?"
"Well he's been hired as your bodyguard."
You tried your best not to laugh. "What, some washed up reject of the Backstreet Boys?” You lowered your voice, knowing damn well the agent a few feet away from you could hear everything.
Leon couldn’t help but cock his head back with a slight scoff, not sure if he should be offended by your insult or impressed by the creativity behind it.
“Agent Kennedy is the best in his field. And our job is to make sure you end up safe back in America. I’m afraid you’re much too valuable to be left to wander back on your own.”
You let out a small huff, crossing your arms over your chest with a stern look of contemplation as you eyed the ground beneath your feet before finally folding. He had a point there, it was dangerous out there. But who's to say you should trust him? You had trouble trusting anyone for that matter. "Do you trust the guy?" You looked up at the colonel, knowing better than to trust a man's word but who else was there. There wasn't really anyone here to protect you but yourself.
"Agent Kennedy is a good man, reliable, I assure you."
You don't know that. "............then I suppose I have no choice but to take your word then." You sighed, knowing there wasn't really a way out of this.
“Good. Go easy on him alright.” The colonel straightened up, placing his hand on the back of your shoulder as he led you back to where the other man stood.
"Agent Kennedy, I trust you'll keep Miss y/l/n here safe."
"Yes sir." Leon nodded his head, attempting to send you a kind smile as if to say you were in good hands but you only stared off into the distance, still unhappy with the decision made. As long as it meant you went back home. Home. Jesus. You don't even know what was awaiting you there.
"She can be quite stubborn at times but you'll get used to it." The older officer added with a chuckle to which you shot back with a quick glare.
"Well that's fine by me." Leon smiled. "I'm a patient man." If only he knew how much you were going to drive him up the wall.
"Well here is the location where she needs to be dropped off." The officer handed Leon a piece of paper. If you have any questions, you know who to call."
"Copy that."
"Can I have a handgun-"
"No." The colonel was quick to interrupt your question. "That won't be necessary."
"Fine." You mumble to yourself. "Guess I'll just use my butter knife then."
Leon quietly watched the interaction between the two of you, slowly getting a clue about the personality of who he was going to be spending the upcoming days with, and he wasn't quite sure how to feel about it. He too would have opted for the same response as the colonel since you didn't look like the type to have ever fired a gun, much less used any weapon at all. And what exactly did you mean by butter knife? Should he be worried?
"Well you'd better get going, you don't want to be traveling at night, not with what's out there."
"Yes sir." Leon nodded his head at the colonel before heading out of the tent.
You turned to follow the tall blond but were stopped by the officer who held his hand up. "Not just yet. I have something here for ya."
You watched as the colonel pulled out a large black case, clicking open the clasps before opening it to reveal a hunting rifle nestled safely inside.
"I thought you said I couldn't have a gun."
"No, I said you couldn't have a handgun."
The colonel stepped aside, allowing you room to take a step closer to examine the rifle better. Was that? You'd recognize that wooden stock anywhere.
"My dad's rifle. How?"
"Had someone retrieve it from your old place. I'm guessing you know how to use it, judging from the way you recognized it so quickly."
"I-Thank you....sir."
"Just make sure you get your ass back to the lab in one piece." The colonel pulled the rifle out from the case before handing it to you, along with a box of some ammo.
"Of course." You sent the colonel a short smile, putting the box of ammo into your backpack before taking the rifle from his hands, feeling the weight of the thing within your grasp, recognizing each scuff mark and scratch that lined the wooden body, the little signs of wear and tear caused by your own clumsiness, each of them reminding you of the times spent with your father at the range when he taught you how to use the thing. It even smelled of him, after all this time. If you weren’t in a public setting you would have curled up into a ball and cried, holding the rifle close to your frame as if it were the remnants of your father, the man who raised and protected you for the majority of your life. And in a way, it was.
"Stay safe out there kid."
“Sure thing.” You gave a nod, slinging the strap of the rifle over your shoulder as you pushed the memories and emotions away, heading over to the entrance of the tent until the colonel called out again.
“Hey kid.”
“Yeah?” You turned back to face the older gentleman. It wasn’t long, the time that you’ve known him, but he seemed to be the only one that looked out for you, the only one that stood up for you when the other soldiers harassed you and uttered vulgar things in your direction.
“Try not to get separated from Agent Kennedy.”
“Can’t promise that.” You turned back around, raising your hand to send him a wave goodbye before pushing aside the flap of the entrance and stepping out into the sunlight. Well, this is it. Another day, another journey.
