#Glutathione and Gastrointestinal Disease

[glutathione12]

Glutathione (GSH) is often termed the “master antioxidant”.  This tripeptide is ubiquitous in nature and is produced by every organism from bacteria, to plants to animals that derives energy from oxidative phosphorylation and respiration.  Glutathione is synthesized in the cytosol of each cell by the action of two enzymes in an elegantly regulated system that allows it to be maintained at different homeostatic levels in different tissue types, with the liver, given its detoxification role, having the highest amounts.  Glutathione plays a pivotal role in most key physiological functions including but not limited to maintenance of cellular redox, neutralising free radicals,  cell cycle regulation, proliferation, apoptosis, xenobiotic metabolism, and the recycling of other cellular antioxidants such as Vitamins C and E.  Glutathione depletion and a corresponding increase in reactive oxygen species (ROS) during microbial infection is a key driver of the immune response and inflammation. Most chronic diseases are related to oxidative stress arising from the affected tissue losing the capacity to maintain glutathione at adequate healthy levels. The severity of many poisonings from drugs, alcohol, heavy metals and environmental toxins are related to an acute depletion of cellular glutathione.  Progressive depletion of cellular glutathione is also used as a mechanism by many viruses to control their replication cycle during infection.

#what is the difference between acute and chronic inflammation #glutathione and chronic inflammation #chronic glutathione depletion #glutathione & inflammation #glutathione and the immune system #Glutathione and Homeostasis #Glutathione Homeostasis #Glutathione and the human body #Glutathione Benefits for Your Health and Body #Glutathione and the aging process #glutathione oxidative stress and aging #glutathione and cancer treatment #glutathione and cancer #role of glutathione in cancer #Glutathione and Gastrointestinal Disease

[spookydonutchild]

#glutathione & inflammation #glutathione and the immune system #Glutathione and Homeostasis #Glutathione Homeostasis #Glutathione and the human body #Glutathione Benefits for Your Health and Body #Glutathione and the aging process #glutathione oxidative stress and aging #glutathione and cancer treatment #glutathione and cancer #role of glutathione in cancer #Glutathione and Gastrointestinal Disease #Glutathione and Lung Disease #glutathione benefits for lungs #Glutathione and Neurodegenerative Disease

[cymbaltawithdrawals]

What Is NAC (N-Acetyl Cysteine) Supplement?

N-acetyl cysteine (NAC) is a synthetic form of cysteine, which is a semi-essential amino acid. Once consumed, NAC breaks down into cysteine, which is then metabolized to glutathione. Glutathione is an important antioxidant for the immune system functioning, detoxification, tissue building and repair.

NAC Benefits Health

There are several health claims surrounding the use of NAC supplements. Some of these claims suggest improved mental health, protection against certain viruses, and relief from respiratory symptoms, although the Food and Drug Administration (FDA) hasn’t approved many of them.

Low levels of glutathione are linked to numerous health conditions, such as aging-related issues, diabetes, and heart disease. Therefore, glutathione supplementation is often recommended to prevent or treat diseases. NAC is frequently used as a precursor to glutathione as it can help achieve higher glutathione levels. However, while NAC is associated with numerous health benefits, many of these claims lack sufficient evidence from human-based research.

NAC is a commonly used, and FDA-approved drug for treating acetaminophen poisoning. Large doses of acetaminophen can cause liver damage, and prompt administration of NAC is essential as it can reduce the extent of liver damage by increasing glutathione levels, which is a powerful detoxifier in the liver.

There is evidence to suggest that NAC may help treat certain respiratory conditions, such as chronic bronchitis or chronic obstructive pulmonary disease (COPD). This is because NAC can break apart and thin mucus secretions in the airways, which makes it easier to clear the airway through coughing.

Preliminary evidence also suggests that NAC may improve certain mental health conditions, such as schizophrenia, mood disorders, substance use disorders, and obsessive-compulsive disorder (OCD). However, more research is required to determine the effectiveness of NAC in treating these conditions.

Some research suggests that NAC may improve brain health and help reduce symptoms associated with neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. It may also help relieve neuropathic pain caused by central nervous system damage.

NAC supplements may also offer some benefits for people struggling with viral infections. Research suggests NAC works against viral infections by boosting the immune system, reducing inflammation, and preventing the replication of viruses.

Some studies suggest that NAC may help improve sperm quality and reduce oxidative stress in infertile men. It may also have the potential to help slow the progression of chronic kidney disease (CKD).

Potential Adverse Effects of N-Acetylcysteine (NAC)

N-Acetylcysteine, commonly known as NAC, is generally considered a safe supplement. However, some individuals may experience side effects when taking NAC.

The most common adverse effects of NAC include gastrointestinal (GI) symptoms like nausea, vomiting, or diarrhea, low blood pressure, anaphylactic reactions such as a rash, swelling, tightness in the chest, or difficulty breathing, increased heart rate, dizziness, or lightheadedness.

Although most of the side effects of NAC are mild, the supplement may not be suitable for everyone. People with specific medical conditions should avoid taking NAC. Individuals with cystinuria, a rare kidney stone condition, or a bleeding disorder should not take NAC. If you are aware of being allergic to NAC, you should also avoid taking it.

Furthermore, high doses of NAC can potentially elevate the levels of homocysteine, an amino acid linked to heart disease, warns Dr. Liu. Therefore, it is essential to speak with your doctor before taking NAC, especially if you have any underlying health concerns or are taking other medications.

