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pestilencedumah · 8 months

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Plague.

Tagging: @adatiiel @azraclx and @conquestofuriel Location: Rome, The Fairy King's Forest, New Rome, and the surrounding countryside. Notes: Dumah: what can I say except you're welcome.

Not that Dumah had needed it, but Uriel had given him his blessing. Amusing, considering that Conquest had been given an ultimatum; his brothers’ and their mindless attempts to believe they were still in control. None of them had any control, they had no say, and they certainly had no choice in the matter. Ulthar’s will was Ulthar’s will and if that meant scrapping and starting from two all over again, then that’s what would be done. When a limb was necrotic you didn’t wait for it to get better. The Old Man might have been asleep, but Dumah had no intention of sitting idle in the event that he showed up again.

Midsommar’s charade had ended, incensed towards greater violence the seraphim removed himself from the city entirely. He’d had a theory before that the poison was specific to Rome, perhaps even the surrounding countryside and within a few days the Blessed began to feel his power returning to him. A week went by and Dumah was once more at full strength, the home of the kindly couple that had sheltered him during this time was abandoned, a plague behind him as violent hatred scorched through the entirety of his being. Impunity would be put down swiftly, Michael had failed and Uriel had failed, distracted by mortal affections that were plain for anyone to see. One had lost his edge and the other had lost his resolve.

Deducing where the poison was coming from was simple, greenhouses owned by The Eye and their subsidiaries, agricultural farms where the Moly was being grown. The water supply was tainted, familiar with this very particular form of warfare, infecting the drinking water was the surest way of transportation. Everything the seraphim ate and everything they drank had been tainted, which was why when Dumah left the limits of the Roman food chain he was able to recover. The mortals had to know that the seraphim would inevitably seek retribution, that the swift hand of their revenge would swing down upon the city. Attacking Labyrinth head on was foolish and Dumah’s survival instinct was too strong to act so recklessly. The rest of the city though? That was a far easier target.

Within Rome there were three water treatment plants along with natural springs and well water. While Dumah’s siblings were inclined to help, one was assigned to each, how they dealt with the mortals within and the methods of contamination were entirely up to them. Dumah suggested levelling the structures, but he wasn’t picky. His attention was elsewhere as he manipulated the energy within the atmosphere, gathering it with the strength of his Grace as he built a storm that would blanket the recovering city in a torrential downpour.

Moly’s effects on seraphim and Grace in general had been documented for ages, long before his or even Michael’s creation it had been used to counter the power of the seraphim. A creature of Pestilence and Plagues, Dumah had found a contagion that worked exceedingly well on the plant that was a bane against various forms of magic. Modified it through delicate application of his abilities until it became something that worked effectively in countering it. Using the same means of transmission, Pestilence drew it into the atmosphere, polluted droplets blanketed the city, New Rome, and the Fairy King’s Forest. Contaminating the earth and the groundwater in the process, wherever the pesky plant had been growing and wherever it had taken root, it would lose its properties, wilt, and die.

Unfortunately, Dumah didn’t stop there.

Mortal arrogance knew no bounds, naturally the seraphim needed to teach the sheep a lesson. The senate that had allowed this to continue, and the Fairy King’s Forest that had brazenly sprouted poison amidst their boundaries.

A modified version of the marburg virus fell across the city, across the stone and into the catacombs below. Supernaturals were fortunate to be possessed of strong immune systems, that would not help them in this case. For the coming war's sake, Dumah spared the supernatural population a strain that would be deadly to them, unless there were extenuating circumstances. The humans would not be so fortunate. Hospitals would soon be overrun, the infrastructure would crumble, and the death toll would be one to commemorate.

#selfpara #musing #more on this later

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i-like-it-when-ju-sleeps · 3 years

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I am the Apocalypse (Part 3)

Pairing: Jay Halstead x Sarah (OC)

Summary: Takes place during Chicago Fire 3x18. Sarah is a doctor at Med and in a long term relationshp with Jay. She is at Med when the grenade goes off.

Part 1

Part 2

The next hour was spent trying to help as many people as they could but at this point, they had seen everybody who needed to be seen and people were just really playing the waiting game. Sarah looked at the woman who was in the room with Hermann and came in, deciding to check on them.

“What you got?” She asked the two and Hermann answered instead of the woman.

“We need to patch in your boyfriend” he stated grimly, and the young woman nodded, getting her phone out.

“He was working with Marburg.” Sarah told the blonde woman as she listened to Jay’s information. “He injected himself with it.”

“What's Marburg?” Hermann asked.

“It's a viral hemorrhagic fever. The Soviets developed it as a biological weapon. Ask them which strain of the Marburg virus.”

“Yeah, which strain?” Sarah transmitted over the phone and listened intently before answering the woman. “Raven.”

“Okay. All right. Okay, so now I just have to see if he was past the incubation period and actually infectious.” She stated clearly and the doctor and the firefighter looked at her expectantly.

“And if he was past the incubation period?” Hermann asked worriedly.

“It means Aleem was a walking biological weapon.” Diane announced and the three of them shared a look before glancing at all of the people outside.

“Alright,” Sarah sighed “Keep me posted, okay?” she asked the other woman before returning outside the room. The ER was still dark and filled with smoke, people anxiously waiting against the walls. Right now, there was nothing left to do but wait, as everyone who could be treated had already been taken care of. Sarah sighed and sat down, a feeling of tiredness taking ahold of her now that she knew she couldn’t do anything more to help. She leaned against the wall and let her head fall backwards, a feeling of dizziness taking over and her head pounding. She lifted her hand to her forehead, where blood was coming out when the explosion happened. There was still fresh blood on the wound but it was not bleeding too much; She refused to believe that it was something serious. Still, she felt a bit nauseous but blamed it on the lack a clean air rather than a mild head injury. Will, noticing that she looked a bit pale, crouched in front of her and she perked up, looking at his concerned features.