You were met outside of the tent with Agent Kennedy, who seemed to have been waiting outside the whole time, hopefully not eavesdropping, not that there was anything important or personal said back there but you just didn’t like people listening in on your conversations.
Straightening up, Leon gave a quick glance over your form before eyeing the rifle on your back. That definitely was not there before. “Where the hell did you get that thing?"
Christ this man talks too damn much and you just met him.
Rolling your eyes, you ignored his question, or rather his whole presence as you headed towards the truck that was set out for you. As much as you didn't want to be rude, you were anxious to get the hell out of this place and return to a place that you at least knew.
“Never mind I guess.” Leon muttered to himself before trying to catch up with you ahead. Jesus you walked with purpose.
Opening up the passenger door of the truck, you threw your backpack and rifle in the backseat before seating yourself in the passenger seat, putting on your seatbelt as you watched Leon walk up to the truck, still a couple feet away.
“Can this dude be any slower?” You muttered under your breath with a roll of your eyes, propping your elbow up on the door window as you stared out of it.
“Someone’s eager to get out of here.” Leon chuckled at the way you had situated yourself so quickly along with the obvious impatient expression that sat on your face as he opened the driver door before getting in himself, putting the keys into the ignition to start the car.
“So uh..........” Leon adjusted the rear view mirror before placing a hand on the back of your seat as a way to back the car out of the parking spot while you only studied his movements from the corner of your eye before glancing out the widow again. Why did you have a gut feeling this guy wasn’t the best driver. “where to huh? My place or yours?” Leon cracked a smug grin, hoping to lighten the mood judging from the unease you must have felt to be left with a complete stranger but quickly changing his mind after seeing the absolute foul, confidence-shattering side-eye that you just threw him.
If this man doesn't shut up-
"Right-" Leon cleared his throat, his expression changing back to his usual resting one as he looked back ahead, changing the gear to reverse as he backed out of the parking spot. Not even a minute with you and he could already tell you were going to be a blast to be around. You were the complete opposite of Ashley. And as much as he preferred a quiet atmosphere, he'd rather take his chances with Ashley all over again.
Some silence had passed between the two of you once you hit the road and left the base behind, the only sounds being the humming of the car and the wind outside. The drive was scenic in a way, if it were not for the situation at hand. But watching the trees and landscape blur by through the car window almost reminded you of the drives you went on with your father and sister, transporting you back to the road trips where the three of you would listen to the radio while fighting over who's turn it was to play the next song.
You missed your father softly singing along to his music that you at one time used to be annoyed by, your sister and you referring to his taste in music as the "Ancient Ballads of Babylon". And oh how he used to get defensive over it, calling it the "good stuff unlike todays junk", though he was never able to hide back the smile from your little slanders. What you would do to listen to his music again, to be in his truck sitting in the passenger seat reading a book before crawling to the backseat to take a nap with your sister, her head resting on your lap while your rested yours against the window.
Due to how quiet you were, Leon couldn't help but to glance over in your direction to make sure you were still alive, noticing the way you had become lost in thought, your gaze seeming to reach miles away. His eyes traced down to the subtle movement of your hands, watching how your fingers toyed with the dainty beaded bracelet that sat at your right wrist. There were a couple white beads situated together, printed with small black letters that formed a word, or rather a name, but before he could have a chance at reading what it was, you had noticed him looking, causing you to swiftly pull the sleeve of your loose sweater over your wrist. The sudden movement from you had caused Leon to clear his throat as he snapped his head back to the road, as if embarrassed at being caught before clearing his throat. "So uh, are you some bigwig's daughter? The president had requested you specifically."
The president? There was still a president? Well shit.
"Look. I'm just trying to know what I'm dealing with here." Leon put his hand up in defense after the annoyed expression you gave him.
You shook your head lightly at his behavior, heaving out a released breath as you propped your arm up once more, resting your head against your hand and discretely wiping away the tear that was starting to fall down the corner of your eye.
"Doctor huh. What are you, UCLA grad? You strike me as a LA city kind of girl-"
"Harvard." You interrupted.
"So you do speak." Leon shot you a quick smirk, surprised at your sudden input before staring back at the road. "Thought it was just me but....looks like I struck a nerve here. Sooo......Harvard huh? You must be pretty brainy then, surviving a med school like that."
"............" Dear god please.
"You know, you look a little young to be a doctor."