According to Dr. Johnson-Arbor, you should tell your doctor about all the medications you are taking, including over-the-counter products, prescription drugs, and dietary supplements. Your doctor can evaluate your medication regimen for potential side effects and check your medication list to ensure that you are not at risk of experiencing drug-to-drug interactions.

It's also important to choose a reputable brand when purchasing NAC supplements. As dietary supplements are not regulated by the FDA for safety or effectiveness, it's essential to conduct research and choose a brand that includes high-quality ingredients. One way to ensure the quality of the supplement is to opt for a brand that has been verified through the US Pharmacopoeial (USP) Convention Dietary Supplement Verification Program, indicating that the supplement has undergone third-party testing.

In conclusion, N-Acetylcysteine may provide numerous health benefits, but it's crucial to talk with your doctor before adding NAC to your regimen to ensure that the potential benefits outweigh the risks.

#NAC #antidepressant

[researchrealmblog]

Glutamic Acid is Beneficial for You in Many Ways

Glutamic acid is regarded as the amplest amino acid. It is the most prevalent form of glutamate found in the human body and is considered a non-essential amino acid for the reason that human bodies can create it from other amino acids.

It is extensively found in the brain and muscles, and it is the forerunner of proline, glutamine, and arginine. It is also there in numerous foods, such as those of animal and plant origin, for instance meat, bone broth, mushrooms and soy products.

Some of the Benefits of Glutamic Acid 

Helps To Improve immunity

The existence of glutamic acid receptors on immune cells specifies that this acid plays a significant role in both the adaptive and innate immune systems. Glutamic acid is also responsible for kidney, liver, lung, heart and immune system tissue function. Scientists are studying the effects of glutamic acid on controlling, B cells, T cells and inflammatory neurodegenerative ailments.

As per a study, glutamic acid is effective on various chronic diseases, cancer and autoimmune ailments. This means it may boost beneficial T cell function in fighting infection and cancer in human body. As per as a study, in a mouse model of multiple sclerosis, these receptors also can inhibit autoimmune expansion and guard the central nervous system against inflammation.

Supports Normal Brain Function

Approximately all excitatory neurons in the spinal cord and brain are glutaminergic neurons. Glutamic acid as the key excitatory neurotransmitter, with the potential to direct signals to the body and the brain. It is also helpful for mental function, learning and many more functions of the brain. In the meantime, it can come in handy for nerve cells communicating with each other as a neurotransmitter. 

Beneficial for the Gut

Glutamic acid from food, offers energy to cells in the stomach and helps in the activation of the digestive system. Diverse transporters mediating glutamate preoccupation are found in the apical membrane of gastrointestinal epithelial cells, chiefly in the small intestine but also in the stomach, although amino acid transports from the lumen to the portal has little or no blood in the colon. It is the key energy source for absorption of nutrients and metabolism. Glutamic acid is one of the key nutrients of intestinal cells.

This acid can also come good in protecting the intestinal wall by producing the antioxidant glutathione. One study found that supplementation with L-glutamate aided to advance the intestinal veracity of piglets, facilitating the absorption and digestion of nutrients. Glutamic acid might also avert gastrointestinal damage brought about by Helicobacter pylori and lasting usage of non-steroidal anti-inflammatory drugs for example aspirin.

 Coming to a Close

 The growing consumption of glutamic acid in the F&B Industry as a food additive and enhancer has powered the demand for this acid all over the world. The total value of the industry will reach USD 19,443.5 million in the next seven years, and who knows beyond that as well.

Source: P&S Intelligence

#Glutamic Acid Market Share #Glutamic Acid Market Size #Glutamic Acid Market Growth #Glutamic Acid Market Applications #Glutamic Acid Market Trends

[helthcareheven]

Ozone Therapy Innovations: Redefining Medical Wellness

Ozone therapy, also known as ozonated water therapy or medical ozone therapy, is an alternative medical treatment that uses ozone gas. Ozone is a triatomic molecule containing three oxygen atoms and is chemically denotes as O3. It is a powerful natural disinfectant that has been utilized for water purification and air purification for over a century. In ozone therapy, either ozone gas or ozonated water is introduced into the body through various methods to stimulate healing and induce other beneficial physiological effects.

Applications of Ozone Therapy Ozone therapy has been used to treat a wide variety of conditions. Some of the major applications of ozone therapy include:

Cardiovascular diseases: Ozone therapy shows potential in treating coronary artery disease, angina, and cardiomyopathy by improving circulation and oxygen delivery to tissues. Preliminary research suggests it may help minimize damage from heart attacks.

Digestive disorders: Conditions like irritable bowel syndrome, colitis, and gastric ulcers have responded well to ozone therapy. It helps reduce inflammation in the gut and stimulate regeneration of tissues.

Immune system support: Studies indicate ozone may activate immune cells and stimulate the release of cytokines and interferons that boost immune response against viruses, bacteria, fungi and tumors. This makes it useful for treating chronic infections and autoimmune disorders.

Musculoskeletal disorders: Ozone is effective in treating herniated or degenerated discs, joint inflammation, tendonitis and osteonecrosis by promoting oxygenation and circulation in tissues. It stimulates the repair and regeneration of cartilage and bones.

