#prespecify

[vhm1ykky6k8k]

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#beckoningly #cruster #TAO #canvas #conciousness #ovulum #multiradial #selenious #prespecify #diggable #Rhee #pamaquine #unsordid #sandstay #microcryptocrystalline #speisses #anagignoskomena #thiohydrolyze #cogue #sharpbill

[fogtvz9nsdwzap]

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#chakras #desirer #pirquetted #self-destadv #beckoningly #cruster #TAO #canvas #conciousness #ovulum #multiradial #selenious #prespecify #diggable #Rhee #pamaquine #unsordid #sandstay #microcryptocrystalline #speisses

[coquelicoq]

unable to comprehend Sentences because i'm parsing every word for crossword-relevant properties Saturday

#every time this happens it's both exciting and annoying #exciting because i have a crossword idea i'm so into that i can't stop thinking about it #annoying because do you know how many of my activities require me to comprehend sentences? #my holy grail would be a database of every word in the english language indexed according to its relationship with every other word #but 'relationship' could mean basically anything and i'm not sure i could prespecify it #that's why every time i get one of these ideas it's just like okay we're taking it from the top. read the dictionary again boy #cruciverbs

[covidsafehotties]

Published Nov 10, 2022

Main takeaway

Abstract

Background

Long-term health sequelae of the Coronavirus Disease 2019 (COVID-19) are a major public health concern. However, evidence on post-acute COVID-19 syndrome (post-COVID-19) is still limited, particularly for children and adolescents. Utilizing comprehensive healthcare data on approximately 46% of the German population, we investigated post-COVID-19-associated morbidity in children/adolescents and adults.

Methods and findings

We used routine data from German statutory health insurance organizations covering the period between January 1, 2019 and December 31, 2020. The base population included all individuals insured for at least 1 day in 2020. Based on documented diagnoses, we identified individuals with polymerase chain reaction (PCR)-confirmed COVID-19 through June 30, 2020. A control cohort was assigned using 1:5 exact matching on age and sex, and propensity score matching on preexisting medical conditions. The date of COVID-19 diagnosis was used as index date for both cohorts, which were followed for incident morbidity outcomes documented in the second quarter after index date or later.Overall, 96 prespecified outcomes were aggregated into 13 diagnosis/symptom complexes and 3 domains (physical health, mental health, and physical/mental overlap domain). We used Poisson regression to estimate incidence rate ratios (IRRs) with 95% confidence intervals (95% CIs). The study population included 11,950 children/adolescents (48.1% female, 67.2% aged between 0 and 11 years) and 145,184 adults (60.2% female, 51.1% aged between 18 and 49 years). The mean follow-up time was 236 days (standard deviation (SD) = 44 days, range = 121 to 339 days) in children/adolescents and 254 days (SD = 36 days, range = 93 to 340 days) in adults. COVID-19 and control cohort were well balanced regarding covariates. The specific outcomes with the highest IRR and an incidence rate (IR) of at least 1/100 person-years in the COVID-19 cohort in children and adolescents were malaise/fatigue/exhaustion (IRR: 2.28, 95% CI: 1.71 to 3.06, p < 0.01, IR COVID-19: 12.58, IR Control: 5.51), cough (IRR: 1.74, 95% CI: 1.48 to 2.04, p < 0.01, IR COVID-19: 36.56, IR Control: 21.06), and throat/chest pain (IRR: 1.72, 95% CI: 1.39 to 2.12, p < 0.01, IR COVID-19: 20.01, IR Control: 11.66). In adults, these included disturbances of smell and taste (IRR: 6.69, 95% CI: 5.88 to 7.60, p < 0.01, IR COVID-19: 12.42, IR Control: 1.86), fever (IRR: 3.33, 95% CI: 3.01 to 3.68, p < 0.01, IR COVID-19: 11.53, IR Control: 3.46), and dyspnea (IRR: 2.88, 95% CI: 2.74 to 3.02, p < 0.01, IR COVID-19: 43.91, IR Control: 15.27). For all health outcomes combined, IRs per 1,000 person-years in the COVID-19 cohort were significantly higher than those in the control cohort in both children/adolescents (IRR: 1.30, 95% CI: 1.25 to 1.35, p < 0.01, IR COVID-19: 436.91, IR Control: 335.98) and adults (IRR: 1.33, 95% CI: 1.31 to 1.34, p < 0.01, IR COVID-19: 615.82, IR Control: 464.15). The relative magnitude of increased documented morbidity was similar for the physical, mental, and physical/mental overlap domain. In the COVID-19 cohort, IRs were significantly higher in all 13 diagnosis/symptom complexes in adults and in 10 diagnosis/symptom complexes in children/adolescents. IRR estimates were similar for age groups 0 to 11 and 12 to 17. IRs in children/adolescents were consistently lower than those in adults. Limitations of our study include potentially unmeasured confounding and detection bias.

Conclusions

In this retrospective matched cohort study, we observed significant new onset morbidity in children, adolescents, and adults across 13 prespecified diagnosis/symptom complexes, following COVID-19 infection. These findings expand the existing available evidence on post-COVID-19 conditions in younger age groups and confirm previous findings in adults.