Geez, if that isn't the first time you've heard that one. You wished the man would just shut up and focus on the road. You swore that if he somehow ended up sending the car off a cliff you were going to personally strangle the blond yourself. Actually, come to think of it, if he talked any more you just might take the wheel and drive off a cliff yourself.
"I take it you're not much of a talker." Leon commented on the way you so obviously tried to ignore him. Jesus, did he rub you the wrong way or what. Or was it just the Ivy League attitude? He had heard the talk amongst his old colleagues back at the station about the Ivy League folk that would sometimes come through the town. Overly-educated and stuck up, some of the officers would call them.....if you consider calling someone overly-educated an insult. Perhaps this was what they meant? Seems like you didn't want to even be associated within the same proximity as him.
Rolling your eyes, you twisted around in your seat to reach for your bag, pulling it onto your lap and opening up the zipper before digging into the contents inside.
Leon watched you with curiosity, opening his mouth to ask just what it was you were up to before seeing you pull out a pair of headphones and a portable CD player that looked like you stole right out of the 90s. Keeping the backpack on your lap, you slipped the headphones onto your head, pressing play on the device before pulling your feet up onto the seat and turning towards the window so that your back faced the man in the driver seat.
Leon couldn't help but to shake his head with a light chuckle, taking this as a sign to shut the hell up and let you be in your own little bubble. Maybe you’re just shy. Or maybe you just don’t like him. Or maybe you’ve been through a lot. Who knows.
You watched the trees once more, listening to the song that played through the speakers of your headphones, Fade Into You by Mazzy Star, letting the soft tunes soothe your nerves. And as much as you tried to force yourself to stay awake in order to stay alert for your own safety, you couldn’t help the drowsiness that took over you. The music playing through your headphones, the blur of the trees out the window, and the subtle vibration of the moving car only added to that effect. And slowly, you let yourself slip, your eyelids growing heavy as you finally shut your eyes.
The drive had felt like hours for Leon, but he didn't mind as much. In fact, this was sort of relaxing, just driving, listening to music he enjoyed as it played softly from the radio, the volume lowered as means to not disturb you. This mission was turning out to be less stressful than the others. Or maybe he shouldn't speak too soon.
The young agent would occasionally find himself glancing over in your direction, perhaps to make sure you were okay and weren't dead. He had a bad habit of making sure the people under his care were alive and well and not breathing their last breath….if you would call that a bad habit. As much as this man hides it behind his cold exterior, I am positive he is just as panicky as the rest of us.
Your lack of movement had started to worry the blond, seeing that you have stayed in that position for a couple hours now as he began to wonder just what the hell you could have been doing the whole time in order to stay in the same exact position. (He has his himbo moments.) But the slow shifting of your form had relieved the young man as he watched you turn over on your other side to now face him, getting a glimpse of your closed lids behind the strands of your loose hair that almost covered the look of calm on your face, hearing the small moan that came from your chest in your state of sleep as you shifted around while your brows furrowed together at the center in a look that he could only describe as discomfort from your curled up position on the passenger seat.
One thing he had noticed though, if he listened close enough, he could hear the slight and faint whistle of the air rushing through your nostrils each time you breathed, a sign that usually meant a deviated septum. He didn’t know why, but that tiny detail had somehow set his mind at ease…something so insignificant…so barely noticeable unless you really paid attention to it…almost as if it had made you more human. And the thought of it was comforting to him.
As he looked over your sleeping form, he couldn’t help but to take note of the details that made you: of your hair that looked as if it had not been brushed through, or the dark circles under your eyes, or the little bump on your nose at the bridge, or the faint signs of hyperpigmentation and small little acne scars that lined certain areas of your face, or the light dust of freckles on your nose that were barely visible unless you really took a closer look. Even down to your wardrobe, your oversized navy blue v-neck sweater and the white tee you wore underneath, and your loose-fitted jeans, and your worn in black doc martens. Leon did not know how to describe it, but there was something comforting about you, something that made him feel…at ease. And maybe…just maybe, this mission might not be as bad as he once thought.
Part 2?
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deep-fried-egg · 8 months
Text
I need you for the oxytocin
This fic includes: g!p, a/b/o, alpha! Billie, Omega! R, r was a little hesitant at first, cockwarming, rut/heat cycles
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SMUT BELOW THE CUT
Sometimes being the assistant of a big musician has it's perks! for one you get to meet a famous person and two... you might be able to help them through a very poorly timed rut.
That's actually what happened tonight. I'm pretty nervous since I'll be helping out the most beautiful woman I have ever met. she's got light blue eyes with a darker shade of blue around the edges of her irises. also she recently dyed the roots of her hair bright red! it looks amazing on her.