Neurological conditions: From multiple sclerosis and Parkinson's disease to migraines and neuropathic pain, ozone therapy improves symptoms by increasing oxygen supply to the brain and nerves.

Skin conditions: It treats chronic wounds, burns, diabetic ulcers, acne, herpes and other dermatological issues by disinfecting and activating repair of skin tissues.

Administration Methods

Ozone therapy employs various methods to introduce ozone into the body depending on the condition being treated. Some common administration techniques include:

- Major autohemotherapy: Drawing a unit of blood from the patient, exposing it to ozone gas in a sealed chamber then reinfusing it to deliver ozone systemically.

- Minor autohemotherapy: Ozone is bubbled through a small amount of blood drawn from a finger prick which is then returned to the body.

- Intravenous infusion: Ozone gas or ozonated saline solution is injected directly into veins.

- Rectal insufflation: Ozone gas is inserted into the rectum via a rectal catheter to treat gastrointestinal disorders.

- Direct injection: An ozone-oxygen gas mixture is injected into triggered points, herniated discs, joints or areas requiring localized treatment.

The Ozone Reaction in the Body

Once ozone comes in contact with living tissues, it initiates a series of controlled biochemical reactions that result in therapeutic effects. Some key steps in the ozone reaction include:

- Ozone inactivates pathogens, viruses and toxins through oxidation, helping resolve infections.

- It triggers the release of cytokines and growth factors that accelerate healing of tissues.

- Acting as a vasodilator, ozone increases blood circulation and delivers more oxygen to hypoxic cells.

- By stimulating the formation of hydrogen peroxide, it aids removal of debris and production of new cells.

- Ozone induces the synthesis of glutathione and superoxide dismutase which are potent antioxidants that reduce inflammation and oxidative stress.

Safety Considerations

When administered properly by trained professionals, medical ozone therapy is extremely safe with no reported fatalities. Minor side effects like headache are occasional. As ozone introducesactivated oxygen into the body, certain precautions need to be followed. People with glucose-6-phosphate dehydrogenase deficiency may not be suitable for treatment. Ozone therapy should also be avoided during pregnancy, lactation or in case of uncontrolled hypertension and bleeding disorders. Proper dosages, frequencies and administration techniques are vital for safety. More research is still required to fully standardize ozone protocols.

Conclusion

With no known toxic or side effects at therapeutic doses, and an ability to treat a wide spectrum of diseases, medical ozone therapy holds promise as a safe alternative or complementary treatment modality. Though studies on its mechanisms and applications are still on-going, preliminary evidence supports its use against various conditions. As research sheds more light on effective protocols, ozone could become a mainstream therapy alongside conventional medicine.

#OzoneHealing #OzoneTherapeutic #OzoneWellness

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Exploring the Potential of Glutathione 500mg: Unveiling Its Versatile Applications

Glutathione 500mg continues to capture attention as a versatile supplement with a multitude of potential health benefits. Despite its widespread use, many are unaware of its diverse applications beyond the realm of traditional health support. Let's delve into some lesser-known but intriguing uses of Glutathione.

Detoxification Support: While Glutathione's role in detoxification is well-established, its potential in aiding heavy metal detoxification deserves recognition. Heavy metals like lead, mercury, and cadmium can accumulate in the body over time, leading to adverse health effects. Glutathione binds to these metals, facilitating their removal from tissues and organs, thereby supporting overall detoxification processes.

Eye Health: Emerging research suggests a potential link between Glutathione levels and eye health. Glutathione is abundant in the lens of the eye, where it acts as a potent antioxidant, protecting against oxidative stress and age-related eye disorders such as cataracts and macular degeneration. Supplementation with Glutathione may help maintain optimal eye health and vision as we age.

Respiratory Support: Individuals with respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), or cystic fibrosis may benefit from Glutathione supplementation. Glutathione exhibits anti-inflammatory properties and helps reduce oxidative damage in the respiratory tract, potentially alleviating symptoms and improving lung function in these conditions.

Fertility Enhancement: Glutathione plays a crucial role in reproductive health, particularly in sperm development and motility. Low levels of Glutathione in seminal fluid have been associated with male infertility. Supplementing with Glutathione may help improve sperm quality and increase the chances of conception in couples struggling with infertility issues.

Neurological Support: Research suggests that Glutathione may offer neuroprotective effects and could play a role in the prevention and management of neurological disorders such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis. By reducing oxidative stress and inflammation in the brain, Glutathione may help preserve cognitive function and slow the progression of these debilitating conditions.

Gut Health: The gut microbiome plays a crucial role in overall health, and imbalances in gut flora can contribute to various digestive disorders and systemic inflammation. Glutathione supports gut health by promoting a balanced microbiome and reducing oxidative stress in the gastrointestinal tract, potentially alleviating symptoms of irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and leaky gut syndrome.

Mood Regulation: Glutathione's influence extends beyond physical health to mental well-being. Studies suggest a link between Glutathione levels and mood disorders such as depression and anxiety. As an antioxidant, Glutathione helps combat oxidative stress in the brain, which may contribute to improved mood and emotional resilience.

Incorporating Glutathione 500mg review into your daily routine may offer a plethora of health benefits beyond its well-known antioxidant properties. Whether you're seeking support for detoxification, eye health, respiratory function, fertility, neurological health, gut health, or mood regulation, Glutathione holds promise as a multifaceted supplement with far-reaching implications for overall health and well-being. As always, consult with a healthcare professional before starting any new supplement regimen to ensure it aligns with your individual health needs and goals.