“You okay?” he asked motioning to her forehead.

“Yeah….” She sighed “I’m fine. Just hit my head during the explosion.” She shrugged as if it wasn’t a big deal.

“And you still ran around for the past couple of hours? Not checking if it was serious?” Will frowned. She felt like a child being scolded.

“You know I’m a doctor, right?” she chuckled quietly. “If it really was serious, I would have noticed. I just felt dizzy because I’ve been on my feet for hours that’s all”

The man in front of her rolled his eyes and got a small light out of his pocket, checking her eyes.

“You could have a concussion, seriously you…”

“Seriously I’m fine stop fussing over me” Sarah cut him off, a little annoyed. She hated when people treated her as if she were made out of glass, and she did not want to have someone taking care of her when so many were in worse shape that she was. Still, she let Will grab bandages and securing one on her forehead, where the wound was finally stopping to bleed.

The young brunette stood up with a sigh once he was done, aware that he was still looking at her carefully, when movement got their attention. Hermann had just gotten out of the room with Diane Claman and wore a solemn expression.

“What is it?” Matt Casey asked worriedly from behind the two doctors.

“Not contagious” Hermann told everyone, a grin breaking onto his face. Sarah’s eyes widened slightly, and she let out a breath she didn’t even know she was holding.

“Influenza A tested positive, but the Marburg virus didn't have time to incubate. Whatever he had in his body died with him.” Diane then said, her helmet off. The crowd cheered, people letting cries of joy and relief. Sarah turned to Will and the two shared a bone-breaking hug, laughing as a way to let out the stress.

“Open up the ER” Will called out and Otis who was close happily complied. Over his radio, Matt informed the chief that it was all clear and cheers could be heard outside. Sarah looked over at Gabby who was still siting with the older man, Jim. She approached them and gave Gabby a side hug before looking at Jim.

“Ready to pull that thing out and get out of here?” She asked with smile and the man nodded gratefully. The two women helped him sit on a wheelchair and watched as a nurse started guiding him towards another part of the hospital. Before he left, he latched onto Gabby’s arm, thanking her for everything. Gabby blushed slightly and brushed it off quickly, watching him leave.

“You know” Sarah said watching her with a smile. “I still remember when you wanted to become a doctor”

“I sure have gone a long way, haven’t I?” Gabby answered with the same small smile.

“Yeah you have.” Sarah chuckled and gave her another hug.

“You know we still all miss you at the firehouse… You sure you don’t want to come back?” she joked

“As much as I miss all of you, I guess I was always meant to be there.” Sarah sighed looking over her shoulder at the doctors and nurses of Chicago Med who were walking around helping people out. Gabby was about to say something else when a very worried Jay made his way towards his girlfriend. He took a few long steps and engulfed the girl into his arms. Gabby left quietly, not wanting to disturb the two as Sarah’s arms went around her lover’s torso, burying her face into his neck. As they broke the hug, Jay’s hand went to her face, his eyes widening slightly at the blood on her forehead.

“It’s nothing” she reassured him with a soft smile. “I’m fine I promise”. Jay let out a deep sigh looking her in the eyes to make sure she was telling the truth before nodding and taking her into his arms again. As they broke their second hug, Will put his hand on his brother’s shoulder, and Jay turned to him, giving him also a tight hug.

It took them a long time to actually transport everyone to different wings of the hospital. Every member of the staff that had been in the explosion had been dismissed, but none of them had actually left, helping around as much as they could. Once the day was over, and every patient had been looked after, Sarah tiredly walked into the resting room, only to find Hannah Tramble, sitting down on the ground, tears in her eyes, and Will’s hand placed on her knee in an attempt to comfort her. Sarah gave the two a week smile, sitting cross legged across from them.

“One hell of a first day huh?” she asked Will, although her tone made it clear that she wasn’t expecting an answer. It was a dark question to end a dark day.

Sarah had finally been able to go home and shower, to wash away the grime, dust and blood from the day. As she wiped the fog on her mirror, she took a look at her reflection. She looked pale, her skin contrasting with her dark brown hair, but also with the purple under her eyes. And on the top of her forehead, hidden among her hairline, there was a purple bruise, on which stood a red angry line. The young woman sighed before concealing her eye bags, applying a bit of makeup and going to her bedroom.

Jay sat on the edge of the bed, simply waiting for her to come out. He hadn’t really been able to talk to her since this morning, as both of them had been busy. He looked up as she entered the room, noticing the tired eyes of his girlfriend.

“We don’t have to go out, you know?” he said quietly “We could stay here and rest if you want to.”

“It’s fine” Sarah answered softly “Everyone is going out and I really need something normal today.” she explained.

Jay stood up and walked towards her, stopping only and inch from her. She could feel his breath as he looked at her, his hand slowly grabbing hers.

“I was so worried about you. When I heard, I hoped that you weren’t there. I just…” he struggled to find his next words, so he settled for simpler ones that he thought conveyed his feelings as best as possible. “I love you”

“I love you too” Sarah answered with a conviction in her eyes that made Jay smile. Jay’s hand rose towards her cheek, touching it as if she was the most precious thing in the world, before their lips connected, a way for them to express what their words couldn’t.