#mask up #covid in children #covid #covid 19 #covid isn't over #pandemic #covid conscious #covid is airborne #wear a mask #coronavirus #long covid

[wizblr-blue-moon-ball]

Hello Magical Friends!! ~☆

As of today it's three days 'till the ball! I'm so excited, this has been a while in the making and seeing so many of you all coming along for the ride is an honor.

As stated in the announcement post, this is the post with the OFFICIAL PROMPT LIST!!!

I spent a decent bit of time making the prompts for this. I wanted to ensure that it was specific enough so you all knew the gist, but also vague enough for all entry types. I really hope you enjoy the final prompt list as much as I do.

-

An important note: Please DON'T POST ANYTHING RELATED TO THE OFFICIAL PROMPTS until the prespecified date!! It's to keep everything neat. Outfit posts are still welcome though!!

And now, drumroll please... 🥁

DAY 01: Dusk (May 19)

You arrive to the ball at dusk and are whisked away into the party after greeting the host.~☆

☆

DAY 02: Gilded (May 20)

Everywhere you look, you're surrounded by opulence. Crystal chandeliers and golden decorations, blue banners adorned with golden embroidery. A glass of sparkling juice is placed in your hands and you walk onto the marble dance floor...

☆

DAY 03: Dancing (May 21)

You take to the dance floor and get swept up in the jovial atmosphere. Do you prefer fast square dances or a slow waltz? Perhaps a tap dance?

☆

DAY 04: Midnight (May 22)

The clock strikes midnight and the ball is officially halfway over. How time flies when you're having fun. What adventures have you experienced thus far?

☆

DAY 05: Feast (May 23)

Having moved to the snack tables, you see them laden with foods from far and wide. You spy foods familiar to you among the many, as no expense was spared to ensure your enjoyment, yum!

☆

DAY 06: Fireworks (May 24)

As the ball begins it's finale, a grand fireworks display lights up the sky, illuminating all in brilliant light...

☆

DAY 07: Dawn (May 25)

As Dawn rises and the ball ends, you leave with a sense of joy and with new friends by your side. What do you do now? Did you enjoy the ball?

☆

The ball will begin on Sunday May 19th!!

I hope to see you all there, as always it's an honor to be your host for the event!

PINGLIST A

@scuttling-comfuddlement @the-gnomest-bastard @kobold-sanctuary-buss-island @satyrs-apothecary @irving-the-pirate-wizard @morbingtime @justagingerwithredhair @chaos-familiar @these-detestable-hands @regina-the-sorceress @combustion-witch @yourlocalbreadenthusiast @selldemapplez @agentldiddy @fractalkitty @wizard-island-trading-co @good-wizard @the-illegal-wizard-council @ash-the-tiefling @mysticminion @blobbiedaykeeppcaway @blaster-fagot @life-is-okay-rn2 @skyethebisexualwolfwizard @thequeerwizardcouncil @dread-the-eldritch-wizard @profeshinul-wizurd @a-squirrel-wizard @the-mighty-dalob @amateur-wizard @chaos-wizard-nyehehe @bertskullhaver @transgender-wizard @flowers-the-sun-witch @thebookshelflord @ceeceelemons @the-silliest-sorcerer @wizard-ghost @a-goose-in-a-trenchcoat @flirtyambiguouswizard @paltering-peculiarity @parkyrtheelvishbard

#blue moon ball updates~☆ #wizard posting #wizardblr #wizardposting #bmb outfit #blue moon ball #blue moon ball art #blue moon ball photography #blue moon ball writing #blue moon ball roleplay

[parse-c]

Nuclear Energy

ىة ي ن و ىه ا ىة ن قًز ينةم ىةنوًىة

‏Nuclear energy

It’s only now I realize it’s precede by a phonetic equivalent of “agape” so they’re adhering to the Christian principle of letting all that you do be done in love.

Or I was; I am that one who typed it. It’s really snarky and ironic that the rest of what I typed was sub Spanish for “is equal to that of the USA.” Started out as a post on water.

On the sly, wherever the programmers are located they said hey. We’ve got something equal to the United States too.

Time passed, things cooled down. And whatever this was became a little playful. And that’s what im going to show you.

This: ‏‎ىةيً نوى زرنقً ز ى ة ن وً ى ة

now translates as “this is a zircon nuclei”

An earlier version, below, is a credible enough guide, made proven by the end of this schpiel.

So, let’s get after it:

‎‏‎ىةيً نوى زرنقً ز ى ة ن وً ى ة

This is a blue nuclei

Despite the plurality of nucleus (nuclei), this contains calligraphic alliants:

‎ز ى ة ن وً ى ة

identifiable reps of“Os”, and “Gu”.

Os is the old Norse word for their supreme God, represented by the rune ᚩ.

Gu is Chinese (古) meaning “ancient,” though they referred to G-D as Shen.

Then there’s a second appearance of “Os” and a similar letter to “j” I can’t explain.

Anyways here the numbers I got from attempting to recombine the digits, using Hebrew and Greek numeric values. Aiming for either RGB or CMYK color coordinates.

‎ز ى ة ن وً ى ة

11, 28, 16, 25, 27, 28, 16

112, 81, 62 | 52, 72, 81

120, 162, 52 | 71, 81, 6

11, 28, 16 | 252, 72, 81

As you can see it took me a few tries.

Kept ending up with leftovers. Then i tried using the prompt as a guide.