#Glutathione 500mg

[bertelsenpenn46]

Three dimensional Genetic make-up Nanomachine Biosensor simply by Developing Genetic Master along with Moving Equipment Cascade Amplification for Ultrasensitive Recognition regarding Cancer-Related Gene

Trial and error reports uncovered disabilities inside lean meats purpose and also morphology between cyclosporine-treated animals. The aim of the analysis ended up being to consider hepatoprotective task associated with peroxisome-proliferator-activated receptors γ (PPARγ) ligands rosiglitazone and 15-deoxy-Δ12,14-prostaglandin J2 (PGDJ2) on CsA-induced hepatotoxicity within trial and error wildlife. CsA was implemented subcutaneously at a serving associated with Fifteen mg/kg/day pertaining to 4 weeks. Equally PPARγ agonists received with regard to 4 weeks 2.A few hr ahead of the supervision involving CsA. Rosiglitazone had been administered orally with a dosage involving 8-10 mg/kg/day and PGDJ2 was presented intraperitoneally at a dose regarding Thirty μg/kg/day. CsA caused lean meats injury has been verified simply by greater serum amounts of aspartate aminotransferase (AST), alanine aminotransferase (T), and bilirubin. Concentrations involving glutathione (GSH) and also glutathione disulfide (GSSG), lipid peroxidation products, nicotinamide adenine dThe preconditioning aftereffect of a mild stress factor is able to reduce the actual ulcerogenic effect of a severe stress factor about the stomach mucosa. The aim of the analysis ended up being check out aftereffect of preconditioning stress on the particular gastric and the little intestinal injuries the consequence of individual procedure of indomethacin (I'm) in mindful subjects. Initial going on a fast (Twenty four hours) rodents were subjected Internet marketing supervision (35 mg/kg, subcutaneously) with preconditioning strain (25 min cold-restraint with 10°C and additional An hour retaining in cages with room temperature) or perhaps with no tension. Plasma televisions corticosterone level, heartrate (HR), blood pressure levels (BP) and also somatic pain awareness (butt flick latency) have been calculated underneath situations with the gastrointestinal IM-induced injuries throughout first pressured along with non-stressed rats. IM government brought on development of stomach erosions properly visible 4 several hours right after its shot. The actual recovery involving stomach erosions regarding 2 days ended up being accompanied by the introduction of a smaller intestinal injury. Corticosterone quantities had been elThe aim of selleck the investigation ended up being to look at the effect of nesfatin-1 about the framework, versatility parameters, as well as term associated with adropin, nesfatin-1, as well as angiotensin II receptor type A single (AT1R) inside the abdominal aorta within ovariectomized subjects. Fragments regarding aortas have been gathered following euthanasia involving feminine sham-operated (CONT) along with ovariectomized Wistar test subjects (EXP), that had been implemented intraperitoneal treatment associated with physical saline (CONT, n = Several; EXP-O, d Equals Seven) or nesfatin-1 (EXP-N, n = 7) in the quantity of A couple of μg/kg b.watts. once daily pertaining to 60 days. The particular instances of aortas ended up obtained for rating involving firmness in addition to histomorphometric, immunohistochemical, FTIR, as well as Raman spectroscopy analysis. The particular ovariectomy triggered a significant surge in the particular width with the complete wall and the levels in the aorta, as opposed to CONT as well as EXP-N groupings. However, the ovariectomy triggered a decrease in how much elastin, bovine collagen (adult, premature collagen, collagen maturity percentage 1660 * 1690 cm-1), and amides, witPancreatitis is really a disease that you'll find so many etiologies nevertheless zero successful treatments. Even though phrase from the pancreatitis-associated protein-1 (PAP-1) serves as a gun for that disease, it's neurological operate can be unknown.

[atamazglobal]

