#brain injury research

[aitadjcrazytimes]

#lmao #for anyone who's curious the process went: #send ask to aita official #blog blows up #someone realizes its a chexer fic #i follow them bc they seem cool #i join their rvb server #their encouragement pushes me to finish the Actual Fic i was working on #i expand the fic to be more of a whole au after it comes out much better than expected #the next fic in the au that i work on has to do with a character's brain injury #this leads me to do research into brain injuries #''......huh. this sounds. a lot like the neurological symptoms that my doctors have been saying is just part of my anxiety disorder'' #think on that for a while #go to the ER for unrelated reasons #remember my theory #bring it up to the doctor #Doctor Immediate Concern #doctors orders a ct scan #''eeyup! that there's some atrophying and a chiari malformation! y'ever had a head injury'' #(i had had several) #''well! shit! time to refer you to neurosurgery :) see if we cant do somethin about all that memory loss and severe pain and shit'' #and now we are here #it also lead me to research osddid systems for the first fic #and now my therapist is having me tested for osdd because i did not know that those symptoms were not a thing everyone experiences #so like. thanks for helping me meet friends who could encourage me to engage with the things i like + learn more about myself #^ ^ <3 #im actually not gonna say ''ok last update fr this time'' bc idfk maybe something WOULD be funny to post on here

[vivekguptahal]

A Data-Driven Approach to Healthcare - Brain Injury and Disease Research

Cloud adoption & data pipeline automation in healthcare

Traditionally, healthcare advancements have progressed slowly due to siloed research and delayed results. However, with cloud application modernization, all that is changing for good. A unique collaboration between life sciences organizations and digital solution providers is offering an unprecedented level of insight into managing conditions and achieving optimal patient outcomes. Cloud modernization is expanding healthcare organizations’ ability to use data pipeline automation to effectively diagnose patients.

A prime example of cloud adoption is a nonprofit research organization dedicated to biomedical research and technology. The organization has been instrumental in facilitating advances in brain injury and disease research through its launch of the first cloud-based and interactive platform that supports information and idea exchange to further progress in neuroscience research. It uses big data to promote computational innovation discovery in brain diseases.

Co-created by Hitachi and other partners, this platform is a trusted portal where clinical researchers, physicians, and organizations can collaborate on research and the validation of emerging therapeutics.

The context of merging human and artificial intelligence for analyzing health data

Medical research data is becoming siloed, diverse, and complex. To break this complexity, a robust IT infrastructure with the capacity to aggregate data across multiple studies is required along with harnessing patients’ data to improve the healthcare system.

The organization needed an interactive and scalable platform that would be capable of integrating diverse cohorts and investigators and equipped with a high computing speed that is essential in machine learning and artificial intelligence applications.

These new capabilities would empower users to gain a comprehensive understanding of signature patterns within existing and emerging large-scale datasets and to foster collaboration to promote the efficient use of the research community’s collective knowledge of brain injuries and diseases.

With time, the organization recognized that meeting these challenges would require the expertise of specialists in data pipeline automation and healthcare data solutions to meet the steep requirements of the healthcare industry. Having heard of Hitachi, the organization turned to us for our Cloud Managed Services.

Leveraging healthcare data analytics solutions to build more sophisticated infrastructure

The organization wanted to collaborate with Hitachi to upgrade the user interface and augment the platform’s experience for researchers and the virtual analytical environment to ensure secure data management.

Hitachi was able to deliver an integrated solution that encompassed each component of the build-out. This streamlined project management made the process more efficient and data-driven healthcare innovation helped to further modernize, streamline, and simplify the health diagnostic system for the research organization.

Infrastructure that enables innovation

Cloud modernization was central to helping the organization maximize value in its transformation journey and boost the lives of people. While the organization began with a vision, advances in cloud-based data management, storage, and security brought that to fruition. The interactive platform now allows the organization to leverage best practices to tap into the potency of data pipeline automation and utilization.

Hitachi’s commitment to social innovation 

For Hitachi, this project has particular resonance because it is aligned with its commitment to social innovation. To have played a role in accelerating this process and in bringing life-changing drugs and therapies to patients more quickly is always rewarding.

