According to a new mouse study, gut bacteria may cause vision loss in certain eye diseases, which could potentially be treated with antibiotics.
Researchers from China and the UK discovered bacteria from the gut in damaged areas of the eyes of mice with mutations in the Crumbs homolog 1 (CRB1) gene, a major cause of inherited eye diseases.
Disclaimer: kitten has already seen a vet, enucleation is planned as soon as she hits their minimum weight. Just asking as a vet student who feels like they have way too many little bits of info floating around in their brain to be sure about anything lol.
Kitten was dropped off at shelter with 0 history (of course), and my knowledge on this case is a little vague. Is this likely just from an infection left too long, that probably sealed the eye shut at some point and worsened? (Like, viral -> bacterial?) It looks it’s proptosed to me, but I’m also not sure if that’s just massive swelling. If it IS proptosed, is that a common sequelae of severe infection? Or do you really only get that with trauma in cats, and then secondary infection?
Not sure if my thinking is way off base, just looking for some general insight into how these eyes end up looking so gnarly. I feel like we’ve had quite a few dropped off this year. Thank you!
Hi, it's Sueanoi here.
I'm glad the kitten is getting some vet attention now. I hope the healing goes as smooth as it can.
As to answer your question, I don't think that's proptosis (eyeball goes out of orbit). I think it is ruptured cornea that has severe inflammation on top.
Anything at all can cause a secondary corneal injury if the eye is irritated, causing the animal to scratch it and worsening the lesion. Over time, superficial ulcers can become perforated.
Over here in SEA, young stray cats are very often infected with feline herpes. It is a very common cause of blindness (as the last consequence of virus-induced ulcer) here.
Your thinking isn't entirely off base, because virus -> bacteria -> catastrophic consequense IS probably correct.
Once it is time to enucleate, I suggest you observe the surgery. I am quite certain that the globe itself is still sitting within the orbit. The things that are coming out of the cat's head is the eyeball's insides that are spilled out of the ruptured cornea.
Keep clean and control infection. There is a chance that the cat won't even need the surgery if the eye shrink down and become enophalmos before it reaches minumum weight (which might take weeks...whichever happen first). Downside of keeping the shrunk eye is having to keep it clean for the rest of its life. So if that is a factor for the cat getting an adoption, removing it anyway for ease of care is still a valid choice.
Crucio in game kind of reminded me of lightning or electrocution. We know Ominis has been blind since birth so we know it’s unrelated (it’s more likely a result of the Gaunt’s inbreeding) but could the crucio spell have made them look like this at least? Enjoy my ophthalmology nerd takes. 👀
I have a theory that (at least part) of the scarring on Makima’s corneas are due to her having had corrective radial keratotomy surgery since CSM takes place in ‘97 and LASIK wasn’t big yet
I’m studying before clinic this morning at this cute cafe I found. Then I’ll go to my school’s poster session this afternoon. A solid Thursday schedule ☺️
A disease we still don't know the cause of (if there's an update I miss, please tell me.) Usually develops in young adult cats, but there are reports of 14 year old cat who has it, and in my case, this is a 4 month old kitten.
This kitten is a former stray, there is no history of injury or any previous medicine use. It just happens very quickly one day, and they present to hospital immediately. The lesion was as seen in the first picture.
The case is referred to me 2 days later. The iris was really inflammed and the blob thingy looks bigger according to owner's observation.
I performed an emergency surgery with third eyelid flap, and prescribed a bunch of medication including topical antibiotics, topical pain relief, topical anti collagenase (acetyl 5%) systemic steroid, and other systemic support.
I hope to keep the flap for 3 weeks. We'll see where this goes.
Note to fellow vets : Most studies that I've read about this disease suggest keratectomy+pedicle conjunctival flap+tarsorraphy. However, newer studies have reported success with only third eyelid flap. The end result look immensely better with minimal scar. I will give this technique a try first, if I fail, I still have the keratectomy option to go for.
this is such a "studying for my COA" post but i've done a quick trawl of the "the terror" ao3 tag and when james fitzjames's eye looks all fucked up near the end that is just a subconjunctival hemorrhage, and any visual consequences of scurvy or botulism or lead poisoning would be completely unrelated and incidental. just so you all know
The ophthalmic nerd in me is coming out and is trying to decide what kind of eye condition Ominis has. We were told that he was born blind but that it couldn't be reversed. That got me thinking that he most likely has ROP (retinopathy of prematurity) where he was born too soon and the blood vessels didn't have a chance to grow normally. One of the symptoms is "leukocoria" or white pupils. Likely because he's a pure-blood Gaunt and their family definitely dabbled in incest to keep that blood line pure. You know...assuming his blindness wasn't some magical happening 😅
"ROP affects the retina, the tissue that lines the internal surface of the back of the eye and transmits visual information to the brain. In order to function properly, the retina requires a blood supply. While a baby is developing inside the womb, blood vessels grow that provide blood to the retina. This growth is usually completed a few weeks before birth. When a baby's born prematurely, the blood vessels of the retina haven't yet fully developed. As a result, the vessels may develop abnormally after birth. In severe cases, bleeding and scar tissue may occur, ultimately resulting in damage to the retina. This can reduce a baby's vision, and in the worst cases, cause blindness."