All You Need to Know About Glutathione IV Therapy

Fountain of youth, gleaming skin, ideal beauty – everyone’s dream. What about you? For ages, individuals have been seeking this one thing – radiant youth. However, how to achieve it? Have you ever heard of glutathione? It’s the key to a youthful look and life. Glutathione is a potent antioxidant that your body produces in throngs. However, the production of this superior molecule may reduce due to age and health conditions. Fortunately, it can be retained by Glutathione IV Therapy. Glutathione IV therapy is a procedure where glutathione is injected into your bloodstream. What is Glutathione? Glutathione is a strong and beneficial antioxidant that your liver produces in your body. It’s a tripeptide, a blend of three amino acids – glutamine, glycine, and cysteine. Glutathione consists of a gummy sulfur chemical group. The group contains all the harmful molecules (free radicals) wandering around in your body to balance them. After eliminating these free radicals, your body fixes the immune system with additional power. By increasing the immune system, glutathione detoxifies your body too. It also induces skin lightening by turning melanin into a lighter shade. It also shuts down the enzyme tyrosinase, which causes pigmentation. Due to age and several health problems, your glutathione level may drop. However, with glutathione IV therapy, you can balance the glutathione status in your body. Glutathione IV Therapy Glutathione IV therapy is a method of inserting glutathione into your body. This effective approach allows your doctor to deliver valuable nutrients directly into your bloodstream by bypassing the gastrointestinal tract. It provides optimum benefit as they don’t crack down on their way. Glutathione IV treatments stay between just 15 to 20 minutes. All you need to do is sit comfortably in a chair while operating your phone. You can produce your routine directly afterward. You can get glutathione in several meals, oral supplements, and liquid forms. However, more than an oral glutathione intake is needed for your body to maintain balance. It only covers 50% of the glutathione range. However, when you take glutathione skin whitening injection intravenously, your body can absorb 90-100% of the glutathione content. Why Do You Need Glutathione IV Therapy? Glutathione is a powerful antioxidant to perform almost all of your physical functions that, include: Boosting the immune system to fight illnesses, including viruses and bacteria. Destroying free radicals from the body. It helps lighten the skin by removing hyper-pigmentation and melanin production in cells. An anti-aging agent that keeps your skin soft and younger by removing wrinkles and fine lines. Improving stamina and mental clarity. Decreasing inflammation in the body. Detoxification enables us to fight against oxidative strain. Enhancing metabolism and weight loss. Enhancing the quality of sleep by fighting stress due to sleep apnea. Can Glutathione Remove Dark Spots? Yes, glutathione IV therapy can clear the dark spots on your skin. Glutathione is a skin-whitening agent. Therefore, it can help clear acne marks, hyperpigmentation, and dark spots. Glutathione IV Therapy Cost The glutathione injection price depends on the quality of the injections and how many shots you require to gain your goal. It also depends on the dose of glutathione used in each skin whitening Glutathione Injection. The cost of skin whitening injection price in India ranges from Rs 8000 to Rs 30000. Glutathione IV Benefits Glutathione is the king of antioxidants. So its benefits are countless. However, a few of the advantages of glutathione are- Inhibits Chronic Illness People with heart disease, chronic fatigue syndrome, Parkinson’s Disease, arthritis, and cancer have one typical characteristic: low glutathione. When you are filled with too many poisons in your body, it is overwhelmed with oxidative stress. So, we get sick. Glutathione injection uses its antioxidant abilities to remove toxins and stress, thus controlling chronic illness. Decreases the Aging Process By releasing free radicals from your body, glutathione skin whitening injection ensures a more powerful tighter hair and nails, brighter skin, and higher energy levels. Improves Athletic Strength Glutathione reduces incidents of muscle damage. It also increases your strength and endurance, makes you more muscle, and decreases recovery times. Controls Inflammation Glutathione, the king of antioxidants, eliminates free radicals and reduces inflammation. Detoxification Of The Liver Glutathione composes toxins and gets them out of your body. Thus, it detoxifies the liver, which helps stave off diseases like fatty liver disease.

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[innovationshealthwellness]

No Need For A Detox Diet

https://s-media-cache-ak0.pinimg.com/736x/0f/5d/ea/0f5dea3e9c08feaa8bcfae7c003e745f.jpg Posted by ANNETTE HAMLIN – Never need to do a detox diet if you incorporate these foods into your normal diet. corehealthcoaching.com.au #Weightloss #Detox

Detoxing your body can do more for your body than just put a glow on your face or help you shed some pounds. The main purpose of following a detox diet is to take the load off organs that detoxify your body and help them function better. Following a detox diet also prevents chronic diseases, enhances the function of your immune system, slows premature aging, provides mental and emotional clarity, and increases energy. Moreover, eliminating toxins and feeding your body healthy nutrients isn’t difficult! If you’re ready to begin detoxing your body, here are ten foods you should include in your diet.

Heart Cleansers #1 Wild Salmon Salmon is rich in omega-3 fatty acids which help protect the heart and reduce triglyceride levels in the blood. These anti-inflammatory healthy fats are also known to reverse arterial stiffness, which is a common side-effect of smoking.

#2 Spinach This leafy vegetable is an essential detox food your heart. Spinach is rich in vitamins A and C- both antioxidants that fight free radicals in the body, thereby keeping cholesterol levels in check. Spinach also has folate which keeps the cardiovascular system healthy and magnesium that helps lower blood pressure.

Liver Cleansers #3 Lemon Being a citrus fruit, lemons are loaded with vitamin C, which is essential to the body in several ways. Among other uses, vitamin C is needed to make glutathione- a powerful antioxidant that detoxifies the liver, in addition to enhancing the immune system and neutralizing free radicals. Lemon also increases the production of bile which is necessary for digestion. At the same time, lemon juice controls the flow of excess bile into the digestive tract, thereby preventing the formation of ulcers. Further, drinking lemon infused water or lemon juice first thing in the morning balances out the acidity of foods consumed the previous day. Lemon juice contains anti-cancer compounds and helps maintain the body’s pH levels too.

#4 Artichokes This wonder vegetable, which is actually a flower bud, helps the liver function at its best by promoting the production of bile. Artichokes are also able to protect the liver owing to the presence of silymarin- a phenol compound. In addition, artichoke leaves are rich in anti-cancer polyphenols and also have anti-viral and anti-fungal properties.

Kidney Cleansers #5 Kale Kale is packed with antioxidants and has anti-inflammatory properties, which is why it is highly recommended by doctors to patients with kidney-related diseases. In addition to flushing out kidneys, kale also is a nutrient-dense food, so you should eat it as often as you can.