At Molly’s, the couple stood with their friends, beers in hand and laughing around when Chief Boden called for everyone’s attention. The room fell silent, looking at him as he spoke.

“Just a quick word.” He explained “Wanna take a moment and let you all get back to the fine cocktails that they serve here at Molly's.”

“Keep talking, Chief.” Hermann interrupted, which made everyone chuckle.

“To the good people at Chicago Med.” He said, raising his beer slightly. “You made us proud today. And we are very grateful for the service that you do for us and for the city. It's not said enough.” He told us, looking over at the different doctors, a small smile on his face.

“Thank you, Chief.” Sharon Goodwin answered for all of the staff that was here. “We want you all to know that every time those doors crash open, there are good people, strong people, people at the top of their game ready on the other side.”

With that being said, everyone raised their drinks, a distinct “hear, hear” to end and terrible day on a good note, surrounded by family.

Sarah leaned into Jay as they spoke to Brett, Mills and Will, and she stopped listening to the conversation for a minute, taking a moment to appreciate being surrounded by people she loved, and she smiled to herself, enjoying the beautiful moment she was living after a terrible day. She had hope that no matter how bad everything could get, she’d always get better.

#jay halstead #jay halstead imagine #jay halstead x reader #One Chicago #Chicago Fire #Chicago PD #chicago med #chicago pd imagine #chicago med imagine #one chicago imagine #OC #fanfic

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hwu-adventures-blog · 3 years

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All that Matters

Fic Description: Alicia Hardy and Ethan Ramsey’s relationship is complicated, it always has been, and after Alicia spends a night helping Ethan cook chicken, things start to be looking up for them getting together. However when death comes knocking at Alicia’s door, and they realise they might have just missed their chance...

Pairing: Ethan x MC (Alicia Hardy)

Taglist (please let me know if you to be added or taken off): @utterlyinevitable

First Chapter

Previous Chapter

Next Chapter

Chapter 5- Running Out of Time

An hour or so later and Alicia found herself and Raf surrounded by their friends, Jackie, Elijah and Sienna who had brought tea and cafeteria pizza for them, Bryce, having rushed down from Kyra’s surgery from this and even Aurora who had raced from Mass Kenmore after hearing about the news, all trying to cheer them up and comfort them. Some of the people she loved most in the world helping her and Raf through this, and although it would have been better with Ethan there as well, Alicia could help but selfishly think even though she knew he was working himself ragged with trying to find a diagnosis and helping in his own way by doing what he did best, the Pizza, was a welcome second place for a bonus, even if she didn’t feel like eating anything.

“Is there any news out there?” Raf asked from his bed he looked exhausted, his eyes sunken, dark bags visible under his eyes, he looked fragile with the breathing tube he was connected to through his nose. It broke her heart to see her friend like this all because of her stupid reckless actions. Alicia watched as Jackie and Sienna exchanged a long deciding look.

“What is it?” She asked

Sienna frowned

“Ethan and I managed to get access to Travis, and it helped us eliminate a lot more possibilities...but just as we were leaving, he died”

Oh no.

“But we’re closer to figuring out what this is!”

“Heads up” Elijah said surprised at the return of the diagnostics team in their hazmat suits, as they passed through the decontamination tent one by one, June, Baz and then Ethan, with Baz carrying a small blue cooler that Alicia somehow didn’t think was full of food or drink.

“We have something that should help you both” Ethan explained

“But not a cure”

Alicia felt a pang of disappointment, although she had not expected it to be a cure, maybe some part of her had hoped deep down it was and all of this would be over, Ethan glanced at her sympathetically and answered her statement, she could tell he hated seeing her like this.

“Not yet. But this should help alleviate some of the worst symptoms”

“Thank....you...” Raf said as Baz extracted two syringes from the cooler, Ethan took one and turning to Alicia, gently ushed her to the bed, not wanting anyone but himself to inject her Alicia suspected, not because he didn’t trust Baz or June but because he needed to make sure everything went right himself.

“You should sit” he said as a matter a fact rather than a suggestion, an gentle overall tone in his voice but with a authoritarian hint, knowing that Alicia, would have probably contested sitting down for the injection on any other day, in any other situation. However it wasn’t any other day or any other situation and she didn’t have the energy to argue with him and besides she was the patient now, and right got now, Ethan knew what was best so she easily conceded to his request.

“Just for a minute”

As she sat down on the bed, waiting for the needle to enter her skin, watching at the doctor, staring at the helpless look in his eyes behind the window of his helmet, wanting nothing more than to reassure him everything will be okay but knowing it wasn’t, her mouth suddenly started to feel as if it had gone dead, a painful prickling sort of sensation and Ethan’s face blurred in and out of focus, new symptoms.

“Alica...” his voice was calm, gentle, soft, as if he was pleading with her to tell him what was wrong, and Alicia realised something.

She now had a decision, she could tell Ethan the truth. The truth about how terrified she was of this whole situation, how petrified she was of losing anymore of her friends lives or even her own life because of a mistake she made, a rash decision she is now paying for, and have him reassure her that he was going to fix it again or tell her he won’t let her go. Or alternatively, she could report these new symptoms she was experiencing, as any bit of information, any new symptoms could or would help with the diagnosis. Admitting how scared she was, Alicia reasoned wouldn’t help anyone, so, purposely hiding away her feelings of terror, she opted to confirm to him what was important in that moment;

“I’m having paresthesia around my mouth and in my feet. And blurred vision”

“And any other developing symptoms?”