I can't stop thinking about her either. She is so beautiful and so talented. I'm so lucky to be allowed to be her assistant!
I had to stop her from going out on stage though. I mean she was going to go into rut SOON. I could smell it on her. and she had an extremely long set! I didn't want her to go into rut on stage and embarrass herself. plus I'm sure there is tons of omegas in the crowd that would go crazy if they smelled her going into rut. I just couldn't let her go out there.
I couldn't betray her like that! not after all of there years working together . It was too late for me to turn back. I had already made the decision to go up to her and tell her to stop.
"Hey Billie I- what are you doing?" I had definitely come into her dressing room at the worst time possible. she was grinding up against the handheld mic.
I guess she hadn't realized that I had walked in yet, so I waited for her to smell my presence. then when I noticed she did, I took a small step back. hoping to hide behind the door to give her some space to finish.
As soon as I took a step back she spoke up.
"I can feel you staring. quit it and help me out. aren't you supposed to be my assistant?" The alpha's voice had gotten deeper, more seductive, more... sexual.
She eventually decided to ignore me and started to grind down again, But now she was making a lot more noise than before.
I think the audience wanted to hear her, they must've been really excited. but it didn't seem to matter to her anymore.
"Billie!" I yelled, "What do you think you're doing!?" I grabbed her by the shoulder and tried to move her away from the mic. she shrugged me off.
"Do you not want to help me? do you want me to ask someone else to do it?"
"Fuck it." I replied. I wasn't going to lose this opportunity to touch THE Billie Eilish. So I moved closer to her and grabbed the handheld microphone she was holding and set it on the counter the alpha was sitting on right in front of the big mirror Billie had in her dressing room.
I took my other hand and cupped Billie's cheek. the alpha's face lit up even more. her skin was soft and warm. it felt amazing to be touching her like this.
she put one hand on my hip and brought the other down to her black and white shorts and pulled them down and off without hesitation. she then started to touch her hard cock through her boxers, looking away from me so she can pay attention to her throbbing dick.
I watched as she rubbed her hand over her shaft and slowly started to stroke it.
after a few seconds she paused so she could slip her boxers off too. then she turned back to me with those ocean eyes of hers. she still had one of her hands gripping my hip tightly, she needed something to ground her to reality while she was in this rut. or perhaps it was just another form of control. I couldn't tell. all I could tell was that the scent of her arousal was overpowering me, filling every cell of my body. it was like the air was thick with lust, sex, and raw animal instincts. it was intoxicating.
"Y'know what? I want you to cockwarm me. let me sit down in my chair." Billie said and pushed herself off the table towards her chair where she sat. I immediately followed suit. she looked up at me through her eyelashes, trying to read the look on my face. I just stared right back at her with my mouth agape. it was like I couldn't take my eyes off her.
I quickly regained my composure and undressed so I could slip her twitching dick inside of me. she groaned and ran her hands over my now bare hips making me flinch from how cold her rings felt against my skin.
I placed one hand on the back of her head and I wrapped my other arm around her waist pulling her into me and burying my nose in the crook of her neck. I gripped the back of her
Chicago Bulls jersey and inhaled deeply. She had to go on stage in about 30 minutes so things had to speed up. I knew that she would just take her suppressants after this so I need to enjoy this while it lasts.
"Could you do my hair for me? I don't know what style to do." Billie asked, pulling my head from her neck, "I always end up doing something weird."
"Sure." I answered, reaching around her to grab the elastics she had on the desk behind her. It'll be hard to focus with the way her dick is throbbing inside of me. she leaned back on the chair as I began to put her hair into two messy little buns on each side of her head.
Billie sat patiently as I tied them off. it took me a bit longer than usual, mainly because Billies huge dick inside of me was distracting me from the task at hand.
Billie softly trusted her hips up, pushing her dick deeper into me. I stopped tying the buns and slid my hands over her thighs, gently rubbing
she moaned "Oh, oh, I'm getting close baby. you feel good." she purred.
It seems like shes trying to mess me up at this point. does she want her hair to look bad? or is she just enjoying her current predicament?
Billie continued to buck her hips up, trying to make my job even harder for me. she's clearly trying to distract me. Its working.
Suddenly I felt billies knot slide out, pressing right against my pussy as she tried to shove it inside of me. we didn't have enough time to wait for her knot to go down though! I mean we only have 25 minutes until she needs to go onstage and perform. I didn't have enough time to tell her that though. as soon as I opened my mouth to ask her to not knot me she did the one thing I didn't want her to do. she fucking knotted me.