#6 Basil This full-of-flavor herb is a great addition to soups, salads, grilled vegetables, and a lot other dishes. What’s more, it is rich in antioxidants and has anti-bacterial properties! Basil also expels unwanted toxins out of the body by supporting the functioning of the kidneys and acting as a diuretic.

Digestive System Cleansers #7 Whole Grains Whole grains such as brown and wild rice, quinoa, and steel-cut oats are complex carbohydrates that are rich in soluble as well as insoluble fiber. The high fiber content ensures regular bowel movement, thereby helping you eliminate body waste efficiently. Apart from this, fiber-rich grains also reduce the risk of colon cancer, and gastrointestinal disorders like duodenal ulcers, irritable bowel syndrome, reflux, and diverticulitis.

#8 Fresh Fruits Fresh fruits are among the most effective foods that can cleanse your digestive system. That’s because almost all fruits contain ample amounts of fiber that aids digestion. Fresh fruits are also rich in essential vitamins, minerals, and other compounds that can nourish the body and help detoxify it. Some fruits that are great cleansers are apples, blueberries, cranberries, avocado, and grapefruit.

Overall Body Cleansers #9 Beetroot A single serving of this delicious root vegetable can work wonders for your whole body. Beetroots contain abundant phytochemicals and minerals that help fight infection, purify the blood, and cleanse vital organs. They also boost the body’s intake of oxygen at the cellular level, making them an excellent overall body cleanser. Additionally, eating beetroots regularly can help fight cancer, boost the functioning of the brain, reduce arthritic pain, and more.

#10 Cabbage This cruciferous vegetable helps cleans the liver and also acts as a diuretic, flushing toxins out of your body. Cabbages also contain sulfur that helps break down toxins so that they can be eliminated easily.

Conclusion Now that you know about these ten amazing detox foods, what are you waiting for? Get started on your detox diet right away! Just make sure you don’t follow fads blindly; a detox diet will benefit you only if you do it right. So eat healthy, take your detox diet slow at first, and you’re sure to bring the balance back into your life by helping your body function as well as it can.

#alfalfa sprouts #arugula #avocado #avocado oil #Broccoli #Brussels sprouts #cabbage #Chard #coconut oil #flaxeed oil #garlic #green blue algae #hempseed oil #kale #lemon #limes #olive oil #onions #Spinach #spirulina #turmeric #wheatgrass #fruit #healthy #motivation #nutrition #veggie #weightloss

[glutathione12]

#Glutathione and Gastrointestinal Disease #Glutathione and sports nutrition #Glutathione Benefits for Sports Nutrition #best antioxidant supplement #Glutathione and Toxicology and Liver Disease

[bargeglider30]

4 Way Sarm Stack, Deca Durabolin O Trembolona

Peptides As Well As Your Wrinkles

Content

What Are Peptides As Well As What Do They Provide For Your Skin?

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Peptide Bond.

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Peptides are a family of protein peptide chains and are extremely essential for the health of our bodies. They are essential for the development of all living things and are involved in many biological processes in living organisms. Peptides can be used for a variety of purposes, and Peptides Types have been developed as effective agents for delivery of these peptides across the membrane.

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Peptides can also be used to reduce the symptoms of inflammation, which can occur with conditions such as arthritis, diabetes and asthma. While inflammation is a natural response to injury or infection, it has been shown that peptides can help to reduce the inflammation process. As a result, you can experience relief from the pain that you have been suffering from without having to take anti inflammatory drugs. a company that offers can be found in many foods and natural supplements, and are not subject to processing. For this reason they offer some of the most peptides advantages, since they are bioavailable and do not need to undergo further processing.

What Are Peptides As Well As What Do They Provide For Your Skin?

Peptides can also be used to treat other conditions such as cramps in the muscles and the nerves, head aches and migraines, and tension headaches. These benefits are especially relevant for those who are deficient in peptides or have a low level of peptide receptors in their bodies. These deficiencies can affect your mental and physical health, and if left untreated, can lead to other medical issues that are more difficult to deal with, and harder to treat. If you are struggling with a condition or are concerned about how low or high your levels are, you should talk to your doctor or health care provider about peptides and how they can benefit your body.

Peptides are used for many functions in modern day medicine. Peptides can be used to treat a broad range of conditions, including inflammation, arthritis, infections, depression, diabetes, HIV, orthopedics, psoriasis, and many more. The most common use of peptides is to treat and prevent disease. Peptides can also be used as medicines, with a variety of different activity profiles.

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Peptides are needed to allow the body to produce antibodies, which are needed to protect the body from viruses, bacteria, fungi and other dangerous pathogens. There is an ongoing research project underway at the Dana institute in Seattle, USA, which is looking at how peptides can help to strengthen the immune system. Peptides can also be useful to the cardiovascular system and blood flow and also to the nervous system.

Peptides can be very useful to those people who suffer from conditions such as HIV/AIDS and cancer. A deficiency of peptides has been linked to a lower immune system and these include monoclonal gammopathy, Lupus, chronic fatigue syndrome and rheumatoid arthritis. A number of different conditions can have an impact on the production of peptides, which can be the result of a number of different causes.

Peptides are found in many foods and some forms of food are even prepared using peptides. This includes some types of dairy products, although the extent to which peptides are found in dairy products is limited. Peptides are also found in some supplements which are chemically engineered. The molecules involved in this process are usually peptides and sometimes amino acids. These supplements are commonly used as appetite suppressants and can be used to manage weight and to boost the immune system.

