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bitch4vanya · 5 years

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Indestructible (Klaus x Reader x Vanya)

Ep 3. Extra Ordinary

Warning: Mention of drugs (cocaine/weed are abused in this series), Swearing, Pretty gay, Female POV but can be easily changed if needed, SPOILERS, it follows the same story line as the show so there’s a ton, gore

Word Count: 1.6k+

You and Vanya had broken up a year before when you saw her book in the stores. The jolt in your heart was extreme and left you shocked in the middle of the sidewalk for a second. Obviously you rushed in and bought it and started reading immediately on your walk to the record store.

Disappointingly, there was absolutely nothing about you.

After seeing the video of Reginald's death, you were unfazed. It was totally obvious that he’d killed himself. And you thought that that was the general consensus so you, admittedly, spaced out. Switching between Vanya, who was listening intently, and Klaus, half paying attention. How you managed to have feelings for a quarter of the academy was… If anything inconvenient. Your attention was drawn back, however, when Grace was brought up.

“Well if her hardware's degrading then- we need to turn her off.” Luther stated, making your jaw drop from your position next to a pillar by Hargreeves’ bar.

“Whoa whoa whoa, wait she’s not just a vacuum cleaner you can throw in a closet she feels things, I've seen it!”

“She just stood there, Diego, and watched our father die!”

“I’m with Luther,” Allison butted in. Making you roll your eyes as Klaus passed you to lean against the pillar next to you. You both exchanged a look of exasperation.

“Surprise surprise.” Diego mocked.

“Shut up,” Allison sneered. All eyes were on Vanya as she stumbled over her words for a second.

“Yeah she shouldn’t get a vote.”

“Alright well,” You were about to defend her when she finally spoke up.

“I was gonna say that I agree with you.”

“Okay, she gets a vote.” Diego smirks, “What about you stoner boy, whatta you got?”

“Oh, so what? You need my help now-well get outta the van Klaus, well welcome back to the van,” He answered, mocking Luther, making you snicker, which naturally filled him with a sense of accomplishment and made his heart flutter.

“What van?” Allison asked.

“What’s it gonna be, Klaus.” Luther changed the subject.

“I’m with Diego because screw you! And if Ben were here, he’d agree with me.” He hissed at the space next to you, making you giggle, assuming Ben’s presence. Diego pointed at you, happy with his majority of votes.

“No, no. She actually doesn’t get a vote.” Luther growled, making you gasp, Diego brushed him off encouraging your vote.

“So she’s losing her mind, I lost mine ages ago.” You say shrugging, making Diego pump a fist in the air.

“So whats that four to two.” Diego smirked holding the ratio on his fingers.

“It’s not final yet.” Allison pushed.

“What?”

“Five’s not here.” Klaus sighed, patting your shoulder before exiting. You followed but parted ways to see your old room.

Sadly it wasn’t much better than your current home. Small and cramped. But posters lined every inch of the previously bare and boring walls. And the small bits that couldn't be covered had been painted with the nail polish that had been such a connecting force for you and the siblings. Whether it was bonding with Allison, joking around with Klaus and Ben, or getting to know Vanya.

You two had such a strong connection. She was warm and sweet and vulnerable and beautiful. You wished she knew that. You had your first kiss in that room. With her, when you two were sixteen. She left months later, leaving you to chase after her.

You brushed your suddenly teary eyes, holding a light blue bottle in your hands, remembering her favorite color. You closed the door behind you and placed the bottle back in the basket under your bed. You turned and take a look at yourself in the mirror that was lazily leaning against the dresser and the wall. It had fallen once during an... incident. And you never bothered to put it back up. You looked different, so different from your once open and bubbly self.

You brushed some hair behind your ear and went through some of your old books, it had been years since you’d been there and weirdly it wasn’t full of awful memories like everywhere else in the house.

Gun shots from upstairs take your mind off the books immediately. You ran, automatically searching for Vanya seeing as she was basically helpless against anything dangerous. You rush the living room where you see a man with a blue bear mask corner her.

A bubbling rage soars through your veins and you shake your head desperately trying to get control. You step in front of her eyes glowing yellow. The man steps back, shocked at your agility and appearance. You turn to Vanya and your nerves calmed, as they always did when you looked at her. You shook your head again and your eyes returned to their natural color.

“Run, hide, tell Klaus if you see him.” You whisper, she nods and you pounce on the prick the moment she turn the corner. You take his gun and completely tear it to shreds as you blank into your enraged form.

When you settle down the masked intruder is long gone and exhaustion over took you. You pulled yourself together and raced into the hallway to search for him. He meets you there and slams a heave spiked morning star into your lower half. Your intestines revolt against the metal and you crouch to the floor as wave after wave of pain sears through you.

“God, that hurts like a bitch, man,” You groan removing and swaying the bloody weapon back to him. You stand, to his shock and from the holes in your shirts he sees your organs heal and the muscles and skin tissue recombine in your abdomen Your eyes glow again and a shot rings out as you collapse back on the ground. Blood streaming from your forehead.

You were fifteen and had been at the academy for a couple of days, getting used to the swing of things. All you knew it that you were part of the 43. At fourteen you had been hit by a bus when riding your bike in the busy streets of New York. Your mother's heart was shattered, sobbing over your unconscious body. You were awake and completely healed by the time the paramedics had arrived.

Your mother decided it was best to at least see Dr. Hargreeves for your new found power. He was… As thrilled as a sociopathic alien could be. You decide to stay for the summer.

So here you were chatting with your new friends and gushing over a certain quiet girl in the corner who was basically begging for attention. Your attention was elsewhere now as you were discussing your powers with Klaus.

“That’s awful.” You frown. He shrugged, insisting it wasn’t a big deal, trying to impress the new pretty girl as was his brother and sisters. Luther was uninterested and annoyed, distrustful of you, and Ben gushed over you, though you couldn’t see him. Five had been gone for years.

“Number Eight,” A commanding voice echoed from his lab.

“Ooh, I have a number now,” You smirk, swaying back to the old man after getting a laugh from Klaus, who was genuinely worried for your safely.

“Sit in the chair,” Reginald instructed back to you and preparing your notes. You did as instructed and were strapped into the device. “Starting with 3 mA.” He started, having Grace pull a lever. An aggressive shock ran through your body. You yelped clenching the arms of the chair.

“What the hell?” You cried when the shocks stopped, Reginald ignored you taking a note.

“10 mA.” He mumbled. Your body convulsed with the current making you scream and your arms to twitch involuntarily.

After 30 mAs you were gasping for breath and coughing your lungs out. All very common reactions to the amount of electricity your body was receiving.

“2000 mAs.” Hargreeves announced, excitedly? You roared at the shock, your heart stomped uncontrollably and your breath aching in your throat. Your arms and fingers clenching. Fianlly you lied still.

In an almost panic Hargreeves stood, Grace’s hands shook as she looked at your unconscious, lifeless body.

After fifteen minutes you awoke, gasping for air but otherwise physically fine.

“Marvelous,” He muttered writing every second down.

Diego walked in to you passed out on Grace’s lap. “She’ll just be another hour or so.” Your head wound had scarred over and your breathing was slow as your body healed itself. Diego sighed staring at his beloved mother with regret and disappointment.

“Mom did you hear anything that was happened down there?” He begged. She didn’t answer, she just continued to stroke your locks out of your face. Diego’s eyes traveled to your exposed arms at the scars from the treatment you had received as a child. They were the only things that ever remained. No matter what injury. Just scars. “Let me take her, mom.” He sighed picking you up with ease and setting you on the couch in the living room before returning to his caregiver.

You wake up in Diego’s lap he stared at one of the animal heads on the wall deep in thought. You shot up, surprising him. “Where’s Klaus?” You asks, your gut screaming at you that something was wrong.

“I don’t know I haven’t seen him since this morning,” You stumbled upstairs. “(Y/N) come back you need to rest!” You ignored him, passing Vanya and looking everywhere, “He disappears sometimes. It’s nothing new.” You sighed and picked up the Walkman from his bedroom floor. Something was off and you knew it.

From Reginald Hargreeves’ notes, July 9th 2004

Subject (Y/F/N) has proven to show that she is very capable of dealing with immense pressure and pain. It is my diagnosis that she has powers such as self regeneration. Studies will continue with various different activities to test her limits and abilities.