I felt all of her cum filling me up, going straight into my womb.
Is it too late to tell her that I'm not on birth control...?
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untitled5071 · 2 months
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I have a Lisa Frankenstein request! If you'd rather not, thats totally okay, but I'd love a modern au of them going to a my chemical romance concert. ^^ it's for me and for one of my friends too, and it would really mean a lot to us! Thank you so much for doing what you do!
I hope you like it!
🪦🪦🪦🪦🪦🪦🪦🪦🪦
“Oh my god oh my god, I think this is it!” 
Even though Lisa’s eyes were trained on the stage in front of her, her arms were busy shaking the daylights out of her husband, her hands on his shoulders while he chuckled adoringly at her enthusiasm. He wasn’t doing too good of a job at hiding his own, either; this concert may have been a gift for Lisa while they ‘traveled’ through Mexico as part of their “don’t get caught by the police” world tour, but he was excited too. 
They hadn’t been to a concert in a long time; after Lisa was reanimated and recovered, the two of them had gotten as far away from Brookside as they could potentially get, and once the dust settled, they decided to do a little traveling to see what the modern world could offer them. They had no end of potential date ideas, but they both particularly liked live music. 
Though their favorite of all time would always be the private one given in the living room of Lisa’s old home, they both enjoyed being among other music lovers and shouting lyrics like maniacs. Granted, he knew he wouldn’t be doing much shouting tonight in the sea of people they found themselves in-both because he knew he wouldn’t be heard and because shouting just wasn’t in the cards tonight, but it was all worth it for the sake of seeing Lisa so happy. 
Speaking of Lisa, her declaration that the show was starting seemed to be right on the money, since the lights were starting to dim, the anticipatory roar of the crowd was starting to get louder and cell phone flashlights were starting to flick on like illuminated eyes across the arena. The creature divided his attention between Lisa and the stage as the sound of a heart monitor was projected over the screams of the fans, and she grabbed his stitched-on hand in a vice grip when a gurney containing a covered body was rolled onstage. 
Lisa’s cheers joined that of the rest of the crowd when the body revealed itself to be the lead singer, clad in a hospital gown over his signature dark outfit and clutching a microphone. The first song was ironically called “The End”, and as the creature expected, Lisa sang every word at the top of her lungs, teased hair flying in every direction as she bounced along to the beat.
He knew buying her that second hand iPod Nano last year was a good idea. 
The first verse ended with Gerard Way ripping off his hospital gown as the biggest curtain they had ever seen opened to reveal the rest of the band, already whaling away on their respective instruments. They all wore black outfits and parade marshal’s jackets (which seemed fitting), and they weren’t the only ones who had dressed the part. 
Lisa had spent hours trying to pick the perfect combination of tights and tops for this concert (all black, of course), and had finally settled on black fishnet tights that she had torn and woven back together herself with more colorful embroidery thread (sticking heavily to purple and green to match her husband’s stitched limbs), a black tulle miniskirt and a black sports bra under a mesh top, complete with black and dark-gray striped arm warmers, to match the fashion of the time. He himself was wearing a leather jacket over a deep red shirt, and his best ripped jeans that Lisa distressed for him, in more ways than one. They blended in perfectly with the ocean of punks around them, and that was just fine by them. 
The band cycled through their set with infectious energy and an electric stage presence, and the creature was surprised that the stadium they were in didn’t collapse under the weight of the stomping and jumping the audience was doing. He was particularly fascinated by the mosh pit that had formed towards the font; it was mesmerizing to see all of those bodies moving in such a disjointed but synchronized way that anyone could immediately understand was dangerous if not done properly. He had to respect it, honestly. 
The biggest problem with it, on the other hand, was that it was blocking their view of the stage, and by the time the band’s most popular started (signaled by a single note that was almost drowned out by the crowd), the frenzied movements of the people closer to the stage got more intense, as did the noise level. 
Lisa was staining herself on her tiptoes to see over the screaming heads in front of them, and when her husband noticed this, he put a hand on her shoulder gently, shuffling in the limited space that they had so that his back was to her, and squatted down slightly. Lisa got the hint immediately and hopped onto his back, and he hoisted her up so she could see over the several hundred flip phones being used to record the show and get a better view of the stage. She was delighted by this plan, holding onto him with her thighs and one hand while waving her other hand in the air, mirroring Gerard on stage. And even though her voice was meshing with thousands of others, even that of the actual lead singer, the creature thought her voice was the clearest and most beautiful of them all. 
