#Liver cancer

[the-kitty-hell-system]

YALL NEVER TAKE CANCER PATIENTS FUCKING SERIOUSLY DO YOU? OH SO I HAVE TO SPOILER MY GODDAMN CONDITION THAT AFFECTS ME WAY MORE THAN IT DOES YOU BECAUSE YOURE UNCOMFORTABLE WITH KNOWING I HAVE CANCER? IM NAWT EVEN TALKING ABT DEATH, I DO PUT A TW FOR DEATH. IM SO DONE BEING TREATED LIKE NONE SHOULD EVER HEAR MY VOICE AND MY EXPERIENCES BECAUSE IN UR MINDS ALL OTHER CONDITIONS R OK TO TALK ABT EXCEPT CANCER. FUCK OFF

#angry cripple #tw caps #tw swearing #cancer #cancer posting #liver cancer #tw death #(just a mention doe) #cripple posting #cripple punk #cripplepunk #cpunk #affo ramble #affo rant

[cbirt]

Scientists Developed a Novel AI Blood Test ‘DELFI’ for Early Detection of Liver Cancer

Scientists from Johns Hopkins Kimmel Cancer Center developed and used artificial intelligence blood testing technology. The new blood testing technology detected liver cancer in more than 80% of participants in a study of 724 people. The technology, which uses a machine learning algorithm to analyze blood samples, showed promise in a previous study for detecting lung cancer. The new study, reported in the journal Nature Medicine, found that the technology was able to detect liver cancer with high accuracy in a real-world setting.

Globally, liver cancer is one of the leading causes of cancer mortality. Identifying individuals at high risks, such as those with cirrhosis and viral hepatitis, can improve survival rates, but current screening methods are inadequate. 

Continue Reading

#bioinformatics #liver cancer #liver cirrhosis #artificial intelligence #machinelearning #health tech #cancer diagnosis #100daysofcode #scicomm #medcomm #stem #health #science news

[snowflaketree]

#livercancerawareness #liver cancer #go fund me #anything helps #rent #treatment #help #please help #mother #food

[bpod-bpod]

Mutation Models

Fibrolamellar carcinoma (FLC) is an often fatal liver cancer affecting young people. The molecular mechanisms driving it are unclear, partly because of a lack of experimental models. Researchers now create human liver organoids (pictured using fluorescent microscopy) of healthy liver tissue (top, left) and, using genetic engineering technology, CRISPR, those that replicate liver with the different genetic faults found in FLC. Most common is the fusion of genes DNAJB1 and PRKACA (top, right), and also found are faults in PRKAR2A and BAP1 genes separately and together (bottom, left to right). FLC organoids mimicked tumour samples from patients and their liver cells regressed to an immature state. However, only faulty BAP1 and PRKAR2A together caused liver cells to turn into progenitor-like cells that, unlike normal liver cells, could grow in liver ducts. Meanwhile, DNAJB1-PRKACA organoids showed milder cancer features compared with other FLC organoids. Together, these FLC models hold promise for studying FLC progression.

Written by Lux Fatimathas

Image from work by Laura Rüland and colleagues

The Princess Maxima Center for Pediatric Oncology, and the Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Utrecht, The Netherlands

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, May 2023

You can also follow BPoD on Instagram, Twitter and Facebook

#science #biomedicine #liver cancer #liver #cancer #CRISPR editing #crispr/cas9 #immunofluorescence #organoids #fusion gene

[mcatmemoranda]

LI-RADS® was created to standardize the reporting and data collection of CT and MR imaging for hepatocellular carcinoma (HCC).

Liver CA is the only type of cancer that can be diagnosed without needing a tissue sample. I remember learning that via OnlineMedEd. This is showing the LI-RADS categories.

#LIRADS #HCC #liver cancer #hepatocellular liver cancer

[lunarian-anarchist]

Hey if y'all could reblog this I'd really appreciate it. Paul is from my temple and his dad needs help with treatment.

#liver cancer #colon cancer #medical expenses #medical billing

[lastlycoris]

Liver transplantation.

The one time you might actually want cancer.

