#filtered permeability trial

[drinkprime]

Emerging Trends in Water Purifier Technology: 2023

Water is the main source of life, an important component that supports all living creatures on our planet. Clean and safe drinking water isn’t a need; it’s an essential human right. In a world where contamination and defilement are on the rise, guaranteeing that the water we consume is free from impurities has ended up a growing concern. Usually, this is where water purifiers come into play, as they have advanced into irreplaceable machines for families around the globe. Water purifier technology has become a lifesaver over the decades by providing clean water to a lot of people.

Latest in Water Purifier technology

These days several advanced technologies and innovations are being used in water purifiers to ensure the delivery of safe and clean drinking water. Here are some of the latest water purifier technology that are in use:

1. Reverse Osmosis (RO) Technology

RO technology is widely used in water purifiers. It involves forcing water through a semipermeable membrane to remove contaminants, impurities, and minerals. Some advanced RO systems also incorporate additional stages like UV purification.

GET 7-DAYS RISK-FREE TRIAL

2. Ultraviolet (UV) Purification

UV technology uses ultraviolet light to disinfect water and kill bacteria, viruses, and other microorganisms. UV water purifier technology is effective at ensuring microbiologically safe water.

3. Ultrafiltration (UF) Technology

UF membranes have smaller pores than RO membranes, making them effective at removing bacteria, viruses, and larger particles. UF is often used along with other filtration technologies.

4. Activated Carbon Filtration

Activated carbon filters are effective at removing chlorine, organic compounds, and odors from water. Advanced water purifiers may use multiple stages of activated carbon for improved performance.

5. Smart Purifiers

Some modern water purifiers are equipped with sensors and IoT (Internet of Things) capabilities. They can monitor water quality in real time and provide alerts or data to users via smartphone apps. DrinkPrime provides a user-friendly app that allows users to monitor their water levels and even place orders.

Apart from these technologies, there is one other technology in water purification that is trending these days.

6. Nanofiltration (NF)

Nanofiltration (NF) is a filtration process is a water purifier technology that uses semi-permeable membranes to separate and purify water by removing particles and solutes with a molecular weight between 200 and 1,000 daltons. NF is often used for tasks like water softening, color removal, and selectively reducing specific contaminants in water due to its ability to let certain ions and molecules pass while blocking others. This technology finds applications in water treatment, food and beverage processing, and various industrial processes requiring precise control over water composition.

Future of water purification

The future of water purifiers is promising and will likely bring about several key advancements.

1. Affordability

First, we can expect increased efficiency and affordability. As technology improves, water purifiers will become more energy-efficient and cost-effective, making clean drinking water more accessible to people worldwide.

2. Smarter water purifiers

Next, innovation will lead to smart water purifiers. These devices will be equipped with sensors and advanced monitoring capabilities, allowing users to receive real-time information about water quality. This will help people make informed decisions about their water consumption.

GET 7-DAYS RISK-FREE TRIAL

3. Sustainability

Furthermore, the materials used in water purifiers will continue to evolve. Manufacturers will develop more sustainable and eco-friendly options, reducing their environmental impact.

4. Nanotechnology

Advancements in nanotechnology and membrane technology will play a significant role in the future of water purification. Nanofiltration and other cutting-edge techniques will enhance the efficiency of water treatment, removing even smaller particles and contaminants.

Overall, the future of water purifiers holds the promise of cleaner, safer, and more accessible drinking water for people around the world. As technology continues to advance, we can expect innovative solutions that address water quality challenges and contribute to a healthier planet with a healthier generation of people.

Emerging water treatment technologies

Emerging water treatment technologies are like the superheroes of clean water. They’re new, exciting ways to make sure the water we drink is safe and healthy. Here are ten of these cool technologies:

1. Advanced Oxidation Processes (AOPs)

Think of AOPs as water cleaners with special powers. They use things like ozone and UV light to break down and remove bad stuff, like chemicals and medicines, from water.

2. Electrocoagulation

Imagine using electricity to make tiny particles in the water stick together and then easily remove them. That’s what electrocoagulation does, and it helps get rid of dirt and heavy metals.

3. Graphene-based Filters

Graphene is like a super-strong and super-thin material. It’s used to create filters that can catch all sorts of bad things in water, from metals to oils.

4. Forward Osmosis (FO)

FO is like a water magnet. It uses special membranes to attract water and leave behind the bad stuff. It’s great for turning salty water into fresh water.

5. Membrane Distillation

Picture water turning into steam, leaving behind all the dirty stuff. Membrane distillation does just that, making water clean by using heat.

6. Biological Nutrient Removal (BNR)

BNR uses helpful bacteria to remove things like nitrogen and phosphorus, making wastewater cleaner.

7. Carbon Nanotube Filters

Carbon nanotubes are like tiny straws that can suck up pollutants in water, like metals and chemicals. They’re like powerful filters.

8. Solar Desalination

Imagine using the sun to turn salty water into fresh water. That’s what solar desalination does, providing clean water in sunny places.

9. Microbial Fuel Cells (MFCs)

MFCs are like machines that eat dirt in water and turn it into electricity. They help clean water and produce power at the same time.

10. Emerging Nanomaterials

Nanomaterials are like super-small particles that can grab onto bad stuff in water. They can help make water cleaner and safer.

Conclusion

With the change and improvement in water purifier technology, every day there is one or the other new thing that arises in every field. Making use of this technology, the water purifiers are also changing accordingly to provide clean and safe drinking water to all while simultaneously preserving nature.

Source: Emerging Trends in Water Purifier Technology: 2023

#water purifier on rent #ro water purifier #drinkprime water purifier on rent #water purifier on rent in bangalore #water purifier for home #drinkprime water purifier

[waterfiltergurus]

The Complete History of Water Softeners & Softening Technology

Water softeners are such a staple in the modern household that it seems like they've been around forever. But actually, water softening systems are a relatively new technology - and they've come a long way since they were first invented. Let's take a look at the timeline of water softener history, and how these systems have been developed since their invention. 📌 Key Takeaways: - The history of water treatment dates all the way back to 1500 BC, but water softening was only discovered and developed in the 1800s. - There are several important dates on the water softener history timeline, including 1830, when lime softening was developed, and 1903, when ion exchange was developed. 🧾 History Of Water Softeners Let's take a look at the history of water softener systems as we know it, and how the water softening process was developed over a period of centuries. 1500 BC - Coagulation Water Discovered The first known water treatment process to be discovered was coagulation. In Ancient Egypt, people discovered that adding chemicals to water could remove solid sedimentation. 1830 - Lime Softening Was Developed Numerous other water treatments were recognized and developed in the centuries following the first known discovery, but it wasn't until the 1800s that hard water would be addressed. In the 1830s, a chemist called Thomas Clark produced the first water treatment solution for hard water: lime softening. Clark discovered that adding a calcium hydroxide solution to water would precipitate the calcium bicarbonate, as well as magnesium and the calcium that has been added, as silicates and hydroxides. These precipitates could then be filtered out of the water. 1903 - Ion Exchange Water Softening Was Discovered It wasn't until the early 1900s that the conventional water softening method that we know today - ion exchange - was developed. Water's mineral content was tested, which led to the development of ion exchange softening. Ion exchange produces softened water by exchanging magnesium and calcium ions with sodium ions. This water softening process was originally used in large cylindrical units filled with lumps of permutit. Hard water would be sent into the units, where it'd percolate through the permutit, removing the calcium and magnesium ions. Source: wikisource.org 1959 - Reverse Osmosis (RO) Membranes Were Invented Reverse osmosis isn't primarily used for water softening (and in fact, excess hard water scale can damage an RO membrane over time). However, since the RO process inadvertently softens water by removing all dissolved minerals, we wanted to highlight its invention in this timeline. Two UCLA scientists, Sidney Loeb and Srinivasa Sourirajan, invented the first modern reverse osmosis membranes in 1959. The scientists used cellulose acetate polymer for their invention. However, the discovery of the first semi-permeable membrane dates back further than this, to 1748, when a chemist named Jean-Antoine Nollet used a pig's bladder to prove the theory of natural osmotic pressure. 1990s - Early 2000s: Water Descalers Were Developed It didn't take long for manufacturers to identify the setbacks of water softeners and work on developing alternative softened water solutions that didn't use the ion exchange process and didn't require salt. After months of testing and trials, the first water descalers were released in the late 1990s and the early 2000s, offering a salt-free descaling process that used electromagnetic impulses to suspend hardness ions in water. 2000 - Now: Water Softeners Development Continues By this point, water softeners had been established in the form that we know them today. But there was still work that could be done and improvements that could be made. As technology improved and became more accessible, manufacturers experimented with convenience features such as Bluetooth connection and efficient performance features, like upflow softening tanks. Many of the most modern water softeners released today boast a whole host of features that help them to do their job as efficiently and effectively as possible, with minimal effort on your part. Water softening systems are now more widely available than ever, in a range of different sizes and configurations, and at a variety of price points. Now, most people can afford softened water if they want it. 2000 - Now: Continued Expansion Of Alternative Softening Solutions Since the discovery of the traditional scale harness removal system, alternative solutions have continued to grow in popularity. Now, there are numerous methods of treating hard water scale, including template assisted crystallization (TAC) conditioners, electromagnetic conditioners, and liquid water softeners. These scale prevention methods have benefits over conventional softening: customers don't need to access water softening tanks to top up salt, and healthy calcium and magnesium minerals are retained in water - just without their scale-forming abilities. However, these systems will likely never overtake conventional softeners in popularity because there's no more effective scale prevention method than ion exchange. 📑 Final Word There's a lot we don't know for sure about the history of water softening. For instance, the exact dates of the inventions of various units that delivered softened water solutions are contested. However, we do know that the history of water treatment dates back centuries, and the history of water softening dates back at least 100 years. When we look at how quickly various water supply systems have been developed since the early 1900s, it's exciting to contemplate the developments for drinking water treatment that are yet to come. ❔ Water Softener History: FAQ When were water softeners invented? The ion exchange softening process, which is now used in conventional salt-based water softener systems today, was first produced after testing was conducted on water's mineral content in 1903. However, it wasn't until the 1950s that domestic water softeners started hitting the shelves. When was the first water softener made? We don't know exactly when the first water softener was made, or what it was - or even whether it left the laboratory. However, we do know that domestic water softening systems were released in the 1950s, so this method of water treatment has been available for residential use for just over 70 years. Who discovered soft water? Soft water was discovered by a chemist called Thomas Clark, who developed the lime softening process in the 1830s. It wasn't until 1903 that the most effective method of producing soft water was established: ion exchange. When did Texas ban water softeners? Texas implemented a state-wide water softener ban in 2001. Amendments to this ban mean that water softeners that meet certain criteria can now be used, so owning a water softener in Texas is not illegal. When were water descalers invented? Again, we don't have any certain date on which the first water descaler was invented, but we know that this technology was being trialed and developed in the 1990s, and electronic descalers were made available in the early 2000s. Read the full article

[imaec-digital]

Is your dialyzer safe to reuse?

Know your dialyzer’s mechanism:

Dialyzers are artificial kidneys that filter the blood outside your body. It filters the blood outside your body when the kidneys are not functioning well. Wastes and excess water are removed during hemodialysis using an external filter called a dialyzer, which has a semipermeable membrane. The wastes are separated by establishing a counter-current flow gradient, with blood flowing in one direction and dialyzer fluid flowing in the opposite. Dialyzers are categorised as low-flux membrane dialyzers or high-flux membrane dialyzers. Low-flux membrane dialyzers have an ultrafiltration rate of less than 15 mL/mmHg/h and a 2MG clearance rate of less than 15 mL/min. Small solutes are effectively eliminated by diffusion, but only trace amounts of middle-sized solutes, which are more toxic and difficult to remove by diffusion, are separated. In comparison to low-flux membrane dialyzers, high-flux membranes have higher hydraulic permeability and a higher solute permeability for middle-sized solutes. 

The diffusion of solute particles through a semipermeable membrane is the primary process involved in dialysis. Urea and creatinine, among other metabolic waste products, flow along the concentration gradient from the circulation into the dialysate (sodium bicarbonate (NaHCO3), sodium chloride (NaCl), acid concentrate, and deionized water). The size of particles impacts the pace of diffusion across the membrane during their diffusion into the dialysate. Although dialysis is the favoured method of restoring kidney function, it has been linked to oxidative stress, thyroid abnormalities, and cardiac difficulties. Dialysis extends a person’s life but does not heal the underlying illness, therefore it stands to reason that dialysis difficulties could be caused by renal inflammation.

Dialyzer reprocessing for reuse of dialyzer:

Dialyzer reuse is a multistep procedure that includes rinse, cleaning, performance testing, and disinfection of dialyzers before they are used again. The procedure necessitates the use of potentially harmful cleaning and germicidal agents, and accidental contact with these compounds could put patients and dialysis personnel at risk. Dialyzer reprocessing or reuse is a procedure that has been used in the United States in the past for supposed benefits to dialysis clinics and patients. Economic benefits, the ability to utilise formerly more expensive high-flux dialyzers, and a positive environmental impact through reduced biomedical waste output are the three main motivations for dialysis centres. There have also been cases of Gram-negative bacteraemia outbreaks due to infection-control system failures, and even low-level exposure to toxins and microbiological contaminants can cause chronic inflammation. Despite these hazards, no randomised controlled trials comparing single-use and reuse procedures exist, and the evidence from observational research is mixed. Bleach, hydrogen peroxide, and peracetic acid are some of the chemical cleaning agents used in dialyzer reprocessing. Formaldehyde and peracetic acids are two commonly used chemical disinfectants and sterilants.