She must have been able to feel his adoring gaze somehow, because as the song ended in a shower of confetti and pyrotechnics, she bent down and kissed his right cheek first, then his left, whispering (or, given the noisy circumstance) said in a normal speaking voice, 
“Thank you. I love you so much.”
And though he was particularly tongue-tied that evening and unable to speak the words back, he hoped that the kiss he gave her amidst the crowd’s raucous applause spoke his feelings adequately. 
They stayed that way as the concert continued, the creature keeping Lisa safe in the arms collapsed around where she was perched on his back and Lisa sneaking little kisses or playing with his hair in between songs, and as the band played one of their slower pieces, the two undead souls swayed together, united in their love of music and each other. 
These are the eyes and the lies of the taken
These are their hearts but their hearts don't beat like ours
They burn 'cause they are all afraid
When mine beats twice as hard
'Cause the world is ugly
But you're beautiful to me
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carlyraejepsans · 7 months
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What did you think of annihilation? Any details you noticed?
REALLY loved the cancer symbolism there. and the way it ties in with the main character's affair. in the initial conversation with her husband when they talk about god, she says god makes mistakes because if it weren't for a certain "biological error", the cell's reproductive cycle would make us immortal. this is, of course, bullshit, as the psychologist makes evident in their discussion about suicide vs self destruction. "not many people commit suicide. a lot of people self destruct". lena looks up when dr ventress lists off ruining a happy relationship as one of the examples, closely tying her to the cell lifespan symbolism when ventress mentions that cells die because it's already programmed into their dna (something lena knows well, being a biologist). death NOT as a mistake by god, as a programmed stage of our life cycle. and what does lena say after her last time sleeping with her colleague?
"This was a mistake."
and the issue is: as harrowing, as unfair as preprogrammed, by-design mortality is, a cell that doesn't die and keeps reproducing forever is, well... a cancer. which is exactly what the shimmer is. it refracts everything, it combines dna regardless of species, it creates doubles, it absorbs and transforms, not so much killing, as annihilating what it touches as a consequence of complete genetic reshuffling, engulfing it into itself.
it's god's so-called "mistake" in cell dna (and thus, as an established parallel, human nature)'s tendency to self destruct that finally stops the shimmer's expansion. when lena gives her clone the grenade and takes its hand to set it off, she essentially teaches it to self destruct, like any (ironically) healthy cell would. no more immortality. no more cancer.
the final scene between lena and kane was also very... interesting. i think if i were to interpret it in any way, i'd say it's a kind of reflection on a biological ship of theseus. in the same way one would ask "if most (if not every) cell in your body dies and is substituted every so and so years, is it even still you"? kane committed suicide. he killed himself and let his clone take his place by lena's side, because his answer to that question was... no. and he couldn't deal with it. lena, as previously mentioned, self destructed and "won" against the shimmer as a consequence. unlike her husband, she remained "her original, non-alien self". kane doesn't think he is the same, and we can't blame him for it. but still, he turns the question over: are you? because she may not be an alien clone, but the shimmer changed her too. cells don't destroy themselves as a mistake or for fate, they do it to prevent cancer, save energy, and maintain the health of the organism. dying, changing, replacement, self destruction: they're all a part of our lives.
she doesn't answer. in the final shot, her eyes change color like his. alien. different. changed.
is she still the real lena?
does it matter?
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science-lover33 · 6 months
Text
Unraveling the Tapestry of Cellular Energy: A Comprehensive Voyage through the Electron Transport Chain 🧬⚙️
Prepare for a deep dive into the labyrinthine pathways of the Electron Transport Chain (ETC), where molecular machinations weave the intricate tapestry of cellular respiration. In this odyssey, we'll navigate the complexities with surgical precision, leaving no nuance unexplored.
1. Prelude at Complex I (NADH Dehydrogenase):
The ETC's overture commences at Complex I, where NADH, a product of glycolysis and the Krebs cycle, surrenders its high-energy electrons. Traverse the serpentine route of flavin mononucleotide (FMN) and a succession of iron-sulfur clusters, witnessing the orchestrated dance that propels electrons toward the enigmatic ubiquinone (Q).
