#angioma

[ramblingandpie]

Update on my brain!

We have a diagnosis: cerebral cavernous malformation (CCM) aka brain angioma.

I will be meeting with a neurovascular surgeon to see if I'm a candidate for surgery, which is... basically the only treatment option. It looks like that depends mostly on where exactly the CCM is and if it's easy to access.

Fortunately, mine appears to be isolated rather than familial (so I'm not at risk of developing more of them) and is not in a location in the brain that puts me at high risk for seizures. So that's good, at least. It still feels like my hand and foot are coated in paint stripper (chemical burny feel) (fun fact once I accidentally got a glob of chemical paint stripper on my elbow! So I know what chemical burns feel like). I can still use a pen fairly reliably but I'll want to learn how to write left-handed. They're apparently prone to flares depending on how leaky/bleedy it gets.

Also I can't crack eggs worth a damn so um if anyone knows any cool AT for cracking eggs when your hands suck I am all ears. Shells e'erywhere when I do it on my own.

#medical #disability #ccm #angioma #cerebral cavernous malformation

[disease]

ANGIOMA // STEPED AND BACK [INSURGENCE EP, 2021]

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[quotesfrommyreading]

The Bowlin family’s malformation can indeed be explained by a mutation—a newly discovered one. Theirs is a deletion in the gene CCM2, and this mutation is dominant, meaning it does not skip generations and has a 50 percent chance of being passed on. Marchuk’s lab didn’t just find it in Bettina’s donated tissue, though; the scientists also found it in seven other unrelated patients all at the same time in 2007. How odd, Marchuk remembers thinking, to see the identical deletion eight times in a row. But, he says, “we couldn’t see any common ethnic heritage, and those eight families, we couldn’t connect them in any way ourselves.” The deletion happens to occur in a natural recombination hot spot—where DNA gets cut and pasted back together—so he figured it might just have happened independently in those families.

Then things got stranger. More families with the exact same deletion started showing up after the Angioma Alliance began a genetic-testing program for people with suspected CCM mutations. In the first year alone, a quarter of participants tested had the same CCM2 deletion. The affected families lived across the U.S., with the exception of the Northeast, but they were concentrated in the South and Midwest. (The Bowlins are from Mississippi.) “About two years in, I could say that if you live in Oklahoma, and I’m about to test you, I can pretty much predict which mutation you’re going to have. Or if you live in Mississippi, Alabama, Louisiana—same thing,” says Connie Lee, Angioma Alliance’s president. The distribution clearly wasn’t random, which suggested the deletion wasn’t showing up by chance. The families probably were related. They just didn’t yet know how.

In search of a connection, the families and Lee created a Facebook group to share stories and names. They scoured census, birth, marriage, death, and other public records. They took AncestryDNA tests. A professional genealogist even came on board and looked for records in person at the Family History Library, in Salt Lake City. In late 2018, a new family joined whose ancestry allowed the group to link up two family trees. That was a crucial clue.

Over the next few months, the families managed to trace their rare mutation back 250 years to a single North Carolina couple born in the 1760s: Matthew Malachi Rushing and Sarah Mae Harrell. Group members couldn’t test the long-dead couple’s DNA directly, of course, but they could infer from the pattern of inheritance in living descendants. Bettina, Margaret, and Susan are the couple’s great-great-great-great-grandchildren. Their migraines, their seizures, their tingling and weakness in the limbs—it all goes back to the DNA of this one couple in colonial America.

  —  How a Rare Brain Mutation Spread Across America

#sarah zhang #history #science #genetics #medicine #neuroscience #genealogy #genetic genealogy #family #brain #angioma #cavernous hemangioma #ccm2 #usa #mississippi #north carolina #angioma alliance #alliance to cure cavernous malformation #douglas marchuk

[ammg-old2]

Of the three Bowlin sisters, Margaret, the middle one, was the first to show signs. She began having seizures as a toddler. Then the eldest, Bettina, had a brief and mysterious episode of weakness in her right hand. In 1986, as an adult, she had a two-week migraine that got so bad, she couldn’t hold food in her mouth or money in her right hand. The youngest, Susan, felt fine, but her parents still took her for an exam in 1989, when she was 19. A brain scan found abnormal clusters of blood vessels that, as it turned out, were in her sisters’ brains too. These malformations in the brain can be silent. But they can also leak or, worse, burst without warning, causing the seizures, migraines, and strokelike symptoms Bettina and Margaret experienced. If the bleeding in the brain gets bad enough, it can be deadly.

At the time, doctors could not tell the Bowlins exactly what was wrong, only that they suspected it ran in the family. The girls’ father, Jerry Bowlin, had the same malformations in his brain (though he had no symptoms), and he knew of an uncle with epilepsy. To understand his daughters’ afflictions, he began mapping out a family tree. Jerry asked around his family and, later, reconnected with long-lost cousins through Facebook, and he kept hearing more stories of seizures and strokelike illnesses. But even as the family tree filled out, the exact cause of these malformations remained elusive.