“I threw up a while back. But we all knew that was part of this, so I guess it’s not really a new symptom”

“.... I see. Thank you for telling me”

Ethan found a vein and pressed the syringe down, inserting the needle into her body, administering the treatment, it stung for a moment but that didn’t matter to her, it was insignificant compared to the pain she was going through in terms of seeing everyone else suffer because of her. Looking across the small room, to distract herself from that thought, she saw June pull out the other syringe from Raf’s arm as she felt Ethan do the same to her.

“Are the FBI going to autopsy the guy who did this?” Raf questioned, something which clearly caused Ethan’s expression of helplessness turn to something akin to frustration and anger.

“Yes, but they’ve informed me they have no intention of sharing those results with us. They’re claiming national security”

“Are you serious? That’s BS.” Elijah almost yelled from behind the window

“It is. But any petition to release it would take weeks, and we have hours. We need to work quickly to find a diagnosis”

“Especially since... since...” Elijah’s voice hitched, Jackie laid a hand gently on his shoulder before turning to Alicia.

“Danny is unresponsive. He’s going downhill fast”

“Oh my god...”

Alicia felt panic well up inside of her, no not Danny, they won’t let Danny die, they can’t can they? They’ll find out what’s wrong, they’ll find a cure in time, they have to! They won’t just-

“We’re not giving up on you... or Danny...” Sienna reassured her almost as if she read her mind and knew exactly what she was thinking.

“Between us and the diagnostics team, we have nine doctors working on this already. We should be able to solve anything” Jackie pointed out

“I’m just a surgeon, but I’ll offer whatever help I can” Bryce stated and Alicia managed a smile

“This isn’t time for that confidence of yours to do a runner, Bryce”

“Yeah you’re not just anything” Sienna added

“Sorry. I mean, we’ve got this!” Bryce grinned

“So here’s where we are.” June changed the subject, Alicia had almost forgotten the diagnostics team was there, even though it was damn near impossible to completely forget that fact. “we’ve ruled out Anthrax, Botulinum, Ricin, Tularemia, and we’re waiting on results for Tabun”

“And the FBI have ruled out half a dozen fungal toxins, Ebola, Marburg’s, and all the Novichok nerve agents” Ethan continued, calmly and professionally although Alicia could tell he was at least a bit worried about the lack of positive results as he looked at her, not tearing his gaze away for a second

“That’s a pretty broad field” Jackie raised her eyebrows

“When you have so little to go on, you need to cast a wide net” Baz pointed out

Alicia watched as Ethan regained his focus, noting Baz’s sad expression

“Still, it’s progress. The fact there’s still no fever means it’s almost certainly not a bacteria or a virus. We’re shifting our focus to-“

Raf groaned in pain, June stopped dead as he clutched his chest and lurched violently sideways, getting up from the bed in one swift motion Alicia raced towards Raf to catch him before he toppled to the floor.

“Raf!” She heard Elijah say from outside.

“It’s alright, he just fainted” she reassured her friends, but couldn’t help but be concerned for what this could mean, she leaned Raf back against the soft pillow. And after a few seconds he opened his eyes again, coming back around, blinking confusedly.

“....what does this mean?” Aurora asked Ethan frowned in response, that mixture of concern and helplessness visible behind the window of his helmet once more, mirroring Alicia’s exact expression and feelings in that moment.

“....means we need to move even faster than we thought.”

#mc x ethan #ethan x mc #pixelberry #playchoices #mc #ethan ramsey #ethan ramsey x mc #choices: open heart #open heart second year #open heart second year spoilers #open heart spoilers #open heart

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onechicago-onefamily · 4 years

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Till it happens to you

Fandoms: Chicago Med, Chicago PD Characters: Jay Halstead, Will Halstead Prompt: Jay tried to save a suffocating Will: Both brothers end up in the hospital. There is a reason why they hate hospitals.

There had been times Jay had regretted getting shot. There was that one time with the Stash house, or that one time with the money heist... Only this time, he didn’t regret it. “Will? Will? Will!” He had been shot in the back, but it had been a through and through. Somehow, he had been lucky. It could have also been the opposite. It didn’t take away the fact that he absolutely hated hospitals. It wasn’t because he was scared or anything. No, the possibility of dying had been a part of his job description since forever. It was more that- “It’s okay mom. It’s okay.” She didn’t do anything else then puking. Yesterday had been all about puking, the day before that had been all about puking- It was like she didn’t know how to stop. If he closed his eyes, he could still see her. A scarf over her head, protecting her bald head from the outside world. Being all pale in her hospital bed. Jay hated hospitals. In hospitals, people died.

