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dykesville · 27 days

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If you have the time and energy: Do you have a link or a title for the longitudinal study about dieting and diabetes that you mentioned in the tags of that one post? I would greatly appreciate it, I'm trying to collect some data to better argue against fatphobia in my job

yeah dude i have like. everything lol

the study is called the look AHEAD (action for health for diabetes) study and it ran between 2000 and 2015. five thousand participants were assigned to either a weight loss program (1200-1800 calorie diet and 25 min/day physical activity) or simple informational counseling with no weight loss component. as health markers, the study looked at rates of cardiovascular disease, weight loss, diabetes remission, and a few more technical indicators.

the results are so instructive on what dieting does and doesn't do for the body. to start: the maximal “weight loss” for our the group peaked at 9% one year in and leveled out at less than 5% by the third year. so, a 200-pound person would be a 182-pound person after the first year and a 190-pound person after the third year (i.e.: still fat, and fatter the second year than the first). this is informative because it is so typical; six months on a diet is the amount of time it takes for the metabolism to react and counteract the incidental weight loss at the beginning of the diet. take any random weight loss trial and you will see the same shape of the curve; for example, these are examples take from a literature review published in 2000 where the authors talk about how no matter what kind of diet they prescribe, the field is not seeing long-term weight loss and, quote, “fresh ideas are needed to push the field forward.” (spoiler alert, these fresh ideas would not be forthcoming.)

while i was ranting in the tags i confused the cardiovascular disease results and the diabetes remission results – it was the CVD that had showed no impacts. ultimately the trial was ended for futility because the hazard ratio between the two groups was so totally identical:

this also is entirely typical. most studies on weight loss show no significant decrease in mortality. for those that do show a small improvement in mortality, it is dwarfed (and confounded) by the much more reliable result that increasing your physical activity improves mortality regardless of weight loss. basically, exercising makes people live longer, and the rare positive mortality impact of dieting is best explained as an aftereffect of the exercise that usually goes along with a diet. not to mention that the weight loss from these trials is so trivial that it’s hard to objectively credit anything to it. for metabolically healthy individuals, weight loss from a diet is associated with a higher mortality risk. like, surprise, cutting calories and working your body past its nourishment is bad for you. glenn gaesser and siddharta angadi talk about this here in one of the best papers to read on this subject if it interests you.

and finally there's diabetes remission. in the first year, 11% of the diet group experienced some remission compared to 2% of the controls. on the surface, that looks like a flatly better remission rate. however.

the total remission rate went down every year after. so, your hba1c or your glycated hemoglobin level describes the percentage of your hemoglobin that has glucose bonded to it. it's the level of sugar in the blood, and it's how we define diabetes: anything higher than 5.7% is pre-diabetic and anything higher than 6.5% is diabetic. what these graphs show is a temporarily decreased hba1c that goes steadily back up the longer the diets continue. this is far from a cure.

eating less food than usual can make your blood sugar drop, especially if you are diabetic. as i understand it – insulin is the hormone that allows your cells to take in glucose, and type 2 diabetics have an excess of insulin in their bloodstreams, so when a diabetic eats less than usual that unregulated excess insulin allows the available glucose to be taken up quickly, resulting in lower blood sugar levels after the fact. this is what you're seeing at the beginning of the study. but like, that effect doesn't continue forever. even if you continue faithfully on the diet, your body rebalances your metabolism against your normal food environment. as a diabetic, that rebalancing takes you out of remission and you don't go back in.

the fact that people remitted for a short time is not nothing. there's no broadly-accepted cure for diabetes, which renders diets as treatment a nuanced subject. like, you're relieved of the diabetes effects for a while, but now you're suffering from the diet itself, and in the long run it exacerbates the scale of the problem by intensifying the underlying metabolic syndrome.

it's early to tell (read: there aren't a lot of vectors putting out this information, so take with grain of salt) but treatment for the underlying metabolic syndrome that causes type 2 diabetes appears to be the path to remitting type 2 diabetes long-term. diabetes is like a series of hormonal triggers failing to cue one after another. you want to address each of those failed triggers through medication and a safe food environment rather than the symptoms-based approach of e.g. a diet, which produces the desired end effect for a while but doesn't actually cure you of the disease. the foremost doctor working on metabolic syndrome is emily cooper, who has a book and a podcast and a medical practice that i recommend. it's good stuff, especially compared to some of the bullshit in this field.

ultimately the look ahead study is a case of an obesity study uncovering relevant results by accident. if you read the text, the authors don't discuss any of their fucked data at all; they instead jump to making excuses for why, surprise, prescribing light malnutrition doesn't cure heart disease. the degree of corporate capture in the obesity treatment field is extreme and due to a cascade of reasons* diets are held as sacrosanct and are not allowed to be aspersed. so authors of studies in this field talk around their data like it's their job (it's their job). it's, like, tobacco research in the 80s bad. the whole field is sick with rot.

but despite the barriers put up by the financially interested, good work still happens and good people are still working. even in the bad work, all of the information is there if you read what the data says and not what its interpreters tell you it's supposed to say. we're coming to a point in history where people can read studies for themselves and plainly see what is and isn't. we're coming to a point in history where the long game of telephone from some corporate exec to the morning news to my doctor to me is arrested at the jump. we're coming to a point in history where we're harder to just lie to. and it's going to feel real good when the truth goes further.

good luck with your job, lmk if you have any other questions 💜

*one: the corporations actually responsible for rising obesity levels don't want to be challenged and the focus on personal responsibility scapegoats them. two: leveling the "disease" of obesity and cultural anti-fatness against people creates a fertile consumer market for pharmaceuticals, diet products, cosmetics, etc. three: the main prescriptions for obesity (diets, drugs, and surgery) don't work long-term, so people stay fat or get fatter and the aforementioned consumer market never disappears. it's real fucked.