Plenty of word play. So I had to get a little more creative.

For example, subjectively the word “This” triggers Arabic “hisan” for me, meaning horse. I once had a paranormal experience resulting in a picture of a blue horse. So I knew to tally the values of the word “this” and plug ‘em in.

I came up with a working schedule.

R: 61

B: 81

G : 152

Key: 45

Cyan : 161

Magenta : 28

Yellow : 27

Ended up scrapping some of the coordinates because they altered the color harmfully once id reached the prespecified destination.

Life’s like that sometimes. Sometimes we have to scrap blind obedience in favor of balance and accord with earlier wishes and what we feel to be right rather than what we are told is right.

Anyways, the key alters the previously entered coordinates. But here’s the hex code: #384a8c.

It’s a beautiful hue of almost an indigo-blue.

Well, thanks for reading. I’ll keep y’all update on more of the universe’s less-than-subtle cues.

#color theory #god #language #linguistics #reading #experimental #experience #chinese #ancient greek #hebrew #nuclear

[kozhergoy]

SPCTЯMRTRTMPRLTY

Insights from a SPHXZ

𐂃༄༉༅༊༣༢༡ ᚹᛜ ᚱᛏᚺ

Google Translate Arabic has lately been teasing my nosy ass with these randomly discovered calligrams that proclaim to be nuclear weapons. Example:

ىة ي ن و ىه ا ىة ن قًز ينةم ىةنوًىة

‏Nuclear energy

It’s only now I realize it’s precede by a phonetic equivalent of “agape” so they’re adhering to the Christian principle of letting all that you do be done in love.

Or I was; I am that one who typed it. It’s really snarky and ironic that the rest of what I typed was sub Spanish for “is equal to that of the USA.” Started out as a post on water.

On the sly, wherever the programmers are located they said hey. We’ve got something equal to the United States too.

Time passed, things cooled down. And whatever this was became a little playful. And that’s what im going to show you.

This: ‏‎ىةيً نوى زرنقً ز ى ة ن وً ى ة

now translates as “this is a zircon nuclei”

An earlier version, below, is a credible enough guide, made proven by the end of this schpiel.

So, let’s get after it:

‎‏‎ىةيً نوى زرنقً ز ى ة ن وً ى ة

This is a blue nuclei

‎ز ى ة ن وً ى ة

identifiable reps of“Os”, and “Gu”.

Os is the old Norse word for their supreme God.

Gu is Chinese meaning “ancient,” though they referred to G-D as Shen.

then there’s “guo”, meaning “cross” in Chinese. A reference to Jesus?

Then there’s a second appearance of “Os” and a similar letter to “j” I can’t explain. Second coming?

Anyways here the numbers I got from attempting to recombine the digits.

‎ز ى ة ن وً ى ة

11, 28, 16, 25, 27, 28, 16

112, 81, 62 | 52, 72, 81

120, 162, 52 | 71, 81, 6

11, 28, 16 | 252, 72, 81

As you can see it took me a few tries.

Kept ending up with leftovers. Then i tried using the prompt as a guide.

Plenty of word play.

For example, subjectively the word “This” triggers Arabic “hisan” for me, meaning horse. I once had a paranormal experience resulting in a picture of a blue horse. So I knew to tally the values of the word “this” and plug ‘em in.

I came up with a working schedule.

R: 61

B: 81

G : 152

Key: 45

Cyan : 161

Magenta : 28

Yellow : 27

Ended up scrapping some of the colors because they altered the color harmfully once id reached the prespecified destination.

Life’s like that sometimes. Sometimes we have to scrap blind obedience in favor of balance and accord with earlier wishes and what we feel to be right rather than what we are told is right.

Anyways, here’s the hex code: #384a8c. It’s a beautiful hue of almost an indigo-blue, just like the translation said it’d be.

Well, thanks for reading. I’ll keep y’all update on more of the universe’s less-than-subtle cues.

I like to look up the Strong’s biblical concordance of the numbers there if things look right and they’re short enough.

However this works, I stemmed to slip into an oxbow of the internets winding river. Rearranging letters and came across this:

#supernatural #god #norse gods #runes art #reading

[bi010gic]

Biologic Scholar Winston Ewert Coauthors New Edition of The Design Inference

The second edition of The Design Inference was recently released. Winston Ewert from the Biologic Institute coauthored the book with William Dembski who wrote the first edition. The original book presented a general methodology for detecting design, which was the most sophisticated framework to date. The second edition represents the culmination of two decades of responding to critics and refining his model. Princeton University mathematician Sergiu Klainerman welcomed the book as follows:

Well argued and eminently readable… I don’t see how any open-minded scientist can ignore this important book.

The first edition of The Design Inference explained how design detection involves identifying patterns that are both highly improbable and specified. A common question raised by readers was the precise definitions for the terms specified and specification. In other words, what exactly makes a pattern specified or special? In many contexts, the answer is simple. For instance, being dealt four poker hands that were all royal flushes would be a very rare and special pattern pointing to someone cheating. Design detection in this example is easy because the category royal flush was already defined (aka prespecified) by the rules of the game. The situation is more challenging when categories of outcomes are not so clearly defined. 

In the new edition, Dembski and Ewert greatly refined the concept of specifications. They defined a specification as a description that requires few words. The description must also only apply to a small proportion of possible outcomes, so the probability of any outcome falling within the specification must be sufficiently small. Patterns that are both identifiable by a short description and highly improbable are almost always designed.  