#umbrella academy vanya #umbrella academy klaus #the umbrella academy #umbrella academy #klaus hargreeves #klaus hargreeves x reader #klaus x reader #tua klaus #vanya hargreeves #vanya hargreeves x reader #klaus x reader x vanya

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chair-leader · 5 years

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Haircuts and Healthcare

I can remember my dear friend Mark O’Donnell telling me a great story years ago. By nature, Mark was a storyteller and Irish embellisher. He was telling a story about his latest haircut. He went in to get his haircut late in the afternoon. Heather, his hairstylist, started spraying his hair with water then cutting it. Mark told Heather, ‘Wait. Wait. Wait. What are your doing?’ His hairstylist said, ‘Oh Mark, I have done this haircut a hundred times this year. Your cut is no different.’ Mark went on to say that this haircut was much different. It was his haircut. Although Heather had done the cut hundreds of times before, this haircut was the most important haircut to Mark. (Mark’s version had many more colorful details. I gave the ‘condensed’ version. But, the principle of the story is the same and very significant.) Enter the healthcare connection...

I cannot guess how many tests, procedures, scans, etc... Richard has had over the past five years. When in the hospital, nurse after nurse, and tech after tech, would enter the room and draw blood, give medications, take x-rays, etc... It was commonplace for the hospital staff. Some talked about the weather or sports. Many said nothing. This was part of their daily routine.

While this was part of the daily routine for hospital staff, it was never part of our daily routine. We would have found it most helpful if nurses would say, ‘Dr. Harper ordered this blood draw. We are testing your INR (International Normalized Ratio). We will have the results back within a few hours.’

Here is what the patients and caregivers want to know... Who ordered the test? What are you testing for? When will we know the results? (And then...we would like to know the results!)

While nurses and techs may do these tests hundreds of times per week, this particular test, at this particular time, to this particular person...is the most important test to us. We want to know the particulars.

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pacific-quest · 2 years

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An Overview of the NMT

An innovative approach for working with at-risk children, the Neurosequential Model of Therapeutics™ (NMT) provides a framework with which to evaluate a child’s history and current functioning. Informed by child development stages, NMT helps clinicians structure their assessment of each child, clearly articulate problems, and identify the child’s strength. Additionally, NMT helps professionals apply educational and therapeutic interventions in a way that best meets each individual child’s needs. Developed by Dr. Bruce D. Perry and his colleagues at the ChildTrauma Academy, NMT aims to translate complex neuroscientific principles into language that can be understood and implemented by therapists, educators, and even parents. Over the past several decades, doctors and researchers have made huge strides in understanding how specific brain systems are affected by traumatic events. Today, many clinicians have a working understanding of basic neurobiology concepts, such as the role of neurotransmitters in mood regulation and the importance of the frontal cortex to impulse control, logic, attention, and empathy. However, this knowledge does not always translate to actual practical interventions with clients. Dr. Perry and his team developed NMT out of their work with children who had experienced trauma, particularly children involved in the child welfare system. Rather than operating as a specific intervention model, NMT is a tool to help clinicians select and implement the best interventions for their clients. This works by equipping clinicians with the ability to estimate the level of function in various parts of the clients’ brains. Once they determine which areas are underperforming, clinicians can choose the interventions that are most likely to be effective in that area. For example, a patient who tends to self-blame for past trauma is underfunctioning in the cerebral cortex and might therefore benefit from a verbal treatment method. On the other hand, an individual who has dysregulation in the brainstem likely experiences fluctuations in heart rate and metabolism. An effective intervention for them might include sensory or rhythmic modalities to help regulate the brainstem. How might a clinician understand which areas of the brain are the best candidates for intervention? Utilizing a “brain mapping” technique, clinicians ask a series of questions that explore an individual’s patterns of sleeping, eating, communication, and other executive functions. This mapping process contributes to the Cortical Modulation Ratio (CMR), a score that describes the cerebral cortex’s ability to manage impulses from lower brain areas such as the limbic system and brainstem. The CMR can help educators, therapists, and caregivers chose between tools such as talk therapy, narrative therapy, and psychodynamic therapy, which are typically only successful when the cortex is more than twice as strong as the lower areas. Along with generating a CMR, NMT brain mapping offers scores in cognitive functioning, relational functioning, self-regulation, and sensory integration. Because these areas develop in a specific order and build upon each other, successful interventions should focus first on the earliest developed area with a low score. From a clinician’s point of view, this means focusing on something such as self-regulation (an earlier developed function) before targeting a function such as relationships. A final key aspect of NMT involves the coordination of therapeutic activities outside of therapy sessions. As with any skill, the brain requires frequent, repetitive activation to achieve positive change. Rather than viewing clinicians as service providers, NMT encourages them to explore ways the client can practice therapeutic activities frequently and repetitively in order to change the brain.

#NMT

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sparxwrites · 6 years

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vanessa-cyndrial replied to your post “so im pretty new to whump, and i was wondering: does “whump” include...”

i'd argue that whump is the hurt part, and when you add the comfort/healing it becomes hurt/comfort, although i'm not super against your 5:1 ratio idea

i gotta disagree with you there - whump needs to be very heavy on the hurt and fairly light on the comfort (at least until the end), but if there’s no comfort (not even a “they got away from the torturer! (and it’s implied they’re going to a hospital now”, or a “there’s someone there to inexpertly bandage their wounds and stroke their fevered brow”) then it’s darkfic / torture porn. (though i do agree, if there’s outright full-on healing and an extended recovery sequence then the whole thing either becomes h/c, or segues into a h/c story after the whump.) a “happy” / not utterly dark and hopeless ending and a caretaker character there to at least witness the suffering, even if they can’t do much to help it, is kind of essential - for me and, from what i’ve seen, for a lot of other whumpers.

certainly the og whump stories i used to read Way Back When (we’re talking 10 years ago, found on a stargate atlantis forum thread that had branched out to include other sci fi fandom whump) pretty consistently included a caretaker character (for doctor who, which is what i was reading then, it was generally the doctor’s companion) who usually couldn’t do much to help, but was there, fussing and worried and scared and trying to help. even now, most tumblr whump blogs have a heavy emphasis on the role of the caregiver character, almost as much as the emphasis on the whumpee themselves .

it’s not exactly comfort, not in the same “and then they went to a hospital / therapist and everything was fixed!!” way that more typical hurt/comfort does it, but there’s still something important about it i think. for me (and i think for a lot of people, probably), whump is about catharsis, and about... “acknowledgement of suffering”? if there’s no one there to witness the character getting hurt, to worry about them, to be scared on their behalf, there’s no kind of emotional resolution or release for the reader, i think. you need a witness, someone either as an emotional self-insert (when you’re putting yourself in the place of the caregiver, and getting your enjoyment from worrying over the whumpee) or as the source of the catharsis (when you’re putting yourself in the place of the whumpee, and getting your enjoyment from “your” pain and suffering being acknowledged and having someone want to help you).

either way, tl;dr: if there’s not at least a caregiver and some kind of a light at the end of the tunnel, imho it’s not really whump, it’s torture porn or darkfic - which are fun in their own ways, but don’t necessarily give me the same stomach-feelings or deep-seated emotional catharsis that whump gives me.

#vanessa-cyndrial #reply #whump #sparx chats

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cannabisrefugee-esq · 6 years

Video

youtube

The Health Benefits of Juicing Cannabis

Juicing requires raw, freshly-picked and properly grown cannabis, taking extra caution to avoid any plant material that may have been exposed to pesticides or other microbiological contaminants. Here are a few key recommendations to consider when juicing raw cannabis:

When it comes to juicing, fresher is better (like most vegetables).

Cannabis that has been dried and prepared for smoking is not suitable for juicing.

Do not be surprised if your local dispensary does not have a fresh supply of raw cannabis available. Many patients and caregivers are required to grow their own medicine to get access to quality starting material.

Dr. William Courtney recommends that patients juice 15 leaves, and 2 large (2 to 4 inches long) raw buds per day.

Raw buds are flowers harvested when the THC glands are clear (rather than amber).

It is recommended that you mix in another vegetable juice to cut down on the bitterness of the raw cannabis. A popular choice is carrot juice, and a ratio of 1 part cannabis juice to 10 parts carrot juice is a good rule of thumb.

Split the juice drink into 3 parts and drink with each meal, or store for up to 3 days in a tightly sealed container in the refrigerator.

