#sensory cells

[bpod-bpod]

Splitting Hairs

Sometimes before repairs can begin, damage must be cleared away. Here macrophage cells (highlighted in blue) set to work engulfing and destroying dead sensory hair cells (red) inside a young zebrafish. Tackling the dead cells from all sides, the macrophages – also found in our own immune systems – are called to the scene in a curious way. Researchers find the cells receive a series of three chemical signals – each one triggering separate signalling pathways, using proteins like messengers to alter the behaviour of the cell. Ultimately, they ‘programme’ it to clean up the mess. Zebrafish regenerate their hair cells after injury, yet – for the moment – humans can’t. Studying the sequence of events after injury in the fish, scientists may find ways to mimic the process in our owns cells, improving our chances of healing hair cells essential to our hearing and balance.

Written by John Ankers

Video from work by Nicolas Denans and colleagues

Stowers Institute for Medical Research, Kansas City, MO, USA

Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, September 2022

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#science #biomedicine #macrophages #hair cell #sensory cells #neuroscience #brain #zebrafish #immunofluorescence

[cuicuit]

A scale from the Linea Lateralis (lateral line organ)

Some fishes have a row of tiny scales on each side of their body, which works as a sensory organ, detecting vibrations in water. The little hole in the middle of the scale let the water penetrate under the scale, into a tiny canal which conducts the liquid in contact with the external structure of a sensory cells' group, connected to a nerve. The impulse that the nerve record depends on the pressure of the fluid : it can detect very low pressure variations, which allow the fish to perceive movements of other fishes around or to regulate its own swimming speed.

#fishes #animals #nature #scales #fish scales #biology #ichtyology #microscope #nerve cells #nerve #sensory #sensory organs #linea lateralis #ligne latérale #ichtyologie #sensory cells #water #fluid mechanics

[caffeinatedopossum]

I don't like eye contact because when I look into someone's eyes, there's either WAY too much there or concerningly little. And no matter which it is, it feels like something you really didn't want me to know

#yes i AM judging you for your empty eyes. i can look straight through them and see the absence of brain cells behind them #im not judging you for having a brain horrifically full either but i am getting second hand trauma from it #uncanny valley shit fr #'hey bro can you stop having eyes? the trauma in them is giving me sensory overload'

[helenwhiteart-blog]

Hypermobility is a spectrum disorder: its not all about subluxations!

There’s a very classic view of what hypermobility syndromes are or look like…in the case of hEDS, many joint subluxations and the like; basically, symptoms that affect joints, not taking into account a whole other range of symptoms that can often present themselves as well as, or instead of, major joint issues. Also a persistent viewpoint, maintained by GPs, that it is a rare condition (by the…

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#anomalous sensory experiences #articles #celiac disease #costochrondritis #dysautinomia #eye health #fibromyalgia #hEDS #Hypermobility #inflammatory bowel disease #interoception #mast cell activation syndrome #neuropathy #PoTS #spectrum conditions

[soldier-poet-king]

Tricked them into taking my nasty bad blood at the donor clinic

<- had the MINIMUM hemoglobin levels to donate despite my taking heavy duty iron supplements daily

#dont ask abt my ferritin stores. we dont talk about my ferritin stores :) #i cannot donate frequently bc this bitch is EMPTY yeet #all my homies (cells) hate iron apparently #but ive got that good good O + blood so we keep trying #out of a sense of duty mostly #anyway. if i get tat next month #could probs donate again in feb if my blood recovers by then #tho thats a big if. again. iron??? we don't know her #body straight up refuses to absorb it #franposting #whatever they make the compression bandages out of???? sensory hell. its so itchy and bad #but i WILL SUFFER to help someone maybe with my good special in demand blood #im already an organ donor. on the living stem cell donor registry #HOW can i take apart my body kote #*my body more to help ppl. no srsly. i need to know #to be clear. i did not trick or lie. its a joke #none of my health conditions preclude donating blood #its just my iron is so fickle #so the finger pricktest is v hit and miss #always a gamble if theyre gonna let me give blood

[systimming]

Bobby fictive with weapon stims!

- Mod Primarina + Mod Sally.