Peptide Bond.

Peptides can be used to increase blood levels of energy, stamina, and immune function. Peptides can also be used to treat allergies, such as pollen and other environmental allergies. having a good Shop Uk sarms test base supplement Sarms are used in the manufacture of various supplements and food additives, as well as in therapy for a variety of medical conditions, including arthritis and cancer.

Can I mix hyaluronic acid with peptides?

You can Use Peptides and Hyaluronic acid Together Yes, you can use hyaluronic acid and peptides during the same skincare session, but you will get the best results when you use them in the right order.

Peptides can be used in a number of different therapy options. They can be used to stimulate bone growth in patients recovering from joint surgery, or to target breast cancer cells with chemotherapy. They can also be used in the manufacture of dietary supplements and medicines, and they are also used to boost the immune system, increase energy, and promote wound healing.

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It is not clear how these supplements work, but it is believed that peptides relieve muscle pain because they stimulate the release of natural pain-relieving chemicals such as endorphins. Endorphins are also released during times of stress and muscle fatigue and this helps to alleviate the symptoms of these conditions. Although the exact mechanism is not known, the body does respond to such stimulation in the same way as it would during periods of physical stress or fatigue. As mentioned previously, peptides have been found to inhibit the growth of cancer cells in laboratory studies and clinical trials, although these results remain controversial. It is currently unclear what role peptides play in the development of cancer, but many scientists are excited by the potential benefits they hold.

Peptides are made from amino acids which can be derived from the food we eat. There are many factories around the world that mass-produce Peptides. These factories can produce vast quantities of Peptides quickly and cheaply. Peptides can be sold directly to the end-users. They can also be stored in pharmaceutical companies' stock rooms for future usage.

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Peptides are used in supplements to boost the immune system by stimulating the antibody producing cells. This is done through stimulating platelet production, which is needed to ensure that the body keeps up an adequate level of blood and oxygen. The supplements also need to contain L-glutathione, which is needed to regulate and control the immune system. As the level of L-glutathione in the bloodstream falls the level of immunity is lowered and an increase in the number of colds and flu is experienced.

Peptides are used in vaccines to stimulate the immune system. They are also used in chemotherapy to prevent cancer and other life threatening diseases. Peptides are used in drug synthesis as well, from simple peptides used in drug discovery to the complex multi-protein peptide chains used in drug manufacturing. They are also used extensively in bio-medical treatments, such as in immune disorders, cancer treatment, and targeted genetic diseases.

Peptides can be used as an alternative to chemical therapies. Their safety has not been extensively studied, but there is some evidence that they might be safe. However, some side effects have been reported, such as nausea and headaches. They may also cause an increase in appetite. Peptides are not recommended as a weight loss treatment, because they tend to slow the metabolism and do not suppress food cravings.

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Peptides are proteins that have a peptide chain attached to them. This chain is the peptide's base make up and is what gives it the ability to be absorbed into the body. The types of peptides that can be found in supplements are considered to be long chains that can be broken down into smaller peptide chains which then enter the bloodstream where they are used for a variety of purposes. They can be found in many food substances as well as medical medication and supplements.

Peptides are used in almost every aspect of medicine today. Peptides are used to prevent and heal infections, such as the flu and MRSA. They are used to reduce the adverse effects of chemotherapy, and stimulate the immune system. Peptides can even be administered intravenously for quick relief of severe conditions, like cancer.

The production of peptides is dependent upon a number of factors and as mentioned before the levels of these substances in the body are closely controlled by the immune system. A number of supplements containing peptides have been developed in order to make them more available for use by individuals with a number of different ailments. Some of these supplements are aimed at relieving gastrointestinal problems, while others have been developed to improve the condition of the liver. Some of these peptide supplements also act as immune modulators and help to balance the affects of allergies and infections.

Peptides are important building blocks of the immune system and are particularly important when it comes to maintaining the health of the gastrointestinal tract and the rest of the body. However, recent studies into peptides have revealed that they may also have a role to play in the management of arthritis and other inflammatory conditions. Peptides are able to penetrate the thick layers of the skin and enter the blood stream where they have the ability to stimulate functions associated with inflammation. These include the repair of the body's tissues and organs and can also reduce the levels of cytokines.

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[brewnbbqhouse-blog]

Top Ten Foods For Men

The avocado is considered a "complete" food whereby it provides in excess of 25 essential nutrients, including: vitamins A, B, C, E and K, iron, copper, phosphorus, magnesium, and potassium. Avocados also provide fibre, protein, "good" fat, and beneficial phytochemicals such as beta-sitosterol, glutathione and lutein.

The avocado's nutritional profile boasts an array of health-promoting properties - antioxidant activity, and heart, eye, kidney and prostate health, to name but a few. The avocado's high monounsaturated fat content is known to improve skin texture, boost energy production, lubricate and reduce inflammation in joints, support the immune system, lower cholesterol, increase metabolism, and they can actually help you to burn off that beer gut!

Beans

Beans are a versatile, low-fat, nutrient-dense food. Rich in protein, beans also contain good doses of folic acid, molybdenum, phosphorus, iron, magnesium, manganese, and potassium. Their soluble fibre content can help to lower cholesterol thus reducing your risk of cardiovascular disease, and their inherent insoluble fibre can help to keep constipation at bay. The other good news is that half a standard-sized tin of baked beans can count as one portion towards your five-a-day - although, look out for reduced-salt and sugar versions.