#juicing #medical marijuana #weed #raw #vegan #cannabinoid system

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paddysnuffles · 6 years

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yes hello you said you did the reading to your self diagnosis and im gonna ask what did you read bc i think i may be autistic too

Hi! The research I did was really extensive as it was for a major project for my science, technology, and medical information class during my Master’s (Library and Info Science). The project was to make a user-friendly starter guide on a topic of our choice, so here are the resources I ended up using:

Is There Really an Autism Epidemic? (by Hal Arkowitz & Scott O. Lilienfeld, Scientific American, 2012)

The article discusses the possible meanings of the drastic change—within the short span of a decade—from the long-held ratio of 1:2,500 people with ASD to one of 1:166, suggesting that better understanding of ASD (and thus better ability to diagnose it) is likely to account for most of the increase. This is a great educational tool on understanding why autism is reported to be on the rise and why the current data on rising prevalence is rather misleading.

How to Think About the Risk of Autism (by Sam Wang, The New York Times, 2104)

An extensive yet approachable look at what the science says about the causes of autism and how to estimate the chances of a person having ASD. The article offers a comparison between how much emphasis the scientific community puts on each probable cause and how the media covers the subject. Genetic research can often be hard to follow even when simplified, so this could be a valuable introduction to the subject.

Survey: One in five believe vaccine causes autism (by Carly Weeks, The Globe and Mail, 2015)The article shows the effects of 18 years of false information fed to the public as science by Andrew Wakefield, starting with his 1998 paper on how vaccines are to blame for the existence of autism (which has been repeatedly disproven) to the 2016 propaganda film Vaxxed: From Cover-Up to Catastrophe. An important issue with serious public health implications.

Steve Silberman on autism and ‘neurodiversity’ (by Emma Teitel, Maclean’s, 2015)

An interview with Steve Silberman, who delved into the history of ASD to prove that the belief that “autism is a historical aberration of the modern world” is not actually correct. It offers an insightful explanation about what neurodiversity is, and serves as a great companion to the essay Mental Disorder or Neurodiversity? included in the topic-specific list.

Autism spectrum has no clear cut-off point, research suggests (by Nicola Davis, The Guardian, 2016)

This story reports the findings of a study that showed that the genes involved in the genesis of autism are connected to an individual’s social skills regardless of them exhibiting symptoms of ASD, “suggesting that “the autism spectrum has no clear cut-off point.” In other words, all individuals could be put within a scale for autistic traits and placed anywhere between the most severely impaired people on one end and the easy-going, social butterflies on the opposite end. The article provides a biological basis that could inform some of the discussion presented in other articles on the suitability of labelling less severe cases as a “disability” rather than a difference.

Autism spectrum disorders in the DSM-V: Better or worse than the DSM-IV? by Lorna Wing, Judith Gould, and Christopher Gillberg—–An overview of the changes brought by DSM-V by removing the category of Pervasive Developmental Disorders and replacing them with Autism Spectrum Disorder, as well as a discussion about the positive and negative aspects of the new criteria. Considering that the changes brought by the new edition of the DSM is one of the most important developments in the area, this article provides a much-needed discussion on the very definition of ASDs. Note: One of the beliefs professed in the article - that autistics cannot feel empathy - has recently been disproven; for details on that see Brewer & Murphy in the referenced works section)

Evidence-Based Practices for Children, Youth, and Young Adults with Autism Spectrum Disorder: A Comprehensive Review by Connie Wong, Samuel L. Odom, et al.—–A look at the current practices for ASD therapy to help children learn coping mechanisms, hone their fine motor function abilities, and other interventions found to be effective through different research projects. This essay will be helpful for an understanding of the therapies and techniques available for families affected by ASD.

Does the different presentation of Asperger syndrome in girls affect their problem areas and chances of diagnosis and support? by Elizabeth Hughes—–The article discusses the differences in how ASD presents itself in females versus males, comparing the diagnostic tools available for ASD and doctor’s perceptions of what ASD looks like in order to determine whether more males tend to be diagnosed with ASD than females due to actual biological differences in prevalence or because of gender bias imbued within the diagnostic tools. In addition to addressing an important issue surrounding ASD, this article also helps with the understanding of the range of symptoms and level of severity ASD can be manifested.

The Ever-Changing Social Perception of Autism Spectrum Disorder in the United States by Danielle N. Martin—Providing a historical perspective on the evolution of the understanding and acceptance (or lack thereof) toward ASD from a social and medical standpoint, this article looks at how past perceptions have shaped the modern stigma toward this disorder. This thesis paper—which was awarded the Michael F. Bassman Honors Thesis Award from the East Carolina University—will helps readers to familiarize themselves with how stigma against ASD manifests itself.

A Minority Group by Charlotte Stace—–Slang and terminology related to ASD are explored from the perspective of the ASD community, offering a unique insight into how the community views itself as well as how it views outsiders. It provides an interesting mirror image to the previous article, which is focused on the point of view of those not living with ASD.

Mental Disorder or Neurodiversity? by Aaron Rothstein—–The author discusses whether differences in how the brain deals with sensory input (such as in ASD, ADHD, and dyslexia) should qualify as “disorders” or whether they are variations on the brain’s “wiring” that helps with our species survival by providing certain individuals with an ability to problem-solve in ways that most people can’t. The emergence of this debate within the community—which is rapidly gaining prominence in media outlets—makes this paper an important read for those interested in a more holistic view of ASD.

Major sources of information (publications)

Diagnostic and Statistical Manual, 5th edition (DSM-V): Although not a source solely focused on ASD (which comprises a relatively small part of the overall publication), it is nevertheless considered to be one of the key sources of information for professionals trying to determine whether a patient might be on the spectrum.

Journal of Autism and Developmental Disorders: The leading peer-reviewed, scholarly periodical about ASD and other closely related disorders; published monthly.

Autism Spectrum Digest: A monthly digital magazine centered around topics of interest to members of the ASD community and their families, such as helpful apps, current news related to ASD, legal/human rights issues, etc.

Electronic resources

Autistic Self-Advocacy Network: An advocacy group about ASD, for autistics and by autistics, which promotes programs, offers a resource library, and provides a source for news relating to the ASD community from an ASD perspective.

Research Autism: A UK organization whose focus is research of interventions in autism, as well as provide objective evaluations of the scientific evidence behind each. It also offers a number of useful resources, such as a database of publications relating to ASD, links to apps developed for people with ASD, and information on legislations and policies relevant to people with ASD.

Authorities

Hans Asperger: Hans Asperger played an important role in the history of Autism Spectrum Disorder. He was one of the first scientists to identify ASD, and the first to theorize that ASD is something that affects a person throughout their whole life rather than only through childhood as Leo Keller claimed (Sole-Smith, 2014). Asperger’s Syndrome, one of the most-known variations of ASD, was named after him (Asperger’s Syndrome, n.d.).

Temple Grandin: Though her formal education deals with animal caregiving, Dr. Grandin is nevertheless seen as a leading authority on autism by both the ASD community and researchers alike. She is recognized as one of the first advocates for autism to actually have autism, and her insights into how autistic people experience the world were instrumental in bringing awareness and some degree of acceptance to ASD. Dr. Grandin has been profiled by the New Yorker, interviewed in NPR and the New York Times, was the subject of a photo essay for Time magazine and was listed in the 2010 Time 100 list in the "Heroes" category (Flatow, 2006; Goldman, 2013; Slaby, 2009; Hauser, 2010). She has written a number of books on Autism, has received honorary degrees from several universities, and was awarded a Double Helix Medal (Cold Spring Harbor Laboratory, 2011; Grandin, 2016).

Key issues

"Neuro-diverse" versus “disabled”: There is surging controversy about whether milder forms of ASD should be considered disorders/disabilities or only a version of how the brain can function (like having a Mac vs a PC - they’re different, but it doesn’t mean one is faulty). A major reason behind this movement is that, as Dr. Grandin explains in her TED Talk, autistics might be worse than most people at some things, but they’re more skilled at others, like breaking down complex systems and understanding how they work (Grandin, 2010). Also in favour of this theory is the fact that those “on the spectrum” often enter professional fields in the area of their special interests and become experts on the subject (Grandin, 2010).

Prevalence of ASD in Women: A number of studies have shown that the signs doctors look for when diagnosing ASD are mainly those that manifest in males, meaning that women are often undiagnosed or misdiagnosed, with some doctors going so far as saying that “women can’t have Asperger’s” even when faced with a classic case according to current diagnosis definitions (Hughes, 2014). There is a slowly growing movement to fix this, but as of yet little has been on an official capacity other than studies repeatedly finding that a drastic change needs to be implemented.