On a limited scale, a method of replacing chemical germicides with hot citric acid has been utilised. One of the main problems with reusing hemodialyzers is that the dialyzer’s capacity to execute the essential duties involved with hemodialysis is unaffected. Electrolyte balance, elimination of small and mid-sized molecular waste products, and water removal are the key functions. Urea has long been utilised as a dialysis effectiveness indicator. When testing a dialyzer in process, the fluid content of the dialyzer blood compartment must be removed and replaced with air. The air must be entirely cleansed from the dialyzer’s blood and dialysate compartments before it can be injected with a high-level disinfectant or sterilant. This is performed in both automated and human reprocessing by first flushing the tested dialyzer with enough treated water to verify that it is air-free and fluid-filled throughout. Flushing ensures that air does not obstruct the passage of fluid disinfectants/sterilants and that chemical germicides are applied to all sections of the dialyzer.

Pros and cons of dialyzer reuse:

Although dialysis is the most common way to restore kidney function, it has been associated with oxidative stress, thyroid problems, and heart problems. Dialysis prolongs a person’s life but does not cure the underlying sickness, so it stands to reason that renal inflammation could be the cause of dialysis complications. The three key benefits for the provider are cost savings, the opportunity to employ high-flux dialyzers, which are generally more expensive, and a positive environmental impact due to reduced biomedical waste output. Economic factors are thought to be motivating the continued use of dialyzer reuse procedures in the United States, in light of falling and increasingly stringent Medicare reimbursement for hemodialysis treatments. Because cheaper single-use high-flux dialyzers are now available, the previous benefit of being able to reuse such dialyzers is no longer valid. Dialyzer reuse must take into account the health risks associated with the use of germicides. Acute inadvertent exposure to high amounts of germicides from the dialyzer or water treatment system can endanger patients and health care staff. Furthermore, long-term exposure to low amounts of germicide residue within the dialyzer has the potential to cause major health problems. Using insufficient germicide concentrations increases the risk of pyrogen reactions and bacteraemia outbreaks.

From 1980 to 1999, the CDC reviewed 16 outbreaks of bacteraemia or pyrogenic responses in haemodialysis patients, eight of which were linked to dialyzer reuse, and four of which were caused by a low disinfectant dosage. Membrane polarity and clearance of small and medium molecules can be affected by changes in membrane integrity caused by reuse. Increased environmental pollution as a result of reuse is also a possible risk. Dialysis service providers, on the other hand, continue to find dialyzer reuse appealing due to cost considerations. However, economic reasons differ around the world and, in many cases, even within the same country. There is a case to be made that the cost-benefit of reuse is minimal in places where the costs of reuse-related employees and safe storage space are considerable. However, relative cost savings are likely to be greater in locations with low people and space costs. Even a little cost reduction would be significant in financially strapped health systems or when individuals split the cost of dialysis treatment.

Secure pro offers total security to dialysis patients:

IMAEC offers a range of dialysis consumables with total security for the dialysis patient. The secure pro haemodialysis concentrated solution is the best solution for safe and effective dialysis. We also provide the anticoagulant for the dialysis process that is Nephure heparin injection. Nephure Heparin injection is an anti-coagulant that keeps blood from clotting abnormally. It keeps severe blood clots from forming in the legs, lungs, and heart. It also prevents clots from becoming larger. Patient care does not stop here. We also provide Nephure iron sucrose injection which is used to treat iron deficiency in patients with chronic kidney disease and on dialysis.

[rubybedsheet]

fitted bed sheets

fitted bed sheets

Online shopping for Fitted Bedsheets  from a great selection at Home & KitchenStore.A fitted bed distance is a distance with an elastic edge that you wrap around your mattress to stretch the distance and keep it in place. Fitted wastes have some natural.

Protect for the stylish fit bedsheets online at sarafabazar. Find a wide range of designs, styles, sizes, and colors that suits your choice and budget.

Buy fitted bedsheet online on Wakefit. Explore decoration designs of cotton bedsheets available in queen size & king size fitted bed distance sizes.

Protect 100 cotton fitted bed wastes online available in different patterns for single & double bed. Buy fitted bed distance Online Now.

Fitted Wastes must fit snugly around the corners of the mattress to produce a smooth face on top of the mattress. Whether you have a king size or queen size.

Buy cotton fitted bed wastes online available in solid & stripe patterns. These elastic bed wastes are for single, double, king & queen size beds.

Cotton, linen, blarney, t- shirt fabric, and satin are used in fitted bedsheets. · Fitted bed wastes are also available in colorful styles to accommodate multiple.

Florida Collection s ultraexpensive quality pure cotton elastic fitted bedsheets king size will help you keep your mattress clean and fresh. The king size bedsheet.

Our Classic Percale wastes point permeable 200TC weave made with 100 cotton for that. 100 nights trial isn't applicable on Fitted BedSheet Set.

Bed wastes- Protect for fitted bed wastes online at Maspar. elect from the new collection of cotton fitted bed wastes online available in India.

Blue Dahlia Has A Huge Selection Of Fitted Bedsheets. Protect Our Luxurious fit Bedsheets Available In A Variety Of Colours, Accoutrements And Sizes. Buy Now.

With the option of buying bed wastes online, it has come indeed more accessible to find the right fit for your room. It has come easier to filter through.

Burnt Orange 100 Organic bathed Cotton Bed distance Set With Pillow Cases Full/ Queen/ King Bed Cover Bedspread Flat distance Set Fitted Bed wastes.

 ADDRESS : Shopping Arcade, 

Hotel Sapphire,

 Jagadhri Road, Yamunanagar

#COLOURED BEDSHEETS | fitted bedsheets| king size bedsheet

[streetsofdublin]

LOWER GRANGEGORMAN

Filtering of through motor traffic was trialled during 2020 in Grangegorman after local residents sought the measure.

LOWER GRANGEGORMAN – JANUARY 2021 Filtering of through motor traffic was trialled during 2020 in Grangegorman after local residents sought the measure. The filtered permeability trial commenced on the morning of 6th July 2020. The trial includes the provision of a series of bollards and temporary planters placed on Grangegorman Lower, with appropriate signage and road markings. Dublin City…

View On WordPress

#Dublin #Dublin City council #filtered permeability trial #Fotonique #Infomatique #Ireland #lower grangegorman #Streets Of Dublin #traffic control #traffic filtering #William Murphy

[nyx3927]

 @musicfeedsmysoul12​ and @lurking96 this is both of y’all’s fault with that thread about how too many fics where Izuku jumps, gets a quirk and just make Bakugo regret it without any actual character change. Just: Izuku goes splat, and now Bakugo is an uwu soft boy who’s really sorry but had no character development visible.

Y’all both get some of the blame for this fic outline I created after a bang, chocolate, and on 2 hours of sleep. It’s still a really rough outline and I don’t have time to polish it up into an actual outline, draft, then fic with my summer classes and job right now. Enjoy my stream of thought with no filter

The Ripple

Izuku has a concussion from Bakugo attacking him at school so his eyesight is off. Everything else is the same up to when All Might leaves him on the roof.

The concussion fucked with his vision, balance, and depth perception. So he ended up accidentally stepping off the side of the building. (Hush, I know that there’s a railing. We’re pretending that when All Might jumped away from Izuku on the roof, he accidentally took like half of it with him.)

Crash, boom, blood. Ambulance carted him off to the hospital and that’s the last we see of Izuku for a while.

They don’t know that All Might was the one who got him up to the rooftop because the notebook with the signature was blown off the roof and into the river. By the time that it was found, it was nothing but mush and the writing was illegible, all runny and blurry. They also just assumed that a villain ripped the railing off in a previous battle and the owner hadn’t gotten it fixed yet.

Inko tells Mitsuki that they think it was suicide because he couldn’t have accidentally gotten up on the roof (No evidence of All Might). Katsuki hears that but refuses to tell anyone that he told Izuku to jump off a roof because that could hurt his chances of being a hero.

Entrance Exam

Fast-forward to the entrance exam, everything proceeds as canon except for the bits with Izuku, which never happened.

Uraraka is stuck under the boulder with the zero pointer bearing down on her. Canon shows no evidence of any pro except Present Mic at the site, and he was last seen at the gates so he isn’t close by to Uraraka.

Uraraka couldn’t escape from the boulder in time and the kill switch takes up to 30 seconds to receive and process. So, the robot steps on the boulder and crushes her leg. She’s rushed to Recovery Girl but the damage is so severe that they have to amputate a leg.

As compensation, UA takes care of all the medical bills and offers her a spot in the Hero Course at UA with her entire tuition paid for all 3 years. Uraraka accepts to make it easier financially on her parents, so she shows up to the first day of classes with a prosthetic leg that she painted pink in an effort to make it less sad.

Quirk Assessment

A random extra is put into 1-A, but they and Mineta are promptly expelled. The extra just didn’t try at all, relying upon the idea that the teacher wouldn’t actually expel anyone on the first day. Mineta was just too pervy/not heroic enough so he got the boot.

Aizawa was reminded of the death of Oboro when Uraraka nearly got crushed, so he’s on high alert to expel those that he believes would never be good at heroics/ would just get themselves killed. Extra not trying and Mineta just focusing on being a perv, made him convinced they would get killed so he just expelled them straight away [No readmission for them]

This shocked Momo who thought he was bluffing and made her more cognizant of the fact that not everyone plays by the same rules as her.

Battle Trial

Battle trials happen. Momo and Uraraka are paired up together and fight twice in the trials. They won both times because Uraraka floated the bomb and Momo in the fight against Todoroki so that it was impossible for Todoroki to capture them. They win against Iida and Bakugo because Uraraka takes advantage of Iida’s unwillingness to hurt someone he views as disabled/helpless and knocks him out with a bat from Momo, then touches the bomb, Momo just created water and soaked Bakugo so he couldn’t use his Quirk and then ran from him.

All other trials proceeded as in canon.

USJ

Since Tsuyu is the only one in the Water Zone [Midoriya not in the story and Mineta expelled], she just went straight for the shore and got back to the entry area via the river. She witnesses the entire beatdown of Aizawa and his fighting, so she’s very traumatized. But because she’s amphibious and is completely underwater [In my hcs, she can breathe underwater as long as water can access most of her skin. So her suit is very permeable and water can get through it], Shigaraki never sees her and so he doesn’t try to kill her.

Rest of the USJ goes as canon dictates including Aizawa getting his head smashed by the Nomu

Sports Festival

Because 1-A has 2 less students, only the first 40 to get to the finish line can pass on. Todoroki ended up getting first place by icing over Bakugo’s legs at the tunnel entrance. Everyone else that originally passed in canon, also passed.

All the teams are the same, except for Uraraka’s team which doesn’t have Midoriya, and Shoji’s who doesn’t have Mineta.

Bakugo is going after Todoroki instead of Uraraka’s team because he’s focused on snagging the winning headband. 

Uraraka uses her Quirk on her team and they just hang out in the sky for awhile, since after the boulder, she practiced to be able to lift more weight so that never happens again. 

Shoji’s team is the same as canon, especially because Mineta never actually did anything important to the team.

Todoroki never uses his fire because he used his ice to create a dome that kept everyone else away from his team. Bakugo runs around stealing other headbands since he can’t get to Todoroki.

At the end of the round, Todoroki is in first, Bakugo is second, Uraraka is third and Shinso is fourth.

Ojiro and Shoda both drop out citing the fact that they couldn’t remember the event as the reason. Shiozaki Ibara and Tetsutetsu Tetsutetsu replace them

So now we have the 1v1 battles with the following students.

Uraraka Ochako

Tokoyami Fumikage

Hatsume Mei

Bakugo Katsuki

Kirishima Eijiro

Ashido Mina

Sero Hanta

Todoroki Shoto

Iida Tenya

Yaoyorozu Momo

Kaminari Denki

Shinso Hitoshi

Aoyama Yuga

Shiozaki Ibara

Tetsutetsu Tetsutestu

Shinso gets a free pass onto the next round because he is a gen ed student so they wanted to allow him the best chance possible and it’s better for the optics of UA for watchers to see a hero student beating up another hero student instead of a gen ed kid.

Todoroki v. Sero -Todoroki won ala iceberg

Kaminari v. Shiozaki  -Kaminari won by sending electricity through her hair and knocking her out because Aizawa forced him to start thinking outside of the box after he nearly died during the USJ [shiozaki has to have nerves to control her vines and nerves have electricity traveling through them. So they’re a conductor and Kaminari can send his electricity down them]

Iida v. Hatsume -He doesn’t accept her gadgets and just pushes her out of bounds. After the Uraraka debacle in his battle trial, he realizes that he can’t just go off his perceptions and has to be wary of them.

Ashido v. Aoyama - Ashido won

Tokoyami v. Yaoyorozu - Yaoyorozu won by creating an explosion of light and blinding them, then pushing them out of the ring. Uraraka taught her to take advantage of what she can do and Aizawa forced her to realize that others don’t have the same rules.

Tetsutetsu v. Kirishima - Kirishima won by charging Tetsutetsu and knocking him out of the ring. Again Aizawa forced him to not just behave as a shield because of the USJ

Uraraka v. Bakugo -Uraraka won by taking off her prosthetic, leaving it as a decoy and floating herself so that he couldn’t hear her coming, and the dust from his explosions had blinded him. She tackled him from above and hurled him out of bounds. He got a concussion and Recovery Girl forced him to stay in the infirmary.

Todoroki v. Shinso -Shinso won by coming after Todoroki’s weak spot and making him talk

Iida v. Kaminari -Kaminari won by shocking Iida’s engines when he tried to grab him. Made him collapse, and then just dragged him out of bounds.

Tokoyami v. Ashido- Tokoyami won by Dark Shadow kicking her out of bounds

Uraraka v. Kirishima -Uraraka won by preying on Kirishima’s desire for manliness and to not hurt a girl. Got close enough to float him and then just push him out of bounds. Aizawa has plans to lecture Kirishima about when to be manly and when to not be.