Why? Because having a primary liver cancer bumps you up on the liver transplant list. But it can't just be any cancer - there's a criteria for acceptable cancer burden for adult liver transplant, which is known as Milan Criteria. Essentially one big tumor smaller than 5 cm or 3 small tumors less than 3 cm each. The tumor can't have left the liver either aka metastasis. However if it's too small (<2 cm ), you don't get priority listing for having that cancer. Kind of like Goldilocks - the tumor has to be just right.

Now first off, you almost never get a primary liver tumor aka hepatocellular carcinoma (HCC) without something wrong in the liver in the first place.

This is usually Cirrhosis aka fibrosis of the liver, which can be caused by Hepatitis C or more commonly drinking too much alcohol too often. The liver fails cause its cells are dead or dying, and the resulting scarring prevents blood from your GI tract from returning properly to your systemic blood. This pseudo-blockage results in fluid backing up in your body, resulting in ascites (fluid in the belly) and pleural effusion (fluid in the lung space) and generalized soft tissue swelling.

The body tries to compensate for this by making alternate paths. Problem is the liver is also a filter, and bypassing the filter through an alternate path affects the brain - a common symptom is confusion and sometimes coma in these patients. Official term is hepatic encephalopathy.

Cirrhosis patients can also literally turn yellow because bilirubin, which occurs from the normal breakdown of red blood cells, can't be processed well by a dysfunctional liver. Liver does a lot of other important stuff too, but I'd go on forever with that - so I'll end that here.

In any case, the only treatment for cirrhosis is getting a new liver - once cirrhosis occurs, it cannot reverse, only worsen. The liver transplant list uses its own criteria known as MELD which I also won't get into here, but generally the sicker you are, the higher you are on the transplant list.

Cirrhosis is essentially a breeding ground for primary liver cancer because cirrhosis is essentially repeated constant inflammation - and all it takes is one cell to heal in the absolutely worst way - and then you have a cancer. This is why cirrhosis patients get yearly liver imaging screening to detect that.

Milan Criteria was created because a good number of liver transplants in cancer patients turned out to have recurrent liver cancer in the new liver. After Milan was implemented, long-term recurrence-free survival improved from 30% to 75%. I believe the sizes used in Milan acts as a surrogate for the likelihood of microscopic metastasis, cancer that's left the liver but too small to be seen in imaging, but don't quote me on that.

Now why did I bring this up? One of the residents asked out loud about why we don't just cut out the cancer.

For one, cirrhosis ensures another one will pop up eventually, and for two, cutting a cancer out also means cutting out good tissue (or semi-okay in a cirrhotic's case) to create the disease-free margin. You don't have much good tissue left in a cirrhosis liver.

You could ablate the cancer by frying it with heat or freezing it, but you again have the issues of damaging normal tissue. Typically excision or ablation is done when there's no chance patient will get a donor liver.

There's also TACE (transarterial chemoembolization) which can be used to shrink tumors, usually back into the limits imposed by Milan criteria. Because if your cancer is too big for Milan, you don't get a liver. There are strict rules for that, and if you break them, your liver transplant service is not getting donor livers.

#liver cancer #cancer tw // #medical //

[bihansthot]

I just have to laugh at this point because I don’t know what else to do, I may have a cancerous lesion on my liver. All I know right now is no bullshit cancer is killing me, I’m going out on my terms, choking to death on Big Matthew’s cock.

#liver cancer #tw: cancer #i give up #this is just ridiculous #fuck everything #bm #nsft

[shartyfart]

https://www.gofundme.com/f/brandy-ziede-pay-for-medical-expenses?utm_campaign=p_cp+share-sheet&utm_content=undefined&utm_medium=copy_link_all&utm_source=customer&utm_term=undefined

heyyy my friends mom has cancer and she has an appointment next month, theyd rlly appreciate donations

#cancer #cancer awareness #go fund them #gofundme #go fund him #liver cancer #pls help

[rjzimmerman]

Excerpt from this story from Inside Climate News:

The ubiquity of the toxic class of substances commonly known as “forever chemicals” is well established. Now, medical researchers have zeroed in on their effects on a crucial component of the human body’s internal filtration system: the liver.

In a peer-reviewed study published this month in JHEP Reports, a sister publication of the Journal of Hepatology, researchers at the Keck School of Medicine at the University of Southern California found that people who had the highest levels of exposure to the chemical perfluorooctane sulfonic acid were 4.5 times more likely to develop liver cancer than those with the lowest exposure.