Vaccines and Autism: A major issue related to autism and ASD is the widespread belief among the general population that vaccines can be to blame for a child’s autism. The problem started nearly two decades ago, with propaganda disguised as science by Andrew Wakefield that was widely spread through the internet and general media outlets. To this day, despite definitive proof to the contrary by a number of research findings, 20% of Canadians still believe that there is a link, while another 20% aren’t sure about it (Weeks). As a result, a number of parents started to refrain from giving their children vaccines, with serious consequences such as illnesses like measles having made a deadly comeback to the country (Weeks).

References

American Psychiatric Association. (2013). DSM V. American Psychiatric Association.

American Psychiatric Association. (2015). DSM V Update. American Psychiatric Association.

Arkowitz, H., & Lilienfeld, S. O. (2012, August 1). Is There Really an Autism Epidemic? Scientific American. Retrieved from https://www.scientificamerican.com/article/is-there-really-an-autism-epidemic/

Asperger’s Syndrome. (n.d.). In Merriam-Webster. Retrieved from

http://www.merriam-webster.com/dictionary/Asperger's%20syndrome

Autism Spectrum Digest. (2016). Autism Spectrum Digest. Retrieved from http://asdigest.com.

Autistic Self Advocacy Network. (2016). Autistic Self Advocacy Network. Retrieved from http://autisticadvocacy.org/

Bradley, E., Caldwell, P., & Underwood, L. (2013). Autism Spectrum Disorder. In J. McCarthy & E. Tsakanikos (Ed.), Handbook of Psychopathology in Intellectual Disability: Research, Practice, and Policy (pp. 237–264).

Brewer, R., & Murphy, J. (2016, July). People with Autism Can Read Emotions, Feel Empathy. Spectrum. Retrieved from https://www.scientificamerican.com/article/people-with-autism-can-read-emotions-feel-empathy1/

Cold Spring Harbor Laboratory. (2011). Cold Spring Harbor Laboratory honors stars of science and sports at sixth annual gala. Retrieved from http://www.cshl.edu/news-a-features/cold-spring-harbor-laboratory-honors-stars-of-science-and-sports-at-sixth-annual-gala.html

Davis, N. (2016, March 21). Autism spectrum has no clear cut-off point, research suggests. The Guardian [London]. Retrieved from https://www.theguardian.com/science/2016/mar/21/autism-spectrum-has-no-clear-cut-off-point-research-suggests-nature-genetics

Dichter, G. S. (2012). Functional magnetic resonance imaging of autism spectrum disorders. Dialogues in Clinical Neuroscience, 14(3), 319–351. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513685/

Flatow, I. (Host). (2006, January 20). A Conversation with Temple Grandin [Television series episode]. In Talk of the Nation. National Public Radio.

Foster, R. (2014). Does the Equality Act 2010 ensure equality for individuals with Asperger syndrome in the legal arena?: A survey of recent UK case law Autonomy, the Critical Journal of Interdisciplinary Autism Studies, 1(4). Retrieved from

http://www.larry-arnold.net/Autonomy/index.php/autonomy/article/view/AR16

Fuentes, J., Bakare, M., Munir, K., Aguayo, P., Gaddour, N., & Öner, Ö. (2014). Developmental Disorders - Autism Spectrum Disorder. In J. M. Rey (Ed.), IACAPAP e-Textbook of Child and Adolescent Mental Health (p. C.2 1–35). Geneva: International Association for Child and Adolescent Psychiatry and Allied Professions.

Goldman, A. (2013, April 12). Temple Grandin on Autism, Death, Celibacy and Cows. The New York Times. Retrieved from http://www.nytimes.com/2013/04/14/magazine/temple-grandin-on-autism-death-celibacy-and-cows.html?_r=0

Grandin, T. (2010, February). Temple Grandin: The world needs all kinds of minds. [Video file]. Retrieved from

https://www.ted.com/talks/temple_grandin_the_world_needs_all_kinds_of_minds?language=en#t-157979

Grandin, T. (2016). Temple Grandin Professional Resumé. Retrieved from http://www.grandin.com/professional.resume.html

Hauser, M. (2010, April 29). The 2010 TIME 100. Time. Retrieved from http://content.time.com/time/specials/packages/article/0,28804,1984685_1984949_1985222,00.html

Hughes, E. (2014). Does the different presentation of Asperger syndrome in girls affect their problem areas and chances of diagnosis and support? Autonomy, the Critical Journal of Interdisciplinary Autism Studies, 1(4). Retrieved from http://www.larry-arnold.net/Autonomy/index.php/autonomy/article/view/AR17

Journal of Autism and Developmental Disorders. Retrieved from

http://link.springer.com/journal/10803

Martin D. N. (2012) The ever changing social perception of autism spectrum disorders in the United States. Honors Thesis, East Carolina University. Retrieved from http://uncw.edu/csurf/Explorations/documents/DanielleMartin.pdf

Medical Library Association. (2016). Medical subject headings (MeSH).

Research Autism. (n.d.). Research Autism. Retrieved from http://researchautism.net/

Rothstein, A. (2012). Mental Disorder or Neurodiversity? The New Atlantis, 36. Retrieved from http://www.thenewatlantis.com/publications/mental-disorder-or-neurodiversity

Slaby, M. (2009). The Perspectives of Temple Grandin. Time. Retrieved from

http://content.time.com/time/photogallery/0,29307,1985143,00.html

Sole-Smith, V. (2014). The History of Autism. Parents. Retrieved from http://www.parents.com/health/autism/history-of-autism/

Stace, C. (2014). A Minority Group. Autonomy, the Critical Journal of Interdisciplinary Autism Studies, 1(3). Retrieved from http://www.larry-arnold.net/Autonomy/index.php/autonomy/article/view/AR13

Teitel, E. (2015, August 25). Steve Silberman on autism and ‘neurodiversity’. MacLean's. Retrieved from http://www.macleans.ca/society/science/steve-silberman-on-autism-and-the-neurodiversity-movement/

Tonge,B., & Brereton, A. DSM-5 Autism Spectrum Disorder Fact Sheet. Retrieved from

http://www.timeforafuture.com.au/factsheets/CDPP%20Factsheet%201.%20DSM%205%20Autism%20Spectrum%20Disorder.pdf

Wang, J. (2014, March 29). How to Think About the Risk of Autism. The New York Times. Retrieved from http://www.nytimes.com/2014/03/30/opinion/sunday/how-to-think-about-the-risk-of-autism.html?_r=1

Weeks, C. (2015, February 6). Survey: One in five believe vaccine causes autism. The Globe and Mail [Toronto]. Retrieved from http://www.theglobeandmail.com/life/health-and-fitness/health/survey-finds-one-in-five-people-believe-measles-vaccines-cause-autism/article22851493/

Wing, L., Gould, J., & Gillberg, C. (2011). Autism spectrum disorders in the DSM-V: better or worse than the DSM-IV?. Research in developmental disabilities, 32(2), 768-773. Retrieved from http://www.sciencedirect.com/science/article/pii/S0891422210002647

Wong, C., Odom, S. L., Hume, K. A., Cox, A. W., Fettig, A., Kucharczyk, S., ... & Schultz, T. R. (2015). Evidence-based practices for children, youth, and young adults with autism spectrum disorder: A comprehensive review.Journal of Autism and Developmental Disorders, 45(7), 1951-1966. Retrieved from http://link.springer.com/article/10.1007/s10803-014-2351-z

World Health Organization. (1994). International classification of diseases (ICD).

Further Resources

Autism Women’s Network

Interactive Autism Network

Simons Foundation Autism Research Initiative (SFARI)

The official site for a research program funded by the Simons Foundation, which focuses on all aspects of autism research

Doctor Temple Grandin’s Site

Dr. Grandin’s site on autism. It has some of her writings on the subject as well as information on conference appearances.

ResearchGate Discussion Forum

A discussion page on ResearchGate on academic papers regarding ASD stigma. You can also search the overall discussion forum for other ASD-related discussions by academics.

Parents miss signs of autism in their daughters by Emily Anthes (Spectrum, 2016)

A study finds that parents of girls with autism are significantly less likely than those of boys to voice concerns about their child’s social behaviour.

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Though mostly useful to familiarize oneself with ASD culture, members of the ASD community also post links to news and resources (usually with commentary on their perspective on the matter). Tags of interest: #asd, #actuallyautistic, #stimming, #aspielife

Stigma and the “Othering” of Autism by Lynne Soraya (Psychology Today, April 1, 2012)

An Aspie’s perspective on the stigma surrounding autism and what it means to support an autistic child.

Autism Speaks, But Not For Autistics by Dane La Born (The Free Weekly, April 6 2016)

An autistic’s perspective on the lesser-known controversy surrounding Autism Speaks, the #1 autism charity in the world.