Shinso v. Kaminari -Shinso won. He could tell that Kaminari was a memelord, so he just took advantage of that and said a meme that Kaminari couldn’t resist completing. [Don’t know what yet, I’ll figure it out later]

Tokoyami v. Uraraka -Tokoyami won. Uraraka lost because she couldn’t use her Quirk on Dark Shadow and Dark Shadow was the one to attack her. [See doc of quirk analysis for more in depth in case we forget]

Shinso v. Tokoyami -Shinso won by mirroring Tokoyami’s speech patterns which knocked him off guard and got him caught into Shinso’s Quirk.

Shinso got first place, Tokoyami got second, Uraraka and Kaminari shared third place.

Hero names

Todoroki -Shoto

Bakugo -King Explosion

Iida -Tenya

Uraraka -Weightless [As a pun on weigh less because of her amputation and her quirk. She’s not quite as bubbly and didn’t feel like uravity reflected her anymore]

Tsuyu -Froppy

Kirishima -Red Riot

Yaoyorozu -Creati [I really want to change this but I don’t know to whaaaat!!! I’ll come back to it later]

Tokoyami -Tsukuyomi

Jiro -EarJack

Shinso -Silencer [Stupid but his quirk makes people silent plus I love MLB silencer design of the , not the helmet tho that is ugly looking and the coloring needs to be more muted imo]

Internships

Shinso gets an internship with Aizawa to assess whether or not he’s fit for heroics. Aizawa also prescreens all of his students' internships to make sure that it’s a good fit for them. [He’s a lot more protective of where they because he wants them to be actually learning useful heroics not shit like how to clean and pose for a camera.]

Mirko offers an internship to Uraraka because she wanted to teach a fighting girl that was perceived as helpless by society. [Society views disabled as helpless, a girl is also viewed as helpless, both is bad combination. Mirko wants to prove anyone can be badass with the right training]

Yaoyorozu gets put with Fatgum because Aizawa sees that she’s struggling with the fat part of her Quirk and knows that if she went with Uwabami, she’d develop more insecurities. [Uwabami is a TV actress/model. She’ll pass on weight/beauty related insecurities because that’s what a lot of actresses have and she seems focused more on a fanbase]

Kirishima goes with Rock Lock to be faced with the blunt truth that ideals are nice, but you can’t have them rule your life as a hero. [Canonly, he’s very blunt and pragmatic, so he’d believe that trying to be manly is fine, but there is a time and place for it.]

Everyone else goes with their canon internships.

The Nomus attack Hosu. Because Gran Torino isn’t there, the Nomus are more dangerous and more civilians die. All the heroes are focused exclusively on managing the Nomus and the interns kinda fall to the wayside since they can’t do anything.

Iida slips away and Manual is too busy putting out fires to notice.

Iida runs off and finds Stain. Battle commences and Iida loses.

Stain calls him and Native fake heroes. Native gets a sliced throat. Stain is a little more lenient with Iida because he is a kid. He goes through the fabric pants and slices the femoral artery to the bone. [Femoral artery cuts can lead to death within minutes especially with Iida running on adrenaline which kicks up the blood pressure and rate of bleeding.]

Endeavour comes through with Shoto burning all the nomus and destroying them. Finally the city is quiet and the search for the dead begins.

Every hero in Hosu grid searched the entire city to retrieve the dead and bring them to the morgue for claiming. 

Manual was the one to find his dead intern and Native. He had to call UA and tell them that he got a student killed while under his supervision. He gets blacklisted by UA and Aizawa puts out a warning on the Underground network that if others are under his care, that he might lose track of them.

Once everyone returned from their internships, they left red spider lilies on his desk as a way to guide him to the afterlife.

Training Camp

The villains still want Bakugo because they saw his aggression, violence, and determination to be the best during the sports festival and the internships. So they think he’d be an easy switch to flip.

This time, Aizawa doesn’t dump them out in the middle of the forest because he’s focusing on forcing his students to interact and bond with each other instead of doing their own thing. So they all stay on the bus and Aizawa makes them talk about something semi-important with a seat partner for 10 minutes before switching so that everyone talks to more than just their friend groups.

When they arrive, Kota is his bratty self and Aizawa shuts that down fast. He tells him that he has two options, one: stay with his aunts and uncle or two: stay with Aizawa. Aizawa can’t have an itty-bitty child running around loose in the forest when 17 hormonal teenagers are letting off their Quirks which are dangerous. [it was an awful idea in canon to let Kota hide in his treehouse. Imagine if one of the kids near the mountain lost control of their quirk.] Kota chooses to stay with his aunts and uncle at all times because Aizawa is scary.

Once the training starts, he pairs everyone up with different partners to force their Quirks to improve.

Ashido-Kirishima to strengthen her acid and his hardening by hurling acid at him

Tokoyami-Kaminari-Aoyama to force Aoyama to maintain his laser beam for longer, Tokoyami to force him to strengthen Dark Shadow against light, Kaminari to power multiple light sources without burning them out and not going into whee mode so he can avoid the laser beam and Dark Shadow

Ojiro-Koda to force Koda to vary the animals that he calls and Ojiro to give him experience with fending off multiple opponents of varying sizes and skill levels without seriously injuring them.

Todoroki-Bakugo-Tsuyu to force Todoroki to be able to control both sides of his quirks and switch them easily, Tsuyu to force her to get accustomed to varying temperatures and making sure they don’t knock her out, Bakugo to force him to sweat more in both cold and hot temperatures so that he’s more versatile.

Jiro-Shoji-Hagakure to force Hagakure to improve her stealth and fighting, Jiro to make her be able to detect people sneaking up on her, and Shoji to improve his locating skills and stealth. [Shoji is a big boy and needs to work on stealth]

Sero-Sato to help Sero with his dodging and speed, and Sato to help him retain more of his planning and forethought while his Quirk is activated

Uraraka-Yaoyorozu to make Uraraka work on her sickness and weight limits and Yaoyorozu to adapt to planning on the fly and create items quickly.

Aizawa forces them to break away from their training partners when it’s time to make dinner and everyone is required to help in some way during the meal. The help can be gathering the ingredients, preparing them, doing the actual cooking, plating, setting the table, cleaning up after, anything as long as they contributed.

Repeat until the trial of courage.

Vlad wants to do the trial and Aizawa refuses to do it. Aizawa is actively trying to squash out the competitiveness of his students in order to make them work together and ask for help so that they’ll survive longer in the hero society. Uraraka lost a leg because people wouldn’t cooperate to help her in the entrance exam and Iida died because he was too focused on himself and didn’t ask for help. The trial would just reignite the competitiveness and ruin his progress.

1-B does the trial on their own while 1-A is given a maze they have to navigate.

The maze is created by Pixie Bob and is huge. It’s large enough that the students on the ground can’t peek over the walls to see the path. There are two students on the ground, the leader and the guide. The leader can see the walls and the turns but has earplugs in so they can’t hear the guide if the guide tries to talk. The guide can hear the directions from the person who sees the entire maze but is blindfolded and has to guide through tapping the shoulders of the leader. The person outside and looking down has to direct their team through the maze quickly without crashing into other teams. The leader can’t just guess a direction because Pixiebob will shift the maze if they try to do that so they can’t backtrack. It’s in teams of three so Aizawa is directing the last team. [Kinda inspired by survivor but with my own twist]

All of them rotate through each position with different teams each go round to impress on them the importance of all the roles.

In the last round, Bakugo was the person issuing instructions, cursing and screaming through the mic the entire time.

That’s when the villains attacked. But there were a few changes in the lineup. 

Toga wasn’t there because the police picked her up and Inko got her case taken on to get her on parole and took her into her home when she saw her at the station while continuing with the criminal charges levied against the owner of the building that Izuku had fallen off of. The appearance of a girl bullied and ostracized for her Quirk, who was going down the path of no return, Inko saw Izuku in her. As such, she wanted to care for her and show her that villainy wasn’t the answer and that there are people who cared for her in spite of her blood Quirk. [Toga is stuck with Inko at this point in time and has a tracking anklet to make sure that she’s behaving. Rehab is going really well with the unconditional care that Inko is providing.]

Dabi got an infection and landed in the hospital ER as an unknown patient and wound up in a coma while his body was busy trying to fight the infection of his staples. [The man’s a walking open wound. You can sneeze in his general vicinity and have a high chance of taking him down in a couple weeks. Haven’t decided if I want to wake him up or not. Depends on my feelings]

Mustard joined the attack via Toga due to them being closer in age and talking. No Toga, no Mustard. [He’s sulking in detention right now.]

So the only ones left are Mr. Compress, Magne, Spinner, Muscular, Moonfish, Twice and the Nomu. Much smaller and no long-range attacks.

Their mission is to get in, extract Bakugo and get out with minimal damage. That’s what happened.

Muscular, Moonfish, and the Nomu all rampage on the opposite side of the mountain to draw attention to them. Magne and Spinner break up the 1-A class and drive them apart. Twice and Mr. Compress work together to snatch up Bakugo in a marble and then they all book it. Muscular and Moonfish are both left behind to keep the heroes distracted long enough for them to get back to Kurogiri and through the portal. Nomu ended up buried in a mountain via a very anger Tiger at the disruption of his naps. The students all worked together to try and bring down the villain to retrieve their classmate, but when that failed, Yaoyorozu managed to attach a tracker to the villains top hat.

Injuries were minimal and the three heavy hitting villains were arrested and locked up. The only casualty was Bakugo being kidnapped.

Kidnapping Arc

Blah, blah, join us you can be stronger and win a villain-Shigaraki

No, fuck off, go fuck yourselves-Bakugo

Repeat until All Might shows up

Then AfO activates goop Quirk [really need a better name for that. better than vomit transport quirk at least. That was my first thought], drags the league and Bakugo to him. Bakugo is held by him, hand on his temple ready to crush him.

Rest of Heroes all show up on the battlefield but aren’t moving so that Bakugo doesn’t get hurt. Essentially a stand off.

You know, you can tell whether or not someone has the potential for villainy by their greatest regret -AfO

AfO has a quirk that allows the user to see someone’s greatest regret, with more details the longer that the quirk is activated. He also has a quirk that allows him to project whatever he’s thinking about in a video format for everyone to see. [the man is old. he probably had a habit of taking whatever quirk he wanted when he was younger before all might turned him into a very ugly potato/alternate darth vader]

Quirks activate and it’s the scene of Bakugo telling Izuku to get jump off a building spliced with the news from Inko that Izuku was suspected of jumping off a building

Interesting. Why is that your greatest regret?-AfO

Quirk gives him more details. 

Bakugo only regrets saying that because if it ever became public, he'd never reach the spot of number one hero which is his only goal in life.

Guess you are nothing but a villain after all. Too obsessed with yourself to see the damage you caused.-Afo 

Afo shoved the boy away from him and forcibly activated Kurogiri’s Quirk to allow the league to escape.

Every hero on site is frozen in shock at the reveal of what a hero student of UA, the most prestigious hero school that graduated most of the top heroes in Japan, actually believed.

At that point, AfO flips All Might the finger and just goes through the portal because the news would shake society’s faith in UA which is really good. He can kill All Might later. [or just wait for any infection to take the man out. He lost his stomach so he probably lost his spleen too which is kinda important for the immune system.]

Fallout

Bakugo is booted to gen ed because Aizawa refused to teach someone that was just going to end up hurting someone later in life. Because Aizawa is an Underground Hero who specializes in information and predication, schools tend to believe in what he says about the potential/future of heroes in training especially when he has evidence to back up his beliefs. So no other school will take him on as a hero student.

Bakugo is essentially blacklisted from heroics because everyone wants to believe that a hero is good and just. And when the illusion is broken before it has a chance to solidify, they have no chance of becoming a hero. 

Aizawa goes and apologizes in person to Inko. Because even though he had no way of knowing, he feels like he should have recognized the abusive tendencies and/or egocentrism  of Bakugo earlier. So, allowing it to continue was a slap in the face to his victims.

Inko accepts his apology because she didn’t know about it either so how could she blame him when she was closer and still missed all the signs. She offers to let Aizawa visit Izuku because Eraserhead was one of his favorite heroes because of how much skill he had. But because Eraserhead was underground, he didn’t have any merch or enough information to write about him.

*Split path here depending on the angst level I want

1. Izuku is in a coma, all healed up, just hasn’t woken up. When they came, Izuku had just woken up a half hour ago so the doctors were busy checking all his vitals, memory, joints, etc. Inko cries, Aizawa stands away because he’s allergic to emotions, and Izuku is just silently fanboying because he sees one of his favorite heroes.

2.Izuku is in a coma and doesn’t wake up. Inko introduces Aizawa to him and tells Aizawa about his dreams and his story. Aizawa makes sure that at least once a week, he comes and visits to talk to him. He also brings other heroes to introduce to Midoriya to make sure that others know about him.

3.Aizawa and Inko go to a graveyard and the name Midoriya Izuku is carved into a family grave marker with flowers and an All Might figure in front of it. Inko tells Aizawa that Izuku died from falling from the building. They thought he jumped randomly, but with the new info, Inko is thinking that Bakugo might’ve pushed him verbally over the edge. Aizawa promises to investigate more.