Scientists’ understanding of the effects of “forever chemicals” has steadily evolved since 2015, when researchers observed that the chemicals—varieties of perfluoroalkyl and polyfluoroalkyl substances, known by the acronym PFAS (pronounced PEE-fahs”)—were present in over 95% of blood serum samples collected from the general U.S. population. Last year, scientists noted the presence of PFAS for the first time in the snow and melted water at the summit of Mount  Everest.

PFAS are known as forever chemicals because of the slow rate at which they break down in the environment and their persistence in accumulating in the human body and other organisms. Commonly used in such household items as nonstick pans, cleaning products and stain-resistant coatings on fabrics and carpet, they have been shown to increase the risk of certain cancers, suppress immune system response, decrease fertility and lead to developmental delays in children.

Although earlier research had linked occurrences of liver cancer in animals to PFAS, the study is one of the first that connects the most common form of liver cancer in humans, hepatocellular carcinoma, to the chemicals.

Jesse Goodrich, an environmental epidemiologist who served as one of the study’s lead authors, said he and his colleagues examined blood samples collected from participants in a large-scale research project conducted in 1999-2000 and then tracked the health histories of those participants two decades later.

#forever chemicals #liver cancer #poly- and perfluoroalkyl substances #PFAS

[katiescancerjourney]

Scares, July+ 2022

I initially was going to write about each scare in detail, but I have been rather overwhelmed lately and do not want to feel like keep up with my blog is homework, which frankly, it kind of does right now. Homework I gave to myself! lol. Maybe one day I'll lay each one out in their own post, but for now, this is a condensed version.

The last couple of months have been difficult, to put it lightly. Starting with anaphylactic shock which was horrifying, then my sacrum pain increasing to the point where radiation was an absolutely necessary next step. There are lost of side effects connected to radiation but the standout one I learned about was the potential of going into menopause… at the age of 34… putting the nail in the coffin for child birth. I was gutted. Luckily after many fights with my insurance, I was approved for proton radiation which lowers those chances. But still, well, fuck you sacrum tumor.

Due to the pain, I had to go on a 24/7 opioid regiment that has introduced many unwanted side effects, the most awful being, often not feeling like myself. I had emergency scans, procedures and exams due to extreme bloating in my abdomen, an ultrasound for swelling in my foot and a blood transfusion because of low hemoglobin levels. Next I needed a pelvic scan and exam for the extreme nerve pain that has taken over my rectum and genitals, which could be referred pain from my sacrum tumor, or could be a whole new issue to add to the pile. I’ve needed to change and increase my meds 3 times to keep up with the relentless increasing pain, making my daily pill count to almost 40. All the while, my liver enzymes have been shooting up week after week, excluding me from chemo and resulting in the need for liver duct stents.

And after going through all of that, not having 1 full week of peace for months, now, when I look in the mirror and see yellow eyes staring back at me, and I see dark urine every time I pee, and it’s impossible not to go there, to not think, for maybe the first time since this all began, that I might not make it.

After my last appointment with my main oncologist, I came out of her office, sat down in the waiting room and leaned back against the wall. I started to tear up as I fidgeted on hemorrhoid pillow, which I literally cannot sit without anymore. My dad asked if I wanted to go lay down on the couch that was free and I said yes. I walked over to the couch, curled up in the fetal position, brought my arms up over my face and sobbed. Not 30 seconds later I felt him sit down next to me and he started rubbing my head. I sobbed and calmed down and sobbed and calmed down, over and over. When I finally brought my arms down and looked up, Dad and Kim's eyes looked like mine, tired and sad. So yeah, I think that's where we're all at right now.

I got some pretty incredible advice from my support group last night which was to stop and look around at everything I have. To see that I’m at one of the best hospitals in the world, my doctor is a fucking legend, I’m getting an amazing type of radiation that is very difficult to get approved and I’m already set up for the liver duct procedure. I’m as ready as anyone could be. They said I need to go on autopilot for a little while. It’s time to trust the doctors, trust the plan, take a deep breath, and let it all go. Autopilot here I come.