Returning to the poker example, the four hands I mentioned could be described or specified by the three words four royal flushes, and the probability of four random hands falling within this specification is less than 1 chance in 100 billion trillion. The short description and very low probability indicate design. 

In contrast, four typical hands of five cards would require a very long description, such as the following:

two of diamonds, pair of threes, pair of jacks; three fours, nine of hearts, ten of clubs; four of diamonds, pair of eights, nine of clubs, queen of clubs; three kings, pair of aces

The probability of four hands falling within this description is low, but the description length is very long. Many sets of four poker hands would fall within a description of that length. The low probability is offset by the large number of sets of four hands with descriptions that are that long. The probability of being dealt four hands with such a long description is not sufficiently low to conclude design. 

Conversely, one could label four generic hands with the description random cards. The description is now short, but the probability is very high of four hands falling within this description. The short description is offset by the high probability. Similarly, the famous face on Mars can be described by the two words fuzzy face. Here again, the description length is short, but the probability of a photograph of the surface of a celestial body resembling a face at least as well as the Mars photo is sufficiently high to occur by chance. 

The face on Mars (NASA/JPL)

The underlying logic of Dembski and Ewert’s methodology is profound. Identifying design requires a pattern being assigned by a mind a special significance. A short description meets this criterion since societies assign words or short phrases to that which they designate as special. 

To illustrate, in the movie The Empire Strikes Back, Darth Vader declares to Luke Skywalker one of the most iconic lines in movie history: "I am your father."

Darth Vader could specify himself by the single word father. The relationship between a father and son is designated by all societies as a very special relationship. Relatively few other people could be specified by such a short description. Consequently, the audience knew Luke’s meeting Vader was not an accident but by design. 

In stark contrast, Dark Helmet in the movie Spaceballs tells Lonestar a far longer statement: "I am your father’s brother’s nephew’s cousin’s former roommate."

The fact that Dark Helmet had to employ such a lengthy description to specify himself reflects that their relationship carried no significant meaning. Such a generic relationship could have occurred by chance. Dembski and Ewert detail how their methodology could be applied in many other contexts with equally reliable results.  

#inference to design #design detection #William Dembski #Winston Ewert

[its-a-hil]

why did no one tell me how bad google slides is at animations oh my god

i cant take a sprite and have it move to a prespecified location?? everything is either entering the screen or leaving it this is atrocious

[stockknock]

Five ways for trading unlisted shares in India

An unlisted company is one that is not listed on any formal stock exchange. However, shares of these company are sometimes available for trade on over-the-counter (OTC) markets. Examples of unlisted companies in India being traded in the OTC markets include: Swiggy, Oyo, Serum, CSK, Reliance Retail etc.  Previously, unlisted investment could only be accessed by big banks, hedge funds, private equity companies etc. However, today since shares are available in dematerialised format and there is much more awareness about the financial industry, it is possible for any investor to invest in trading unlisted shares. Today we will discuss some of the commons ways investors can trade in unlisted shares in India.

Pre-IPO Funds

The first way we can invest in unlisted shares is to invest via Pre-IPO funds. Pre-IPO funds specialise in investing in companies that are currently unlisted but will soon get listed on a formal exchange. Pre-IPO Funds pool money from investors and give them an opportunity to invest in companies before they go public at lower valuations and then to reap rewards of the post-IPO valuation. These funds are often availed by prominent retail investors, HNI’s and large family offices. The first AMC to come with dedicated Pre-IPO funds is IIFL AMC. As per information, they are managing Rs 10,000 crore in pre IPO funds, with returns in the range of 10%-15%. Recently, Kotak Investment Advisors also raised Rs 2000 Crore in their Kotak pre-IPO Opportunities Funds. 

Portfolio Management Services or Alternative Investment Funds

Another way to buy unlisted stocks as an investment is to avail Portfolio Management Services (PMS) or Alternate Investment Funds (AIF). These funds are professionally managed investment portfolios backed by extensive due diligence by a team of highly qualified research analysts. These portfolios are actively managed so that they are always adapting to market trends and performances. Investors can invest in PMS or AIF that specialise in unlisted shares. There is less risk via this route due to (i) thorough research (ii) professional management (iii) diversification of capital.

Intermediaries

There are intermediaries likebrokerage firms and wealth management firms that specialise in investing in the unlisted space. Investors can open a DEMAT account with these intermediaries and carry out the transaction through them. The payment gets completed upfront, and the delivery is done in T+3 days. Due to lack of official regulation in the unlisted space, there is counterparty risk involved. Counterparty risk is if the payment is made, however the delivery of the shares is not completed successfully. However, if the intermediary is of reputable name, the counterparty risk involved is minimised.

Employee Stock Ownership Plan

Some large-scale organisations offer their employees stock options known as ESOPs whereby employees get equity ownership in the Company. These ESOPs allow employees to buy the Company's shares at a prespecified rate and after a predefined period. If the employees wish to redeem or sell off their unlisted shares holding, investors can purchase unlisted equity from them.

Private Placement

Private placement is where promoters of a Company want to liquidate their own stake in the Company and therefore put their equity ownership up for sale. Usually, this process is carried out by wealth managers or intermediaries. This route allows investors to trading unlisted shares and to achieve a significant stake in the Company as promoters generally have high ownership percentage with them.