Then, in 2004, Bettina began having seizures multiple times a day. Her face would go numb, and she couldn’t speak. A scan showed a malformation in her brain and one in her spinal cord that needed to be removed immediately in two surgeries. Around the same time, Susan also began feeling a tingling in her cheek. It got worse and worse over the course of a day, until she started slurring. She couldn’t read. She couldn’t hold a pencil. She was rushed to the hospital, where doctors eventually found a massive bleed in her brain; one of her malformations had burst. “At one time, we had one daughter in ICU in New Orleans, and one daughter in ICU in Biloxi,” their mother, Charlene Bowlin, told me. Both of them recovered, but Susan has permanent numbness on her right side and Bettina still experiences nerve pain and can’t feel hot or cold on her right side.

The family found a silver lining during this terrible period. Through a patient advocacy group called the Angioma Alliance, Bettina learned she could donate tissue from her second surgery to a lab that studies the genetics of unusual blood vessels in the brain, known formally as cerebral cavernous malformations, or CCMs. (An angioma is another term for vascular abnormalities; CCMs are a type of angioma.) Her tissue donation led to a major breakthrough in understanding her family’s brain malformations, the cause of which was then traced all the way back to the 1760s.

#history #science #genetics #medicine #neuroscience #genealogy #family #brain #angioma #cavernous hemangioma #usa

[alrustomlaser]

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[cseller]

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[bor-zeeo]

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[abimee]

they look nothing like cherry angioma tho

#cherry angioma are skin growths these are noithing at all like a skin growth mostly because theyre not skin growths #theyre like the opposite. theyre inside my skin underneath the main layer and not at all protrusions

[kon-igi]

Cià Kon.

Ho quarant'anni. Durante una ecografia di routine al fegato l'ecografista ha visto tre o quattro macchie che, ha detto, sono probabilmente emangiomi - ma per sicurezza meglio fare una risonanza magnetica (che farò domani). Per motivi vari faccio ecografie al fegato abbastanza di frequente, e nessuno aveva mai visto queste macchie (ma magari gli altri ecografisti le hanno viste e se ne sono fregati? Io che ne so)

Cosa devo aspettarmi? Ho già letto la pagina di wikipedia sul carcinoma epatocellulare e non è esattamente questo il regalo che vorrei mettere sotto l'albero per i miei figli.

Grazie.

Firmato, ScorpioncinoPreoccupato83

Accostare un angioma epatico a un carcinoma epatocellulare è un po' come paragonare un dito pestato a una testata contro un treno in corsa.

Credimi se ti dico che se ognuno di noi ricevesse un buono per una risonanza magnetica ultra total body HD di sette ore, nessuno ne verrebbe fuori simile a quelle belle immagini che vediamo sugli atlanti di anatomia.

Siamo pieni di stenosi, cisti, dilatazioni, dislocazioni, agenesie, schiacciamenti, atrofie, ipertrofie, ipotrofie, distrofie e tutto questo fino ad arrivare alla tomba senza mai accorgercene.

Per cui giusta la risonanza magnetica per dirimere il dubbio ma è molto facile che sia solo una degenerazione del tessuto vascolare che se avessi avuto sulla pelle avresti chiamato 'voglia di fragola'.

[ego-sum-imperator]

What if Caranthir didn’t fled south with Amrod and Amras during Dagor Bragollach and earned his name of « Caranthir », « red face » at that moment?

To begin with, I’ll come back to the etymology of the name of Caranthir is the sindarized version of the name « Carnistir » which mean « red face »and which is the mother-name of the character. (Elves have three names: the mother-name, the father-name and the chosen name (the name they chose when they turn 20 and by which they’re known)).

We can note that this is a rare case of reuse of the mother-name, as it usually the father-name that is kept and considered the most important.

Caranthir (‘s father-name is Morifinwë which mean « Dark Finwë and later he’s known as Caranthir the Dark.

We don’t know exactly why Nerdanel named him « red face »

He was red when he’s born because he cried a lot?

Got a lot of freckles (later in life because we’re not born with)?

Presence of an angioma on his face?

I’m currently drawing the last two hypotheses, but I’ll put them aside for a new one I had for this « What if? ».

During the Dagor Bragollach in F.A. 455 (« Battle of Sudden Flame »), the siege of Angbang is broken and the armies of Morgoth were able to invade and ruin the Northland (Dorthonion, Lothlann, Thargelion, etc.).

In Thargelion, Glaurung come and burned the lands at the foot of Ered Luin while the cohorts of Orcs move more far in the North and took Caranthir’s fortress in Mount Rerir. And when it happen, Caranthir fled South with his brothers.

BUT!!!

What if Caranthir earned his name at that moment?