((Sources of gifs: x, x, x | x, x, x | x, x, x ))

#Stim #Stimmy #Sensory #Dead Cells #Bobby #Ours #IRL Weapons #Knives #Knife tw #Fashion #Pants #Axe #Bats #Guns #Guns tw #Shooting #Purple #Black #Stimboard #Gif

[cubot]

The problem with being very good at connecting 1-to-1 with children is that there may be three teachers in the room at one time, but every child is zoning in on me at once to the point where the other teachers have to metaphorically bat them away with a "Josie is busy."

#ramblings #it's like sensory overload but they're kids so you want to validate their feelings #gotta “one moment one moment” them repeatably and give them a turn order of who can talk to me next #a girl tried to call me on a pretend cell phone while i was sorting out a toy car issue between two boys #and i told her i would call her back in one minute #and then a kid made me restaurant food while another girl asked me to show her how to make pipe cleaner flowers #so i had to talk on the phone eat food and go to the table in quick succession #but i did it funny so no one felt bad i was going fast

[poptartmochi]

the maggie gioia thoughts strike yet Again 🤏🏻🕶️🤨

#so i never realized it but magdalena and gioia Both have their own synch meters that are analogous to the devil trigger bar yk #and gioia's is for the like.. the telepathic connection between her and the agathos. almost like a cell phone connection yk! the more full #the bar is‚ the stronger the connection between them is + the easier it is to execute more complicated manuevers and attacks #it is a similar idea w maggie but ofc more Internal.. it's like trudging through snow or clawing your way through sensory overload #i always imagine hers as like.. the clearing of static. or washing up on shore after being shipwrecked.. like the two consciousnesses #become more aligned with each other and she is able to make sense of things which in turn allows her to do cooler stuff #to make a long story short‚ gioia's thing is very external and maggie's is wholly internal right. #anyhow. the Realizashun...... 🤌🏻 gioia's is very much so like. a natural development of her being a warrior/ #duelist/??? you know? she was Raised and Trained to fight so that is natural for her! that's why the bar manifests as like. the natural #cohesion between two comrades in the trenches who don't have time to speak. they just Get Each Other and know each other's next moves #instinctually. Meanwhile Magdalena was a civilian her whole life!! she doesn't have that same kind of battle experience #her entire situation is new and terrifying! so her sync meter is very self-focused.. like a dead-eyed stare becoming more focused and sharp #and as she gains better footing in the situation‚ the synch between her and the seeker becomes stronger+ only then is she able to exert her #willpower on her surroundings 🧃 i think that is a fun leetle inversion between them 😈 the soldier vs the poet ykwim! #you know. i think magdalena's thing would function pretty similarly to vergil's concentration gauge.. the cleaner you play‚ the more crazy #shit you can do 😝 but the implications between the concentration and synch gauges would be. Very Different 😎 #sriracha.txt #nero prime #💃🏻

[seasonallydefective]

It’s so hard to articulate the weird intersection of being neurodivergent and chronically ill, where some days I look/act very functional and competent …

But other days, I’ve had to skip showering and can’t even sit up because I hurt, cant figure out clothes because my skin is sensitive and my sensory processing issues make it feel like everything is made of needles, and I can’t figure out how to make/obtain a meal that will agree with me so I just … don’t … eat …

The pain and the overstimulation and the not-knowing if something will make it better or worse forms a horrible, high-energy stasis that I just can’t break out from.

#chronic pain #chronic illness #actually autistic #actually adhd #actually disabled #ehlers danlos syndrome #postural orthostatic tachycardia syndrome #mast cell activation syndrome #sensory problems #fibromyalgia #fibro flare #fibro fog #brain fog #sea rambles

[thecraftgremlin]

Microfiber is one of the absolute worst materials in the world to touch. It’s cheap fleece x1000.

#I haaaaate it #when I describe materials like this as ‘dry’ I feel like it really doesn’t communicate the sensory hell #it feels like it’s sapping the moisture from my skin #it feels like it’s caught on every one of my skin cells and wants to peel them off

[dragonfireridge]

The Fighter, Part 4

The Dragon flattened her scaled ears and shied away. To most, her colored mutations would look garish and ugly. But, really… if you looked closer… you’d find that the frills adorning her head were actually very iridescent. Purple mixed with black and blue to cast a glorious sparkling—mixed in with some green for coloration, too.