You can use the Stock Knocks website and app to get detailed information on unlisted stocks and hidden gems in India. Just Knock !

Source link: https://www.stockknocks.com/blogs/five-ways-for-trading-unlisted-shares-in-india

#unlistedshares #stockmarket #financials #communityplatforms

[moremedtech]

USFDA approves Pfizer's ZAVZPRET nasal spray for migraines

USFDA approves Pfizer's ZAVZPRET nasal spray for migraines. ZAVZPRET is the first and only calcitonin gene-related peptide (CGRP) receptor antagonist nasal sprayfor the acute treatment of migraine in adults. Expands Pfizer’s migraine portfolio, which includes oral therapy for both acute and preventive treatment, to further meet the needs of people living with this debilitating disease. NEW YORK, March 10, 2023 - Pfizer Inc. (NYSE: PFE) today announced the U.S. Food and Drug Administration (FDA) has approved ZAVZPRET™ (zavegepant), the first and only calcitonin gene-related peptide (CGRP) receptor antagonist nasal spray for the acute treatment of migraine with or without aura in adults. In its pivotal Phase 3 study, ZAVZPRET was statistically superior to placebo on the co-primary endpoints of pain freedom and freedom from most bothersome symptoms at two hours post-dose. The pivotal study also demonstrated pain relief as early as 15 minutes in a prespecified secondary endpoint versus placebo. “The FDA approval of ZAVZPRET marks a significant breakthrough for people with migraine who need freedom from pain and prefer alternative options to oral medications,” said Angela Hwang, Chief Commercial Officer, President, Global Biopharmaceuticals Business, Pfizer. “ZAVZPRET underscores Pfizer’s commitment to delivering an additional treatment option to help people with migraine gain relief and get back to their daily lives. Pfizer will continue to build its migraine franchise to further support the billions of people worldwide impacted by this debilitating disease.” The FDA approval is based on two pivotal randomized, double-blind, placebo-controlled studies that established the efficacy, tolerability and safety profiles of ZAVZPRET for the acute treatment of migraine. In these studies, ZAVZPRET was statistically superior to placebo on the co-primary endpoints of pain freedom (defined as a reduction of moderate or severe headache pain to no headache pain) and freedom from most bothersome symptom at two hours post-dose (defined as the absence of the self-identified most bothersome symptom). The pivotal Phase 3 study published in The Lancet Neurology found ZAVZPRET showed broad efficacy by also demonstrating statistically significant superiority to placebo across 13 of 17 prespecified secondary outcome measures, including early time point endpoints (e.g., 15 and 30-minute pain relief and return to normal function at 30 minutes), return to normal function at 2 hours, and durable efficacy endpoints (e.g., 2-24 and 2-48 hour sustained pain freedom and sustained pain relief). On the 14th endpoint, return to normal function at 15 minutes post-dose, the difference between ZAVZPRET and placebo was not significant. Consequently, in keeping with the trial’s statistical analysis plan, the remaining secondary endpoints were not formally tested. “When a migraine hits, it has a significant negative impact on a person’s daily life,” said Kathleen Mullin, M.D., Associate Medical Director at New England Institute for Neurology & Headache. “Among my migraine patients, one of the most important attributes of an acute treatment option is how quickly it works. As a nasal spray with rapid drug absorption, ZAVZPRET offers an alternative treatment option for people who need pain relief or cannot take oral medications due to nausea or vomiting, so they can get back to normal function quickly.” ZAVZPRET was well tolerated in clinical trials. The most common adverse reactions reported in at least 2% of patients treated with ZAVZPRET and at a frequency greater than placebo were taste disorders (including dysgeusia and ageusia), nausea, nasal discomfort, and vomiting. ZAVZPRET is contraindicated in patients with a history of hypersensitivity to zavegepant or to any of its components. Hypersensitivity reactions, including facial swelling and urticaria, have occurred with ZAVZPRET in clinical studies. ZAVZPRET is anticipated to be available in pharmacies in July 2023. Nearly 40 million people in the United States suffer from migraine and the World Health Organization classifies migraine as the second leading cause of disability in the world. Migraine is characterized by debilitating attacks lasting four to 72 hours with multiple symptoms, including pulsating headaches of moderate to severe pain intensity often associated with nausea or vomiting, and/or sensitivity to sound (phonophobia) and sensitivity to light (photophobia).

CGRP Receptor Antagonism

Small molecule CGRP receptor antagonists represent a novel class of drugs for the treatment of migraine. For acute treatment, this unique mode of action offers an alternative to other agents, including those patients who have contraindications to the use of triptans have a poor response to triptans or are intolerant to them. CGRP signal-blocking therapies have not been associated with medication overuse headaches (MOH) or rebound headaches, which can limit the clinical utility of other acute treatments. Zavegepant is a third-generation, high affinity, selective, and structurally unique, small molecule CGRP receptor antagonist and the only CGRP receptor antagonist in clinical development with both intranasal and oral formulations.