#fatphobia #anti-fat bias #body positive #fat positivity #me talking about my hyperfixation on my blog for almost the first time?? crazie

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espresso-lessdepresso · 2 years

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"Putting an arm around the other’s waist"

fluff

t/w: Blood donation, blood, needles, mention of Schlatt having a phobia of blood and needles

Schlatt’s leg stopped bouncing out of anxiousness as you opened the door and entered the blood donation room. Catching his eye, you brought your hand up and shook a small juice box at him.

Schlatt had decided to join you when you mentioned that you were going to donate blood at a donation camp near where you lived. Unfortunately, you were not eligible to donate since your hemoglobin was lower than accepted. Schlatt on the other hand was in perfect condition to donate. The only problem you two discovered was that Schlatt had a slight phobia of needles and blood. It was only small fear, nothing too serious. He only needed to hold your hand in his suddenly sweaty one and look one-eighty degrees away from where the nurse inserted the needle.

Most of the chairs at the camp were occupied by either nurses or donating patients, so you opted to simply stand next to Schlatt. He dodged the box of orange juice that you were handing him and grabbed your hand instead. The juice was to aid the weakness that often came with draining a unit of blood but Schlatt found your hand better suited to help.

“Schlatt,” You poked his cheek, “This will help with the lightheadedness.”

The man simply closed his eyes and furrowed his brows together, “Can’t. Both hands are full.” Schlatt's right hand was squeezing a stress ball so that the blood pumped to the packet below his chair, which was attached to his forearm by a needle. Seeing the needle for the first time, Schlatt definitely did not remember some gruesome alien movie and scare himself. His left hand was holding yours, as had been the past half hour.

“Well,” You attempted to snake your hand out of his grasp, “if you let go then-”

“Nope. Not happening.” As stubborn as always. His long and slender hand held yours delicately, focusing his thumb to brush over your knuckles, one by one and not letting his mind wander to the discomfort in his right arm.

As much as you adored this side of him, where he for once was seeking comfort in you, you still wanted him to drink the juice. You were familiar with the weakness and headaches that came along with donating blood, and you didn’t want him to grumble any more than he already had today. “Schlaaat.”

Schlatt interlocked your hands in response. His fingers pressed firmly on the back of your hand, preventing you from further trying to escape his hold.

Puncturing the juice box with its straw, you sighed, “Guess I’ll just have to hold this to your mouth like the little baby man you are.”

Schlatt slowly opened his eyes to squint at you. He was well aware of what you were trying to do. “That’s slander...”

“Little baby man.” You smirked to yourself, not meeting his eyes as you fiddled with the straw. “Little baby man, very much the opposite of-”

“Wait till I’m done with this, I’ll show you who's the little baby man.”

“Mhm!” You nodded sarcastically.

“Ugh, what a pain.” Schlatt rolled his eyes. The feeling of his lightheadedness increased. In a swift motion, he grabbed the juice box and hooked his arm around your waist, pulling you close so that he could rest his head on your front. Hmpf, he sipped the juice with a scowl on his lips, pretending to be irritated by you.

Chuckling to yourself, you stated, “There we go. Now that wasn’t too difficult was it?”

Schlatt drank juice quietly, only now realizing that he was parched. “Fuck off,” he grumbled. Satisfied, you let out another small laugh when he pulled you closer, nuzzling the side of his head on your chest.

What a stubborn man.

Read d3, the after events of r6.

++++++

A crumb of comment kind fellow? Engage and let me know if/how you like the writing. Reblogging/Sharing is much appreciated.

prompt credit: Fluff Prompt List by rainysoot

master list

#jschlatt #schlatt #jschlatt fanfic #jschlatt fanfiction #schlattfanfic #schlatt fanfiction #jschlatt fluff #schlatt fluff #jschlatt imagine #schlatt imagine #jschlatt x reader #schlatt x reader

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consult-sherlockholmes · 1 year

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I just huffed paint for the first time it was an accident but it's fuckin fun right but I'm curious now like, what's the dangers? How long does a high like it last? Doesn't feel too crazy, already feeling less high, which makes sense. Anyway it was an accident but now I'm curious. It's fun but I didn't mean to. So yeah. What's the dangers of it? Thanks Shezza xoxo lmao

'Accident' for sure. I know a lot about such 'accidents'.

The dangers would be brain damage and shrinkage, cerebellum and white matter atrophy, as the solvents kill nerve cells, and the inhalants restrict air flow to the nerve cells, and they rapidly deteriorate and die without oxygen. The result is mental impairment, loss of motor control and issues with vision and hearing. But you know to get brain damage one has to have a brain to begin with, so for you there shouldn't be any dangers regarding this.

Toluene is in many products the main solvent, and a central nervous system depressant causing the intoxicating effects, by interacting with dopamine, glycine and GABA receptors causing sedation, disorientation and euphoria. However the high is very short lived, although after-effects of dizziness, nausea, confusion and other side effects can continue for several hours. And toluene is known to be neurotoxic, already damaging nerve cells in a single exposure, so well done. It is also suspected to increase leukemia risk, but not conclusively proven yet. Toluene also affects the heart destabilising it's electrical signaling, and destroys hemoglobin in the erythrocytes, causing anemia and worsening oxygen transport further. Other high-inducing solvents would be butane or benzene.