#boku no hero academia #my hero academia #bnha #mha #fic outline #fic ideas #anti bakugou #consequence #cw suicide attempt #doesn’t actually happen #but characters think it did #aizawa shōta #alternate universe #canon divergence

[sirjustice1007]

New TV

Curved TV the other way on the short vertical sides either outwards or inwards not as the normal way in the link below, reduces spirit of people keen with ya if u watch such, so can be again glued to ya screen 4 more hours dude

https://news.samsung.com/global/hot-tips-for-choosing-a-cool-tv-part-3-a-wall-mount-or-stand

Guava in carrot in raised bar like huge rock or big pole and then chop kale on the ground in the dark or scoop to grab like paw paw seeds or cereals as millet or hide from the pillar below as if of shame squatted 2 people 1 holding on 1 arms, if u want it the up way do such above the bar with the heap maybe on drone or if next to a water body chop carrot inside boat or mix water with urine now the heap on the ground or chop paw paw or guava with panga, broken glass or sickle dude

Made in Africa ships images links below

https://www.thelivefeeds.com/photos-fg-donates-made-in-nigeria-drugs-to-cameroons-train-accident-victims/

https://abovewhispers.com/2020/08/12/ghana-build-naval-boats-locally/

https://www.alamy.com/stock-photo/aircraft-lockers.html

https://www.theguardian.com/travel/2020/jan/09/worlds-fastest-driverless-automated-bullet-train-launches-beijing-china-olympics

https://blog.lamresearch.com/silicon-snack-pilotless-passenger-jets-more-than-a-blue-sky-idea/

https://southsoundbiz.com/boeings-unmanned-passenger-aircraft-completes-first-flight/

https://www.bbc.com/future/article/20130502-pilotless-planes-plan-to-take-off

https://safety4sea.com/40-consider-unmanned-ships-to-be-viable-within-20-years/

https://phys.org/news/2017-09-unmanned-ships-cargo-industry-dearly.html

https://www.businessinsider.com/rolls-royce-drone-ships-2014-2?IR=T

https://www.foxtechfpv.com/foxtech-diamond-6s-22000mah-semi-solid-state-lipo-battery.html

With trains and some ships u hide the marble, cotton wool, cattle bones and more inside small dug holes or in the water with ship heap in between u hide the marble or flowers inside coolers on both side or make holes on floating timber and hide the same as with Xmas lights b4 doing ya boom process and even with most jets and choppers dude or all the placed sideways in the factory house where their is the heap on its two side create ditches or tunnels with enclosure inside water to heap every fruit or marble used in the boom process 4 the gadget u want to come out or under mattress with water dude placed in side holes bro Or sometimes can be placed and hidden upward as with the airplane or bus inside luggage storing facility dude but runs horizontally to the hole as florescent bulbs are hanged on the ceiling dude or AC metallic ventilators or the veggies, fruits, bones, marbles placed on each side of the boom heap can be hidden in boxes or containers and even bags as polythene of different colors 4 different machines as its trial and error until u unearth or get it dude

U can even hide in made holes outside or within the factory house or just above the floor or ground surface dude

Dog meat when cooked rejuvenates ya hairline, so can be placed in boom process of some produce as medicine or other meat produce and vegetables and milk or juices to have that ripple effect in small magnitude but if taken 4 a long time gets ya hairline back or mixed in injection drugs to do the same bro and its utility

With some fruits or veggies hidden divide into 2 or many sides and try as well with such and in some situation divide not dude

Built in Ghana yachts in the links below

https://web.facebook.com/OhemaaLXI/?_rdc=1&_rdr

https://www.atelier55design.com/travel-ghana-cruising-lake-volta-with-the-ohemaa-lxi/

https://www.tripadvisor.com/Attraction_Review-g147311-d19457950-Reviews-Soma_Yachts-Montego_Bay_Saint_James_Parish_Jamaica.html#photos;aggregationId=&albumid=&filter=3&ff=468302283

The  Electric yacht in the link below made when illuminated photo from the project rest on heap of paw paw then u chop guava on another boat the other side of the heap in the lake or trample on rodents as rat or maize  cereal or drop coconut on timber on the shore side in smokey environment in moonlight or place white guava in kale then chop mango in  hay presence on 2 boats in between the heap floating on water or spit  saliva unto the ocean water from the drone as much as drop flowers unto  the kale guava heap dude and boom ya yacht bro in dark this time

https://pro-yachts.com/en/the-best-electric-yachts/

Same  as below can be built using armored glass tunnel instead of concrete that rust not by placing hay in kale in floating woods on ya wanted train path after taking the underground survey of shallow point and leveling with made stones, rustles metals with holes all around to be permeable to allow air on water circulation to avoid water smelling and  even armored glass itself b4 lowering the final tunnel as above, after  placing hay in kale then hurl with cucumber or kojet in bright day or night or with cabbage, mango or lemon seed and boom ya armored glass tunnel all way through the floating on boards heap or break camara stick  or on both sides of the heap many small boats hurl salt unto the heap  or paw paw unto the sea water and lemon unto the fresh water lake water  or operate washing machines on such boats dude. Not rocket science dude

https://www.devdiscourse.com/Article/headlines/270896-update-1-us-and-uk-reach-new-post-brexit-deal-on-air-services

Armored  glass cylinder with same glass lid made when hay placed kale then u chop ripe banana or chop boxes, leaf onion or drop cabbage on water from  another boat, the heap above in dump truck in sea shore or flattened  land just adjacent to the shore u off shore or next to the sea and the  heap or in yacht far away from the shore but in water. Hay in kale then  trample on paw paw trunk in the sea close to the shore in moonlight  makes such gas cylinder off the boat carrying the heap in the middle 2  of u doing the same on each side and with many gadgets or on both sides  of the dump truck or shoot paw paw, palm tree back, grown or  artificially planted 4 the same and even any big tree around dude

War ships made in Nigeria images in the link below

https://www.nairaland.com/951727/jonathan-commissions-nns-andoni-warship/2

Kale  in much onion then u on small boats on each side of the heap in twilight or evening with smoke fumes around and flowers scattered on water side or paw paw leaves, u urinate with pipes unto the heap or unto  the water adjacent or chop corpse hand or mango seed or carrots as much  as cucumber on a norther floating boat from a boat in-front of the heap  on both sides and boom ya big ship as in the link below or on water  close grass floating drop detergent unto it or paw paw unto the heap cow  dung floating like in a wood piece bro

https://spectrum.ieee.org/transportation/marine/the-struggle-to-make-dieselguzzling-cargo-ships-greener

Or  illuminate 3d camera on floating heap of any fruit, veggies or leaf and  u on the shore or on two boats as above try all the boom process as  dropping, trampling and chopping is concerned until it comes out dude,  Xmas lights or marble floating on card-boards from each side either in  heaps or straight line or paw paw and many other floating fruits as those in the link above in below dimension dude as most other none water  operating gadgets made same way as u can try dude and even in rivers  bro and even on land with many gadgets needs 2 sides even in drop  theorem, either u drop on the flat ground or into a dug shallow way in a  synchronized manner dude like with Gas cylinders and Brazier as Jikos  and much electronics either squatted, sited down, bending or standing  and others on 4 sides while others on triangle way meaning 3 sides all  boom process done synchronously while others in a sole manner bro. In  some cases u cry kinda or close eye and sometimes wink and or wide eyed  dude or sometimes lying on the ground looking heaven, side ways or on ya  belly dropping from side hands, seeing or not seeing and sometimes just  need a touch of any veggies or fruits and boom ya machine. Try all the  tricks until it come out what u want with projector way which fails not  dude. Sometimes heap to be dropped or placed upon in raise bars as rocks or buckets or stools b4 u do the same dude and sometimes hanged from a stand or tree or sometimes in a boat or car boot. All direction same direction or different dude South, west, north or East, up or down or looking sideways, back bent or sometimes nodding head dude, sometimes 1 hand on the ground while place not sited or sited with the other hand, kinda, in toilet dude. U can even hide in made holes outside or within the factory house or just above the floor or ground surface dude.

They give lame excuse, that if u dont do that way u risk not  getting well ahead in life, not with me, try with another 1 those silly  tricks of ya own making not listening dude

Made in Nigeria military weapon in the link below, check it out dude

https://www.nairaland.com/1917837/yes-nigeria-what-it-takes

https://www.businessinsider.com/it-looks-like-an-armed-chinese-made-drone-crashed-in-nigeria-2015-1?IR=T

https://twitter.com/africaupdates/status/1053887766369656832/photo/1

https://www.youtube.com/watch?v=awycpN0luSQ

http://makerfaireafrica.com/2012/11/05/tuktuk-mods-in-nigeria-limo-jeep-and-a-bike/

http://makerfaireafrica.com/2012/11/05/tuktuk-mods-in-nigeria-limo-jeep-and-a-bike/

[irispublishersgastroenterology]

Fodmap’s Restricted Diet in Patients with Irritable Gut Syndrome: A Systematic Review

Authored by Sander BQ*

Introduction

Introduction: Irritable bowel syndrome (IBS) is an inflammatory bowel disease that has a high prevalence among the world population. Dietary interventions are considered an important intervention for the treatment and control of IBS. The diet restricted in FODMAPs, a group of fermentable carbohydrates, has been studied, since it is able to reduce symptoms such as abdominal pain, bloating and diarrhea.

Objective: To verify the role of the FODMAP’s restrictive diet in the treatment and control of irritable bowel syndrome.

Methods: The most relevant studies originally published in English, Portuguese and Spanish were analyzed using the MEDLINE (National Library of Medicine and National Institutes of Health) and SciELO databases as reference. In order to select the studies with the greatest scientific evidence, we only contemplate clinical trials and review studies. The search strategy used the following keywords: “irritable bowel syndrome” and “FODMAP’s restricted diet”. To identify the designs of the studies, the following terms were used: clinical trials.

Results: Initially, 117 studies were identified involving irritable bowel syndrome and the Foodmap diet. However, after applying the Clinical Trials filters, 10 studies were found. After reading the articles found and excluding them from the abstracts, 5 articles were selected involving the theme for analysis and inclusion in the scope of this review.

Conclusion: The restricted diet in FODMAPs proved to be very effective in improving general and specific symptoms of irritable bowel syndrome, especially abdominal pain, bloating and diarrhea.

Keywords: Irritable bowel syndrome; Restricted Diet in FODMAP

Introduction

Irritable bowel syndrome (IBS) is an inflammatory bowel disease that has a high prevalence among the world population. The disease is believed to affect 7-15% of the world population, mainly women, under 50 years old. Symptoms are characterized by recurrent episodes of functional gastrointestinal symptoms whose pathophysiological mechanisms are not completely clear, including abdominal pain, bloating, constipation and / or diarrhea [1]. Although one has a pathophysiology not yet clarified, it is known that the diet has an important role in IBS. Hypersensitivity to certain foods can play a role in causing low-grade intestinal inflammation, increased permeability of the epithelial barrier and visceral hypersensitivity. Bioactive chemicals in food, for example salicylates, can also contribute and trigger gastrointestinal symptoms in IBS, possibly inducing visceral hypersensitivity after chronic exposure [2]. The restriction of a group of fermentable carbohydrates, called FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides and polyols), which include fructooligosaccharides (FOS), galacto-oligosaccharides (GOS), disaccharides (for example, lactose), monosaccharides (for example, fructose ) and polyols (eg, sorbitol), came into question for the treatment of IBS [3].

Their logic is that there are several individuals who barely absorb or are sensitive to FODMAPs and, if these foods are eaten, they can result in symptoms such as bloating, diarrhea, gas, constipation or abdominal pain that are often interpreted as IBS. FODMAPs, when poorly absorbed, are highly osmotic substances that can cause an influx of water in the colon and result in diarrhea, or by fermentation by colon bacteria can lead to excessive gas production [4]. The aim of this study is to verify the role of the FODMAP’s restrictive diet in the treatment and control of irritable bowel syndrome.

Method

Research Strategies

The most relevant studies originally published in English, Portuguese and Spanish were analyzed using the MEDLINE database (National Library of Medicine and National Institutes of Health). In order to select the studies with the greatest scientific evidence, we only contemplate clinical trials and review studies. The search strategy used the following keywords: “irritable bowel syndrome” and “FODMAP’s restricted diet”. To identify the designs of the studies, the following terms were used: clinical trials. The inclusion and exclusion criteria were applied based on the types of studies, language and type of therapy from the points raised in each exposed item.

Results

Initially, 117 studies were identified involving irritable bowel syndrome and the Foodmap diet. However, after applying the Clinical Trials filters, 10 studies were found. After reading the articles found and excluding them from the abstracts, 5 articles were selected involving the theme for analysis and inclusion in the scope of this review. In (Table 1) we will present a summary of the works selected and reviewed in the present study.

Discussion

Irritable bowel syndrome (IBS) is a chronic inflammatory bowel disease that has a high prevalence and incidence. IBS affects 7 to 15% of the general population, being twice as frequent in women and is diagnosed more frequently in patients under 50 years of age. It is characterized by recurrent episodes of functional gastrointestinal symptoms whose pathophysiological mechanisms are not completely clear. The most common symptoms include abdominal pain, bloating, constipation and / or diarrhea [1]. Dietary interventions are considered an important treatment for IBS. However, these patients generally initiate dietary interventions without specific guidance, leading to an increased risk of nutritional inadequacy. This is because many of them consider their symptoms related to meals. In the past, the most common diets for IBS patients have focused on fiber, caffeine, alcohol and fat restriction, but in recent years, the low FODMAP diet has been considered a newcomer to IBS dietary management and a considerable amount evidence on the mechanisms and clinical efficacy of this new diet [5].

FODMAPs are a group of compounds that includes oligosaccharides, disaccharides, monosaccharides and polyols. The definition of the components is based on functional characteristics such as being poorly absorbable and highly fermentable in the intestine. These compounds can exacerbate IBS symptoms by increasing the volume of water in the small intestine, producing colonic gas and intestinal motility [6]. However, FODMAPs have an important physiological effect, since they increase the volume of feces, improve calcium absorption and modulate immune function, in addition to decreasing serum cholesterol levels, triacylglycerols and phospholipids. Along with this, these compounds help the growth of some microbial groups, such as bifidobacteria [7]. Studies have shown that a diet with a low intake of FODMAPs significantly reduced the symptoms of irritable bowel syndrome, including abdominal bloating. This is because ingestion of FODMAP increases the delivery of readily fermented substrates and water to the distal small intestine and proximal colon, causing luminal distention and functional bowel symptoms. The hypothesis of the FODMAP concept is that a global constraint should be more effective than a constraint, in controlling IBS symptoms [8].