But these fighters weren’t looking at the Dragon for her beauty. Hell, they barely seemed to care if she had genetically modified features—features that came from pure, real life dragon DNA.

No, these fighters were here for… something else. Something… horrible.

With a shrinking feeling, the Dragon realized she was outnumbered.

She watched, warily, as the other fighters smirked, streaming in around her, their eyes like hungry wolves.

Or… like four young, strong male lions staring down a single, aged male.

The Dragon knew this fight wasn’t gonna go her way.

So… she… resisted. Pulling back against her short chains, she swung her head and growled.

And was utterly surprised, when the strange glowing thing lit up and chirped at her. Small, flappy wings resonated across the cell.

The Dragon jumped back in SHOCK. She… she wasn’t expecting THIS!

She was afraid, but… she stared at the glowbug. It’s wide wings twitched. 

Slowly, very slowly, she began to creep towards it.

“Ha,” a voice chortled. “She likes your glow-bug, Mariam.”

“What?! She can’t like—“

“Look,” one of the fighters cut off, nudging the other gently. “It seems she really does like your glow-bug.”

And the Dragon did.

It had been thirty-three cold, hard years, of loneliness, pain, and struggle. The Dragon had never even seen something like the glow-bug before.

“Aw… look.” One of the other fighters’ voices was hushed with awe. “The big bad Dragon wants to pet your glow-bug, Mary.”

The Dragon had leaned gently forwards, uncaring for the danger.

She just wanted this nice, sweet, amazing thing, that had just come to life in front of her.

#Whump #dragons #chains #cell #mine #thefighter #Pitfighting #arenafighting #cuffed #caged #sensory depeivation

[falled-over]

learnt that way fewer dendrites die in autistic brains than allistic ones from childhood to adulthood, which actually could not make more sense

#neuro lesson: #in your brain there are a bunch of cells that look like trees #branches on one end and roots on the other #unlike trees the branches and roots want to grab onto one another. thats how connections are formed #when you're born you have very few connections. and the trunks of the trees are poorly insulated so it takes a long time for information to #get through them (think of this like a wire) #when you're a child everything is pretty connected because you're yet to learn rigid pathways #which is why children always say such interesting and unexpected things. the irregular pathways havent died off yet #and as you learn more about how to fit into the world and how it works unnecessary roots and branches are culled so that signals can get #through faster and more efficiently. #the insulation helps everything get through faster. this is naturally formed in all adult brains (and is chipped away in old age) #and in an autistic brain a lot more connections are kept. which explains sensory overloads and creativity

[autisticslp]

I love olive oil as much as the next person but when it’s the only oil I can use for cooking the whole “smoke alarm goes off every time I cook and I cry” cycle gets a little old

#fuck my mast cells and fuck sensory issues #MCAS #actually autistic

[er-cryptid]

#studyblr #notes #medblr #medical notes #med notes #biology #biology notes #bio #bio notes #olfactory receptor cells #receptor cells #olfaction #human senses #sensory #sensory organs #dendrites #dendrite cells #proteins #epithelium #epithelial cells #epithelial tissue

[asbestieos]

ohh narunui we are in it now

#you wouldnt think an eye doctors lobby could give you sensory ickiness but there re so many sounds and every cell in my boddy wants to cry #astaposting

[chilope]

well. this is the worst period ive had in a bit, my allergies are kicking my ass, my whole body hurts like hell, and i have to run experiments on a $60 thousand dollar machine that my boss does not want to have to pay for today. so its going great.

#yall the sensory experience im having rn is unmatched #i wish i could put myself in a cardboard box and ship myself somewhere that has no sensory information #no temperature no noise no light #i would like to crush my body in a trash compactor please #i want to unzip my skin and remove it and scrub down my bones with bleach and then leave everything on a clothes line to dry #i want someone to wash my insides with one of those carpet squeegie things #i wantto arrange my innards on a piece of black construction paper and glue them down with a glue stick and label them with a white gel pen #i want someone to gently drape me over the porch railing and beat me with a broom to get the dust off #i hate the way allergies make all of my cells feel itchy and dirty