"A team of researchers at Washington University in St. Louis has developed a real-time air monitor that can detect any of the SARS-CoV-2 virus variants that are present in a room in about 5 minutes.
The proof-of-concept device was created by researchers from the McKelvey School of Engineering and the School of Medicine at Washington University...
The results are contained in a July 10 publication in Nature Communications that provides details about how the technology works.
The device holds promise as a breakthrough that - when commercially available - could be used in hospitals and health care facilities, schools, congregate living quarters, and other public places to help detect not only the SARS-CoV-2 virus, but other respiratory virus aerosol such as influenza and respiratory syncytial virus (RSV) as well.
“There is nothing at the moment that tells us how safe a room is,” Cirrito said, in the university’s news release. “If you are in a room with 100 people, you don’t want to find out five days later whether you could be sick or not. The idea with this device is that you can know essentially in real time, or every 5 minutes, if there is a live virus in the air.”
How It Works
The team combined expertise in biosensing with knowhow in designing instruments that measure the toxicity of air. The resulting device is an air sampler that operates based on what’s called “wet cyclone technology.” Air is sucked into the sampler at very high speeds and is then mixed centrifugally with a fluid containing a nanobody that recognizes the spike protein from the SARS-CoV-2 virus. That fluid, which lines the walls of the sampler, creates a surface vortex that traps the virus aerosols. The wet cyclone sampler has a pump that collects the fluid and sends it to the biosensor for detection of the virus using electrochemistry.
The success of the instrument is linked to the extremely high velocity it generates - the monitor has a flow rate of about 1,000 liters per minute - allowing it to sample a much larger volume of air over a 5-minute collection period than what is possible with currently available commercial samplers. It’s also compact - about one foot wide and 10 inches tall - and lights up when a virus is detected, alerting users to increase airflow or circulation in the room.
Testing the Monitor
To test the monitor, the team placed it in the apartments of two Covid-positive patients. The real-time air samples from the bedrooms were then compared with air samples collected from a virus-free control room. The device detected the RNA of the virus in the air samples from the bedrooms but did not detect any in the control air samples.
In laboratory experiments that aerosolized SARS-CoV-2 into a room-sized chamber, the wet cyclone and biosensor were able to detect varying levels of airborne virus concentrations after only a few minutes of sampling, according to the study.
“We are starting with SARS-CoV-2, but there are plans to also measure influenza, RSV, rhinovirus and other top pathogens that routinely infect people,” Cirrito said. “In a hospital setting, the monitor could be used to measure for staph or strep, which cause all kinds of complications for patients. This could really have a major impact on people’s health.”
The Washington University team is now working to commercialize the air quality monitor."
-via Forbes, July 11, 2023
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Holy shit. I know it's still early in the technology and more testing will inevitably be needed but holy shit.
Literally, if it bears out, this could revolutionize medicine. And maybe let immunocompromised people fucking go places again
Also, for those who don't know, Nature Communications is a very prestigious scientific journal that focuses on Pretty Big Deal research. Their review process is incredibly rigorous. This is an absolutely HUGE credibility boost to this research and prototype
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given historical ranges of different species, what kinds of frogs could have been present for the plague of frogs in exodus?
Fantastic question. Let's assume that the Egyptians considered toads and frogs to be different organisms, and therefore the stories referring to frog plagues indeed mean frogs other than Bufonidae (I think this is a reasonable assumption). If this is the case, there are basically two key candidates: Ptychadena nilotica and Pelophylax saharicus. Ptychadena have the edge over Pelophylax because they are somewhat more tolerant of drier habitats. Sometimes they occur in huge densities, so that every step sends dozens springing away. Both can lay enormous clutches, many thousands of eggs, and in a particularly wet year, I could easily imagine a boom in froglet development that would cause a 'plague'. And because the frogs would be trying to disperse, but heading into habitat that is too dry for them to persist long-term, you would quickly have a lot of dead frogs.
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An Arrangement in Black (part 1) - angst war contribution
@goodomensafterdark @daneecastle @gleafer @gahellhimself-blog @vavoom-sorted-art
I'm ENTERING THE DANCE
Part 2 - End
Word count: 145 words
Dum.
Thus went the bells of the church in the dead of night, announcing the passing to a new day.
Dum.
Thus went the path of the demon Crowley, damning the gardens under the holy establishment.
Dum.
Thus went the dark smoke following him from over the moors.
Dum.
Breathing a gas that meant death, the colony of rats trailed his path, critters travelling in a single motion.
Dum.
His plague mask on and hiding under a long, black cloak, he felt like the personification of Death themselves.
Dum.
Patient Zero.
Dum.
Infested house.
Dum.
Coughing. Shivering. Heart burns. Bleeding. Suffocating.
Dum.
The stench of rotting bodies taking the entire village.
Dum.
The new dawn was approaching.
Dum.
His plague mask fell to the ground.
Dum.
Thus went the bells of the church under the midday sun, calling the mournful to rest in its shade.
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