INDICATION

ZAVZPRET™ (zavegepant) is indicated for the acute treatment of migraine with or without aura in adults. Limitations of Use: ZAVZPRET is not indicated for the preventive treatment of migraine. Read the full article

#Brain #medtech #medtechnews #migraine #usfda

[gormanlin86]

Dabrafenib reduces left ventricular bulk

1 Being unfaithful.3 years) implanted using the EPIC self-expanding nitinol stent program throughout 166 de novo or perhaps restenotic iliac artery lesions on the skin smaller when compared with Is equal to Tough luck centimetres lengthy. The key endpoint has been the actual 9month main adverse celebration price [i.elizabeth., device- or procedure-related dying Long-chain-fatty-acid-CoA ligase inside of 30 days, myocardial infarction through the catalog hospitalization, goal vessel revascularization (TVR), or perhaps directory branch amputation]. Follow-up occurred at hospital discharge at 1, In search of, and 1 year. An impartial key research laboratory examined ultrasound examination results from 1, 9, and also 1 year. Benefits:The key endpoint achieved the prespecified overall performance target, with simply Three.4% (4/117) associated with people encountering a serious unfavorable celebration simply by 9 weeks (r small compared to Zero.0001). By simply 12 months, 6 (5.4%) of 111 patients had TVR; it's unlikely that any got a catalog Gamma-secretase inhibitor branch amputation. Your ankle-brachial list, Walking Problems List of questions, and also Rutherford varieties all revealed sustained improvements by means of Yr. Main patency was 4.4% along with related most current listings for wounds viewed as complicated (TASC 2 C/D 92.5%) or non-complex (TASC The second A/B 95.0%). Bottom line: Your Impressive stent program proven security along with success by means of Yr, such as advancements regarding complex wounds. The actual Legendary stent is a practical alternative to surgical procedure with regard to patients along with sometimes intricate or even non-complex wounds.City Monte Carlo (MMC) trap refinement has become performed on the about three extracellular loops (ECLs) regarding rhodopsin along with opsin-based homology models of the actual thyroid-stimulating bodily hormone receptor transmembrane site, a class A kind G protein-coupled receptor. Your Monte Carlo testing method, making use of torsion sides of amino side chains and native moves for your 6 sequential anchor torsion angles, provides previously duplicated the particular conformation of varied coils using acknowledged gem structures using precision constantly less than Two angstrom. A grid-based potential map, such as truck der Waals, electrostatics, hydrophobic as well as hydrogen-bond possibilities pertaining to volume necessary protein surroundings along with the solvation effect, has been used in order to drastically reduce the computational expense of power assessment. A modified sigmoidal distance-dependent dielectric purpose has become put in place in conjunction with the desolvation and hydrogen-bonding terminology. A protracted high-temperature sim together with A couple of kcal/mol repulsion probable resulted in substantial trying with the conformational space. The particular slow annealing resulting in your low-energy constructions expected secondary construction https://www.selleckchem.com/products/dabrafenib-gsk2118436.html by the MMC approach. Molecular docking using the reported agonist modelled the presenting site within just 1.A few angstrom. Virtual testing carried out on the three lowest constructions showed that your ligand-binding function within the inter-helical area is dependent on the ECL conformations.The experience along with balance of economic laccase (DeniLite starting) within a few different water dissolvable ionic liquids (ILs) (1-ethyl-3-methylimidazolium 2-(2-methoxyethoxy) ethylsulfate, [emim][MIDEGSO(Some), 1-ethyl-3-methylimidazolium ethylsulfate, [emim][EtSO4], along with 1-ethyl-3-methylimidazolium methanesulfonate, [ernim][MeSO3]) have already been Analyzed and to the next by 50 % organic and natural chemicals (acetonitrile along with dimethyl sulfoxide). Initial molecule routines were related one of the ILs if the exact same problems were used.

#Dabrafenib #DAPT #Long-chain-fatty-acid-CoA ligase

[juulgrossman44]

Progression of multi purpose nanocomposites for controlled substance delivery as well as hyperthermia.