Discover how Hitachi is unlocking value for society with Social Innovation and Digital Transformation in Healthcare :

#advanced healthcare analytics #application modernization services #big data storage #brain disease research #brain injury research #cloud adoption healthcare #cloud modernization #cloud application modernization #data driven healthcare #healthcare analytics solutions #healthcare data analytics #healthcare data infrastructure #healthcare data intelligence #healthcare data management #benefits of cloud computing in healthcare

[phantommermaidqueen]

Corpse Bride is still one of my most favorite movies of all time. And a question I am asking myself a lot lately is "Why not make x Destiel?" So here we go, Destiel Corpse Bride thing.

@letsdrawcastiel

#Destiel #myart #I had to include a dorky looking maggot #had to #I just wanted to drae some bones and I even researched wing bones #but my hand is unsteady so it didn’t turn out how i anticipated #no idea what the story would be for this #I really jyst knew I wanted Cas to have the Emily injuries/decay #excuse my typos please #and please do not look at Dean's legs because they are atrocious because my brain cannot grasp how it works for legs to be connected #to the rest of the body #which is just another readon I prefer to draw merpeople

[weighted-notebook]

Does anyone here have some advice on how to write a character with frontal lobe damage? Y'know, other than "study Phineas Gage", because that's one example of how a frontal lobe injury altered one specific person. I'm pretty sure there are more people out there who've experienced frontal lobe damage who have been affected in different ways. I've looked into symptoms and effects and such, but I wanna know if there's anything else I should know before writing

...yes, this is for a FNaF fanfic, but I want it to be accurate, y'know?

#brain injury #frontal lobe #five nights at freddy's #fnaf #research #writing

[rauchendesgnu]

me: I should do research on how to treat wounds and sickness so my writing is based on facts and the treatment sounds believable, especially in a historical/fantasy setting

also me: *gets queasy when people describe historical ways of treating injuries to the point where he has to stop reading/watching*

#help I just want to write a believable healing process #brain why can't you just let me learn the thing #anyway Martin will now go spread honey on Jon's burn (thank fuck it's not feces or mud or boiled frogs) #writing #injury and healing #research for writing #tma #jonmartin

[covenawhite66]

The experiment involved little blobs of human brain stem cells tissue transplanted into rats. Then neurons integrated into the rat's brain so well the organoids started to respond to visual stimuli made of black and white images.

The experiment stopped after 3 months because of the rat rejecting human tissue despite the immunosuppressant medication.

The next experiment is to transplanting human brain tissue into adult rats with large cortical injuries, to see if they, too, can show functional integration

Brain organoids created from human pluripotent stem cells represent a promising approach for brain repair. They acquire many structural features of the brain and raise the possibility of patient-matched repair. Whether these entities can integrate with host brain networks in the context of the injured adult mammalian brain is not well established.

#science article #scientific research #brain cells #neurology #stem cell research #experimentation #rodent testing #brain injury #tissue transplant

[dreambones-art]

[Dated 20/10/2023]

A package courier found shot in the head near Goodsprings has reportedly regained consciousness and made a FULL RECOVERY.

a sketch turned into a full portrait of my amnesiac f:nv courier, caravan! reports of his recovery were...greatly exaggerated. with no memory of who he was before, a nasty bit of brain damage, plus an identity crisis while he's trying to track down the bastard that shot him makes for tough living.

but he meets a fellow ghost in the novac dinosaur who helps him as much as he helps the sniper. (and they become hopelessly codependent.)

#{my art} #{my characters} #{2023} #fallout new vegas #courier six #the courier #i actually did a good bit of research trying to accurately represent caravan's brain damage #his facial recognition is shot along with his spatial awareness and hand-eye coordination #making him terrible with a gun and constantly needing boone to haul his ass out of the fire #not to mention the emotional lability...hoo boy. #one of these days im hoping to having a complete document of the extent of the brain injury and any later injuries he got himself #if/when i post a fic for him on ao3 ill probably post it somewhere

[nam-on-jo]

me seeing that there ten (10) total pil do x ji woo fics on ao3:

#logically speaking I know for a FACT you can survive certain traumatic brain injuries as a psych major #and I spent a long time trying to conspiracy myself that beth was alive in twd because I was in love with her #so I *know* you can #I’m just rusty on the research and like research more than writing lmao #will I actually write it? who knows #but it’s CRIMINAL that there are next to no fics for them #WHERE ARE THE FIX IT FICS #WHERE ARE THEY #my name 2021 #my name #yoon ji woo #jeon pil do #ji woo x pil do #jiwoo x pildo #kdrama #netflix korea #Netflix #references #mine

[impeachy]

You can eat the fungi/mushrooms in the last of us!! eat them bitches back!!!