“Jay? Jay, can you hear me? Please, come back to me.” He felt like he was waking up from a dream, but he knew that it was just his brain getting back to reality. He looked straight into Hailey her eyes, who had been sitting next to his bedside the entire day. “You know Hank is probably gonna give you a lecture about what you did?” Everything had come back to him in a split second. Jay could hear his blood rushing through his veins. The abandoned warehouse they had gotten as their location had to be it. It just had to be. “Follow us inside!” Hailey yelled to the paramedics. She ran towards the building. Jay kicked the door in. “Will! WILL!” They cleared every chamber but knew they’d found it when they entered the main room. In the middle of the room there was an iron square, looking like the outside of a huge ass cooling cell. “Hailey, call it in.” “51 George to main-” Jay started to pull at the door like his life depended on it. It opened surprisingly smooth. “Will! Oh no-” Hailey pulled him away while the paramedics barged in. Somewhere Jay was happy for it, because he found himself unable to move. “He isn’t breathing!” He could feel the tears streaming down his face and his mouth opening up. Was he screaming? He probably was. He wasn’t sure. When the paramedics started to defibrillate his brother, Jay felt he was fighting Hailey, just so he could go to Will- But the blonde wasn’t buging. All sound and common sense started to return to him when his brother’s heartbeat appeared on the monitor. “Jay? Jay, I’m gonna need you to take slow breaths for me okay? Let the medics do their job. Let them do what they’re good at. I’m not going to leave you. We’re gonna follow them to MED with the car. I’m not going to leave you alone.” After that, it had all gone to hell. Will his abductors had still been there. Shots had been fired, and Jay had done a not by Hank Voight approved move to protect the medics and his brother, resulting in getting shot in the back. He knew Voight would probably give him a lecture the minute he deemed Jay ready for it. He also knew that somewhere, the old sergeant would understand. “They have Will intubated in the ICU. They don’t know how long he has been without oxygen, so they don’t know the amount of damage that has been done. If you want to, doctor Marcel cleared you to visit him-” This made Jay look Hailey straight in the eyes. He wanted to say something, but nothing came out. “ But you’ll have to be in a wheelchair and you’ll need to take it really easy. That okay?” Jay didn’t answer again, but when Hailey reached her hand out to help him get out of bed, he grabbed it. Oh how he hated hospitals.

***************************************************************************************

Will had to admit it: He had done and seen some pretty horrible things in life. He had almost been the victim of the Marburg virus, he had shagged with wrong single women, but he had also shagged with married women, but choking in your own carbon dioxide: That was an entire new world.It had been the most terrifying moment of his entire life. He had felt the oxygen getting drained from his limbs, from his brain, knowing that if they weren’t fast enough when he had gone unconscious- Somehow he had woken up in darkness. He had been unable to open his eyes. If he were dead, he didn’t knew. He did knew that if he were alive- What if? Where they resuscitating him? Had they dragged him to the icu? He had no clue. He did know one thing: He hated being a patient in his own hospital. His colleagues having to treat him, his mother rotting away from cancer- He absolutely hated being in the hospital himself.

He didn’t know when his eyes had started to feel easier, not that heavy. Change in his senses- That was a good thing. It would mean he was alive! Great! Although, the doctor in him told him it could also mean something truly awful- How long had he been without oxygen? What damage would have been created? He knew he had to fight, fight to open up his eyes. He had to show them he was alive, despite everything that came with. Lights became available. The lights were bright, a voice- “You can do it man, take your time. You’re in the hospital, you’re okay.” A moan escaped his mouth, realizing he was intubated, but he didn’t feel the urge to resist the intubation. That wasn’t good. “Come’on Will, open up. Let them see, come-on.” The lights became normal. He looked straight into the face of his little brother. “You’re okay. I know, I hate them too. You can go back to sleep now.”

#Will Halstead #Jay Halstead #Chicago MED #chicago PD #One chicago #One chicago one family #one chicago fanfiction

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rudrjobdesk · 2 years

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कोरोना के बाद चमगादड़ से फैलने वाले इस खतरनाक वायरस ने दी दस्तक, जानें लक्षण

Image Source : REPRESENTATIVE PICTURE Corona And Marburg Virus Highlights पश्चिमी अफ्रीका में मारबर्ग वायरस ने दी दस्तक, 2 की मौत WHO ने इस नए वायरस को लेकर चेतावनी जारी की भारत में बीते 24 घंटे में कोरोना के 18,840 नए मामले Corona And Marburg Virus: देश में कोरोना की रफ्तार एक बार फिर तेज होने लगी है और 24 घंटे में 18 हजार से ज्यादा मामले सामने आए हैं, वहीं दूसरी तरफ पश्चिमी अफ्रीका में नए…

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usashirtstoday · 3 years

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sciencespies · 4 years

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President Trump Receiving Remdesivir For Covid-19 Coronavirus, What Does This Mean?

https://sciencespies.com/news/president-trump-receiving-remdesivir-for-covid-19-coronavirus-what-does-this-mean/

President Trump Receiving Remdesivir For Covid-19 Coronavirus, What Does This Mean?

U.S. President Donald Trump wears a face mask while leaving the White House for Walter Reed National … [+] Military Medical Center to get care for his Covid-19 coronavirus diagnosis. (Photo by Drew Angerer/Getty Images)

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One thing’s for sure about President Donald Trump’s recent Covid-19 coronavirus infection diagnosis. Every bit of news that emerges about his condition is going to get analyzed and re-analyzed more than Kim Kardashian’s clothes. And the latest news is that he has received remdesivir, an antiviral treatment. This is what Sean Conley, DO, the Physician to the President, said in a statement shared last night by White House Press Secretary Kayleigh McEnany via a tweet:

The statement is a bit like that “Blue (Da Ba Dee)” song from Eiffel 65. It didn’t say a whole lot. Trump is now at Walter Reed National Military Medical Center, which is in line with the fact that a Covid-19 coronavirus infection is not just like a cold, a case of sniffles, or even a routine case of the seasonal flu. It’s not as if Walter Reed necessarily has more tissues or toilet paper than the White House. The trip there reflects heightened concern and access to more medical equipment and treatments than the White House can offer.

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“Doing very well” is not an official medical term and can be quite relative and subjective. Certainly the phrase sounds better than “doing very badly.” Nevertheless, “doing very well” is about as specific as the phrase “it me.” The only real substantive statements are that Trump is “not requiring any supplemental oxygen” and that the doctors “have elected to initiate Remdesivir therapy.”