Before being known as «Caranthir», he was known as Morifinwë or by another name he choose and Carnistir isn’t his mother-name.

In y mind, Glaurung lea the orcs to lake Helevorn where the abode of //Caranthir// is. As a Lord, he’s insured that his people unable to fight were able to flee before leaving with the soldiers in oder to fight the dragon and the orcs. Without sucess…

This bring me to the essential point of this « What if? »

During the battle between Morgoth’s forces and those of //Caranthir’s//, the latter found himself in direct confrontation with Glaurung. A fight in which the elf was badly burned in the face, leaving him with a severer burn later on, hence it’s name « Caranthir », « red face ».

Wounded, //Caranthir// was taken prisoner with some of his soldiers by Glaurung and the orcs, and then imprisoned in Angbang.

No one would have known what had happened to //Caranthir// since neither he nor his soldiers returned from Mount Rerir.

No one would have known that he was alive (albeit in a bad way) in Angbang's prisons and would have been considered dead.

#tolkien #the silmarillion #silmarillion #lotr #elves #jrr tolkien #caranthir #mount rerir #thargelion #glaurung #orcs #angbang #beleriand #first age #feanorians #feänorian #morofinwë #caranthir the dark #carnistir #silmarillion headcanon #tolkien headcanons #caranthir headcanon #tolkien headcanon #headcannons #headcanon #silm headcanons

[papayajuan2019]

it was fading away, but the cherry angioma on my arm came back

[barbieaemond]

Thank you so much for your kind messages <3 more under the cut if someone is sensitive to blood

I’ve suffered from nose bleedings for years due to angiomas that would form and break, causing bleedings. Today it would not stop so I had to go to ER and they put a nasal swab through my nostril to stop the bleeding, I could feel it INTO MY FUCKING FOREHEAD WORST FEELING EVER

Anyway all’s well that ends well, says Willy, so…

#personal #liv lives

[alrustomlaser]

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[faecaptainofdreams]

God. I’m sick of my body and of my hypochondria. Tired of bladder, bowel and pelvic floor struggles, intense phobias of norovirus, anaphylaxis and cancers, feeling dread and anxiety about every little changing thing in me from the cherry angiomas that plague me in the dozens to my throat clicking when i swallow and feeling like there’s a lump in it. The anxiety hits so bad and it’s so unbearable because there’s nothing i can do about any of it and it makes daily life so painful and full of dread. I’m going through it tonight. Can’t sleep because the weird lump in my throat has my attention.

Always wondering when the mole under my right tit will be discovered malignant.

Always wondering what will happen first; esophageal cancer from GERD, or kidney failure brought on by the meds i take to suppress it.

Always wondering when i’ll learn my angiomas are malignant.

Always wondering if my ever-changing period will finally ruin my life for good.

Always wondering if I’m going to pass out, or eat something that sends me into an emergency, or that i’ll need to go to the ER and no one will be there for me (a phobia produced from experience).

My medical trauma is so extensive. Sometimes I really just wanna be held and reassured and to feel like i can count on someone around me to not make my situation more horrible when i need them…

[anglerflsh]

Hey actually yes can you please talk about how people made retractable pins to forge evidence during witch trials I'm curious now

YES alright the context for this one is that it was generally believed a lot of the damage caused by witches was made specifically by their familiars/imps while the witches themselves were asleep- and that those familiars were fed with the blood of their owner. That feeding did, however, leave a mark on the body, commonly called a "witch's mark", which was usually either a mole or an angioma. And because that was the part where the familiar drew blood, it wasn't supposed to bleed out once pricked with a pin.

Of course in actual trials people did bleed, so when Witch Finder General Matthew Hopkins had to gather evidence for trials, he used pins that retracted into themselves when used, so the people that were "pricked" did not bleed nor feel pain and that would be evidence they were witches!

#it's also why a commonly used method to torture witches was sleep deprivation! Their familiars could only do harm when the witch was asleep #so they'd just force them to stay awake! #interesting stuff honestly #[.asks] #anonymous #spiral emoji you want to ask me about witchunting so bad spiral emoji

[mintmatcha]

Wait. Are you literally blasting the melanin out of your skin?

Yes but no? IPL's mechanism affects pigment of any kind, including vascular spots. I'm really using it for a cherry angioma and dry eye symptoms, so mole removal is just a bonus. I also do it in the office I'm currently working at and I administer it lol.

IPL basically destroys chromophores and breaks them down, then your little lymphocytes come and take everything away.

this is clearly not a treatment for everyone because of what it does fundamentally. HOWEVER, we also offer another treatment for dry eye

#we were between two machines and my dr almost didnt get the one than had RF #and i went #girl we live in the south i dont think we should limit our potential clients to only white people #and she agreed #they are hesitant to use ipl on HER because shes asian #so she was like. mint thank you that was a good call