Another danger is 'sudden sniffing death', which occurs either because the lungs have been completely filled with the inhalant, making it inaccessible to oxygen, causing painful suffocation. Or because the inhalants or the oxygen deprivation can cause rapid and irregular heartbeats, which end in cardiac arrest, causing sudden death. The inhalants make the heart more sensitive towards adrenaline, thus when someone who is using an inhalant gets startled, it could cause a sudden heart attack. Even in young people, there was a case of a 16-year old male dying because he used too many body spray cans in his room without properly ventilating it, even without the intent to abuse it. They suspected some sort of foul play or murder, but in reality he just died because he excessively and obsessively sprayed himself with deodorant, completely filling his room with butane until it reached toxic levels.

So for such a short-lived and small high the risks are definitely not worth it. I would say it is even more dangerous than cocaine or morphine with such a sudden death, but weirdly products containing such solvents are for sale everywhere and everyone has them in their home, even though they could potentially be so dangerous and addictive. Really makes you question drug regulations and penalties, doesn't it?

So have fun huffing your paints, if you still dare to.

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greenhousethree · 1 year

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hi! i thought your meta was interesting on wizards and genetics. i'm wondering what you think about how magical diseases work, and why only wizards can get sicknesses like dragon pox!

OMG I love this question, thank you so much!

I hadn't given the idea of magic-specific diseases much thought, but it would have been a really interesting (and potentially confounding) factor to introduce when I wrote that meta. And honestly, I don't know that my answer will be satisfying to other biology/genetics folks in fandom, but I'm always happy to chat about the topic if anyone's got more points to add! I'm writing this next to my lab bench of cell cultures today, so here goes...

First of all, I want to throw away the idea that Muggles aren't affected by magical afflictions because they aren't exposed to them. Wizards live under the noses (literally) of Muggles; if non-magical people could contract Dragonpox and Spattergroit, they would.

This then leads to the question: assuming a magic/nonmagic binary, how have these two populations evolved such different physiologies or genotypes that they can behave similarly and mate with one another, but aren't affected by the same diseases?

Because this question can be answered from sooo many different angles, I've come up with an answer that's basically a headcanon, based on my knowledge and what I think would be a cool way for this to work:

A little non-magical, biology background: there are a lot of ways that our genes affect our physiology. The scientific community has a really good foundational knowledge of how these things work, but we're constantly finding new ways that, for instance, genes we thought only were meant to regulate inflammation also majorly affect lung development. These are multi-factorial genes that affect a lot of specific, but disparate, parts of our physiology.

My favorite example of a genotype that follows a simple Mendelian genetic model occurs in the HBB gene, which encodes a part of the hemoglobin in our red blood cells. When a recessive mutation is passed on by both parents to their offspring, the result is sickle-cell anemia, a heritable condition that affects red blood cells. That's all well and good on a dominant/recessive trait model, but what we continue to learn is that there are also effects of being a carrier of sickle-cell (having only one recessive copy). Carriers have an increased resistance to malaria... not only compared to sickle-cell affected patients, but also to compared to otherwise "healthy" non-carriers. Sickle-cell and malaria are two diseases that seem completely different (heritable vs. parasitic), but they both affect the blood, and carrying one copy of the sickle-cell mutation actually makes carriers' blood just different enough that they become worse hosts for the malaria parasite. This is just one example, and there are a lot of other ways that genes can have protective effects (including by regulating other genes), but I think you get the picture.

Long story short, there are heritable traits that don't seem to be connected, but can really impact one another. I think that whatever that magical "gene" is must work this way, too: it protects against certain Muggle diseases, somehow, and perhaps upregulates or unlocks whatever makes wizards susceptible to magical ones (I haven't even gotten into whether Dragonpox or Spattergroit are viral, bacterial, fungal, or a secret fourth option, but that's for another day). I don't have a proposal for this mechanism, per say, because there are just too many options. But I like to think that there's a little bit of physics and a little bit of magic at work, here.

A few questions that came to me while thinking about this: can half-bloods or Muggle-born wizards contract both magical and Muggle diseases? What the hell to poor Muggle parents do if their pre-eleven-year-old wizard child contracts an illness that the doctors have no idea what to call? I'd be really curious to read some sort of epidemiology text written by a Healer-turned-Muggle-physician, a Carlisle Cullen of wizards, if you will...

(speaking of which, can we talk about how RIDICULOUS it is that vampires, werewolves, and humans apparently all have different numbers of chromosomes? Ugh. I digress...)

Thanks again, anon! 🌱

#anon ask #answered #harry potter #more wizard genetics #meta #thanks anon for giving me a biology soapbox #scicomm

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kagrenacs · 2 years

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This pride month I wanted to discuss my transition a bit, I’ve had a couple people thinking about going on hrt wondering about what testosterone therapy is like. Up front I wanna say I wasn’t on it for very long at all, voice dysphoria was my problem, so I only needed to go on for 8 months until I was happy. I also messed up my dosing for four of those months, instead of 0.5ml I took 0.05 ml of T -_-

I’m lucky to have had a fairly easy time going on T. There’s a few doctors who have sacrificed so much for our community. The woman I saw was fired twice for providing a legal medical service to trans people. When going through the system, it can take up to five years to get referred T, pre-Covid. (I was going to DIY it if they denied me, at the time I had found a supplier of T gel, unfortunately it seems down though)

We discussed risks, namely being the production of too many red blood cells which can lead to stroke and tissue damage, however the risk is small, (one study says 11%) less than that of smokers. Your primary care provider usually monitors your hemoglobin levels because of this. Our main concern was the fact that I have premenstral dysphoric disorder, and have really struggled with really severe depressive episodes before my periods. Unfortunately there isn’t too resources or much discussion on pmdd and it’s interaction with HRT, beyond women undergoing feminizing hormone therapy potentially having pmdd symptoms. Ultimately though I don’t think I noticed any significant impact on my mood, and I don’t have periods.