Ce que signifient les étapes du développement chez un enfant autiste by Kathleen O’Grady (Huffington Post Quebec, 2016)

The Autism Speaks Controversy by Brianne McDunnough (Reporter Magazine, 2014)

Where Autism Got The Right Treatment In 2015 by Emily Willingham (Forbes, 2015)

Proteins that spark learning may play key part in autism by Ann Griswold (Spectrum, 2016)

Autism Spectrum Disorder Linked to Mutations in Some Mitochondria by (Neuroscience News, 2016)

Autism gene needed for growth of neurons during gestation by Jessica Wright (Spectrum, 2016)

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bangkokjacknews · 4 years

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Thailand sets itself up as DEMENTIA CARE destination

British families are sending elderly relatives with dementia overseas to #Thailand in a small but growing trend.

Researchers visiting private care homes in Chiang Mai have found eight homes where guests from the UK are living thousands of miles away from their families, because suitable care in their home country was impossible to find or afford. “Thailand already has a long history of medical tourism and it’s now setting itself up as an international hub for dementia care,” said Dr Caleb Johnston, a senior lecturer in human geography at Newcastle University. Some of the facilities are British-run; some are Thai-run but with substantial investment from British citizens; and some are Swiss-run. All have the backing and support of the Thai government. “The government and private investors are very active in cultivating this as part of their economic development,” Johnston added. There are an estimated 850,000 people living with dementia in the UK. Local authority residential care costs up to £700 a week, with private care around £1,000. There are no prescribed staff-to-guest ratios in the UK but, with annual staff turnover exceeding 30% and 122,000 job vacancies, levels in state and private facilities tend to be around 1:6. In Thailand, in contrast, 1:1 around-the-clock residential care with fully-qualified staff – in award-winning facilities that look like four-star hotels – costs around £750 a week. Johnston spent nine weeks in Thailand along with Prof Geraldine Pratt, head of geography at the University of British Columbia, interviewing families and staff in residential care homes. “There aren’t yet any official numbers as to how many people are moving out to Thailand to receive care,” said Johnston. “Relative to the total number of people living with dementia, it is a low number. But with the number of people with dementia set to increase, and the cost of looking after them also getting higher, it is likely to be an option that more and more people consider.” Paul Edwards, the director of clinical services at Dementia UK, said: “I can well understand people choosing this option, given the state of anxiety about care in the UK. “It’s an emerging market that I can see becoming more popular because our failing and ailing system – which no politician is even trying to find a solution for – causes fear for those whose loved ones have to use it.” Nonetheless, those who take their loved ones abroad talk of the distress in having to choose between the physical, emotional and financial hardships of caring for them in the UK and outsourcing their care to the other side of the world.

Swiss guests with Alzheimer’s disease in a care home in Chiang Mai, Thailand. Photograph: Apichart Weerawong/AP Annie (not her real name) has moved her husband into Vivobene Village, a Swiss-run home near Chiang Mai. She initially tried finding care close to her home in the south of England, but was forced to move to Yorkshire. “There was care for him there but there was no one for me to turn to there,” she said. “So then we moved again to the north of England. But then I needed respite. The home we were recommended for my husband cost £900 a week and one afternoon, my son-in-law went to take out and he wasn’t dressed or shaved. He was just looking out of the window. We bought him home and a few months later, I put him into another care home and the same thing happened again.” Shortly afterwards, the couple flew out to see their daughter in Bangkok and heard about the care home. “He’s never left here since that day. We just said, ‘this is perfect’,” said Annie, in an interview with Johnston and Pratt. Annie now visits her husband three times a year, staying for two to three months at a time. “I think he’s very happy here,” she said. “The people around him are so nice and he reacts to that. For him, I think his life is as good as it could be. It’s worse for me than it is for him.” Peter Brown moved to Thailand from the UK and opened a four-star hotel resort in Chiang Mai 11 years ago. He founded the Care Resort Chiang Mai six years ago, after becoming unhappy with the quality of care his mother was receiving in her British care home. “I don’t believe there are any relatives in the world who want to export their mother and father to a different country,” he said. “What they want is care for their mother and father that they are entitled to and unfortunately, their local city is incapable of giving them. “They don’t want their mother and father locked away for 23 hours a day, sat in a corridor for one hour then put back into their room, so they start to look around for alternative options. There are plenty of options in a separate country, so how can you blame them for taking it? “You should find the solution at home. But the solutions aren’t good enough or affordable in the UK. Dementia sufferers need a lot of time and that doesn’t fit in with the western lifestyle any more. The advantage with somewhere like Thailand is that the staff are a lot cheaper and the strong family culture here. People respect the elderly as a norm. In the west, we don’t respect the elderly any more. “The British state does need to do more because the best place for people to be looked after is where they are now.” There have been recent reports of people with Alzheimer’s disease being forced from Thailand because of changes to immigration rules, but for Allan Sims, from the south of England, his experience is “as close to perfection as you can imagine”. Sims and his wife had been going on holiday to Thailand for years, and when she developed Alzheimer’s disease four years ago, the couple moved to Ko Samui and lived in a four-star hotel. When his wife’s condition worsened, their daughter found a Chiang Mai care home on the internet. “We have three to four carers for every dementia guest here and my wife’s caregivers are my close friends now,” Sims said. “I’m so impressed. My wife needs someone with her 24/7. When I get overwhelmed and my daughter takes me away for a break, a carer doesn’t just care for my wife but shares the bed with her . “If I was in the UK, we might get a carer for 15 minutes in the morning and 15 minutes in the evening, or some ridiculous thing,” he said. “I despair about the care in the UK.” – You can follow BangkokJack on Instagram, Twitter & Reddit. Or join the free mailing list (top right) Please help us continue to bring the REAL NEWS - PayPal Read the full article

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mariebenz · 4 years

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Seizure Cluster Patients Suffer From More Severe Disease and Lower Remission Rates

MedicalResearch.com Interview with:

Dr. Eun Jung Choi Eun Jung Choi, MD, PhD; Senior Director, New Product Launch, Neurology UCB MedicalResearch.com: What is the background for this study? Response: Patients experiencing seizure clusters, a type of seizure emergency impacting an estimated 150,000 patients in the U.S. with uncontrolled epilepsy, are at risk for potentially serious consequences including hospitalization, mortality, physical injury, neurological damage, and status epilepticus. Although unmet needs of seizure clusters are intuitively well accepted, the burden of seizure clusters has not been well characterized and evaluated in a systemic matter. As a result, the seizure cluster patients are overlooked, and burden of seizure clusters is under-recognized. So we systematically assessed the clinical, humanistic, and economic burden associated with seizure clusters to provide the comprehensive body of evidence about burden of seizure clusters. MedicalResearch.com: What are the main findings? Response: Our analysis showed that more severe epilepsy patients (high seizure frequency at baseline, history of status epilepticus, failure of two or more antiepileptic drugs, and prior history of clusters) was associated with seizure clusters. The incidence of status epilepticus in seizure cluster patients was higher than in non-seizure cluster patients with odds ratio of risk ranged from 1.8 to 3.0. Additionally, remission rate of epilepsy was lower in patients with seizure clusters than without seizure clusters. As suspected, we found the overall quality of life in seizure cluster patients was lower than in seizure-free epilepsy patients on several dimensions: Seizure clusters negatively affected patients’ ability to drive (73% of patients), independence (67%), and travel (59%). Patients’ seizure clusters adversely affected their caregivers in mood (55% of caregivers), travel (52%), vacation (52%), and productivity (48%). Seizure clusters adversely affected patients’ productivity (69%); most of these patients had experienced a seizure at work (62%), or stopped working for some time (53%) due to seizure clusters. Additionally, about 30% of seizure cluster patients used an emergency room over 1 year. Seizure-related hospitalization was more common in seizure clusters compared to non-seizure cluster patients (odds ratio 5.3). MedicalResearch.com: What should readers take away from your report? Response: Results of this analysis suggest that patients with seizure clusters are associated with more severe epilepsy and have a high risk of status epilepticus and poor quality of life. Therefore, physicians should actively identify seizure cluster patients among uncontrolled epilepsy patients to address these high unmet needs. Additionally, while the data on humanistic and economic burden are limited in this under-studied population, it is clear that seizure clusters not only affect the quality of life of both patients and caregivers, but they can also significantly impact their work productivity, and cost of care. We hope that our analysis brings a great attention to physicians to identify high risk of seizure cluster patients and develop an acute treatment plan with new therapy to address the burdens of the condition, help them terminate seizure clusters and return to living their best lives, such as the recently approved midazolam nasal spray, the first and only nasal option approved by the FDA to treat seizure clusters in more than 20 years in the U.S. The newly available treatment is indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient’s usual seizure pattern in patients with epilepsy 12 years of age and older. Please see full Prescribing Information, including boxed warning. Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. The ready-to-use solution that is designed for seizure emergency gives new hope to patients with seizure clusters who go untreated because of limited treatment options. MedicalResearch.com: What recommendations do you have for future research as a result of this work? Response: With a new treatment option for seizure clusters, there is a great research opportunity to understand how early intervention of seizure clusters could improve clinical, humanistic, and economic outcome and burden as we evaluated in this research. Disclosures: This was a UCB, Inc. sponsored study. The results of this systematic literature review are based on data already available in the scientific literature. Citation: 2019 American Epilepsy Society Meeting abstract A systematic review of the clinical, humanistic and economic burden of seizure clusters, Eun Jung Choi, MD, PhD; Steve S Chung, MD; J Claire Wilson, PhD; Saifuddin Kharawala, DPM, MBBS; Gavneet Kaur, MPharm Abstract 2.263 December 8, 2019: Last Modified: The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website. Read the full article