#cancersucks #katiesmithsfightclub #katiesfightclub #coloncancer #stage4cancer #coloncancerawareness #livercancer #liver cancer #colon cancer #fuck cancer

[the-kitty-hell-system]

kinda hating how cancer and chemotherapy and shit is such a hush topic like. yes i dont have hair because of chemotherapy that i am on because i have liver cancer. why are you telling me to not talk abt the CONDITION that affects me more than it does you. like ur not the one who COULD die from this and needs a transplant?

#tw death #cancer #chemotherapy #cpunk #cripple punk #physical disability #actually disabled #disability #liver cancer #affo ramble #affo rant

[wotchergiorgia]

today I dissected a heart, a brain and a liver for the first time in my life and I couldn't be happier.

#medicine #med studyblr #dissection #brain dead #a piece of heart #liverhealth #liver cancer #dissectible #dissective #med school #white coat

[marmotclaw]

Ravenpaw

Warrior name: Ravenflight

Name meaning: Usually black, mysterious, clever, free thinker

Small, sleek, skinny, jet-black demi-tom with a tiny white dash on his chest and amber eyes. He has a long, thin, white-tipped tail.

Cause of death: Liver cancer at 7.75 years

Voice claim: Spike Spencer

Family and Education

Mother: Dappletail

Father: Patchpelt

Brothers: Featherkit, Longtail, Dustpelt

Sibling: Cricketkit

Mate: Barley

Mentor: Tigerstar

Unofficial Apprentices: Bellaleaf, Rileypool

Nature

INFP

Lawful good

Condition(s): Generalised Anxiety, PTSD

Social

Platonic Love: Bellaleaf, Dappletail, Dustpelt, Patchpelt, Rileypool, Violet

Romantic Love: Barley

Friend(s): Firestar, Greystripe, Redtail, Sandstorm

Enemies: Bone, Hoot, Jumper, Scourge, Snapper, Tigerstar, Willie

Favourite food: Adder

#warrior cats #warriors #deceased #starclan #thunderclan #lionclan #loner #ravenpaw #raven- #-paw #infp #lawful good #disabled #generalized anxiety disorder #ptsd #cancer #liver cancer #tpb #tnp

[bpod-bpod]

Liver Delivery

Worldwide, obesity has tripled since 1975, creating a global health crisis. Being obese increases our risk of 13 different cancers, including the most common liver cancer, hepatocellular carcinoma (HCC). If you have HCC, being obese increases your risk of dying by up to four times. Understanding how obesity triggers this cancer is key to identifying at-risk people and finding new treatments. Here, we see a liver (red) from a mouse missing the BNIP3 gene. When scientists treated mice with a chemical that causes HCC, tumours (white) grew faster and bigger in those lacking BNIP3. Researchers also showed that people with HCC and low BNIP3 activity have fattier livers and worse survival rates. This gene slows the growth of HCC by delivering fat stores in the liver to our cellular disposal machinery. Finding ways to switch BNIP3 back on in HCC could be a new strategy to treat the disease.

Written by Henry Stennett

Image from work by Damian E. Berardi and Althea Bock-Hughes, and colleagues

The Ben May Department for Cancer Research, The Gordon Center for Integrative Sciences, W-338, The University of Chicago, Chicago, IL, USA

Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Science Advances, October 2022

You can also follow BPoD on Instagram, Twitter and Facebook

#science #biomedicine #liver #hepatocellular carcinoma #cancer #liver cancer #obesity #fat #tumours #gross appearance #oncology

[drpriya]

The following tips may be helpful in the prevention of liver diseases:

Quit alcohol consumption

Do not take more than the recommended dose of OTC medications

Do not take the maximum recommended dosage of a particular medicine for an extended period of time

Follow the doctor’s drug prescription dosage precisely

Inform your doctor about any supplements or drugs that you may be taking

Get addiction treatment if you are a drug or alcohol abuser

Avoid taking medicines containing phenytoin or acetaminophen if you have a known liver disease 

Follow safety rules while using any solvents or chemicals at work

Keep all the medicines and drugs at your home at a place where they are out of reach for children 

There are many hospitals in Bangalore where liver transplant is done with great success.

#health #fatty liver #liver failure #liver transplant #liver disease #liver cancer #liver cirrhosis #hepatitis