I found this chart really helpful as a general guideline to what changes happened when. Everything is dependant on your genetics, looking at cis male relatives can be a good pointer to how your puberty will be.

I noticed skin oiliness first, even with my T micro-micro dose. (However there’s prescriptions to help with acne). I’d get acne around where chin hairs were coming in, near the 3 month of proper dosing, 6 months total mark. The thicker, coarser hair sticks around, I’m not sure if mine is growing as fast, or if i’m just not noticing more hair come in. But it still grows and I still like to shave it back a bit. I never got too much body hair besides leg hair, I have a little bit of belly hair and some slightly longer arm and breast hairs. I believe this is a genetic thing though, my brother isn’t particularly hairy yet either.

I saw a bit of changed patterns of fat distribution around month 4/7, I also increased T by .10 mL at this time. The veins in my arms and hands became much more prominent, I had less round cheeks, though nothing really noticeable. I’ve been off T for 3 months now and everything has returned to pre-t patterns.

A little after the fat redistribution I saw increased strength in small ways, especially in my hands. I was skeptical of that being real, but I managed to cut through some pork so well I cut right through an old plastic plate D: Bottom growth also happened around that time.

It took about 16 weeks total, about 4 weeks proper dosing to first hear the start of the voice changes. I tapered by dose off around 25 weeks, doing it every 2 weeks to slowly inch to where I wanted, and I was happy by 30 weeks. I was starting to grow moustache hairs around then, won’t lie that’s partly why I stopped T, I don’t like moustaches. My voice did change afterwards, I have the ability to pitch it a bit higher now, but it didn’t go to my pre-T voice. I think this snippet I found on google beautifully sums it up.

#transgender #nonbinary #detrans #(<- tagging it as that bc i think it could help for the wide variety of experiences under that umbrella I still am trans tho)

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foxymoxynoona · 11 months

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Omg. You had a surgery? Please be rested and take care of yourself. What surgery did you have btw? Is it too painful now?

Fun fact: this surgery for this type of rare tumor I guess has never been done before and my surgeon joked he's going to name it after me 😂😁 I'll put more info below the cut for those who don't want medical stuff on their TL.

I had a VERY large tumor in my small intestines --now confirmed to be totally benign, but no one understands how it got that big or why because it just doesn't happen. My surgeon couldn't believe I hadn't already had an emergency blockage, it was so big. It's also been taking all my blood and nutrients for a while, so my nutrition is, as they put it, "shitty." Mainly I just was aware I've had really really bad anemia for the past few years, and I was hospitalized in May with a hemoglobin of 5 (which you basically die under, that's so critically low.) They weren't sure what would be necessary to remove the tumor, so I had an open exploratory laparotomy where they basically just go in and figure it out, but we had expected I would need a whipple procedure which is a VERY risky precedure where they remove a bunch of your digestive organs and re-route what's left. (I can explain more why if anyone is curious, I learned a lot about it haha.) FORTUNATELY once they got in there, I didn't need the whipple! They were able to remove the tumor and only my gallbladder and a couple bile ducts along the way.

Even this was still a major surgery though with lots of risks and I've had a few complications that wound up lengthening my hospital stay. 2 days after surgery, I developed a leak which can be a fatal complication or need an emergency surgery to fix, so that was scary, but my body managed to maintain and fix it all on its own after some scary days and only minor assistive procedures! I kept having random white blood cell increases they feared were infections but then I'd fight them off. They also put me on IV nutrition through a PICC line to try and repair my malnourishment as best they could, but also because I can't eat a normal amount of calories yet, so my blood and nutrition levels are still not back to normal ranges but improving!

I finally got to come home after 13 days. It's still early recovery days and I'm still on soft food diet and strict rest and have follow up appointments and all that, but I'm doing a little better each day! It's been a really scary journey getting here, but hopefully things can continue to improve from here. The pain is pretty bad and I have a gnarly midline scar now but I'm coping and it's getting better and and someday soon I may feel better than I've felt in years so that would be really great! And hopefully no more scary life-threatening hospital stays or anemia!

#asks #anonymous #personal #tw: medical #tw: surgery

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outerspacekenz · 4 months

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Trans Women in Sports

I am using this blog post to talk about my opinion on the trans women in sports debate, as well as include information that has been studied to back up my reasons why trans women should be able to be on women’s sport teams. I will say sports is not one of my favorite things but I can still understand that there is inequality in sports.

What started this was chapter 2 of “Gendered Voices, Feminist Visions” (Susan M. Shaw, Janet Lee) the topic of institutions came up. Institutions are “social organizations that involve established patterns of behavior organized around particular purposes, that are based on social norms”. There came the topic of institutions in sports. Many people know that sports are primarily a male dominated industry and women’s sports are grossly underrepresented. Another thing they addressed was transgender women in sports, stating “Trans girls and women are prevented from participating in some sports at some levels and have to demonstrate minimum testosterone levels”. While there have been laws passed to prevent or let trans women play on women’s teams, there is still much discourse on the subject.