Irl these mushrooms are edible!! Its called cordeyceps, completely edible, but if you think about it you could totally eat them straight off an infected person, well maybe not straight off

at the beginning of the show they said that the fungi couldnt infect humans because they couldnt survive the internal body temp of humans, and an average humans body temp is around 90° F, so a higher temp could in theory kill the virus in the fungi, so techically you could possibly eat the mushrooms back.

edit: it has been brought to my attention that the spores were in bread which is baked BUT those arent fully formed mushrooms, they can grow, basically justs seeds, so in theory you could wear a gas mask and clean ur shrooms, sautè them up and bam tasty tasty mushrooms

#This is only a brain thought #i am not liable for sickness or injury if attempted in show #the last of us #cordyceps #on nom nom a bitch is hungry #i have no credibility for this #give a mushroom a lil lick #eat a bloater #it cant take ur nerves if its not alive to do so #i did the bare minimum research for this tbh

[hum--hallelujah]

I have so many autistic/low empathy/otherwise neurodivergent Dr Benzedrine headcanons in my drafts that I'm afraid to post bc I'm not autistic/low empathy and don't know enough to know if I'm being accurate/respectful in all the details

#most of the low empathy stuff in my ideas came from like... he basically had a traumatic brain injury #I haven't decided yet if when I write it it'll be a regular type of thing or if it'll be some drug or experiment but either way the effects #are very similar. I'm considering it essentially a tbi #and honestly I think I need to do more research bc I want to talk about this and write it but I also want to be respectful of #real people's experiences yknow? #anyway the main thing is Benze being worried about his capacity for love and friendship when he doesn't Feel those things normally anymore #so... yeah. if anyone wants to weigh in on any of this feel free my asks are open :) #she speaks! #(I am a bit adhd but pretty well managed so. different type of neurodivergence yknow?)

[eleilinnrallin]

Looking for information on how pre-existing motor tics (specifically head-jerk) would interact with a severe head injury within an hour of the injury being sustained. Does anyone have any experience with this?

All I'm finding is information on the interactions between stimulants and tic disorders or a general 'yeah tics can get worse within a few weeks/months after severe head injuries' and that's not what I need for what I'm working on.

I specifically want to know what that looks like tic-wise in the moment to a medical professional or onlooker who can recognize tics (could it trigger tics? exacerbate them? not effect them? How would a head-movement tic be influenced by a head injury?)

I'm acting in a drill where we are given fake injuries. I am currently signed up for a serious head injury. However, last time I participated, it triggered my tics, and I didn't prepare my acting to include how that would have affected my injury. This time I want to be more prepared, especially if I need to change what injury I have due to physical acting limitations.

(Even if you can't help, reblogs/boosts are appreciated! I have until March 25th to get an answer, and my research over the past two days has come up with nothing helpful.)

#acting research #I'm completely fine xD #tics #motor tics #medical #emergency medicine #tourettes #tic disorder #tic #brain injury #head injury #traumatic brain injury #injury #research #motor tic #acting #last time when I asked about ticcing during the drill they said go ahead because that's something that can happen irl #you'll have patients with preexisting conditions and you need to know how to take care of them #last time it made it so I didn't get correct treatment :/ but half of that was likely my poor acting skills #anyways I'm being a Problem Child in the drill xDxP /lh because I'm not what they expect really #tics aren't on the list of acting things or even the 'patients with pre-existing conditions exacerbated by the incident' list #which ig goes both ways because it means my exacerbated pre-existing condition gets added to an acted injury #meaning it's a level of complexity you can see in real life but the drill otherwise does not have #but at the same time it means they might not be prepared to deal with it (good for them to find out ig?) #anyways this time I want to act it right so I get proper treatment in the drill #and am not having a broken bone and internal bleeding ignored because the tics are more obvious and more easily dismissed #(fake injuries btw it was for the drill) #(but still bothersome) #(I had declining vitals cards and didn't get anything done about them :P so idk how much was my acting and how much was them) #or at least this way I'll know it's not my acting causing any negligence

[emberoops]

trying to figure out how many visitors would be allowed into the fictional trauma ward of my book led me down a rabbit hole.

turns out there is a study *specifically about* family caregivers and their role in visitation of people with moderate-to-severe TBI, which is exactly what im writing in these scenes.

god, i love this.

now we'll see if i can actually understand everything they wrote down - so far im muddling through alright, although when it comes to methodology i genuinely do not know all of the theories they're name-dropping, so i can't evaluate their appropriateness.