#AmEpilepsySoc #epilepsy #ucb_news

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marrincostello · 5 years

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Alzheimer’s memory loss reversed by new head device using electromagnetic waves

Source: IOS Press

There is finally some encouraging news for the millions of Americans suffering from Alzheimer’s Disease. NeuroEM Therapeutics today announced findings from an open-label clinical trial showing a reversal of cognitive impairment in Alzheimer’s Disease patients after just two months of treatment using the company’s wearable head device for in-home treatment.

Results demonstrate that TEMT was safe in all eight participating patients with mild to moderate AD and enhanced cognitive performance in seven of them, as measured by their ADAS-cog score, which is the benchmark for testing AD therapeutics. The study is being published in the new issue of the Journal of Alzheimer’s Disease.

The investigators had previously demonstrated that treating AD mice with electromagnetic waves in the radiofrequency range resulted in protection against memory impairment in young AD mice and reversal of memory impairment in aged AD mice.

For the present clinical study in humans, the investigators used the same treatment (twice daily for 1-hour) through creation of NeuroEM’s first-in-class MemorEMTM head device. The device has multiple, highly-specialized emitters positioned within a head cap that are activated sequentially, with treatments easily administered in-home by the patient’s caregiver. As well, the device allows for near complete mobility to perform nearly all household activities during treatments.

“Perhaps the best indication that the two months of treatment was having a clinically-important effect on the AD patients in this study is that none of the patients wanted to return their head device to the University of South Florida/Byrd Alzheimer’s Institute after the study was completed”, said Dr.Gary Arendash, CEO of NeuroEM Therapeutics. One patient even exclaimed “I’ve come back.”

The investigators indicated they have strong evidence that TEMT is directly affecting the Alzheimer’s disease process by easily penetrating the brain and brain cells to break up aggregates of two toxic proteins inside brain cells called A-beta and tau.

TEMT’s ability to disaggregate both toxic proteins inside brain cells (neurons) appears to be key to stopping and reversing the cognitive loss of AD. Present AD drugs in clinical trials have great difficulty getting into the brain and then into brain cells. Even if they succeeded in doing so, they do not yet have the capacity to target the small aggregates of A-beta and tau proteins that appear to be causative to AD.

NeuroEM Therapeutics is planning for a pivotal clinical trial to begin recruitment of approximately 150 mild/moderate AD subjects later this year for treatment with the company’s MemorEMTM device. If that trial shows continued safety and cognitive benefits, NeuroEM Therapeutics plans to ask the FDA for approval of the MemorEM device for treatment of AD. The clinical locations for this multi-site trial have not yet been determined.

“Despite significant efforts for nearly 20 years, stopping or reversing memory impairment in people with Alzheimer’s disease has eluded researchers,” said co-author Amanda Smith, M.D., Director of Clinical Research, University of South Florida Health, Byrd Alzheimer’s Institute, the clinical center for the study. “These results provide preliminary evidence that TEMT administration we assessed in this small AD study may have the capacity to enhance cognitive performance in patients with mild to moderate disease.”

After two months of treatment administered at home by their caregivers, none of the eight patients in the study exhibited any deleterious side effects on behavior or physiologic measures, as recorded by caregivers in daily diaries. Moreover, post-treatment brain scans revealed no visible induction of tumors or brain bleedings called microhemorrhages.

Using the benchmark ADAS-cog task to assess a variety of cognitive measures, seven of the eight AD patients collectively responded to treatment with a 4+ point increase in cognitive performance by the end of the 2-month treatment period — the results indicate a very large and clinically-important effect.

Since AD patients typically show a 4+ point decline in ADAS-cog performance over a given one year period, the 4+ point improvement provided by TEMT was as if the treated patients had gone back in time to their better cognitive performance of one year earlier.

“We were particularly surprised that this highly significant improvement in the ADAS-cog was maintained even two weeks after treatment was completed”, stated Dr. Arendash.

“The most likely explanation for continued benefit after cessation of treatment is that the Alzheimer’s Disease process itself was being affected.”

Cognitive abilities were improved in other tasks as well, such as the Rey AVLT task, wherein clinically important increases in word recall were present after treatment for 2 months and at two weeks thereafter. Even a 50% reduction in forgetting was observed in this important task.

In addition to cognitive assessment, the study also involved analysis of AD markers in both the blood and the cerebrospinal fluid (CSF) before and at the end of the 2-month treatment period. These AD markers were changed in directions expected for TEMT disaggregating the two toxic proteins (A-beta and tau) that appear to be the disease’s root causes.

Also, MRI brain scans in individual AD patients revealed evidence of increased communication between neurons in a brain area critical for cognitive integration called the cingulate cortex/cingulum.

This is a patient wearing MemorEM. The image is credited to credited to NeuroEM Therapeutics, Inc.

The investigators believe that TEMT may be an entirely new therapeutic intervention against Alzheimer’s disease and that NeuroEM’s bioengineering technology may be succeeding where drug therapy against this devastating disease has thus far failed.

Based on the findings and the enthusiasm for continued treatment that all patients expressed, patients were offered and accepted continued TEMT in a now on-going extension study averaging 17 months between initial study start and extension study finish. More information about both the completed and on-going clinical trials is available at NeuroEM’s website.

More Information About the Study

The open-label study was a single center, single arm trial in eight patients 63 years of age and older with mild to moderate Alzheimer’s disease (AD) to evaluate the safety and initial efficacy of Transcranial Electromagnetic Treatment (TEMT). Patients were enrolled at the University of South Florida Health/Byrd Alzheimer’s Institute, which also conducted most clinical study assessments. Treatment was administered in the patient’s home by a caregiver (spouse, relative), using the MemorEM device.

Patients received TEMT for one-hour periods twice daily for two months. Although limitations of this study include the small number of subjects, not having a control group, and being of relatively short treatment duration, 120 treatments were administered in-home and the cognitive benefits observed were clinically important/meaningful at the highest levels. Providing additional credibility to the observed cognitive enhancements were the beneficial changes in AD markers in blood and CSF, as well as the enhancement in brain MRI imaging.

About this neuroscience research article

Source: IOS Press Media Contacts: Bill Gordon – IOS Press Image Source: The image is credited to NeuroEM Therapeutics, Inc.

A Clinical Trial of Transcranial Electromagnetic Treatment in Alzheimer’s Disease: Cognitive Enhancement and Associated Changes in Cerebrospinal Fluid, Blood, and Brain Imaging

Background: Small aggregates (oligomers) of the toxic proteins amyloid-β (Aβ) and phospho-tau (p-tau) are essential contributors to Alzheimer’s disease (AD). In mouse models for AD or human AD brain extracts, Transcranial Electromagnetic Treatment (TEMT) disaggregates both Aβ and p-tau oligomers, and induces brain mitochondrial enhancement. These apparent “disease-modifying” actions of TEMT both prevent and reverse memory impairment in AD transgenic mice.

Objective: To evaluate the safety and initial clinical efficacy of TEMT against AD, a comprehensive open-label clinical trial was performed.

Methods: Eight mild/moderate AD patients were treated with TEMT in-home by their caregivers for 2 months utilizing a unique head device. TEMT was given for two 1-hour periods each day, with subjects primarily evaluated at baseline, end-of-treatment, and 2 weeks following treatment completion.