2. Interlude with Succinate (Complex II - Succinate Dehydrogenase):
As the symphony progresses, Complex II takes the stage with succinate as its protagonist. Succinate dehydrogenase, fueled by succinate from the Krebs cycle, orchestrates a parallel electron flow. Behold the ballet of electrons navigating iron-sulfur clusters and flavin adenine dinucleotide (FAD), converging upon ubiquinone (Q) in a seamless choreography.
3. Cytochrome Waltz (Complex III - Cytochrome bc1 Complex):
The narrative crescendos at Complex III, the cytochrome bc1 complex, where Q takes center stage. Through a series of mesmerizing redox reactions, Q gracefully shuttles electrons to cytochrome c. This transient dancer becomes the ethereal messenger, ferrying electrons with finesse towards the climactic rendezvous at Complex IV.
4. Grand Finale with Complex IV (Cytochrome c Oxidase):
In the climactic finale, Complex IV, personified by cytochrome c oxidase, awaits the electron ensemble. Watch as electrons, guided by a cascade of copper and iron centers, engage in a captivating pas de deux with molecular oxygen. Witness the alchemical metamorphosis as oxygen is humbly transmuted into water, marking the zenith of our electron saga.
5. Proton Symphony and ATP Synthesis:
Simultaneously, the proton symphony unfolds as protons, displaced during electron transit, accumulate in the intermembrane space. This sets the stage for a grand energy transfer. The finale crescendos with protons flowing back through ATP synthase, a molecular turbine, culminating in the synthesis of ATP—the lifeblood of cellular energy currency.
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References:
1. Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., & Walter, P. (2014). Molecular Biology of the Cell (6th ed.). Garland Science.
2. Nelson, D. L., Cox, M. M. (2017). Lehninger Principles of Biochemistry (7th ed.). W.H. Freeman and Company.
3. Berg, J. M., Tymoczko, J. L., Gatto, G. J. S., & Stryer, L. (2019). Biochemistry (8th ed.). W.H. Freeman and Company.
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animalshowdown · 3 months
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Phylum Round 1
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Cnidaria: Jellyfish, anemones, corals, box jellies, and hydroids. They have a gelatinous body with radial symmetry, a decentralized nervous system, and tentacles surrounding a simple mouth. The defining feature of this phylum are their cnidocytes, or stinging cells. There are two different body plans of the Cnidaria; an immobile "polyp" attached to a surface, or a free-living "medusa" which can swim or drift in the water column. Many polyp Cnidarians, such as corals, live in colonies. Free-living medusa Cnidarians must return to the seafloor in a polyp-like stage as a part of their life cycle.
Phoronida: Horseshoe Worms. Living in chitinous tubes, these animals resemble feather duster worms, but are a completely different phylum. These worms are defined by their large horseshoe-shaped crown of tentacles, which generate a water current to bring food to the mouth via filter feeding. Another unique trait of the Phoronids is their "ampulla", which is a bulb-like structure at the base of their tails that helps anchor them and acts as a fulcrum to quickly retract away from predators. Some species are able to bore into coral or rock using caustic chemicals in their mucus.
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covidsafehotties · 18 days
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Abstract
Early stages of deadly respiratory diseases including COVID-19 are challenging to elucidate in humans. Here, we define cellular tropism and transcriptomic effects of SARS-CoV-2 virus by productively infecting healthy human lung tissue and using scRNA-seq to reconstruct the transcriptional program in “infection pseudotime” for individual lung cell types. SARS-CoV-2 predominantly infected activated interstitial macrophages (IMs), which can accumulate thousands of viral RNA molecules, taking over 60% of the cell transcriptome and forming dense viral RNA bodies while inducing host profibrotic (TGFB1, SPP1) and inflammatory (early interferon response, CCL2/7/8/13, CXCL10, and IL6/10) programs and destroying host cell architecture. Infected alveolar macrophages (AMs) showed none of these extreme responses. Spike-dependent viral entry into AMs used ACE2 and Sialoadhesin/CD169, whereas IM entry used DC-SIGN/CD209. These results identify activated IMs as a prominent site of viral takeover, the focus of inflammation and fibrosis, and suggest targeting CD209 to prevent early pathology in COVID-19 pneumonia. This approach can be generalized to any human lung infection and to evaluate therapeutics
Comment from Dr. Harry Spoelstra on twitter:
"Macrophages, white blood cells that normally kill microorganisms, like viruses, but SARS-CoV-2 predominantly INFECTS these activated interstitial macrophages (IMs) and takes control.....