Another study carried out in 2014, involving 162 patients, concluded that the restricted diet in FODMAPs leads to adequate relief of gastrointestinal symptoms in 57% of patients, compared with 38% of patients who receive false dietary advice. Although this finding has not reached statistical significance, all of the reported clinical results point to the clinical efficacy of the restricted diet in FODMAP, compared to placebo, making it directly relevant to clinical practice [9]. Several clinical trials, therefore, have reported that reducing foods with a high FODMAP index achieves adequate symptom relief in approximately 70% of patients with IBS [10]. In a recent meta-analysis, Marsh, et al. [11] reported the effectiveness of a low diet in FODMAP on gastrointestinal functional symptoms associated with irritable bowel syndrome, and found a significant improvement in symptom severity and quality of life scores compared to patients who received a normal Western diet. Significant reductions in abdominal pain and bloating have also been reported in patients who received a low FODMAP compared to those who received a medium or high FODMAP diet. Therefore, there is evidence that a diet restricted in FODMAP can have a favorable impact on IBS symptoms, especially abdominal pain, bloating and diarrhea. However, it remains to be demonstrated whether a diet with a low FODMAP index is superior to conventional diets for IBS, especially in the long term [10].

Conclusion

Irritable bowel syndrome is an inflammatory bowel disease with high prevalence among the population. The dietary restriction of some food groups is shown as an alternative to reduce the symptoms caused by the syndrome. In this systematic review 05 articles were analyzed, evaluating the effectiveness of the restricted diet in FODMAPs in controlling and treating IBS. It was concluded, then, that diet restricted in FODMAPs proved to be quite effective in improving general and specific symptoms of irritable bowel syndrome, mainly abdominal pain, bloating and diarrhea.

Read more..FullText

For more about Iris Publishers Covid-19 please click on https://irispublishers.com/COVID-19.php

For more articles in Academic Journal of Gastroenterology & Hepatology (AJGH)  Please click on https://irispublishers.com/ajgh/

#Iris Publishers #Iris Publishers LLC #Irritable bowel syndrome #Abdominal pain #Bloating

[wesmartlight]

What Needs of Anti-Virus Face Mask for You?

Along  with various other safety procedures, such as social or physical distancing and appropriate hand hygiene, face masks might be a very easy, economical, as well as possibly efficient way to stay secure as well as flatten the COVID-19 curve.

Health agencies, consisting of the Centers for Disease Control and Prevention (CDC), currently motivate all people to wear Anti Virus Face Mask or face covering when out in public.

So, which kind of face mask functions best for avoiding transmission of the new coronavirus when you're out in public? Continue analysis to get more information about the various types of masks and also which one you ought to use.

Why do face masks matter with this coronavirus?

With the brand-new coronavirus, referred to as SARS-CoV-2, the biggest quantity of viral losing, or transmission, occurs early in the course of the illness. As a result, individuals might be contagious prior to they even begin to reveal signs and symptoms.

In addition, scientific versions recommend that as much as 80 percent of transmission comes from asymptomatic service providers of the virus.

Emerging research recommends that prevalent mask use may assist limit the transmission of the virus by individuals that don't realize that they may have it.

It's likewise possible that you could acquire SARS-CoV-2 if you touch your mouth, nose, or eyes after touching a surface area or object that has the virus on it. Nonetheless, this is not believed to be the primary manner in which the virus spreads.

What kinds of face masks function best?

Respirators                                                

Fit- as well as seal-tested respirators are made from tangled fibers that are very efficient at filtering system virus in the air. These respirators must fulfill the strenuous purification standards established by the National Institute for Occupational Security and Health(NIOSH).

The diameter of the coronavirus is estimated to be 125 nanometers (nm). Maintaining this in mind, it's practical to recognize that:

Certified N95 respirators can filter 95 percent of particles that are 100 to 300 nm in dimension.

N99 respirators have the capacity to filter 99 percent of these bits.

N100 respirators can filter 99.7 percent of these bits.

Some of these respirators have shutoffs that allow breathed out air to get out, making it much easier for the user to take a breath. Nevertheless, the drawback of this is that people are prone to the fragments as well as viruses that are breathed out with these shutoffs.

Frontline health care as well as other workers who require to use these Disposable Surgical Face Mask as part of their job are examined a minimum of annually to confirm correct respirator dimension and fit. This likewise includes looking for air leak using particular test bits. These regular tests help make sure that damaging fragments as well as microorganisms can't leak with.

Surgical masks

There are different kinds of medical masks Normally, these disposable, single-use masks are cut into a rectangle shape with pleats that broaden to cover your nose, mouth, as well as jawline. They are composed of breathable artificial textile.

Unlike respirators, surgical face masks don't have to meet NIOSH filtering criteria. They aren't calling for to create a closed seal versus the location of your face that they cover.

Just how well surgical masks filter virus differs extensively, with records ranging from 10 to 90 percent.

Regardless of differences in fit and also purification ability, a randomized trial discovered that surgical face masks and also N95 respirators minimized individual risk of numerous breathing health problems in similar ways.

Adherence-- or correct and regular use-- played a more critical role than the sort of medical-grade mask or respirator put on by research study individuals. Other researches have actually been considering that supported these searches for.

Cloth masks.

Do-it-yourself (DIY) cloth masks are much less efficient at protecting the user due to the fact that many have spaces near the nose, cheeks, and jaw where small beads can be breathed in. Likewise, the textile is usually permeable and also cannot keep out small droplets.

Although fabric masks tend to be less effective than their medical-grade counterparts, experimental outcomes suggest they are much better than no mask in any way when worn as well as built properly.

    What materials function best for a homemade mask?

The CDC recommends using 2 layers of tightly woven 100 percent cotton fabric-- such as quilter's product or bedsheets with a high string count-- folded up in several layers.

Thicker, top-quality cotton masks are generally much better at filtering tiny fragments. Nevertheless, stay away from materials that are as good thick, such as vacuum bags.

As a whole, a bit of breathing resistance is expected when using a mask. Materials that don't let any type of air with can make it difficult to take a breath. This can put stress on your heart and also the lungs.

Built-in filters can improve the efficiency of Do It Yourself face masks. Coffee filters, paper towels, and practically any other filter can help boost security.

When is it essential to use a mask?

The CDC suggests putting on towel, face masks in public settings where conformity with physical distancing actions may be tough to achieve and preserve. This is key in areas where community-based transmission is high.

This includes, yet is not restricted to, settings such as:

Supermarket

Drug stores

Hospitals and also other healthcare setups

Work sites, particularly if physical distancing actions aren't feasible

Does everybody require to wear a mask?

Surgical masks as well as respirators remain in high need and also supplies are restricted. Therefore, they need to be reserved for frontline health care workers and first responders.

Nevertheless, the CDC advises that practically everyone uses a fabric face mask.

Individuals who cannot remove the mask on their own or have taken a breath issues should not wear masks. Neither need to children under the age of 2 as a result of the threat of suffocation.

If you aren't certain if a face mask is secure for you to wear, make sure to speak with your physician. They can encourage you on what kind of face covering might be best for you if you need to be out in public.

Face Mask Security Tips

Usage appropriate hand health each time you put on, remove, or touch the surface of your face mask.

Put on and take off the mask by holding it by the ear loops or ties, not by touching the front of the mask.

See to it the face mask fits comfortably as well as the straps fit securely over your ears or behind your head.

Prevent touching the mask while it's on your face.

Sterilize your mask properly.

Run your fabric mask with the washing machine as well as clothes dryer after each usage. Wholesale Lighting Distributors Clean it by washing, cleaning agent. You can likewise position the face mask in a paper bag and shop it in a warm, dry place for 2 or more days before wearing it once again.

If you have to recycle your respirator or medical mask, isolate it in a breathable container such as a paper bag for at the very least 7 days. This helps make certain the virus is inactive as well as no more contagious.

The bottom line

In addition to physical distancing and utilizing correct hand health, lots of health professionals think about making use of face masks to be an essential measure in aiding to stop the spread of COVID-19.

Although homemade cloth masks aren't as effective at filtering out tiny fragments as respirators or medical masks, they offer a much more defense than not using any kind of face mask at all.

The efficiency of homemade face masks can be improved with proper building, wear, as well as upkeep.

As individuals go back to work, proceeded use appropriate face masks might help reduce a boost in virus transmission.

Smart Light Industries offers high quality antivirus face mask KN95 Respirator of 20 pack which helps spread the Corona. Visit us our website to buy an anti viral face mask, high quality disposable face masks kn95, dust masks KN95.

#Wholesale Lighting Distributors #Anti Virus Face Mask

[thrivous]

A new treatment developed by Tel Aviv University induced the destruction of pancreatic cancer cells in mice (see below), and could work in humans, Jerusalem Post reports.

"The mice were treated with a molecule called PJ34, which is permeable in the cell membrane but affects human cancer cells exclusively," explained research leader Malka Cohen-Armon. "This molecule causes an anomaly during the duplication of human cancer cells, provoking their rapid cell death. Thus, cell multiplication itself resulted in cell death in the treated cancer cells."

A month after being injected with PJ34 daily for 14 days, the pancreatic cancer cells in the tumors of the treated mice experienced a relative drop of 90 percent. In one mouse, the tumor completely disappeared.

"It is important to note that no adverse effects were observed, and there were no changes in the weight gain of the mice, nor in their behavior," added Cohen-Armon.

According to a Tel Aviv University press release, this mechanism acts efficiently in other types of cancer resistant to current therapies. The molecule PJ34 is being tested in pre-clinical trials, according to FDA regulations, before clinical trials begin.

Moving from mice trials to human trials would take "at least two years on the condition that we get enough funding," Cohen-Armon told Jerusalem Post. "I am optimistic," she concluded.

A cure for cancer covered in Jerusalem Post rings a bell. In fact, in Pulse 96, I wrote about another rumored cure for cancer covered in Jerusalem Post, and a hatchet job (with evident political motivations) lamentably published in Wired. There’s no direct relation, but I can’t help thinking that the new Tel Aviv University results confirm that, sometimes, medical research results in spectacular advances.

Pancreatic Cancer Reduced by 90 Percent in Mice

Scientists led by Tel Aviv University have found that a small molecule has the ability to induce the self-destruction of pancreatic cancer cells.

The research was conducted with xenografts. They are transplantations of human pancreatic cancer into mice with an impaired immune system.

A research paper published in Oncotarget reports that treatment with a molecule called PJ34 reduced the number of cancer cells in tumors. The reduction reached 90 percent a month after being administered.

Artificial Neurons Mimic Real Neurons

Researchers at Universities of Bath, Bristol, Zurich, and Auckland have developed artificial neurons that successfully reproduced the electrical properties of biological neurons onto semiconductor chips.

A study published in Nature Communications describes how the researchers designed silicon neurons that precisely mimicked real living neurons, responding to a range of stimulations. The researchers accurately replicated the complete dynamics of hippocampal neurons and respiratory neurons from rats, under a wide range of stimuli.

The research results are believed to have “enormous scope” for medical devices. They may enable cures for chronic diseases such as heart failure, Alzheimer’s, and other diseases of neuronal degeneration.

Genetically Modified Immune Cells Boost Cancer Immunotherapy

Researchers at Stanford University have developed a new approach to programming cancer-fighting immune cells called CAR-T cells.

A paper published in Nature shows that genetically modified CAR-T cells stay active for a longer time and are more effective against human cancer cells grown in the laboratory and in mice. Mice injected with human leukemia and bone cancer cells lived longer when treated with the modified CAR-T cells than with the regular CAR-T cells.

The researchers are hopeful that their findings will lead to the next generation of CAR-T cells. That could make a significant difference for people with many types of cancers.

We Can Control Alpha Waves in Our Brains and Be More Attentive

MIT researchers have found that people can enhance their attention by controlling their own alpha brain waves. They did this based on neurofeedback that they received as they performed a particular task.

Brain waves are oscillations generated by the combined electrical signals of neurons in the brain. Alpha waves, brain waves in a special frequency range, are believed to play a role in filtering out distracting sensory information.

A study published in Neuron shows that participants were really able to control their alpha waves and be more attentive. And they were able to do this even though they didn't have any clear understanding of how they were doing it.

Bioprinting Life-Like Human Tissues for Regenerative Medicine

Scientists at Wake Forest Institute for Regenerative Medicine have used bioprinting to print a tracheal tissue construct comprised of multiple functional materials.

As reported in a study published in Biofabrication, the scientists used a biodegradable polyester material and hydrogels containing human mesenchymal stem cells. And they printed different designs of smooth muscle and cartilage regions in artificial tracheal substitutes, showing similar mechanical properties to human tracheal tissue.

According to the scientists, the study shows that bioprinting could someday enable regenerative medicine treatments.

High Energy Light May Treat Cancer

Researchers at UC Riverside and UT Austin have achieved photon up-conversion. This is the emission of light with energy higher than the one that excites the material. They did this using carefully designed structures containing silicon nanocrystals and specialized organic molecules.

The accomplishment is described in a paper published in Nature Chemistry. It brings scientists one step closer to developing minimally invasive treatments for cancer.

Originally published at thrivous.com on December 09, 2019 at 09:08PM.

[twitterfaves]

From Twitter: The Central Area Committee have agreed to extend the trial of the filtered permeability for Grangegorman.Trial continues until Jan 2021. pic.twitter.com/5hzfia1hhz— Cllr. Anthony Flynn (@AnthonyICHH) September 8, 2020

http://twitter.com/AnthonyICHH

#IFTTT #Twitter

[imsohealthy1]

The Role of Glutamine in Gut Health

Glutamine is probably the most ample amino acid in our physique, and it additionally performs a serious position in the well being and performance of the intestine. In actual fact, ample analysis exhibits that glutamine influences our intestine well being in two vital methods: one, by its results on the intestine barrier, and secondly, by its results on our intestine microbiota! Let’s check out how this superior amino acid works its magic by these two avenues.