Results: No deleterious behavioral effects, discomfort, or physiologic changes resulted from 2 months of TEMT, as well as no evidence of tumor or microhemorrhage induction. TEMT induced clinically important and statistically significant improvements in ADAS-cog, as well as in the Rey AVLT. TEMT also produced increases in cerebrospinal fluid (CSF) levels of soluble Aβ1-40 and Aβ1-42, cognition-related changes in CSF oligomeric Aβ, a decreased CSF p-tau/Aβ1-42 ratio, and reduced levels of oligomeric Aβ in plasma. Pre- versus post-treatment FDG-PET brain scans revealed stable cerebral glucose utilization, with several subjects exhibiting enhanced glucose utilization. Evaluation of diffusion tensor imaging (fractional anisotropy) scans in individual subjects provided support for TEMT-induced increases in functional connectivity within the cognitively-important cingulate cortex/cingulum.

Conclusion: TEMT administration to AD subjects appears to be safe, while providing cognitive enhancement, changes to CSF/blood AD markers, and evidence of stable/enhanced brain connectivity.

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plxyboi-blog · 5 years

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Nutritionist Maya Feller's 5 best health tips for women of color

New Post has been published on https://healthy4lives.com/nutritionist-maya-fellers-5-best-health-tips-for-women-of-color/

Nutritionist Maya Feller's 5 best health tips for women of color

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Americans are risking their well being. A lack of diet instruction, workout and healthy food selections has remaining a brunt of the populace susceptible to coronary heart ailment, diabetic issues and being overweight.

These hazards are notably superior for women of colour.

According to the Centers for Disease Command and Avoidance, 45 percent of black women and 49 percent of Latinas are viewed as obese, as opposed to 38 percent of white women. Black women are 60 percent more very likely than white women to have a coronary heart assault and 1-3rd of Mexican-American women have cardiovascular ailment.

Nutritionist and dietician Maya Feller is on a mission to carry those numbers down. Founder of Maya Feller Nourishment, she specializes in threat reduction and management of diet plan-similar chronic illnesses. Her very first cookbook, which will come out in October, is named “The Southern Comfort and ease Food stuff Diabetes Cookbook: In excess of 100 Recipes for a Healthy Lifetime.”

“Most Americans are often and continuously eating rapid and processed meals at this sort of a clip that has unfavorable, unfavorable well being results,” stated Feller told NBC News well being editor Dr. Madelyn Fernstrom. “So it is definitely about scaling back. It really is about on the lookout for goods that are lower in sodium … It really is about modifying the proportion.”

Economics are stacked in opposition to women of colour, and there is no substitution for systematic change. Nevertheless, there are smaller methods women can consider to assistance improve their well being, and the well being of their people.

one. Educate by yourself on diet.

Nourishment is not an intuitive science, and it’s not taught in educational facilities. By and significant, persons in The us have no thought what they are putting into their bodies and what the impact may possibly be.

“Especially when we look in these communities of colour, that is not component of what is actually getting taught,” stated Feller. “They never know their numbers. They never know about their blood force. They never know about their lipids. They never have an thought of the reality that the website link between what they are putting into their bodies in fact has a scientific final result with regard to those numbers.”

To compound the concern, a lot of persons in the U.S. really do not take a look at a normal medical doctor who knows their heritage, patterns, and hazards.

“People are using crisis rooms as their primary care. Hence, there’s not this through-line of getting a medical doctor that’s pursuing you and also educating you.”

Until finally these larger sized societal troubles are addressed, women can examine diet labels and teach on their own on essential information. Nourishment is exceptionally challenging, according to Feller, but there are quick hacks to profitable the diet label game.

“I notify my clients, ‘If you happen to be on the lookout at fat and you happen to be on the lookout at salt, something that’s near to five percent is small. Just about anything that’s near to twenty percent is superior.’” stated Feller. “So if you happen to be using a packaged fantastic, you happen to be usually heading to want to look for five percent, or ten percent. Which is moderate and small, specially in those regions of fat and sodium.”

Feller also proposed a superior ratio of leafy greens, as opposed starchy vegetables like yams and potatoes.

“This is exactly where I say, ‘Look at what is actually on the plate, and look at the ratio. 50 % the plate as non-starchy vegetable, a quarter is lean protein, and a quarter is starch.’ Which is definitely a wonderful type of visual system.”

Avoid trans-fats, stated Feller. And if you are eating saturated fat, hold it moderate and plant-based, like avocados and olive oil.

The CDC also recommends superior fiber, small included sugar, and small refined carbohydrate intake.

two. Substitute, really do not dismiss

Feller stated a lot of women of colour are choosy about what they take in, at times to their detriment.

“I frequently listen to ‘I’m not heading to take in it if it does not style fantastic.’ They are meals that we are accustomed to eating,” stated Feller. “Historically, persons would make meats and vegetables, and they would be well, well-seasoned. A short while ago, I would say due to the fact of the change in how agriculture and enterprise are joined, we see those meals getting created with included sugars, fats and salts.”

Feller suggested generating the similar dishes, but steering clear of additives and generating healthy substitutions.

“A whole lot of my Latino clients … definitely really like to have the blend of rice and beans. A single of the swaps that we did was instead of the white rice, we switched to brown rice and instead of canned beans, we switched to dried beans … As a substitute of frying the meat we sauteed it or stewed it. Relatively than browning it in sugar, we began with a tomato paste, even now sweet, garlic, onion, pepper, and then instead of frying the plantains, we both boiled them or bake them in the oven. So you happen to be acquiring the similar dish, but you happen to be generating a swap.”

3. Be energetic in innovative means.

Feller stated women of colour are at times performing two or 3 work and really do not have time for workout. Their lack of exercise also compounds their tension stages, and there’s a website link between tension, hypertension, and cardiovascular ailment, she stated.

“There are not ample areas for persons to engage in intentional, secure, physical exercise,” stated Feller.

Nevertheless, 30 minutes of physical exercise are proposed every single working day, which could not be reasonable for every person. Feller mentioned some innovative recommendations.

“If you happen to be dwelling in an city heart, you can do things like acquiring off the subway or the bus 1 quit before so you wander, taking the methods rather than the escalator…If you happen to be dwelling in a rural space, I say, ‘Start with ten minutes of strolling. Go at a slow or moderate pace.’ One more detail that also counts is cleansing your individual residence, ideal?…I would say washing your dishes could not be an aerobic exercise…Nevertheless, vacuuming your residence for 30 minutes in a way and type of dancing and relocating could be aerobic and exciting.”

4. Exercise sleep hygiene

Slumber is a critical component of well being and tension management, stated Feller, and it’s frequently forgotten. Bad sleep patterns can guide to superior blood force, diabetic issues, and being overweight, according to the CDC.

“You know, there’s this thought that sleep is not essential. It really is exceptionally essential. It really is a time for rejuvenation and rest,” stated Feller. “If someone is sleeping four hours a evening, normally with my clients I say, ‘Okay, is there a way that we can boost it to six?’ I’m not heading to talk to for the full eight at the top…So perhaps for the duration of the 7 days, I am going to say, “Ok, aim for six.’ And on the weekend, I am going to say, ‘Aim for 7. [Choose] smaller methods.’”

five. Design fantastic diet for the loved ones.

Gals of colour at times stay in neighborhoods that lack healthy grocery retailers, according to Feller. This indicates their small children are principally uncovered to establishments like dollar retailers that provide hugely processed meals. This, alongside with a lack of nutritional instruction, leaves small children specially susceptible to unfavorable influences. A fantastic diet plan, however, can be modeled by a loved ones member.

“Usually there is the primary caregiver. It could be a mother, a grandmother, even a father, aunt, uncle. After they make a decision to type of make that change about what is actually heading to be on the plates of the persons in the loved ones, we see it trickle down. If we can teach the elders and the persons that are serving the food, then the small children and individuals beneath are more very likely to engage in beneficial eating behaviors.”