➡️ I remember some specialists telling us Sars2 doesn't infect WBC's 😬"
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maaarine · 26 days
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Invisible Women: Exposing Data Bias in a World Designed for Men (Caroline Criado-Perez, 2019)
"Digging deeper into the numbers, another issue the authors completely failed to address is whether or not the drugs were tested in women at different stages in their menstrual cycles.
The likelihood is that they weren’t, because most drugs aren’t.
When women are included in trials at all, they tend to be tested in the early follicular phase of their menstrual cycle, when hormone levels are at their lowest – i.e. when they are superficially most like men.
The idea is to ‘minimise the possible impacts oestradiol and progesterone may have on the study outcomes’.
But real life isn’t a study and in real life those pesky hormones will be having an impact on outcomes.
So far, menstrual-cycle impacts have been found for antipsychotics, antihistamines and antibiotic treatments as well as heart medication.
Some antidepressants have been found to affect women differently at different times of their cycle, meaning that dosage may be too high at some points and too low at others.
Women are also more likely to experience drug-induced heart-rhythm abnormalities and the risk is highest during the first half of a woman’s cycle.
This can, of course, be fatal. (…)
Perhaps most galling from a gender-data-gap perspective was the finding that females aren’t even included in animal studies on female-prevalent diseases.
Women are 70% more likely to suffer depression than men, for instance, but animal studies on brain disorders are five times as likely to be done on male animals.
A 2014 paper found that of studies on female-prevalent diseases that specified sex (44%), only 12% studied female animals.
Even when both sexes are included there is no guarantee the data will be sex-analysed: one paper reported that in studies where two sexes were included, two-thirds of the time the results were not analysed by sex.
Does this matter? Well, in the 2007 analysis of animal studies, of the few studies that did involve rats or mice of both sexes, 54% revealed sex-dependent drug effects. (…)
It’s a tantalising finding that inevitably leads to the following question: how many treatments have women missed out on because they had no effect on the male cells on which they were exclusively tested?"
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lensman-arms-race · 6 months
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Some Skibidi Toilet horror ideas
(Well, beyond the innate horror of humans transforming into toilet monsters, assuming that's how skibidis are formed.)
Hardware units that are beyond repair are broken down and used for spare parts. Their hard drives are wiped before being used to build new units or replace parts in existing units, but there's sometimes still some residual 'echo' left behind, leaving units sometimes experiencing snatches of memories of their 'past lives'.
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Unit 'zombies':
(This idea assumes that the units can get some power from solar.)
If a unit is incapacitated in battle but not killed, and not retrieved by the alliance (e.g. potentially, brown-coated cameraman trapped under scaffolding at the end of episode 57), it will eventually run out of energy and power down. If they have exposed solar cells, they might get some power back every now and again, but eventually their batteries will become unviable from repeated failed discharge/recharge cycles. Dead unit. However, if metal dendrites eventually form in their decaying circuitry, the dendrites could bridge the gaps between electrodes and allow the dead battery to act as a conductor, and the unit to be powered directly from its solar panels. This would probably result in a unit that 'came back wrong'.
This sort-of happens with real life satellites that have died and not been de-orbited. There are old dead satellites up there that broadcast random gibberish when the sun hits their solar panels just right.
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Most skibidis seem to be quite happy with their fate - zipping around with a zest for life despite being abominations in the eyes of both the alliance and any remaining humans. However, some skibidis mourn for their old human existence, and have disbanded from the skibidi faction in an attempt to research a cure by themselves. None have fully succeeded but some have had partial success. Unfortunately, these horrible morasses of rampant flesh-growths and porcelain-shards appear to be trapped in an even worse existence...
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Similar to the above but in the reverse direction: some human survivors live constantly fleeing from the skibidis, fearful of being transformed. Some of these nomads research ways to make themselves immune from the skibidi curse, transforming themselves into something that's not quite human enough to be skibidi-fied. Whatever they are, they look wrong but there is still some intelligence behind their fearful eyes...
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Some humans are naturally immune to the skibidi curse. However, not all of them fight against the skibidis. Some of these immune humans are in 'skibidi cults' that have fallen for the skibidi propaganda that to be transformed into one of them is a high honour and the next stage of advancement and enlightenment for humanity. These immune cultists therefore see themselves as akin to bodhisattvas (individuals in Buddhism who are capable of achieving enlightenment but have chosen not to go through with it so they can help as many other people as possible reach enlightenment.)*
Therefore, if you're a human survivor and think you've found help in the form of a friendly human face... maybe you haven't.
* Feel free to correct me if I used the wrong term for that.
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Feel free to add more!
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