While reading “Gendered Voices, Feminist Visions” (Susan M. Shaw, Janet Lee) I questioned a few things, like what about athletes that use steroids? Or what about cisgender (relating to a person whose gender identity corresponds with the sex registered for them at birth)? Women can have high testosterone and a common cause is usually PCOS (polycystic ovary syndrome). They are not expected to have their testosterone levels tested. So I decided to do a bit more research since it is so unfair transgender women would not be able to be on a women’s sports team.

The first thing I decided to research was seeing what testosterone does, in regards to athletic ability. In reading the article “Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance” by authors; David J Handelsman, Angelica L Hirschberg, and Stephane Bermon. How they explained what testosterone does and how it helps in athletic ability, “The striking male postpubertal increase in circulating testosterone provides a major, ongoing, cumulative, and durable physical advantage in sporting contests by creating larger and stronger bones, greater muscle mass and strength, and higher circulating hemoglobin as well as possible psychological (behavioral) differences”. Overall a man's strength and muscle which does help with their abilities in sports (they produce about 30 times more testosterone than women), which is why sports are split between men and women.

So even though a trans woman could have more testosterone in their bodies than a cisgender woman they should still be able to be on women’s teams. I have two reasons to talk about that I think would help enforce this opinion. Firstly, I would like to talk about how cisgender women can also have high testosterone. The most common reason for this is having PCOS (polycystic ovary syndrome), there are also other conditions that can affect a woman's thyroid. These women are not kicked out of sports because of this and they are not forced to control or minimize their testosterone levels, like how transwomen are expected to. They only test those with XY disorders and chromosomes.Secondly, many transgender people start on hormone replacement therapy, either to enhance the male or female hormones depending on the person. In this case we are talking about feminizing hormone therapy, this adds female hormones to one's body making them present more as a woman. The article “Feminizing hormone therapy” from the mayo clinic website states “Feminizing hormone therapy involves taking medicine to block the action of the hormone testosterone. It also includes taking the hormone estrogen. Estrogen lowers the amount of testosterone the body makes”. Which means that a trans woman's testosterone levels would go down and they would have more estrogen making their hormones fit cisgendered count. There is always a possibility it could still be higher than an average cisgendered woman but as we know even they can have higher levels of testosterone. That doesn't stop them from playing in women’s sports. So if a woman is transgender that should not affect their ability to play on the women's team.

Finally, to answer my first question, what about athletes that use steroids? Well steroids basically just act as testosterone, by building muscle tone and body mass. Steroids do not directly improve an athletes ability, in this article “Anabolic Steroids and Sports: Winning at any Cost” by the New York state department of health they stated how “Many factors determine athletic ability, including genetics, body size, age, sex, diet and how hard the athlete trains”, so really sports is more about what an athlete does to effect their skills and abilities. Sports are for everyone and if someone does not connect to the gender they were assigned at birth, that should not stop them from being on the sports team of the gender they present as.

Sources:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391653/#:~:text=The%20striking%20male%20postpubertal%20increase,well%20as%20possible%20psychological%20(behavioral)

https://www.mayoclinic.org/tests-procedures/feminizing-hormone-therapy/about/pac-20385096#:~:text=It%20blocks%20male%20sex%20hormone,of%20testosterone%20the%20body%20makes

https://www.health.ny.gov/publications/1210/#:~:text=Anabolic%20steroids%20help%20build%20muscle,how%20hard%20the%20athlete%20trains.

"Gendered Voices, Feminist Visions” (Susan M. Shaw, Janet Lee)

#transgender #trans woman #trans women in sports #sports #gender inequality #pcos

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veiledfox · 6 months

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An Experiment Most Marvelous [ II ]

"Sixty feet, twenty meters. Lady Kyuushi has reached the depth necessary for her to suffer the effects of the Curse of the Abyss. According to the notes she shared with me from her prior experiments, she experiences the earlier effects of the Curse sooner and sooner with each layer. After her experience with the Fifth's Curse, she should be experiencing the dizziness and nausea of the First upon first beginning her ascent."

Hotaru spoke clear, precise, aloud. Keeping information clear and understandable for the Sovreign behind her. Monitoring the Kitsune's vitals every second, eyes darting from reading to reading quickly. Heart rate elevated a little higher than normal, cortisol still high, oxygen in her blood slowly draining. Everything was fine otherwise so far.

"It's admirable that Lady Kyuushi took such thorough notes of her experience with the Curse. No one would willingly put themselves through the pain it can cause just to understand how it effects them in our 'Realm' as you two call it." Bondrewd spoke up to comment in compliment.

"Lady Kyuushi also asked that you remain quiet. I need to focus and keep watch on her vitals." A slight hint of annoyance in the Doll's otherwise polite tone. Glancing to the distance between her and the Kitsune, seeing it start to be reduced. Immediately catching her heart rate and cortisol both rising further. "She's ascending."

"Fifty feet. Second Layer Curse." Another rise in her heartrate and cortisol. Nothing too alarming still, thankfully, but the more it climbed the closer it got to being dangerous. Even for a Kitsune, who could normally handle much more extreme vitals than Humans could. Hotaru's eyes were glued to the conjured display, keeping track of everything.