The specialized medical prognostic values regarding equally solitary and also put together proteins phrase have been looked at together with univariate and multivariate tactical analysis. Benefits: Weighed against standard lung tissues, your proteins levels of mTOR/p-mTOR, p-Akt1 Ser473/Thr308, and P70S6K/p-P70S6K ended up greater (all G < .05), although p-PDK1 had been lower (P < .05) throughout tumor tissues. p-mTOR term had been connected with histological difference, histological sort, lymph node attack, and also period (just about all S < .05). Overall survival throughout NSCLC patients was significantly shorter in the event with positive phenotype pertaining to p-mTOR, p-PDK1, along with p-P70S6K (most R < .05). Themes along with coexpression of the Regorafenib Only two regarding p-mTOR, p-PDK1, p-Akt1 Ser473, and p-P70S6K exhibited worse prospects than these revealing absolutely no biomarker or any 1 biomarker on it's own (almost all R < .05). Multivariate examination indicated that the combination involving p-mTOR/p-P70S6K is definitely an independent prognostic take into account accessory for cancer phase. A conclusion: These studies offers medical data that stimulated aspects of mTOR walkway, not necessarily complete protein, are usually predictors associated with inadequate prognosis within NSCLC. Furthermore, assessing protein-expression information of such molecules can be quite a brand-new way of personal remedy in themes together with NSCLC. Cancers The new year;117:3763-73. (C) This year American Cancer Modern society.A novel two-component hemolysin, erylysin A along with N (EryA and EryB), had been isolated from a good passable mushroom, Pleurotus eryngii. Hemolytic task had been exhibited merely through the EryA and also EryB blend. EryA confirmed one band in 15 kDa upon SDS-PAGE although EryB confirmed a couple of bands with 20 kDa (EryB1) as well as Thirty-seven kDa (EryB2). MALDI-TOF Microsof company established that the particular molecular multitude of EryA, EryB1 as well as EryB2 have been 18,945 Fordi, Fourteen,593 Nrrr and also Thirty seven,417 Fordi, correspondingly. EryA and also EryB have been very similar to pleurotolysin A along with T regarding molecular size, and the N-terminus along with internal sequences. In ph 6.Two, EryA is available as a homodimer whilst EryB exists like a heterodimer regarding B1 along with B2. Compact disk spectrum analysis confirmed T-m ideals associated with 48 diplomas D along with Thirty seven certifications D pertaining to EryA and also EryB, correspondingly. EryB had been specifically unpredictable. (D) 2010 Elsevier Ltd. Most privileges earmarked.Unilateral medical futility plans, which enable health-care suppliers to be able to limit or even pull away life-sustaining treatment more than affected person or surrogate objections, are generally increasingly made about any step-by-step strategy. Health-related or values committees have a prespecified process, the actual finale of which is any rationalized decision about whether continuing treatment should be taken out as well as removed. These types of processes have about three periods. First, health-care providers have to research to refer individuals regarding deliberation over whether continuing treatment is futile. Next, your committees involved must decide whether continuous treatment solutions are in fact ineffective.

#SAHA #Regorafenib #Lorlatinib #Fulvestrant #Tofacitinib #Iron sucrose #B02

[neumanncurtis60]

Transcatheter Valve-in-Valve Aortic Control device Alternative instead of Medical Re-Replacement

Target: To gauge dimension equivalence in the Singaporean Language and also Chinese language types in the EuroQol Group's 5-domain set of questions (EQ-5D) inside cancers people. Study Design and style along with Establishing: Seven hundred along with seventy-one ethnic Chinese sufferers throughout Singapore ended up enrolled, and they clarified sometimes a uk or a Chinese form of the EQ-5D. Seven days later, much the same list of questions within the same language has been sent on the patients. Regression investigation was utilized to gauge equivalence of the imply values attained by using the a pair of vocabulary types. Your quality, receptiveness to switch, and reliability of both variations with the EQ-5D ended up evaluated and in comparison. Results: Depending on the prespecified equivalence edge involving +/- 10% for binary final result, +/- 2.05 with regard to utility catalog, and also +/- A few points in the visible analogue range, both the vocabulary variations with the EQ-5D gave similar mean valuations from object as well as scale ranges. Additionally, they demonstrated similar traits throughout quality, responsiveness. along with dependability. As an example, the test-retest trustworthiness values to the EQ-5D electricity index in the a pair of vocabulary trials were the same by 50 percent significant numbers: 3.79. Conclusion: Your Singaporean British and also Chinese language versions in the EQ-5D were confirmed throughout cancer malignancy patients along with were consideration to achieve dimension equivalence. (C) 08 Elsevier Corporation. Almost all rights reserved.With different brand new concise explaination person likeness, many of us bring in a greater collaborative selection (ICF) formula, that could enhance the algorithmic precision and variety together. Inside the ICF, rather than the standard Pearson coefficient, the actual user-user parallels are generally acquired by simply developing the warmth conduction as well as mass diffusion techniques. Your simulator final results over a benchmark information established suggest how the related algorithmic accuracy, measured by the rating credit score, is improved upon by Half a dozen.7% within the optimal situation when compared to the normal collaborative filtering (CF) criteria. More importantly, the diversity in the professional recommendation databases can be improved through 63.6%. Considering that the user similarity is vital for your CF protocol, the project may possibly lose a few gentle regarding how to enhance the algorithmic efficiency giving precise selleck kinase inhibitor similarity measurement.Background Sorafenib happens to be the only real accepted systemic treatments consideration to possess usefulness within the management of advanced hepatocellular carcinoma (HCC). Recent surveys claim that hepatitis H (HCV)-related HCC sufferers obtain more clinical take advantage of sorafenib compared to additional subgroups, nevertheless the device just for this impact is actually unidentified. Throughout vitro files declare that sorafenib may have to put out anti-viral components, and therefore our own intention within this examine would have been to assess potential anti-viral action regarding sorafenib inside sufferers along with HCV-related HCC. Aim To assess potential anti-viral task regarding sorafenib inside patients using HCV-related HCC. Approaches Many of us prospectively enrolled people using HCV-related HCC addressed with sorafenib for about A few months.