“Not requiring supplemental oxygen” suggests that Trump doesn’t have significant lung problems from the infection. Assuming that you are not a block of cheese, you need oxygen to survive. You breathe in oxygen through your respiratory tract and lungs. Your lungs then swap the oxygen into your bloodstream where it is carried by the hemoglobin in your blood cells to different parts of your body. Oxygen to your cells is like chocolate. They can’t survive without it.

Typically, between 95 to 100 percent of your hemoglobin should be carrying oxygen. Levels may fall below this range when your lungs can’t breathe in enough oxygen or lung damage prevents your lungs from transferring this oxygen to your bloodstream. If any of this occurs, doctors may choose to put you on supplemental oxygen, that is oxygen beyond what is in the air. This may be via a nasal canula or a mask.

Getting remdesivir certainly isn’t like getting Tylenol. You typically won’t say, “I am not feeling that great. I could use some avocado on a tray-shaped piece of carbohydrate infused with walnuts and cheese with early girl tomatoes, salt, and some remdesivir.” Remdesivir is an intravenous medication. It costs about $520 per vial, based on the price announced by Gilead Sciences in June. This would mean five days of the stuff could set you back about $3,120. That’s about how much 520 pounds of cole slaw would cost to give those hoarding cole slaw some perspective. Not everyone in America happens to have that kind of cash laying around or the BTS-autographed shirts to sell to raise that amount. That being said, if you are on certain U.S. government programs, you could get it for cheaper. And Trump is on a government program.

Gilead Sciences Inc. developed and manufactures remdesivir. (Photo by Liu Guanguan/China News … [+] Service via Getty Images)

China News Service via Getty Images

Gilead Sciences originally developed remdesivir in 2009 as an antiviral treatment against hepatitis C infections. That didn’t work out so well. Since then, doctors have tried using remdesivir versus other viruses such as the Ebola virus disease, the Marburg virus, and now the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2).

Remdesivir is still considered an investigational treatment for SARS-CoV2. “Investigational�� does not mean that it should be widely used. If someone says that they cooked an “investigational dish” for you, be wary. An “investigational treatment” means that there isn’t yet enough data to justify its broader use beyond clinical trial settings and special cases. Trump, however, in many ways, is a special case.

The treatment is supposed to act by binding to the RNA-dependent RNA polymerase of the SARS-CoV2. This is an enzyme that the virus uses to reproduce itself. Lab experiments have shown that binding to the enzyme can blocks the ability of the virus to reproduce itself. In short, the medication is supposed to prevent the virus from replicating, doing the nasty, knocking spikes, or whatever term you want to use for making new copies of itself. Keep in mind that what works in the lab doesn’t necessarily work in the “real world” in humans.

Scientists have found that rhesus macaque monkeys who received remdesivir soon after being infected with SARS-CoV2 ended up having less virus in their lungs and less lung damage. A publication in the scientific journal Nature described these findings. Of course, Trump is not a rhesus macaque monkey.

So what’s the evidence that remdesivir can work in humans against SARS-CoV2? Well, most of the evidence so far comes from the Adaptive COVID-19 Treatment Trial (ACTT-1), a multinational, randomized, placebo-controlled trial that included 1,063 patients hospitalized with COVID-19 and evidence of lower respiratory tract infection. According to a publication in the New England Journal of Medicine, those treated with IV remdesivir for 10 days (or until they were discharged from the hospital) had a shorter time to recovering from the infection (a median of 11 days) than those who had received placebo (15 days). There were also differences in mortality by 14 days: 7.1% of those remdesivir did not survive by 14 days compared to 11.9% of those who had received placebo. That meant that those receiving remdesivir were 70% as likely to have died. Typically, patients will receive remdesivir for five days straight. In some cases, as in ACTT-1, this can be extended to up to 10 days. All of this is “encouraging” but doesn’t mean definitely that remdesivir will help everyone with Covid-19. It also doesn’t mean that it is a cure for Covid-19.

If you want the most reliable information in the U.S. on possible Covid-19 treatments, go to the National Institutes of Health (NIH) COVID-19 Treatment Guidelines. Yes, these are more reliable and accurate sources than that dude on Facebook or an economics adviser who has suddenly turned into a supposed infectious disease expert. According to these guidelines, “There are insufficient data for the Panel to recommend either for or against the use of remdesivir in patients with mild or moderate COVID-19.” The guidelines also state, as of October 3, “because remdesivir supplies are limited, the Panel recommends prioritizing remdesivir for use in hospitalized patients with COVID-19 who require supplemental oxygen but who do not require oxygen delivery through a high-flow device, noninvasive ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation (ECMO).”

So can you divine much about President Trump’s condition from this information alone? Not really. Trump is not an everyday American. That’;s for sure. He will have access to treatments, resources, and expertise that most people wouldn’t. Hearing that Trump is getting remdesivir may not be the same as hearing that your friend is getting the same treatment, unless your friend somehow has access to the nuclear codes. Doctors may give Trump medications as precautionary measures in ways that don’t quite follow guidelines for everyone else.

Plus, everything that you hear in a statement from Trump’s physician will probably have been thoroughly vetted by others in the Trump administration, more thoroughly than an outfit on the TV show Project Runway. In effect, these announcements are on a “tape delay.” The information that you get may already be old news.

Over the ensuing week, don’t expect real-time information about the President’s condition. There aren’t play-by-play announcers providing updates on the President’s breathing and bowel movements. Only Trump’s doctors, whoever they may all be, will know for sure what’s happening. One thing’s clear. The White House seems to be treating Trump’s Covid-19 coronavirus diagnosis quite seriously. This virus is not going to just go away.