#head trauma cw #brain injury cw #(( #ic for ooc? #sort of? #im writing it ooc so it can be written ic but im posting about the process ic #its recursive.)) #((Also because I actually AM writing this - I know I have a few followers who have experience in the subject. #Anyone willing/interested in talking on that is welcome to - although I have interviewed someone in recovery from a more minor TBI #and am doing a LOT of research to make this more accurate if possible. #anyways this is a really fun project #even if the ways it blurs the lines between ic and ooc is somewhat uncomfortable sometimes #i love writing books and this one is a very new genre for me in many ways #which is extremely fun))

[fivehundredwords]

Alzheimer's Disease: biomarkers and neuroimaging markers cheatsheet for research articles

As Alzheimer's Disease (AD) research skews toward understanding the brain than the pathogenic proteins, studies exploring biomarkers and neuroimaging are hopeful toward developing a method for successful prevention of AD. A biomarker is a molecule, whose presence indicates abnormality or disease, and thus, is crucial in diagnostic procedures. Levels of certain molecules is notably altered in cerebrospinal fluid and in blood plasma, which helps in diagnosing the occurrence of AD. Neuroimaging involves the use of techniques such as magnetic resonance imaging and computed tomography to observe neuronal activity in the brain. This is good news, especially for AD, as the asymptomatic stage of the disease can be identified early enough.

Although the exact function and involvement in clinical practice is not profuse, altered concentrations of these biomarkers in plasma or cerebrospinal fluid encourage further research:

Amyloid and tau serve as the unsurprising biomarkers of AD pathology.

Neurofilament-light chain (NF-L) and visinin-like protein-1 (VILIP-1) are the most promising biomarkers of neuronal injury.

Post-synaptic protein neurogranin (Ng) and pre-synaptic proteins synaptosome-associated protein-25 (SNAP-25) and synaptotagmin-1 (Syt-1) are considered major biomarkers of synaptic injury.

Brain and CSF levels of tumor necrosis factor alpha (TNF-α) and increased levels of interleukin group of proteins (ILs) indicate intensified microglial response to neuroinflammation.

TREM2 receptor and YKL-40 glycoprotein are also reliable indicators of inflammation and impaired clearance of amyloid beta.

Heart-type fatty acid-binding protein (hFABP) could be a marker for pathology in blood vessels supplying the brain. Some vascular markers also show potential as markers of vascular injury in AD: von Willebrand factor (vWF) and monokine induced by γ-interferon (MIG, also known as CXCL-9).

Concentrations of TAR-DNA binding protein (TDP-43) in the brain and plasma and serum indicate, even contribute to, inflammation, mitochondrial dysfunction, and neuronal/synaptic injury in AD.

Neuroimaging techniques reveal structural, functional, and diffusion-related activities of the neurons. To identify them, markers are tracked in images obtained. Each marker is determined with the activity and biochemistry of the group of/individual neurons being studied.

Structural MRI will show location and severity of atrophy which can be identified in grey scale images by applying programs that create analogous color grading.

Functional MRI relies on blood oxygenation level dependent (BOLD) signal which reflects changes in blood oxygenation levels in response to neural activity.

Diffusion weighted imaging (DWI) focuses on diffusion of water molecules. A tensor model is applied to images obtained from DWI. The diffusion tensor imaging (DTI) metrics thus obtained help in studying connectivity through structural integrity of white matter tracts.

Tractography involves 3-D reconstruction of white matter as observed in DWI, which provides a more detailed look into a patient’s neural networks.

In positron emission tomography (PET), markers are identified and labelled so their features or functions can be traced during this procedure to obtain a resulting PET scan. The imaging procedure is named according to its marker: amyloid-PET, tau-PET, FDG-PET, inflammation-PET, receptor-PET.

FDA approved drugs Galantamine, Rivastigmine, and Donepezil alleviate symptoms such as memory loss and confusion in mild to moderate AD, although their effects seem to be negligible. They also cause nausea and vomiting as side effects and are not suitable for every patient. Recently approved drugs, Aducanumab and Lecanemab focus on removing accumulated amyloid. Their effectiveness is still doubted on the basis of studies finding that targeting amyloid has little to do with curbing the actual progression of the disease.

bibliography -

Tarawneh R. Biomarkers: our path towards a cure for Alzheimer disease. Biomarker insights. 2020 Nov;15:1177271920976367.