#Natural Product Library #Ferroptosis inhibitor #Duvelisib #Capecitabine #Almorexant #Elacridar #Lumacaftor #Bosutinib #LY411575 #SB-3CT #UK 5099 #CBL0137 #Remodelin #Topotecan #Entrectinib #Disulfiram #Pracinostat #Go 6983 #MS023 #Sotagliflozin #Emapalumab #Pamrevlumab #Evolocumab #Omalizumab #Vedolizumab #Epigallocatechin #Bardoxolone #G150 #Enzastaurin #Itacitinib

[tolstrupedwards79]

Floor characteristics regarding genomic DNAs upon reducing the pH, within the existence of graphene/AgNPs-based SERS discovery podium

The diagnosis of patients with a severe ARCA2 phenotype may also be executed on such basis as organic files, we.at the. lower ubiquinone amount as well as useful proof of ubiquinone insufficiency. This kind of analysis is essential since the nerve standing of a number of people might be improved simply by ubiquinone therapy.Background Nearly all cultures involving algae nowadays are expanded because monocultures. The reason for this definitely seems to be that specific traces associated with algae retain the high-value products that are generally desired regarding pick. Nevertheless, inside algae ethnicities developed mostly regarding lipid production, or even as being a period inside wastewater removal, mixed algae nationalities may minimize ecological danger. Outcomes Four-strain blended cultures associated with algae ended up developed within simulated wastewater, alongside the monocultures, beneath diverse temperatures and also illumination problems. Beneath most circumstances the actual blended cultures ended up a smaller amount successful than the nearly all suit monocultures for each and every scenario, however easier than the very least fit monocultures. Mathematical examination V-9302 order according to an great progress type of the actual monocultures also recommended which blended ethnicities are in fact easier both in regards to bio-mass as well as fats than only the sum of the monocultures. Conclusuions A combined tradition made up of different in the same way effective stresses with many optimum developing circumstances would be a smaller amount vunerable to environment adjustments than the usual monoculture. This research demonstrated your promise of a good properly identified blended tradition to cut back danger in applications such as wastewater removal along with lipid creation that won't depend on specific strains containing high value products. (chemical) Next year Community regarding Chemical substance IndustryBackground: Discomfort opposition has been of an undesirable long-term final result in sufferers using atherosclerotic coronary heart, however more research is necessary. Speculation: The objective of these studies would have been to investigate the influence regarding aspirin resistance, assessed from the Platelet Perform Analyzer-loo (PFA-100) (Dade Behring Corporation., Deerfield, Not well., United states) about the long-term prognosis in sufferers along with non-ST segment elevation severe heart syndromes (NSTE-ACS). Methods: As many as 496 sequential people were researched. The particular 1-y chance regarding aerobic demise was the actual prespecified review endpoint. The sufferers were broken down, according to the valuations regarding PFA-100 bovine collagen epinephrine drawing a line under time (CEPI-CT) on business presentation, directly into pain killers sensitives (people that have a new PFA-100 CEPI-CT >193 securities and exchange commission) along with discomfort resistants (those with a new PFA-100 CEPI-CT <Equals 193 securities and exchange commission's). Results: Aspirin resistants were a young adult (p-value = 2 '04), and much less frequently hypertensives (p-value Equates to 2.05) or even diabetes patients (p-value = 2.'04) when compared with discomfort sensitives. By A single y simply, the actual occurrence regarding heart massive within the whole cohort ended up being A dozen.

[mi6-rogue]

Safety and immunogenicity of SARS-CoV-2 self-amplifying RNA vaccine expressing anchored RBD: a randomised, observer-blind, phase 1 study

Preliminary report; BACKGROUND VLPCOV-01 is a lipid nanoparticle-encapsulated self-amplifying (sa) RNA vaccine that expresses a membrane-anchored receptor-binding domain (RBD) derived from the SARS-CoV-2 spike protein. METHODS A phase 1 study of VLPCOV-01 was conducted at Medical Corporation Heishinkai OPHAC Hospital, Japan. The investigational vaccines were administered to participants, between February 16, 2022, and March 17, 2022. Participants aged 18 to 55 or [≥]65 years who had completed two doses of the BNT162b2 mRNA vaccine 6 to 12 months previously were randomised to receive one intramuscular vaccination of 0{middle dot}3, 1{middle dot}0, or 3{middle dot}0 {micro}g VLPCOV-01, 30 {micro}g BNT162b2, or placebo. Solicited adverse events were collected up to 6 days post-administration, with follow-up on all adverse events until week 4. Interim immunogenicity analyses following data cutoff at day 29 included SARS-CoV-2 IgG and neutralising antibody titres. (The trial is registered: jRCT2051210164). FINDINGS 92 healthy adults were enrolled, with 60 participants receiving VLPCOV-01. No serious adverse events were reported up to 26 weeks, and no prespecified trial-halting events were met. VLPCOV-01 induced robust IgG titres against SARS-CoV-2 RBD protein that were maintained up to 26 weeks in non-elderly participants, with geometric means ranging from 5037 (95% CI 1272-19,940) at 0{middle dot}3 {micro}g to 12,873 (95% CI 937-17,686) at 3 {micro}g, in comparison to 3166 (95% CI 1619-6191) with 30 {micro}g BNT162b2. Among elderly participants, IgG titres at 26 weeks post-vaccination with 3 {micro}g VLPCOV-01 were 9865 (95% CI 4396-22138) compared to 4183 (95% CI 1436-12180) following vaccination with 30 {micro}g BNT162b2. Pseudovirus-Neutralising antibody responses were observed against multiple SARS-CoV-2 variants and strongly correlated with anti-SARS-CoV-2 IgG (r=0{middle dot}950, p https://www.medrxiv.org/content/10.1101/2022.11.21.22281000v1?rss=1%22&utm_source=dlvr.it&utm_medium=tumblr Read more ↓