Glutamine and the Gut Barrier

The intestine barrier consists of a single layer of firmly linked cells lining the gut, serving as a barrier between the exterior world (our digestive tract, which is technically a tube that runs “exterior” our physique!) and our inside setting (the within of our physique). When this barrier is functioning correctly, it prevents international antigens, pathogens, and bacterial toxins from coming into our system, whereas additionally selectively permitting important vitamins and water to filter by. When this barrier isn’t functioning correctly (as is the case with leaky intestine), protein fragments, endotoxin, waste, pathogens, and different dangerous substances can go away the intestine and enter circulation. In that state of affairs, immune cells in the intestine launch an assault on the international invaders, resulting in a cascade of immune reactions and ongoing irritation. In brief, intestine barrier perform is crucial for protecting us wholesome, and when it’s in a compromised state, so are we! (For extra on the intestine barrier and the way leaky intestine develops, take a look at “What Is A Leaky Gut?”,  in addition to my Gut Health Fundamentals on-line course.)

So, the place does glutamine come into play?

For one, glutamine is the popular gas supply for cells lining the intestine. In actual fact, the intestinal mucosa makes use of about 30% of the physique’s complete glutamine, demanding greater than 15 grams of it per day! Our gut truly competes with different tissues in our physique to be used of glutamine from our meals and from our physique’s amino acid pool! Glutamine is required in order for these intestinal cells to develop and differentiate (mature), and does so by activating mitogen-activated protein kinases (MAPKs;  which orchestrate cell proliferation and differentiation), and by augmenting the consequences of development components (like epidermal development issue, remodeling development factor-α, and insulin-like development factor-I). In vitro research have proven that, with out sufficient glutamine, two sorts of epithelial cells (caco-2, a line of human epithelial colon most cancers cells that’s broadly used to review tight junctions and which I used to make use of for cell tradition research means again in my cell biology analysis days, and IEC-6) exhibit slowed development. Likewise, glutamine supplementation has been proven to lower mucosal atrophy and scale back oxidant harm in fashions of ulcerative colitis, because of its position in supporting intestinal epithelial cell development!

Secondly, glutamine modulates the expression of tight junction proteins, which tightly be part of collectively epithelial cells to create the intestine barrier. Experiments have proven that glutamine deprivation reduces the expression of a number of completely different tight junction proteins (together with claudin-1, ZO-1, and occludin, all of which I used to review, so simply writing that is bringing again reminiscences of hours and hours in the confocal microscopy suite), considerably will increase epithelial cell permeability (AKA leaky intestine), and outcomes in villous atrophy (when the intestinal villi erode away, like what occurs in celiac illness). And, including glutamine to glutamine-deprived cells has been proven to enhance the barrier perform, enhance the expression of ZO-1 and occludin proteins (indicating the formation of tighter tight junctions), and forestall chemically induced disruptions of the tight junctions and their permeability. Analysis utilizing caco-2 cells has proven that glutamine deprivation results in higher bacterial translocation.

Though the mechanisms aren’t fully understood but, glutamine seems to affect signaling pathways associated to completely different tight junction elements, together with the regulation of phosphorylation states of tight junction proteins through the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. On high of that, glutamine might assist keep the stability between proliferation (replica) and apoptosis (programmed loss of life) of the epithelial cells lining the gut. These cells have a fast turnover price of each 4 to 5 days, and if an imbalance happens between mobile replica versus mobile loss of life, a web loss of epithelial cells may result (which we see in situations like ulcerative colitis, celiac illness, and intestinal bacterial an infection!). A spread of mobile stressors like nutrient deprivation, lack of development issue, endotoxemia, or gut-harming brokers that make their means into our our bodies can result in elevated apoptosis. However, glutamine might play a key position in stopping this! Research have proven that glutamine supplementation suppresses the chemically-induced apoptosis of intestinal epithelial cells, and when there’s a scarcity of obtainable glutamine, apoptosis of intestinal cells will increase.

Glutamine’s anti-apoptotic properties work by a range of mechanisms. One is thru its potential to modulate mobile stress responses, together with autophagy (a catabolic course of that happens throughout metabolic stress situations, sometimes called a “Spring cleansing” of mobile organelles) and endoplasmic reticulum stress (which has been proven to set off sustained apoptosis). One other is through glutamine’s position as a precursor for the antioxidant tripeptide glutathione (GSH), which is essential for sustaining regular mobile redox standing. When glutathione is depleted, extreme oxidative stress can induce apoptosis! Moreover, glutamine can improve the expression of warmth shock proteins, which seem to modulate programmed cell loss of life by serving to cells adapt to tense situations. In animal experiments, administering glutamine to rats with sepsis was capable of considerably enhance the expression of two warmth shock proteins (HSP-70, which is my private favourite warmth shock protein as a result of I studied it throughout my PhD analysis, and HSP-25), whereas glutamine deprivation decreased the expression of warmth shock protein genes and led to elevated cell loss of life. And lastly, glutamine regulates the activation of caspases, a household of protease enzymes that act in live performance in a cascade to set off and execute apoptosis. Research have proven that glutamine-deprived cells reveal larger caspase-Three exercise, resulting in higher ranges of cell loss of life. In animal fashions and human colon most cancers cells, administering glutamine has been proven to cut back caspase exercise and shield towards apoptosis.

So, in a nutshell, glutamine is a large boon for our intestine barrier because of the some ways it retains our epithelial cells wholesome and proliferating!

Picture tailored from: Kim MH, Kim H. “The Roles of Glutamine in the Gut and Its Implication in Intestinal Illnesses.” Int J Mol Sci. 2017 Might 12;18(5):1051. doi: 10.3390/ijms18051051.

However, it doesn’t finish there! Glutamine additionally performs a job in intestinal immunity. Specifically, glutamine enhances the secretion of immunoglobulin A+ (IgA+) and intestinal secretory immunoglobulin A (SIgA), which helps defend the intestinal mucosal floor towards pathogens and enteric toxins. Glutamine can be wanted for the expansion of immune cells, and never surprisingly, glutamine insufficiency has been proven to extend susceptibility to an infection.

Glutamine and the Gut Microbiota

Together with benefiting our human cells, glutamine can affect the composition of the intestine microbiota—the huge neighborhood of microbes inhabiting our intestine, and which performs a serious position in human well being. (Be sure you take a look at What’s the Gut Microbiome? And Why Ought to We Care About It?)

Protein is crucial for the expansion and survival of the micro organism in our digestive tracks. Amino acids are utilized for the synthesis of bacterial cell elements or catabolized (damaged aside) by completely different pathways. Sure amino acids have been recognized as seemingly important for optimum development of intestine micro organism, together with arginine, aspartate, asparagine, glutamate, glutamine (yay!), glycine, lycine, serine, threonine, and the branched-chain amino acids (leucine, isoleucine, and valine). Curiously, our intestine micro organism appear to have a choice for glutamine (and arginine, which I’ll speak about in a future article), which is why it may profit intestine microbial composition.

In a trial of obese and overweight adults, consuming 30 grams of supplemental glutamine every day for 2 weeks resulted in a useful discount in the Firmicutes to Bacteroidetes ratio (from 0.85 to 0.57), decrease ranges of Actinobacteria, a change related to leanness and weight reduction. The micro organism genera Dialister, Dorea, Pseudobutyrivibrio, and Veillonella (all members of Firmicutes) additionally considerably decreased.

One investigation appeared on the intestine microbiota and a range of metabolites (together with fatty acids, lipids, glucose, and amino acids) in 531 Finnish males. The researchers discovered that glutamine ranges had been positively related to microbial richness, in addition to with larger ranges of Clostridales.

Animal research have additionally make clear the consequences of glutamine on the intestine microbiota. In a single experiment with mice, supplementing with 1% L-glutamine for 14 days resulted in a useful lower in the Firmicutes to Bacteroidetes ratio. In a rat mannequin of colon most cancers, glutamine remedy protected towards a chemotherapy-induced decline of Clostridium cluster XI and Enterobacteriaceae. Constipated animals supplemented with glutamine noticed a rise in useful members of Bacteroidetes and Actinobacteria, which performed a job in the amelioration of constipation (extra particularly, glutamine seems to cut back constipation by affecting nitrogen stability and protein synthesis in the small intestinal microbiota). A examine utilizing pregnant constipated pigs discovered that supplementing the food plan with 10 grams of glutamine was sufficient to cut back their constipation and prompted a rise in pleasant micro organism, whereas lowering ranges of the possibly dangerous micro organism Oscillospira and Treponema.

Fascinatingly, glutamine additionally appears to affect how our intestinal micro organism metabolize different amino acids. In a single experiment, the addition of glutamine to blended bacterial cultures in addition to particular person micro organism strains (together with species from Streptococcus, Escherichia coli, and Klebsiella) decreased the bacterial utilization of asparagine, lysine, leucine, valine, ornithine and serine, with larger concentrations of glutamine inflicting higher decreases in the utilization of these amino acids, known as an amino acid sparing impact. That is vital, as a result of the metabolism of amino acids by our intestine microbes impacts how a lot of them can be found for the remainder of our physique!

How one can Get the Advantages of Glutamine

So, how can we reap the gut-health rewards of glutamine? Though this amino acid is barely thought of conditionally important (that means that below regular circumstances, we will produce sufficient of it internally), sure conditions can enhance our demand past what our our bodies can provide us with. This contains instances of stress, vital sickness, an infection, wound therapeutic, trauma, extreme burns, gastrointestinal problems, and intense train (in truth, decreased glutamine concentrations might play a job in the transient immunosuppression we see following strenuous train!). In different phrases, specializing in getting loads of glutamine isn’t a nasty concept!

In our food plan, the perfect sources of glutamine embody broth, seafood (particularly crustaceans like shrimp, crab, and lobster, but additionally saltwater fish), organ meats, poultry, pork, pink meat, and protein-rich dairy. Sure plant meals like cabbage, asparagus, and broccoli are additionally wealthy in glutamine! Basically, aiming for a protein consumption of 100 to 150 grams per day, together with some glutamine-rich meals, can assist guarantee we get sufficient of this wonderful amino acid to expertise its advantages. (See additionally Why Broth is Superior, Broth: Hidden Risks in a Therapeutic Meals?, Bone Broth Dangers: Skim the Fats!, Why Fish is Nice for the Gut Microbiome, Oysters, Clams, and Mussels, Oh My! Diet Powerhouses or Poisonous Hazard?, The Mercury Content material of Seafood: Ought to we fear?, Ought to We Be Apprehensive About Radiation from Fukushima?, Grass-Fed Beef: A Superfood well worth the Premium Value, Why Everybody Ought to Be Consuming Organ Meat).

In some instances, glutamine supplementation can deliver added advantages, resembling gastrointestinal problems, intestine dysbiosis, and “leaky intestine”, whether or not main or secondary to one thing like autoimmune illness. Most profitable trials have used supplementation at ranges of 20 – 30 grams of glutamine per day. As a result of amino acids compete with different high-affinity amino acids for binding with their transporters inside the gut, it’s vital to take glutamine on an empty abdomen (an hour after meals, or 30 minutes earlier than meals) in order that our our bodies can absolutely put it to use!

Citations

Achamrah N, et al. “Glutamine and the regulation of intestinal permeability: from bench to bedside.” Curr Opin Clin Nutr Metab Care. 2017 Jan;20(1):86-91.

Dai ZL, et al. “L-Glutamine regulates amino acid utilization by intestinal micro organism.” Amino Acids. 2013 Sep;45(3):501-12. doi: 10.1007/s00726-012-1264-4. Epub 2012 Mar 24.

de Souza AZ, et al. “Oral supplementation with L-glutamine alters intestine microbiota of overweight and obese adults: A pilot examine.” Diet. 2015 Jun;31(6):884-9. doi: 10.1016/j.nut.2015.01.004. Epub 2015 Jan 29.

Gleeson M, et al. “Dosing and efficacy of glutamine supplementation in human train and sport coaching.” J Nutr. 2008 Oct;138(10):2045S-2049S.

Kim MH & Kim H. “The Roles of Glutamine in the Gut and Its Implication in Intestinal Illnesses.” Int J Mol Sci. 2017 Might 12;18(5). pii: E1051. doi: 10.3390/ijms18051051.

Lacey JM & Wilmore DW. “Is glutamine a conditionally important amino acid?” Nutr Rev. 1990 Aug;48(8):297-309.

Li N, et al. “Glutamine regulates Caco-2 cell tight junction proteins.” Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G726-33. Epub 2004 Might 6.

Morris CR, et al. “Acquired Amino Acid Deficiencies: A Concentrate on Arginine and Glutamine.” Nutr Clin Pract. 2017 Apr;32(1_suppl):30S-47S. doi: 10.1177/0884533617691250. Epub 2017 Feb 1.

Org E, et al. “Relationships between intestine microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort.” Genome Biol. 2017 Apr 13;18(1):70. doi: 10.1186/s13059-017-1194-2.

Perna S, et al. “The Role of Glutamine in the Complicated Interplay between Gut Microbiota and Health: A Narrative Evaluation.” Int J Mol Sci. 2019 Oct; 20(20): 5232.

Rao R & Samak G. “Role of Glutamine in Safety of Intestinal Epithelial Tight Junctions

Ren W, et al. “Dietary L-glutamine supplementation modulates microbial neighborhood and prompts innate immunity in the mouse gut.” Amino Acids. 2014 Oct;46(10):2403-13. doi: 10.1007/s00726-014-1793-0. Epub 2014 Jul 15.

Rao R & Samak G. “Role of Glutamine in Safety of Intestinal Epithelial Tight Junctions.” J Epithel Biol Pharmacol. 2012 Jan;5(Suppl 1-M7):47-54.