#News

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jesseneufeld · 4 years

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Fasting with a Cold: How Does Fasting Impact Viral and Bacterial Infections

Fasting is a great tool for so many things. You can use it to regulate food intake and lose body fat. Fasting can help you shift body composition, normalize your appetite, and gain control over your relationship to food. Many people report cognitive enhancements from fasting, and it’s a surefire way to speed up the transition into ketosis and full-blown fat adaptation. There’s strong evidence that we look, feel, and perform best skipping the occasional meal—that it’s the evolutionary norm for humans not to have constant, unceasing access to food. After all, we didn’t always have 24 hour grocery stores and fast food restaurants. But what about fasting with a cold?

And what about intermittent fasting and the immune system? Should you fast at all when you’re sick? What about fasting with the flu? Or how about bacterial infections—can fasting help with those? These are actually some of the most common questions I receive. Because intermittent fasting seems to help with so many other conditions, it makes sense to wonder about its relationship to the immune response.

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There are two main types of infections that most people worry over: viral infections and bacterial infections.

Viral infections include influenza (flu), the common cold, viral gastroenteritis, and the various coronaviruses. There are also things like measles, chickenpox, and viral meningitis, but most people aren’t very worried about catching those these days.

Bacterial infections include pneumonia (most pneumonias are bacterial in origin, though some can be viral), bacterial gastroenteritis, food poisoning, and bacterial sinus infections.

Fasting With a Cold – Viral Infections

In general, fasting doesn’t look like a great idea if you’re dealing with a viral infection like the flu or common cold. Why?

Studies on Fasting and Viruses

Animal studies show that mice who fast have a worse response to subsequent viral infections. In one paper, mice were either fasted every other day or placed a normal diet, then exposed to a “viral mimetic” (a type of chemical that replicates a viral infection). The mice who fasted ended up with higher cortisol, a more inflammatory immune response, more severe symptoms, and acted sicker than the mice who ate.1

Another mouse study found that in animals exposed to an infectious virus, a fat-based (fasting) metabolism was detrimental to survival and a glucose-based (fed) metabolism was beneficial.2

Viruses Deplete Nutrients

Viruses are much smaller than bacteria and generally cause trouble by hijacking cells and using your body’s machinery to replicate. To do so, they often steal nutrients from the host. One example is selenium, a crucial nutrient for viral replication. Studies show that viral infections can induce selenium deficiencies and that correcting those deficiencies by, well, eating selenium-rich foods can improve the outcome of infections.3

Most viruses will deplete nutrients and you need to eat to replenish them.

Fasting Inhibits MTOR, Which is Good and Bad

Blocking MTOR (mammalian target of rapamycin) through fasting reduces expression of another major immune component: the interferon-inducible transmembrane protein (IFITM). 4 Think of the IFITM as a barrier preventing some viruses from gaining a foothold in your body, including influenza, Ebola, SARS, MERS, Marburg, Dengue, and hepatitis C. These are IFITM-sensitive viruses, but there are also IFITM-resistant viruses, like the common cold.

In fact, one study found that increasing IFITM levels increased vulnerability to infection by the common cold virus.5 Using fasting to reduce mTOR and lower IFITM expression could conceivably increase resistance to the common cold while increasing vulnerability to flu (and the others like Ebola and so on). Double edged-blade.

Or perhaps it’s triple-edged.

Part of dealing with an infection is learning from it. Our immune systems have to seroconvert antibodies so that when we encounter the infection again, our immune system is better equipped to head it off at the pass. This is the concept behind vaccination—a measured dose of the infective agent that trains our immune system to defeat the real thing in the future. As it turns out, inhibiting mTOR through fasting could affect our ability to seroconvert antibodies in response to viral infections.

In studies of older adults, higher levels of mTOR predict lower rates of seroconversion, and giving them an mTOR inhibitor improves seroconversion after a flu vaccine. If fasting reduces mTOR (and it does), it should in theory improve the antibody response to a vaccine or infection.

Weird, right? Fasting reduces mTOR, which could impair your short term response to an infectious insult (or improve it if it’s the common cold) while improving your long term response. You might still get sick but at least your chances of developing longterm immunity should increase.

Fasting With a Cold – Bacterial Infections

In general, fasting looks like a better idea when you’re sick with a bacterial infection.

Research on Fasting and Bacteria

Animal models of bacterial infections find that mice tolerate them much better in a fasted, ketogenic state. In fact, the ketone body beta-hydroxybutyrate is able to directly nullify some of the oxidative stress associated with bacterial infections;6 while “ketogenesis was required for survival in bacterial inflammation, it was dispensable in the case of viral inflammation.”

Bacterial Infections Reduce Appetite Naturally

One indicator is that your appetite often falls off a cliff when you have a bacterial infection. The last you want to do when you’re dealing a bout of food poisoning is eat. This doesn’t usually happen with viral infections, and I believe that’s important. In those “base” states of survival, what you crave is a good indicator of what you need.

Fasting Improves Phagocytosis (and Sugar Inhibits It)

A key component of the innate immune system’s ability to deal with bacterial infections is phagocytosis: When a class of immune cells called neutrophils surrounds, engulfs, and destroys individual bacteria. The phagocytic index describes the number of bacterial cells a neutrophil is able to engulf and nullify in a set time. Generally speaking, higher phagocytic activity means you have a better response to bacterial infections.

