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dailyfigures · 4 months

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Hatsune Miku ; Vocaloid ☆ PLM

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kalid796 · 6 months

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From the river to the sea, Palestine will be free.

#quotes #art #free palestine #gaza #palestine #gazaunderattack #free gaza #gaza strip #save gaza #palestinians #middle east #occupation #genocide #palestinian lives matter #plm

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cbirt · 2 months

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In living organisms, different types of proteins are essential for a variety of critical processes. The structural and functional diversity of many protein types is greatly influenced by post-translational modifications (PTMs), which allow cells to respond to changes in their environment and control intricate biological processes. Though they do not take into consideration the effects of PTMs, large protein language models (pLMs) such as ESM-2 and ProtT5 precisely capture the structural, functional, and physicochemical features of input protein sequences, they only scratch the surface of proteome diversity. By adding PTM tokens to the pLM training regimen, researchers bridge this significant gap in protein sequence modeling.

In this study, Duke University researchers introduce PTM-Mamba, a PTM-aware Protein Language Model that makes use of an extensive collection of PTM tokens to enhance performance on a range of PTM-specific tasks. The model vocabulary gets around Transformers’ quadratic time complexity using effective hardware-aware primitives. The first and only pLM that inputs and representations wild-type and PTM sequences in a unique way is PTM-Mamba. This makes it ideal for downstream modeling and design applications that are tailored to post-translationally modified proteins.

#bioinformatics #ptm #protein #plm #llm #ai #science news

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publicite-francaise · 6 days

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Cannes, PLM, par Henri Tanconville (Henri Garnier), 1910.

#Henri Tanconville #1910 #PLM #cannes #tourisme #transport

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frenchcurious · 9 months

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PLM-Wagon 1947. - source Martha Ghaly Szabo via Golden Age Of Travel 1830-1955.

#plm #louis maes ainé #belgique

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propadv · 1 year

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1935 Teleski Combloux PLM

Source: Pinterest / Fabienne Jerot

Published at: https://propadv.com/railroad-poster-and-ad-collection/chemins-de-fer-de-paris-a-lyon-et-a-la-mediterranee-poster-and-ad-collection/

#1935 #PLM #Combloux #Railway #Railroad #Travel #Ad #Advert #Advertising #Poster

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dysco-lymonade · 11 months

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Smut ask: your take on penis wings please! Jk. First time Clexa uses a glass toy?

Dear god not the 🍆 🪽

Don’t bring that shit over here! 😂

Anyways, moving on to the ass glass.

Unedited nonsense involving anal so like, read at your own risk, aight? And go easy on me this is a first for me to write 😂

It’s Clexa’s one year anniversary and Raven sent Clarke off with a little black gift bag, and told her she and Lexa had to open it together.

“It’s from Raven, I’m afraid to open it.” Clarke deadpans as she enters Lexa’s apartment.

Lexa just rolls her eyes and takes the bag from Clarke, reaching inside and unsure what she’s feeling in her hand as she’s removing the item.

She bursts out laughing when she sees the small glass butt plug. It’s rainbow marbled in color with a bright red heart on the end.

“I’m going to fucking kill her.” Clarke reaches for the plug to toss it back in the bag.

Lexa, still laughing, spins away from her girlfriend. “Now wait a minute,” she turns a bit more serious, bites her lip, and gives Clarke a little smirk. “I could be into it.”

Clarke’s ears perk up at this. They’ve yet to explore this territory.

-

After a bath filled with wandering hands and half a bottle of wine, they stumble into the bedroom.

“You sure, baby? We can forget we even have this thing.” Clarke checks in one more time.

“I trust you.” Lexa reaches into the nightstand for the little bottle of flavored lube they keep handy, and tosses it onto the bed next to the glass plug.

And with that, they fall into the bed in a tangle of limbs, bath towels forgotten.

They’re so worked up from their time in the bathtub that Clarke gets straight to work with her tongue between Lexa’s legs.

“Turn over for me, gorgeous.” Clarke gives a light slap to the side of Lexa’s thigh.

Lexa wastes no time in rolling over onto her stomach. Clarke sits back on her haunches and grasps Lexa firmly by the hips, hoisting her up onto her knees.

It pulls a cute little squeal out of Lexa when Clarke gives a couple of light smacks to her ass and a murmured, “Good girl.”

Clarke starts off by fingering Lexa’s pussy, slow and deep, working her into a writhing mess bent in front of her. She’s pushed herself up onto her forearms, and looks over her shoulder to tell Clarke she’s ready.

Without missing a beat, Clarke grabs the lube, flicks the cap open, and let’s a small stream fall right where they need it. She sends Lexa a teasing grin after she yelps at the cold and proceeds to warm the lube up while gently running her fingers around the tight ring.

Clarke slowly pulls her fingers from Lexa’s pussy, and starts to press one finger just slightly inside of Lexa’s ass, letting the lubricant in.

“Try to relax, cutie.” Clarke gently massages Lexa’s ass cheeks as she slowly works her finger little by little deeper inside. “You’re doing really well, baby.”

“Fuck.” Lexa gasps out once Clarke’s finger is pushed all the way in. “God, Clarke. I didn’t know it would feel like this.”

“Ready for a little more?” Clarke runs her hand up Lexa’s spine, and brings her nails back down, scratching just hard enough for a few faint red scratches to appear on Lexa’s flushed skin.

Lexa pushes her hips back into Clarke in response and breathes a sigh when she feels Clarke start to pull her finger out, just slightly, and push it back in. While she’s slowly fucking into Lexa’s ass, Clarke pours lube onto the plug with her free hand, duvet cover be damned.

She warms the plug in her hand, rolling it around to make sure it’s nice and lubed up.

Lexa has relaxed enough that Clarke’s not feeling much resistance anymore.

“You ready, babe?” Clarke brings the plug up so the top is ready to push in when she removes her fingers.

Lexa nods frantically and moans out an affirmative, not quite able to form words.

Clarke makes the switch and Lexa takes it like a seasoned champ. The plug, just a bit thicker than Clarke’s finger, slides in with little resistance. Clarke pushes it in slowly, eyes constantly watching Lexa for any signs of discomfort.

“Fuck, Lex, you are so goddamn sexy.” The plug is all the way in, and Clarke has to take a moment to appreciate the sight of her girlfriend looking so goddamn pleased with herself as she gives her ass a little wiggle when she looks back at Clarke.

“Is it a look? Should we send Raven a picture?” Lexa, the little shit, teases and Clarke practically growls at the thought of sharing this sight with anyone else.

“Oh it’s a look. And I’ll take a picture for you to see. But first, I owe you an orgasm.”

Clarke stands from the bed and swiftly pulls Lexa down to the edge, earning herself an excited squeak from her girl. Still on all fours, Lexa pushes her knees apart wider, bringing her pelvis down closer to the bed, and opening up beautifully for Clarke to devour from behind.

#anon #smut asks #pretty little mess #plm #ankle monitor au #when did my blog turn into filth?#not mad about it but damn this took a turn 😂

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little-princeesss · 2 years

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✨you’re getting attached again. just keep in mind what happened to you last time.✨

#terminato #imbecilo #plm #cheated #left

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cuprikorn · 1 year

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