"Fourty feet, her ascent is slowing a little. Third Layer Curse." Looking over the readings, her cortisol had thankfully seemed to lower some, but her heartrate kept at the increased pace. Other readings showing hints of odd brain activity and... a hint of dopamine? Whatever was going on, she was growing curious. Though she kept her focus, and she could sense the Sovreign was getting more and more invested in what was happening too, hearing his boots shuffle a bit and a deep long hum.

"Thirty feet. Fourth Layer Curse... Hemoglobin starting to fall... she's bleeding somewhere. It's minor right now thankfully, and... fluctuating? Lady Kyuushi must be using active healing Magicks." The instant she said such a word, the Doll could hear Bondrewd perk up with interest.

"Magic?"

"Yes, Magic, it's a very natural thing in our Realm and Kitsune's generate large quantities of it. Their Magic also becomes stronger the more tails they have. Regenerative capabilities included in their natural repitoir, they reach their peak in such field throughout their seventh, eigth, and ninth tails. Lady Kyuushi, possessing eight of her nine, seems to be utilizing her healing to fend off the effects of the Curse as much as she can."

"Marvelous..."

"Twenty feet. Fifth Layer Curse. Sensory Deprivation should be kicking in about now according to known knowledge of the curse and her notes. Her ascent has slowed to a stop..." Heartrate rising, cortisol climbing again, brain firing off in panic and fear, adrenaline surging through her system. Hotaru could see it all, see how her body was working, fighting against the Curse to continue. "Slow ascent, oxygen starting to run low."

Worry was starting to truly take hold of the Doll seeing the state the Kitsune was in begin deteriorating so quickly. Shifting on her feet, starting to tap a foot on the ground below her, even raising a hand to gnaw at a knuckle a bit. She knew Kyuushi was capable, but this...? Even this was starting to look too dangerous for her.

"Ten feet." Glancing ever so quickly down to the water in front of her, catching sight of bubbles rising to the surface then returning immediately back to the vitals. "Sixth Layer Curse... theoretically..." Kyuushi's status just got worse and worse the more she watched on. Heart rate climbing dangerously high, oxygen and hemoglobin dropping, Kyuushi was somehow still ascending though.

At least, she was. A sudden spike in heartrate and surge in brain activity making the vitals display flash red. Hotaru, immediately, moves to the water's edge to look down into the waters. Bubbles, countless bubbles rising from the Kitsune who, from what it seemed, was within five feet of the surface.

Getting down onto the ground, Hotaru lays herself out flat on her front reaching a hand deep into the water, up to her shoulder, trying to reach for Kyuushi. Calling upon some of her own Magic to extend an ethereal grasp for the Kitsune, feeling around until suddenly he feels an arm. Quickly grabbing on, she uses all her strength to pull the Woman up and out of the water.

Once she had her out of the waters, though, the Kitsune's screaming became clear right away. Horrid, blood curdling, loud. Her body convulsing, twitching, twisting this way and that, Hotaru struggled to move her much further from the waters with it all. Though before the could start attempting to do anything to help her charge, blue flames would suddenly erupt around her, not mere ethereal fire, but true and proper flame.

A pyre, a pillar of blue raging fire, all from Kyuushi's body as it writhes and contorts. The Doll and the Lord of Dawn witness to the pillar climbing higher and higher, growing brighter and brighter, and the searing heat it was giving off. It would be difficult to see through the flames with how bright they were getting, but within was still Kyuushi.

The Kitsune, who's body was creaking, groaning, snapping. Her form starting to shift rapidly and uncontrollably. Her Human guise dropping and giving way to her true Humanoid figure, Kitsune and Oni features both clear as day. Her body shrinking down and changing to her true form. Figure shifting and bending to any and all states that it could possibly take between them.

Skin splitting and healing time and again, bones snaping and setting, hair and fur growing longer, falling out in patches, and regrowing. Limbs twisting in ways they shouldn't, fingers bending impossibly, blood that was being spilled burning away almost instantly upon leaving her body within the inferno. Nothing that was happening should've been possible. It was horrid to watch, but it was all that Hotaru could do, watch on as the Woman who had commissioned her creation broke over and over. As her body degraded, regenerated, and changed.

The Curse of the Sixth layer was anything but a joke, this was cruel, terrifying. She didn't even want to attempt imagining what this could do to a regular person from this Realm. Yet the Man standing just meters away had subjected people to this for his experiments? If not for her concern for Kyuushi, Hotaru felt as if she could tear the foul 'Scientist' limb from limb for what he had been doing.

Between the screams of excrutiating pain, the roaring blue pyre, and the disturbing cackling that had begun from the Sovreign of Dawn, she could hardly hear the high pitched whine starting and stopping from the vitals display. Once they had registered in her mind though, her attention was drawn to the readings. To a heartrate flatlining, spiking into such a rapid pace, evening out, and fluctuating wildly between the three states without any rhyme or reason. To brain activity that was flaring across every part of the mind and other readings registering as errors impossible to track.

She was dying, but at the same time she was fine? A disturbing limbo between life and death that was tearing her body appart while it fought to keep itself together at the same time. This level of healing Magicks though, it shouldn't be possible, not for a Kitsune with eight tails, or even a Kitsune with nine. Not from what Hotaru had researched of healing Magicks. Ancient or modern, it didn't matter which, nothing was as strong as this save for the most powerful artifacts in their World.