Luckily, we know pretty well how to increase and decrease phagocytic activity in people. To decrease phagocytic activity (make neutrophils worse at engulfing and destroying pathogenic bacterial cells), you simply feed a person sugar.7 It could be orange juice, honey, sucrose, fructose, or glucose—any simple source of sugars—and if you give 100 grams to a person, their phagocytic capacity drops for at least five hours. Give the person nothing—let them fast—and their phagocytic capacity climbs. Even at 5 hours after eating the sugar, the phagocytosis still hasn’t caught up to that of the fasting person.

Later studies confirm that low fasting blood glucose is a strong predictor of a strong neutrophil:leukocyte ratio8. Lower glucose, more neutrophils available to take on bacterial pathogens. Fasting is a reliable way to drop your blood glucose.

Phagocytosis doesn’t work so well against viral infections because a virus sequesters itself in the host’s cells. Neutrophils can’t engulf and kill the host cells; that’d just be counterproductive and probably quite dangerous. However, there’s evidence both ways: that neutrophils can enhance the immune response to viral infections but they can also exacerbate the damage done to host tissues. It isn’t clear what role they play so I’d advise against consciously manipulating them through fasting.

Intermittent Fasting While Sick: Making Sense of it All

There are no easy, straightforward rules governing the optimal fasting strategy for infections, whether viral or bacterial. Each virus is different. Every bacteria is separate. Nothing in biology is simple. What we do know:

If fasting stresses you out, it will be bad for your immunity. Cortisol depresses the immune system.

If fasting ruins your sleep, it will be bad for your immunity. Proper sleep is absolutely essential for an optimal immune response.

If you’re hungry, let that be your guide. Eat. Don’t force the issue.

If you’re not hungry, skip the meal. Again, let your body’s signals be your guide.

When faced with an immune insult, or if something’s “going around,” cut back on the fasting or at least keep it shorter than normal. 16 hours instead of 30. 20 instead of 48.

Realize that fasting is not a panacea. It’s not the answer to everything.

Understand that bacterial and viral infections often tag along with each other. A virus will weaken the host enough to allow bacterial pathogens to flourish. You’ll often be dealing with both at once. I’d imagine that something that allows you to stay fed while also enjoying a fat-based metabolism—like a lazy ketogenic diet—could work well here.

Fasting can prune damaged parts of your immune system and replace them with renewed components.9 This is good for long term immune health, but if an infectious agent happens to catch you in the middle of an extended fast while you’re doing the pruning, your risk of infection probably goes up. There’s always a give and a take.

There are no magic bullets, but it cuts both ways. You are resilient. While most of the humans throughout history didn’t make it through hundreds of thousands of years of death, destruction, famine, and disease, your gene line did. So don’t think you have to pick one or the other—fasting or feeding—in response to illness. Go with what feels best, don’t get dogmatic, and just take it easy.

What’s your go-to feeding strategy for dealing with sickness? Do you differentiate between viral and bacterial illnesses? Let me know down below!

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The post Fasting with a Cold: How Does Fasting Impact Viral and Bacterial Infections appeared first on Mark's Daily Apple.

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lauramalchowblog · 4 years

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Fasting with a Cold: How Does Fasting Impact Viral and Bacterial Infections

Instantly download our FREE guide: 10 Foods You Should Be Eating for a Healthy Gut

There are two main types of infections that most people worry over: viral infections and bacterial infections.

Bacterial infections include pneumonia (most pneumonias are bacterial in origin, though some can be viral), bacterial gastroenteritis, food poisoning, and bacterial sinus infections.

Fasting With a Cold – Viral Infections

In general, fasting doesn’t look like a great idea if you’re dealing with a viral infection like the flu or common cold. Why?

Studies on Fasting and Viruses

Another mouse study found that in animals exposed to an infectious virus, a fat-based (fasting) metabolism was detrimental to survival and a glucose-based (fed) metabolism was beneficial.2

Viruses Deplete Nutrients

Most viruses will deplete nutrients and you need to eat to replenish them.

Fasting Inhibits MTOR, Which is Good and Bad

Or perhaps it’s triple-edged.

Fasting With a Cold – Bacterial Infections

In general, fasting looks like a better idea when you’re sick with a bacterial infection.

Research on Fasting and Bacteria

Bacterial Infections Reduce Appetite Naturally

Fasting Improves Phagocytosis (and Sugar Inhibits It)

Intermittent Fasting While Sick: Making Sense of it All

If fasting stresses you out, it will be bad for your immunity. Cortisol depresses the immune system.

If fasting ruins your sleep, it will be bad for your immunity. Proper sleep is absolutely essential for an optimal immune response.

If you’re hungry, let that be your guide. Eat. Don’t force the issue.

If you’re not hungry, skip the meal. Again, let your body’s signals be your guide.

When faced with an immune insult, or if something’s “going around,” cut back on the fasting or at least keep it shorter than normal. 16 hours instead of 30. 20 instead of 48.

Realize that fasting is not a panacea. It’s not the answer to everything.

What’s your go-to feeding strategy for dealing with sickness? Do you differentiate between viral and bacterial illnesses? Let me know down below!

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References

https://ift.tt/2ReSKSj

https://ift.tt/2clHUbj

https://ift.tt/2VR06wO

https://ift.tt/2Kqsu3z

https://ift.tt/2wZsSDb

https://ift.tt/2clHUbj

academic.oup.com/ajcn/article-abstract/26/11/1180/4732762

https://ift.tt/2KoYvsP

https://ift.tt/2VNFohw

The post Fasting with a Cold: How Does Fasting Impact Viral and Bacterial Infections appeared first on Mark's Daily Apple.

Fasting with a Cold: How Does Fasting Impact Viral and Bacterial Infections published first on https://venabeahan.tumblr.com

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