Rhode T, et al. “Glutamine, train, and the immune system–is there a hyperlink?” Exerc Immunol Rev. 1998;4:49-63.

Wang B, et al. “Glutamine and intestinal barrier perform.” Amino Acids. 2015 Oct;47(10):2143-54. doi: 10.1007/s00726-014-1773-4. Epub 2014 Jun 26.

Zhang Y, et al. “L-Glutamine Supplementation Alleviates Constipation throughout Late Gestation of Mini Sows by Modifying the Microbiota Composition in Feces.” Biomed Res Int. 2017;2017:4862861. doi: 10.1155/2017/4862861. Epub 2017 Mar 12.

The submit The Role of Glutamine in Gut Health appeared first on The Paleo Mother.

Unique supply: https://www.thepaleomom.com/the-role-of-glutamine-in-gut-health/

7 Day Detox Plan

#7 Day Detox Plan

[fqtoxicity]

New Post has been published on My Quin Story

New Post has been published on http://www.myquinstory.info/chloroquine-zinc-covid-19/

Chloroquine, Zinc & COVID-19

The Coronavirus or SAR Cov2 or COVID-19, depending on what name you prefer, continues to rage on around the world.  Chris Martenson of Peak Prosperity calls the virus the “Honey Badger” because of its reputation as being a relentless mean enemy.  It just keeps coming, often underappreciated, in its relentless growth around the globe.

I first heard of this new SARS ‘like’ virus in December.  My first sources that something was amiss were not medical sources but were instead statisticians.  Guys who were financial ‘number crunchers’ that were sounding the alarm that the numbers were not adding up, both in the disease statistics and the money markets.  I started to pay attention in a cursory fashion.

I started seriously taking notice when, shortly thereafter, a Facebook friend, who is an ex-navy seal and an individual who analyzes global flash-points as a profession, started raising the alarm.   Having been around the world extensively, even in the midst of other outbreaks, he told me that this outbreak was one to keep my eye on.  He went on to tell me to ‘have a plan in place.”

In January I started telling my family to prepare, hoping that this information was wrong.  So far, these sources have proved to be very accurate in their predictions.  As a matter of fact the number crunchers are predicting very dark times ahead for the U.S.; a perfect storm so to speak, where global supply chains, just in time inventory, and a very real and nasty pandemic, are converging to set the stage for a perfect storm.  

I have to admit it was very awkward at first and I did meet with some resistance and even ridicule from some friends but when the first wave of panic hit the U.S. those in my immediate family and even a few of my friends, were not caught up when the third stage of truth, (acceptance) set in.  When acceptance sets in, that is when toilet paper flies off the shelves according to Martenson.

Ambiguity

One thing that has fascinated me since the beginning of the COVID-19 outbreak is the ambiguity.  Having had extensive education in psychology, the various personal viewpoints about this virus and the public presentation of information regarding this virus is fascinating.  I have heard every conceivable conspiracy theory that ranges from the plausible to the outright insane.  What is really fascinating is the how various biases and paradigms create extreme barriers to truth.  

The same ambiguity that surrounds COVID-19 in a general sense, filters down, more specifically, to proposed treatments for this dreaded virus.  Again, I have heard a massive amount of speculation, and a massive amount of misinformation.  

Although my goal with this article is not to clear up all the speculation, for that feat would be insurmountable, what I can do is clear up a few bits of speculation surrounding Zinc and Chloroquine.

I have been writing about quinine on and off for the last decade in its relation to the quinolone family of antibiotics, more specifically the fluoroquinolones (FQ’s).   I have even begun a book about the Dark History of the Fluoroquinolones in which I am documenting the traceable history from quinine’s discovery through the creation of the FQ’s. You can read the first section here.

Enter Chloroquine

When Chinese scientists first started using Chloroquine to fight the COVID-19 virus I started receiving questions and comments from floxed individuals who had justifiable concerns.  The sheer amount of opinion and misinformation surrounding Chloroquine was staggering.   But before I get to the point of this article, I want to state something right up front: 

I am not a fan of any drug that is based on the quinoline pharmacophore.  I believe there is something inherently wrong with the all drugs that are based on this substrate.  There is a thread of idiosyncratic toxicity that is poorly understood that spreads out like a crack in the foundation and loosely affects all of the drugs based off of this platform.

The Zinc Connection

It has been known for a very long time that Zinc inhibits viral replication. That is why, in the past, that zinc has been used to shorten the duration or stop the onset of viruses like the common cold.  It is known that Zinc can block the replication of the coronavirus.

Researchers found that the more Zinc in the cell, the more inhibition in viral replication.

While on the surface it is great that Zinc appears to stop the replication of a viruses, it is not as simple as that. 

Zinc has a hard time entering the cell without help. 

In order for Zinc to enter the cell in needs the help of something called a “ionophore.” An ionophore is a substance which is able to transport particular ions across a lipid membrane in a cell.  In other words it makes the cell wall permeable so that Zinc can enter the cell and inhibit the viral reproduction.

Why Use Chloroquine?

Chloroquine, despite its toxicity, is a Zinc ionophore, in an of itself.   The greater the concentration of Chloroquine in the cell, the great amount of zinc (as seen in the chart to the right).

Often in drastic situations, when you are faced with a terrible foe, such as the coronavirus, scientists will look for ‘off the shelf’ treatments that do not have to go through the clinical trial testing.

We have seen this with researchers who work with FQ’s.  They do not They will often look for older drugs that, are available in sufficient quantities, and can be obtained easily to handle the situation.

Is Zinc A Treatment?

Like I mentioned earlier, it is not an easy answer.    I do know that, like toilet paper, Zinc has been flying off of the online supplement stores like crazy for the last few weeks.   The stockpiling of Zinc seems to have been caused by the same fear that caused many to stockpile toilet paper and can also be traced, in part, to the advice of a veteran pathologist, James Robb, that has circulated social media in recent days.

The following was is the excerpt from the post that caused the flury of Zinc hoarding…

“Stock up now with zinc lozenges. These lozenges have been proven to be effective in blocking coronavirus (and most other viruses) from multiplying in your throat and nasopharynx. Use as directed several times each day when you begin to feel ANY “cold-like” symptoms beginning. It is best to lie down and let the lozenge dissolve in the back of your throat and nasopharynx. Cold-Eeze lozenges is one brand available, but there are other brands available.“

In defending himself Dr. Robb said, “It was my email to my family and close friends ONLY. Someone put it on their Facebook page. It was intended to be a monologue – not a dialogue. I do not use any social media and may have been too naive about what “sharing” means today.“

Dr. Robb went on to clarify, “In my experience as a virologist and pathologist, zinc will inhibit the replication of many viruses, including coronaviruses. I expect COVID-19 [the disease caused by the novel coronavirus] will be inhibited similarly, but I have no direct experimental support for this claim. “

Robb didn’t intend, or predict, reaching a global audience, or triggering a zinc buying spree.

Zinc often needs help getting into the cell in sufficient quantities to inhibit viral replication so loading up on Zinc may not be an easy answer. 

I am not a medical doctor, but I do believe that Zinc, in general, is a good supplement for various reasons and I have taken 30mg a day with trace cooper for many years. However, in some, too much Zinc can be toxic and cause unwanted side effects including the leaching of copper from the body or interference with iron absorption.  

If I were to attempt to use Zinc as a preventative measure I would consult with a trusted medical expert and be on the lookout for the Signs and Symptoms of Zinc Overdose.

Chloroquine: History Repeating Itself

It is important to note that Chloroquine, after its discovery, was initially ignored for a decade because it was considered too toxic to use in humans.  Basically, Chloroquine was “re-discovered” during World War II by the United States because of it was desperate to find a treatment for malaria (source). 

It is my belief that nothing changed about the toxicity of Chloroquine. The U.S. Government just ignored Chloroquine’s toxicity to be able to use the drug to combat the scourge of Malaria that the G.I.’s were facing in WWII.

Will Chloroquine be used, or possibly be pushed, in the same manner to fight COVID-19?  Only time will tell.

For more information:

To learn more about Chloroquine toxicity or researching medical disorders caused by poisoning by mefloquine, tafenoquine, chloroquine, and related quinoline drugs please visit the Quinism Foundation.

Also see my article “Fluoroquinolones: Their Connection to Older Anti-Malarial Drugs” where I discuss the Chloroquine/FQ connection and also touch on Chemotherapy. 

#Advocacy #Chlo #Chloroquine #Community News #History

[glenmenlow]

Applying A Go-To-Market Lens To Your Brand

It’s a truism these days that best-in-class organizations see brand as core to their end-to-end business operations, as well as to their end-to-end customer and talent experiences. “Brand is more than a logo”; you’ve heard it, you know it.

So of course, most smart marketers ensure that any product, service or experience that their organizations deliver to their markets has been thoroughly filtered through the brand lens. The goal is that not only is it visually and verbally in lockstep with the brand standards, but the attributes of the brand are also woven in to all communications and every moment of interaction with a customer, employee or candidate, partner, supplier or other stakeholder.

This is done using brand as a core tool informing answers to some fundamental, critical questions about products and services.

And this is where the structural elements of go-to-market strategy might well be a smart set of ideas to bring into your brand development, strategy and application portfolio of tools.

Flipping The Lens Of Brand And Go-To-Market Strategy

Often, go-to-market strategy is a technical exercise rooted in the sales organization, aiming to ensure that a range of key considerations and issues have been addressed in bringing a value proposition to customers and creating the right experience. Go-to-market strategy typically addresses some key questions:

What markets do we pursue?

Which customers do we target?

Which channels fit with how our customers buy?

How do our offerings fit with our markets and channels?

What is our unique value proposition to each target customer?

Those are the basics; a robust go-to-market approach can go much deeper. Bain proposes 65 best practices across commercial system design, sales and channel effectiveness, product / portfolio, marketing effectiveness, commercial operating model and pricing.

Clearly, these issues go beyond the purview of marketing and into sales, operating model, and other areas of your business.

But regardless of how well a brand (and its management practice) is ingrained into the organization, brand tends to live at a level above specific go-to-market strategies and product / service messaging. In practice, this means that brand shapes and defines how the product and service is experienced in the marketplace. An organization will define its market and customer segments to ensure that it is exploiting the right operational and communication channels to match customer behaviors and best express the value proposition for a product / service. Brand can and should play a role in helping a leadership team define what markets should be served with what products and services; but significantly it should also be a tool to make sure that the product and service is expressed in line with a broader belief system, informing the kinds of experiences created around the product / service.

In other words, typically speaking, a business has a product or service that it believes can win in the marketplace based on its go-to-market strategy, and the brand provides a lens through which the product or service is best positioned and projected into the marketplace across all touch points and customer moments.

As brand strategy and business strategy start working together, the resulting practices begin to bring brand managers closer to and deeper into workflow and planning around innovation, service development, business model and operations. It’s therefore worth thinking about bringing go-to-market efforts into the brand strategy, development and activation realm — or at least bringing some go-to-market thinking into the brand world.

What if we were to look at a brand as a product / service rather than the more common approach of branding a product / service? Today the type of structured discipline I’m talking about is often applied only to the visual side of a brand launch. (A new logo means new business cards and truck decals across the company, etc.) But how often do you see companies reviewing and refreshing every piece of existing website content, every office space, every legacy pricing model, and every recruitment and onboarding asset based on a new verbal brand platform? And how often is a brand launch tied to specific KPI goals across business units?

So as brand strategy and business strategy become more tightly intertwined and mutually dependent — and the resulting practices begin to bring brand managers closer to and deeper into workflow and planning around innovation, service development, business model and operations — I believe that a more formal go-to-market approach will become crucial to the successful development and activation of brand strategy.

Brand As Product / Service

Admittedly, in theory this idea might appear to be pretty nebulous. In practice, however, brand fundamentals can benefit by being better informed by the more robust, tangible and operational “nuts and bolts” criteria and questions that typical go-to-market development offers.

Interestingly enough, in researching this article the vast majority of online resources focus on highly operational and tangible aspects of go-to-market: highly technical segmentation, features and benefits, pricing decisions, operating models, sales and distribution channels. It was on Wikipedia where we found the broadest, most holistic perspective on go-to-market strategy. Wikipedia suggests seven Ps of go-to-market success (augmenting the 4 Ps some of us were steeped in at school):

Product — including design, technology, usability, usefulness, value, quality, brand and warranty.

Place — including retail, wholesale, local-export and internet.

Price — including penetration strategy, cost-plus, loss leader, premium and opex vs. capex (e.g., XaaS).

Promotion — including advertising, recommendations, special offers / trial, gifts and user testing.

People — including founders, employees, culture and customer service.

Process — including service delivery, complaints and response time.

Physical evidence — including user stories, recommendations, office premises and performance / results.

“Brand” appears as a single point under “product” in this model. But I’d argue that your brand should touch and inform all of these decisions and many more (including the 65 best practices from Bain) as you bring a product or service to market.

Moreover, you could use all of these lenses as a way to help ensure that your brand itself is brought to market in a consistent, clear, impactful and sustainable manner, and that it drives tangible results across your suite of offerings and your business as a whole. What if your brand development process addresses each of these factors, making them explicitly referenced parts of your guidelines, standards and overall brand management operation?

What Next?

Many advanced brand practitioners already bring this thinking to the table. Just the same, here are three suggestions for where to take this thinking next:

1. Chicken, Or Egg? Ask yourself (and be honest): “Does brand play a role in every one of my go-to-market conversations and processes, or is it brought in at a later stage to make sure everything is ‘aligned’? Would my company’s performance and competitiveness be improved if brand thinking were present earlier?”