Cavedo E, Lista S, Khachaturian Z, Aisen P, Amouyel P, Herholz K, Jack Jr CR, Sperling R, Cummings J, Blennow K, O’Bryant S. The road ahead to cure Alzheimer’s disease: development of biological markers and neuroimaging methods for prevention trials across all stages and target populations. The journal of prevention of Alzheimer's disease. 2014 Dec;1(3):181.

Medications for Alzheimer's Disease Stanford Healthcare. Accessed 21-04-2023.

#aging #alzheimers #dementia #neuroscience #clinical medicine #diagnostics #diagnosis #brain injuries #neurological conditions #neurodegenerative disorders #neurodegeneration #neurons #neurology #brain research #neurological disease #neurological disorders and injuries #chronic illness #neuroinflammation #neuroimaging #science #science side of tumblr #research paper #academic writing

[taylorpixiedust]

me, existing:

my insurance, suddenly: hey do you want to track down the dude who gave you a severe concussion that’s still hurting you to try and get him to reimburse your medical bills

me: bro that was in high school. and an accident. we were playing dodgeball.

insurance: you were a minor and also dodgeballs are. not that big. dude had to be throwing it awfully fast to cause a concussion

me:

me, overthinking: ok. time to bed

#for context #some dude in high school threw a dodgeball straight at my face #caused a bad concussion #still in pain from it #also it fucked up my glasses! a lot! #might have even broken my nose #and it was one of the foam ones too #so the thing was hella light #that was in 2019 #cut to today #insurance sends me a letter like #hey your doctor said that you had a physical injury that was caused by someone? #yeah do you want to track him down and take legal action #and i went into a mild amount of research into dodgeball physics #and now i'm having a panic attack #i probably did the math wrong somewhere #the pain and other medical issues have cost my family and I a lot so #getting reimbursed would be nice #but we were in high school? #and another part of my brain is like #ok that's also assault of a minor #im a wreck #im going to bed #because thinking about this is not the greatest thing for me #if anybody does the math for some reason #tell me and ill probably panic more idk

[cozycreaturescorner]

i can and will request 8 referrals at once

#emmett is yelling #mamma mia i gotta see someone about my knee bc apparently it being clicky and painful and swollen All the time is. #a sign of an injury i need help treating. oops #thought my joint was Just Doing That but . Extra #also. pissed off a little about care that needs to be specialized like this cause. #bc so so often it falls mostly if not entirely on the patient to find the correct specialists they need and contact them and keep track #etc etc. #which . when you have a genetic disorder that causes major amounts of fatigue and pain and brain fog on a daily basis?? #is so hard to. #it would be hard for someone Without all those symptoms to research and schedule and keep track of all of that so. why

[girderednerve]

"C.T.E. is the subject of furious controversy. Some of the debate has been stoked by researchers affiliated with the sports industry, who argue that we still don’t know for sure that head blows in football, hockey, soccer, or rugby can lead, decades later, to the dramatic mood problems, the personality changes, and the cognitive deterioration associated with C.T.E. These experts maintain that, before we rethink our relationship with these sports, we need scientific inquiries that meet highly rigorous standards—including longitudinal studies that would take fifty to seventy years or more to complete. In the meantime, millions of children and high-school, college, and pro athletes would continue butting heads on the field.

[Stephen Casper, a historian of science and medicine,] believes that the science was convincing enough long ago. 'The scientific literature has been pointing basically in the same direction since the eighteen-nineties,' he told me. 'Every generation has been doing more or less the same kind of studies, and every generation has been finding more or less the same kinds of effects.' His work suggests that, even as scientific inquiry continues, we know enough to intervene now, and have known it for decades.

Casper’s historical work, begun in 2015, painted a clear picture: for at least seven decades, if not longer, many prominent physicians and sports organizations, including the N.C.A.A., had been well aware that concussions from a variety of sports could cause cumulative, crippling brain damage. 'People who wanted to know could know,' Casper told me. 'People who wanted to warn could warn.'

The standards of scientific rigor that C.T.E. skeptics invoke were widely adopted only in the late nineties. According to Casper and other critics, their main effect in the controversy over concussions in sports has been to emphasize uncertainties and obfuscate what’s known."

#it's super bowl sunday! #although actually casper's research was part of former NHL players' suit #traumatic brain injury #chronic traumatic encephalopathy #screeching about this the way i did about black lung diagnostic standards #do you really need an x-ray & a full medical account of how coal dust impedes lung function to begin working on amelioration? #no but maybe you'd like to insist you do if you're a coal mine operator!