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addictionrecoveryassistance · 5 years

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sparxwrites · 6 years

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so im pretty new to whump, and i was wondering: does “whump” include the aftercare/comfort or is it primarily the Hurting? with caleb last episode, for example, does wanting him to get hugs from nott after his backstory-dump fit in? or scenes from caleb’s days in the asylum where he’s sick but being cared for by healers? or is it more of a niche hurt/comfort thing? i love to see him hurt but i also like to see him be healed

hey!! so the best way to get an idea of what constitutes whump is probably poking around in the whump tag and seeing what other people have to say (or reading stories tagged whump on ao3, also a good option).

the exact definition of whump is somewhat debated, but there’s some stuff that’s commonly agreed on:

heavy on the hurt - there needs to be a lot of hurt, and it needs to be pretty bad / scary. “oh no, they have the flu” isn’t really whump, but “oh no, they have pneumonia and their fever’s climbing and they’re struggling to breathe” is pretty good. same with “oh they have a minor-to-moderate injury that’s healed pretty quickly” vs. “they’ve got a minor injury but they’re hiding it and it gets infected / tears open further / leads to internal bleeding”.

hurt has to be physical - there can be (and almost always is!) emotional hurt / angst to go along with, but if they’re not Physically Injured in some way then it’s not really whump imho?

caregiver character - whether they’re there mostly as an Observer to the injury and kind of. reluctantly slap a bandage on it and feel bad for the hurt person, or whether they’re desperately trying to care for the hurt person and crying over the fact they can’t do more... like there’s flexibility here but it’s usually not whump if there’s not someone there during or after as a witness / helper.

comfort / healing afterwards - short term, provided by the caregiver character (and usually not a hospital immediately? they gotta suffer a lil bit w inexpert care for a while so the caregiver and whumpee can Bond), but long-term usually all their friends get pulled into it. comfort is usually short compared to the actual hurt tho; maybe a 5:1 ratio of hurt to recovery?

so the caleb backstory-dump in and of itself isn’t exactly whump. it’s top-quality angst, and good whump fodder, but that actual scene wasn’t whump itself. bits of the story though - the torture, the asylum etc. do sound whumpy, tho. i’m praying for some fic elaborating on that tbh.... or future flashbacks and elaboration or sth, idk. i’m just saying, tho, vulnerable adolescents being tortured, starved, brainwashed, and conditioned into killers is very winter soldier-esque and i’m living a real good trope tbqh.

tl;dr: wanting to see caleb healed after being hurt it like... basically the Essence of whump tbh. “break them apart and then put them back together”, and all that :3c

#anonymous #ask #whump #sparx chats #faq #tbh there's been a bunch of stuff popping up recently that's real light on the hurt and caretaking #being tagged as 'whump'#and it's Annoying me bc i get my hopes up every time n then it's like 'they bumped their head!! now they're fine tho'#and i'm like that's!! not whump!!!!#smfh #anyways i'm always stoked when someone says they're getting into whump: welcome to the club friendo!!

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vsplusonline · 4 years

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Coronavirus: No easy fix for problems in Canada’s nursing, retirement homes

New Post has been published on https://apzweb.com/coronavirus-no-easy-fix-for-problems-in-canadas-nursing-retirement-homes/

Coronavirus: No easy fix for problems in Canada’s nursing, retirement homes

For years, those living and working in nursing and retirement homes across the country have struggled as overburdened caregivers tried to maintain a basic level of care and dignity for aging and ailing Canadians.

It happened behind closed doors, said Carole Estabrooks, a professor in the faculty of nursing at the University of Alberta, with people typically only knowing the state of things if they or their loved ones moved into a long-term care facility.

Then the coronavirus pandemic struck, and the deficiencies turned deadly.

READ MORE: How Canada’s nursing homes can be fixed to avoid repeat of COVID-19 outbreak

“It didn’t just shine a light, it shone a cascade of halogen lights,” said Estabrooks, who has collected data on long-term care for 15 years.

“And the public’s horrified and they’re listening now,” she said. “But my God, what it took.”

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A man in his 80s died of COVID-19 in early March after becoming infected with the novel coronavirus at the Lynn Valley Care Centre in North Vancouver, B.C. It was Canada’s first death related to the pandemic, and the beginning of a rash of outbreaks — and a crisis — in care homes across the country.

1:55 ‘She didn’t want to die alone’: Heartbroken daughter speaks out about mom’s final days in Calgary nursing home

‘She didn’t want to die alone’: Heartbroken daughter speaks out about mom’s final days in Calgary nursing home

Deaths in long-term care facilities now account for more than 80 per cent of the roughly 4,500 deaths from COVID-19 in Canada.

“I call it benign neglect,” said Estabrooks, the scientific director for the university’s Translating Research in Elder Care, a program aimed at improving the system.

“Nobody set out to plan a system that will hurt older adults.”

READ MORE: Coronavirus: Trudeau promises more COVID-19 aid to come from Ottawa

That is what has happened, though, she said, and while policy-makers and politicians have vowed to find a fix, the path to change remains unclear.

While the data suggests long-term care homes across the globe have suffered unduly from COVID-19, residents in Canada’s system seem to be suffering more than others.

[ Sign up for our Health IQ newsletter for the latest coronavirus updates ]

International data is difficult to compare, though an analysis by researchers at the University of Ottawa, University of British Columbia and the London School of Economics have awarded Canada the troubling distinction of having the highest proportion of COVID-19 deaths related to care homes of the 14 countries studied as of April 26.

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A fundamental resdesign is needed, Estabrooks said, but it is an incredibly complex task. Long-term care is a provincial jurisdiction, and it differs from province to province.

2:15 Brampton mayor concerned after 105-year-old grandmother’s pleas for water at nursing home go unanswered

Brampton mayor concerned after 105-year-old grandmother’s pleas for water at nursing home go unanswered

One thing they typically have in common, she said, is being staffed by low-wage, part-time workers _ and understaffed, at that.

Personal support workers do the bulk of the caregiving in these homes, but they’re largely unregulated. There’s no standards for their education, they’re unlicensed and entry requirements vary from jurisdiction to jurisdiction.

That makes it difficult to count how many there are, let alone know if Canada has enough.

Estabrooks and her team have been gathering what data they can on those workers, and found many are immigrant women, working in several care homes to cobble together the hours they need to make a full salary. They’re often without benefits, or even sick days, and the job was incredibly difficult and stressful even before the pandemic.

Prime Minister Justin Trudeau recently announced a $4-billion plan to boost pay for front-line workers, including those in long-term care homes.

But Canada can’t go back to paying these workers minimum wage after the pandemic is over, said Hassan Yussuff, president of the Canadian Labour Congress.

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READ MORE: Live updates: Coronavirus in Canada

The organization has published 21 recommendations to improve long-term care once the crisis has passed, including higher wages and legislating staff ratios. It also recommends the elimination of private homes and an increase in federal oversight by making long-term care a part of the Canada Health Act.

The congress said private homes and public health-care interests are diametrically opposed, as they attempt to maximize profit, often on the backs of workers.

It’s a plan the federal NDP already supports.

2:09 Nursing home staff in Bobcaygeon, Ont. file lawsuit over false-positive COVID-19 test results

Nursing home staff in Bobcaygeon, Ont. file lawsuit over false-positive COVID-19 test results

Some literature has suggested private homes are associated with lower quality of care, according to Elizabeth Kwan, senior researcher at the Canadian Labour Congress.

The Ontario Health Coalition, a booster of public health care, gathered data related to COVID-19 deaths in for-profit, non-profit and public homes in that province from April 28 to May 5.

In homes where there were deaths, the proportion of deaths out of the total number of beds in for-profit homes was nine per cent. The proportion was 5.25 per cent in non-profit homes and 3.6 per cent in public municipal homes. The analysis looked at about 95 homes in Ontario, even though there were nearly 200 homes with outbreaks at the time.

Dr. Samir Sinha, director of health policy research at the National Institute on Ageing at Ryerson University, said it’s not yet clear if there are major differences between for-profit or private homes this early into the pandemic. All models of long-term care have been struggling with the same problems for a long time, he said.

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READ MORE: What to know before removing loved ones from nursing homes amid COVID-19

Canada’s population is getting older, people are living longer and with more complex health and social needs. Rates of patients with dementia in long-term care homes is rising.

“I don’t think that the funding of these homes has kept pace to the level of care they’re expected to be providing,” Sinha said.

Ontario’s Minister of Long-Term Care Merrilee Fullerton acknowledged that province’s system is “broken” and has endured years of neglect. She promised a review once the pandemic is over.

And that’s what all of Canada needs too, Sinha said.

1:41 Trent Valley Lodge Nursing Home “goes above and beyond” for their residents

Trent Valley Lodge Nursing Home “goes above and beyond” for their residents

“I don’t know how many deaths we need before we actually do that,” he said.

Federal Health Minister Patty Hajdu said April 23 that she’s considering the idea of a “long-term national project” to examine the issue across all levels of government.

“There is a significant appetite of Canadians and of politicians to fix this situation once and for all — for seniors all across the country, and for their families who love them,” she said.

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