2. Incubator Can your brand as a go-to-market asset actually act as the starting point for R&D, innovation and product / service development conversations? For strategy reviews? HR transformations? A robust go-to-marketesque process operated through the brand lens might well be a way to unleash disruptive thinking and breakthrough ideas for innovation and improvement.

3. Permeable Membranes Brand, marketing, sales, service: typically these operate in distinct silos. Many organizations struggle to cross-fertilize and integrate thinking, practices and ideas across these business units in ways that deliver seamlessly in the market. Could go-to-market thinking help dissolve barriers in ways that bring your brand promise to reality both internally and externally? And could it be a useful discipline to apply to other aspects of organizational design and development, business model evolution, and operations?

I’d love to hear your thoughts. Let’s continue the conversation.

Contributed to Branding Strategy Insider by: Kevin Keohane, director of brand and talent strategy, PartnersCreative

The Blake Project Can Help You Grow: The Brand Growth Strategy Workshop

Branding Strategy Insider is a service of The Blake Project: A strategic brand consultancy specializing in Brand Research, Brand Strategy, Brand Growth and Brand Education

FREE Publications And Resources For Marketers

from WordPress https://glenmenlow.wordpress.com/2019/03/27/applying-a-go-to-market-lens-to-your-brand/ via IFTTT

#IFTTT #WordPress

[markjsousa]

Applying A Go-To-Market Lens To Your Brand

It’s a truism these days that best-in-class organizations see brand as core to their end-to-end business operations, as well as to their end-to-end customer and talent experiences. “Brand is more than a logo”; you’ve heard it, you know it.

So of course, most smart marketers ensure that any product, service or experience that their organizations deliver to their markets has been thoroughly filtered through the brand lens. The goal is that not only is it visually and verbally in lockstep with the brand standards, but the attributes of the brand are also woven in to all communications and every moment of interaction with a customer, employee or candidate, partner, supplier or other stakeholder.

This is done using brand as a core tool informing answers to some fundamental, critical questions about products and services.

And this is where the structural elements of go-to-market strategy might well be a smart set of ideas to bring into your brand development, strategy and application portfolio of tools.

Flipping The Lens Of Brand And Go-To-Market Strategy

Often, go-to-market strategy is a technical exercise rooted in the sales organization, aiming to ensure that a range of key considerations and issues have been addressed in bringing a value proposition to customers and creating the right experience. Go-to-market strategy typically addresses some key questions:

What markets do we pursue?

Which customers do we target?

Which channels fit with how our customers buy?

How do our offerings fit with our markets and channels?

What is our unique value proposition to each target customer?

Those are the basics; a robust go-to-market approach can go much deeper. Bain proposes 65 best practices across commercial system design, sales and channel effectiveness, product / portfolio, marketing effectiveness, commercial operating model and pricing.

Clearly, these issues go beyond the purview of marketing and into sales, operating model, and other areas of your business.

But regardless of how well a brand (and its management practice) is ingrained into the organization, brand tends to live at a level above specific go-to-market strategies and product / service messaging. In practice, this means that brand shapes and defines how the product and service is experienced in the marketplace. An organization will define its market and customer segments to ensure that it is exploiting the right operational and communication channels to match customer behaviors and best express the value proposition for a product / service. Brand can and should play a role in helping a leadership team define what markets should be served with what products and services; but significantly it should also be a tool to make sure that the product and service is expressed in line with a broader belief system, informing the kinds of experiences created around the product / service.

In other words, typically speaking, a business has a product or service that it believes can win in the marketplace based on its go-to-market strategy, and the brand provides a lens through which the product or service is best positioned and projected into the marketplace across all touch points and customer moments.

As brand strategy and business strategy start working together, the resulting practices begin to bring brand managers closer to and deeper into workflow and planning around innovation, service development, business model and operations. It’s therefore worth thinking about bringing go-to-market efforts into the brand strategy, development and activation realm — or at least bringing some go-to-market thinking into the brand world.

What if we were to look at a brand as a product / service rather than the more common approach of branding a product / service? Today the type of structured discipline I’m talking about is often applied only to the visual side of a brand launch. (A new logo means new business cards and truck decals across the company, etc.) But how often do you see companies reviewing and refreshing every piece of existing website content, every office space, every legacy pricing model, and every recruitment and onboarding asset based on a new verbal brand platform? And how often is a brand launch tied to specific KPI goals across business units?

So as brand strategy and business strategy become more tightly intertwined and mutually dependent — and the resulting practices begin to bring brand managers closer to and deeper into workflow and planning around innovation, service development, business model and operations — I believe that a more formal go-to-market approach will become crucial to the successful development and activation of brand strategy.

Brand As Product / Service

Admittedly, in theory this idea might appear to be pretty nebulous. In practice, however, brand fundamentals can benefit by being better informed by the more robust, tangible and operational “nuts and bolts” criteria and questions that typical go-to-market development offers.

Interestingly enough, in researching this article the vast majority of online resources focus on highly operational and tangible aspects of go-to-market: highly technical segmentation, features and benefits, pricing decisions, operating models, sales and distribution channels. It was on Wikipedia where we found the broadest, most holistic perspective on go-to-market strategy. Wikipedia suggests seven Ps of go-to-market success (augmenting the 4 Ps some of us were steeped in at school):

Product — including design, technology, usability, usefulness, value, quality, brand and warranty.

Place — including retail, wholesale, local-export and internet.

Price — including penetration strategy, cost-plus, loss leader, premium and opex vs. capex (e.g., XaaS).

Promotion — including advertising, recommendations, special offers / trial, gifts and user testing.

People — including founders, employees, culture and customer service.

Process — including service delivery, complaints and response time.

Physical evidence — including user stories, recommendations, office premises and performance / results.

“Brand” appears as a single point under “product” in this model. But I’d argue that your brand should touch and inform all of these decisions and many more (including the 65 best practices from Bain) as you bring a product or service to market.

Moreover, you could use all of these lenses as a way to help ensure that your brand itself is brought to market in a consistent, clear, impactful and sustainable manner, and that it drives tangible results across your suite of offerings and your business as a whole. What if your brand development process addresses each of these factors, making them explicitly referenced parts of your guidelines, standards and overall brand management operation?

What Next?

Many advanced brand practitioners already bring this thinking to the table. Just the same, here are three suggestions for where to take this thinking next:

1. Chicken, Or Egg? Ask yourself (and be honest): “Does brand play a role in every one of my go-to-market conversations and processes, or is it brought in at a later stage to make sure everything is ‘aligned’? Would my company’s performance and competitiveness be improved if brand thinking were present earlier?”

2. Incubator Can your brand as a go-to-market asset actually act as the starting point for R&D, innovation and product / service development conversations? For strategy reviews? HR transformations? A robust go-to-marketesque process operated through the brand lens might well be a way to unleash disruptive thinking and breakthrough ideas for innovation and improvement.

3. Permeable Membranes Brand, marketing, sales, service: typically these operate in distinct silos. Many organizations struggle to cross-fertilize and integrate thinking, practices and ideas across these business units in ways that deliver seamlessly in the market. Could go-to-market thinking help dissolve barriers in ways that bring your brand promise to reality both internally and externally? And could it be a useful discipline to apply to other aspects of organizational design and development, business model evolution, and operations?

I’d love to hear your thoughts. Let’s continue the conversation.

Contributed to Branding Strategy Insider by: Kevin Keohane, director of brand and talent strategy, PartnersCreative

The Blake Project Can Help You Grow: The Brand Growth Strategy Workshop

Branding Strategy Insider is a service of The Blake Project: A strategic brand consultancy specializing in Brand Research, Brand Strategy, Brand Growth and Brand Education

FREE Publications And Resources For Marketers

[joejstrickl]

Applying A Go-To-Market Lens To Your Brand

It’s a truism these days that best-in-class organizations see brand as core to their end-to-end business operations, as well as to their end-to-end customer and talent experiences. “Brand is more than a logo”; you’ve heard it, you know it.

So of course, most smart marketers ensure that any product, service or experience that their organizations deliver to their markets has been thoroughly filtered through the brand lens. The goal is that not only is it visually and verbally in lockstep with the brand standards, but the attributes of the brand are also woven in to all communications and every moment of interaction with a customer, employee or candidate, partner, supplier or other stakeholder.

This is done using brand as a core tool informing answers to some fundamental, critical questions about products and services.

And this is where the structural elements of go-to-market strategy might well be a smart set of ideas to bring into your brand development, strategy and application portfolio of tools.

Flipping The Lens Of Brand And Go-To-Market Strategy

Often, go-to-market strategy is a technical exercise rooted in the sales organization, aiming to ensure that a range of key considerations and issues have been addressed in bringing a value proposition to customers and creating the right experience. Go-to-market strategy typically addresses some key questions:

What markets do we pursue?

Which customers do we target?

Which channels fit with how our customers buy?

How do our offerings fit with our markets and channels?

What is our unique value proposition to each target customer?

Those are the basics; a robust go-to-market approach can go much deeper. Bain proposes 65 best practices across commercial system design, sales and channel effectiveness, product / portfolio, marketing effectiveness, commercial operating model and pricing.

Clearly, these issues go beyond the purview of marketing and into sales, operating model, and other areas of your business.

But regardless of how well a brand (and its management practice) is ingrained into the organization, brand tends to live at a level above specific go-to-market strategies and product / service messaging. In practice, this means that brand shapes and defines how the product and service is experienced in the marketplace. An organization will define its market and customer segments to ensure that it is exploiting the right operational and communication channels to match customer behaviors and best express the value proposition for a product / service. Brand can and should play a role in helping a leadership team define what markets should be served with what products and services; but significantly it should also be a tool to make sure that the product and service is expressed in line with a broader belief system, informing the kinds of experiences created around the product / service.

In other words, typically speaking, a business has a product or service that it believes can win in the marketplace based on its go-to-market strategy, and the brand provides a lens through which the product or service is best positioned and projected into the marketplace across all touch points and customer moments.

As brand strategy and business strategy start working together, the resulting practices begin to bring brand managers closer to and deeper into workflow and planning around innovation, service development, business model and operations. It’s therefore worth thinking about bringing go-to-market efforts into the brand strategy, development and activation realm — or at least bringing some go-to-market thinking into the brand world.

What if we were to look at a brand as a product / service rather than the more common approach of branding a product / service? Today the type of structured discipline I’m talking about is often applied only to the visual side of a brand launch. (A new logo means new business cards and truck decals across the company, etc.) But how often do you see companies reviewing and refreshing every piece of existing website content, every office space, every legacy pricing model, and every recruitment and onboarding asset based on a new verbal brand platform? And how often is a brand launch tied to specific KPI goals across business units?

So as brand strategy and business strategy become more tightly intertwined and mutually dependent — and the resulting practices begin to bring brand managers closer to and deeper into workflow and planning around innovation, service development, business model and operations — I believe that a more formal go-to-market approach will become crucial to the successful development and activation of brand strategy.

Brand As Product / Service

Admittedly, in theory this idea might appear to be pretty nebulous. In practice, however, brand fundamentals can benefit by being better informed by the more robust, tangible and operational “nuts and bolts” criteria and questions that typical go-to-market development offers.

Interestingly enough, in researching this article the vast majority of online resources focus on highly operational and tangible aspects of go-to-market: highly technical segmentation, features and benefits, pricing decisions, operating models, sales and distribution channels. It was on Wikipedia where we found the broadest, most holistic perspective on go-to-market strategy. Wikipedia suggests seven Ps of go-to-market success (augmenting the 4 Ps some of us were steeped in at school):

Product — including design, technology, usability, usefulness, value, quality, brand and warranty.

Place — including retail, wholesale, local-export and internet.

Price — including penetration strategy, cost-plus, loss leader, premium and opex vs. capex (e.g., XaaS).

Promotion — including advertising, recommendations, special offers / trial, gifts and user testing.

People — including founders, employees, culture and customer service.

Process — including service delivery, complaints and response time.

Physical evidence — including user stories, recommendations, office premises and performance / results.

“Brand” appears as a single point under “product” in this model. But I’d argue that your brand should touch and inform all of these decisions and many more (including the 65 best practices from Bain) as you bring a product or service to market.

Moreover, you could use all of these lenses as a way to help ensure that your brand itself is brought to market in a consistent, clear, impactful and sustainable manner, and that it drives tangible results across your suite of offerings and your business as a whole. What if your brand development process addresses each of these factors, making them explicitly referenced parts of your guidelines, standards and overall brand management operation?

What Next?

Many advanced brand practitioners already bring this thinking to the table. Just the same, here are three suggestions for where to take this thinking next:

1. Chicken, Or Egg? Ask yourself (and be honest): “Does brand play a role in every one of my go-to-market conversations and processes, or is it brought in at a later stage to make sure everything is ‘aligned’? Would my company’s performance and competitiveness be improved if brand thinking were present earlier?”

2. Incubator Can your brand as a go-to-market asset actually act as the starting point for R&D, innovation and product / service development conversations? For strategy reviews? HR transformations? A robust go-to-marketesque process operated through the brand lens might well be a way to unleash disruptive thinking and breakthrough ideas for innovation and improvement.

3. Permeable Membranes Brand, marketing, sales, service: typically these operate in distinct silos. Many organizations struggle to cross-fertilize and integrate thinking, practices and ideas across these business units in ways that deliver seamlessly in the market. Could go-to-market thinking help dissolve barriers in ways that bring your brand promise to reality both internally and externally? And could it be a useful discipline to apply to other aspects of organizational design and development, business model evolution, and operations?

I’d love to hear your thoughts. Let’s continue the conversation.

Contributed to Branding Strategy Insider by: Kevin Keohane, director of brand and talent strategy, PartnersCreative

The Blake Project Can Help You Grow: The Brand Growth Strategy Workshop

Branding Strategy Insider is a service of The Blake Project: A strategic brand consultancy specializing in Brand Research, Brand Strategy, Brand Growth and Brand Education

FREE Publications And Resources For Marketers