Whatever was keeping Kyuushi alive, it couldn't have been her own Magicks. Not at the rate this was going, there was no way she was conscious enough to control her Magick like this. She wanted to wonder what it was, what was keeping her from perishing, but right now all she could bring herself to care for was whether she would survive in the end.

All the while the Lord of Dawn seemed to be thriving as he watched this all unfold. His laughter never ending as he approaches the pillar of flame, arms outstretched as he seems to take in the raging heat it was putting out. "Marvelous! Truly marvelous!" He shouts over it all. "The Abyss demands it's sacrifice! Even from a being not of our world! Yet it can't seem to claim it's demanded life, the Abyss is being denied! What will relent first, I wonder?! The Abyss?! Or our dear Lady Kyuushi?!"

It was almost as if the White Whistle had given a command to the Abyss, as mere seconds would pass after he speaks before everything suddenly calms. The raging pyre becoming reduced from the inferno it had become to a mere enveloping flame as the Kitsune's body goes still. The wildly fluctuating readings on the conjured display stabilizing. Heartrate weak, brain activity low, but the Kitsune was alive.

Turning her attention back to the Woman herself, Hotaru hurries to her side. Carefully reaching toward the still flame-enveloped Mythos, the fires were still warm, but not painfully so anymore. Easing her hand into the flame... ethereal, safe to reach into and touch Kyuushi. Which she would, reaching for the Woman's shoulder to oh so gently turn her over.

Humanoid form again, as she had been when this experiment began. Though her inhuman features were present now, as her Human guise had been undone amid everything that was happening. Beyond checking the Woman's body for any remaining injuries, she would take in and make note of anything that had changed from before.

Looking carefully over her features, her Oni horns looked... longer? They had stood at the same height as her ears, an added six inches above the top of her head, originally. Now they appeared to be twice the length, and to curl further back over the head. Still a shallow curve, but certainly more noticeable now. The blue gradient of skin on her forehead having spread, now reaching down to her brows suggesting it was the entire top of her head now this coloration.

Carefully prying an eye lid open, her sclera were black now instead of white, bloodshot, pupils vacant in her unconscious state. Easing her jaw open, her teeth seemed fine, though her canines seemed sharper now. The Vestigial Oni fangs longer, more prominent, like a secondary set of canines. Continuing her examination of the Kitsune with the sides of her head, briefly feeling the back, then continuing along her neck toward her torso.

Noticing quickly all the fresh wounds healing over, dark marks across her body as the flesh recovers bit by bit. Pressing gently at various spots along her collar, chest, abdomen, and stomach. Her muscular structure seemed more... defined? She took only a quick glance to Kyuushi's arms, only needed a quick glance, to notice the blue gradient that had been crawling up her hands was now farther up her arms too. From what she could see through the sleeves of her shirt, it reached her elbows now.

Had the Curse... given her a 'blessing' instead? Did it utilize her Oni genetics to do so? Her claws were even longer now, larger and sharper too. Yet... if this was the 'blessing' she was given, why was it so different from what transformation Bondrewd had experienced? Why did it leave her so intact and relatively unchanged? Did her adaptation perhaps finally take hold amid everything?

Ever so carefully she would turn Kyuushi onto her side and rested against her knees briefly, moving a hand to retrieve her tails and pull them out from under her. First to count them, then to check their condition. Though right away she could feel that they were heavier, longer, and their core seemed thicker. Their fur longer too, a strange mix of soft and rough, denser for sure.

One, two, three from the central base.

Four, five, six from the right base.

Seven, eight, nine from the left base.

Nine tails. The experiment was an ordeal severe enough to grant the Kitsune her last tail. At only one year past her first century too. It made the Doll worry what the future may have in store for the Kitsune, for her to have her nine tails just past her first century. In what little record of Kitsune history still existed in their Realm, not one notable Kitsune had their full set of tails this soon, and most the population had simply just gained their tails over time, back when their population was more abundant.

It didn't seem Kyuushi was going to wake any time soon, however, nor did she expect that she would. Though with her condition having stabilized, and her healing Magicks clearly subconsciously working to repair whatever damage she was still suffering from, it would surely just take time. Time best spent in the Shrine Lands, instead of here in the cold dark depths of the Abyss under the Sovreign of Dawn's ever present gaze.

"Marvelous!" His damned voice rising again, hands clapping together in applause. His boots clacking against the stone as he makes approach. "The Abyss is defeated! Lady Kyuushi yet lives, and though minor... it does appear she has experienced some changes. I do wonder if she has received the Abyss' blessing in this endeavor. Though I suppose we won't be able to tell unless she awakens and returns to test the Curse again. I would most certainly enjoy being present for such experimentation, whenever it may occur."

Hotaru, hardly paying him any mind, had started to cautiously ease her arms under Kyuushi to get a proper hold and lift her. Carrying her sideways across both arms, held closely and securely to her so she could move back over to where the Kitsune's belongings had been set down. Easing down with her so that she could retrieve everything, setting it in the Woman's lap to be able to bring it with them as she stands again.

"I will be sure to inform her of your... disturbing interest in her suffering." She responds finally, malice on her tongue as she glares back at the White Whistle. "But in her current state, Lady Kyuushi needs rest and care. Good day, Lord of Dawn." Taking a step as a tear opens in reality, letting her step through and closing shut behind her. Leaving Bondrewd on his own, looking over the scorched space where Kyuushi had been while her body was ravaged by the Curse.

The Doll carefully stepping out under the Tori at the center of the lake onto the surface of the water below. Quickly starting to make way back to the homestead atop the white sands to the left. To return Kyuushi to her room, her bed, so that she may rest and be cared for as needed.

#The Kitsune {Kyuushi}#The Dolls {Hotaru and Hoshi}#Veiled Legends {Story}#Truths Among Myths {Headcanons}

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exceleurnet · 9 months

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#how to cure pcos permanently #how to increase hemoglobin in a week

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homeremediestube · 7 months

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Toxicity Risks of Common Supplements: Exploring the Dark Side of Overdosing

Supplements can be a great way to boost your health and well-being, but it's important to take them safely and responsibly. Too much of a good thing can be harmful, and certain supplements can be toxic if taken in excess.

Vitamin A

Vitamin A is an essential nutrient that plays a role in vision, immune function, and cell growth and development. However, excessive intake of vitamin A supplements can be toxic. Symptoms of vitamin A toxicity can include nausea, vomiting, dizziness, headache, and blurred vision. In severe cases, vitamin A toxicity can damage the liver and other organs.

Iron

Iron is an essential mineral that is necessary for the production of hemoglobin, which carries oxygen in the blood. However, too much iron can be harmful. Symptoms of iron overdose can include nausea, vomiting, diarrhea, abdominal pain, and constipation. In severe cases, iron overdose can damage the liver, heart, and other organs.

Selenium

Selenium is an essential trace mineral that has antioxidant properties. However, excessive intake of selenium supplements can lead to selenosis, a condition characterized by hair loss, skin rash, and digestive problems. In severe cases, selenosis can cause neurological problems and even death.

Vitamin D

Vitamin D is an essential nutrient that is important for bone health and immune function. However, excessive intake of vitamin D supplements can lead to hypercalcemia, a condition characterized by high levels of calcium in the blood. Symptoms of hypercalcemia can include nausea, vomiting, weakness, constipation, and kidney problems.

Other supplements

In addition to the supplements listed above, there are a number of other supplements that can be harmful if taken in excess. For example, high doses of zinc supplements can interfere with copper absorption and cause anemia. High doses of omega-3 fatty acid supplements can increase the risk of bleeding. And high doses of herbal supplements, such as ephedra and kava, can cause serious side effects, including heart problems and seizures.

Safety tips

To avoid the potential dangers of excessive supplement intake, it is important to follow recommended dosage guidelines and consult with a healthcare professional before starting any new supplements. Here are some additional safety tips:

• Read the supplement label carefully and follow the dosage instructions.

• Be aware of the potential side effects of the supplements you are taking.

• Tell your healthcare professional about all of the supplements you are taking, including herbal supplements and over-the-counter medications.

• Avoid taking supplements if you are pregnant or breastfeeding, unless directed to do so by your healthcare professional.

Supplements can provide benefits when taken in appropriate doses. However, it is important to be aware of the potential dangers of excessive supplement intake. By following the safety tips above, you can help to ensure safe and effective usage of supplements.

Supplement Overdose: What You Need to Know to Stay Safe

We all strive to live healthy lives and often turn to supplements to support our well-being. While these products can offer benefits when taken responsibly, it's crucial to understand that even natural or herbal supplements can pose risks if consumed in excessive amounts. In this article, we'll explore what you need to know about supplement overdose and how to handle such situations.

1. Recognizing the Signs:

Identifying a supplement overdose can be challenging, as symptoms can vary depending on the specific supplement and dosage. However, some common signs to look out for include nausea, vomiting, dizziness, rapid heartbeat, confusion, and difficulty breathing. If you or someone you know experiences these symptoms after taking supplements, it's essential to act quickly.

2. Seek Immediate Medical Help:

If you suspect a supplement overdose, don't hesitate to call emergency services or rush to the nearest emergency room. Prompt medical attention is crucial in such situations. While waiting for professional help, try to keep the affected person calm and monitor their vital signs if possible.

3. Provide Information:

When seeking medical help, provide accurate information about the supplements ingested, including the brand name, dosage, and any other medications being taken. This information will assist healthcare professionals in providing the appropriate treatment.

4. Avoid Self-Remedies:

It's crucial not to take matters into your own hands by inducing vomiting or administering any substances without medical guidance. Incorrect interventions can potentially worsen the situation or lead to complications. Trust the expertise of healthcare professionals to guide you through the necessary steps.

5. Prevention Is Key:

Preventing supplement overdose is always better than dealing with its consequences. Here are some tips to keep in mind:

a. Consult a Healthcare Professional: Before starting any new supplement regimen, consult with a healthcare professional who can assess your specific needs and recommend appropriate dosages.

b. Follow Recommended Dosages: Always adhere to the recommended dosages provided on the supplement packaging or as advised by a healthcare professional. More is not necessarily better when it comes to supplements.

c. Be Mindful of Combinations: If you're taking multiple supplements or medications, be aware of potential interactions. Some combinations can lead to adverse effects or decrease the effectiveness of certain substances.

d. Store Supplements Safely: Keep supplements out of reach of children and in a cool, dry place as directed on the packaging. This helps maintain their potency and prevents accidental ingestion.

Supplements can be beneficial when used responsibly, but it's crucial to understand the risks of overdose. If you suspect a supplement overdose, seek immediate medical help and provide accurate information to healthcare professionals. Remember, prevention is key, so consult with a healthcare professional, follow recommended dosages, be mindful of combinations, and store supplements safely. By being informed and cautious, you can make informed choices about your well-being and enjoy the benefits of supplements without compromising your health.

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