Broccoli

Despite its low-calorie status, broccoli packs a punch in the vitamin, mineral, and phytochemical stakes. It is an excellent source of vitamins A, B6, C, E and K, as well as folic acid, phosphorus, potassium, magnesium, and fibre. Broccoli's lutein content has potent antioxidant properties, and is essential to eye health. Broccoli is a fantastic cancer-preventative food and, in fact, preliminary studies indicate that broccoli's indole-3-carbinol compound can actually arrest the growth of prostate cancer cells. This compound also assists the liver's detoxification of toxic compounds such as alcohol, over-the-counter drugs, and environmental pollution.

Cayenne pepper

Cayenne pepper's intense heat is attributed to its high concentration of capsaicin and this compound does a lot more than add 'va-va-vroom' to your food! Capsaicin is renowned as an effective pain reliever and digestive aid, and for its cardiovascular benefits. Capsaicin can lower body temperature which is ideal for the hot, sweaty days ahead, and it can also increase your basal metabolic rate and burn fat for energy. Note that although chilli powder may strongly resemble cayenne pepper, the former is actually a combination of several spices - cayenne, cumin, ginger, oregano and turmeric, for example.

Ginger

Ginger is an excellent remedy for gastrointestinal problems including wind, bloating, indigestion, nausea, and vomiting ... just what you need after a night on the beers! An effective antioxidant, ginger also has powerful anti-inflammatory action and is therefore ideal for all manner of aches and pains, particularly when you've been overdoing it at the gym.

Oats

Oats are a good source of vitamin B1 and various minerals including magnesium, manganese, selenium, iron, and phosphorus. Oats are also an excellent source of soluble dietary fibre which helps to lower cholesterol thanks to its rich beta-glucan content. Indeed, one bowl of porridge a day can typically lower total cholesterol by 8-23% in men diagnosed with high cholesterol. Oats are also good for blood-sugar balance which is essential for sustained energy, good mood, and optimal brain function.

Oysters

Oysters contain the highest concentration of zinc of any food which may explain their reputation as nature's aphrodisiac. Research indicates that zinc may be essential to male sex hormone function - particularly testosterone, reduced prostate enlargement, and it is a key nutrient for sperm production and motility. Zinc has a number of other essential functions within the body including immune system support, healthy skin and wound-healing, and the maintenance of sight, taste and smell.

Salmon

Salmon is a high-protein fish and contains vital nutrients including potassium, selenium, vitamin B12, niacin, and phosphorus. Additionally, salmon is rich in omega-3 fatty acids which are essential to cardiovascular health, brain function, joints and bones, and immunity. Where possible, opt for wild salmon as this has been shown to have 20% more protein and 20% less fat than farmed salmon.

Tomatoes

Tomatoes are an excellent source of vitamin C, biotin, and vitamin K. It is their lycopene content, however, which make the tomato a top-ranking food. The carotenoid lycopene is a powerful antioxidant and has been shown to be extremely protective against various cancers - especially those of the colon, lungs, skin, and prostate. Tomatoes are also beneficial for eye health, and they are known to lower the risk of heart disease. Note that processing enhances this fruit's lycopene content whereby you actually get up to five times more lycopene from tomato purée and tomato juice than you would from its raw state. To really boost your absorption of lycopene, combine your tomatoes with a drizzle of olive oil.

[juniperpublishers-sciences]

Nanotechnology, A Promising Tool to Combat the Pitfalls of The Phenolic Transport across Blood- Brain Barrier-Juniper Publishers

Abstract

The growing interest in natural polyphenols during the last years is aimed to identify new applications to these natural compounds of biological interest, as well as to design new uses in the field of health care. In this regard, to date, it has been demonstrated a wide range of positive health effects for phenolic compounds, being most research studies focused on the anti-oxidant, anti- inflammatory, anti-microbial, and anti-aging effects, while the biological potential demonstrated for these compounds have led to search for specific applications in the field of neurodegenerative diseases. Indeed, brain related diseases factors like antioxidant and anti-inflammatory capacities, as well as proteins defibrillation and mitochondrial regulation have been pointed as the advantages of the use of all kind of phenolics. However, the transport of these molecules to can be prevented by specific biological barriers developed to protect these sensible structures. In this short review, the effects of phenolic compounds described in nervous tissues and cells, has been studied, as well as the downsides of their use, and how nanotechnology can help to provide new valuable alternatives to get enhanced biological impacts despite de constraint represented by the blood-brain barrier.

Keywords:  Phenolic compounds; Nervous system; Blood-brain barriers; Bioavailability; Bassive transport; Bioactivity

    Introduction

For several decades, it has been experienced a growing interest in natural phenolic compounds as bioactive molecules present in edible and non-edible plant material with potential effects on human health. The main goal of this trend is to find new applications to these natural compounds of biological interest and design new uses for them in the field of medical treatments [1-3]. Indeed, to date it has been demonstrated a wide range of positive health effects for phenolic compounds, being most research studies focused on the anti-oxidant, antiinflammatory, anti-microbial, and anti-aging effects. In the last years, the biological potential demonstrated for phenolic compounds have led to the interest in assessing their effects in the treatment of neurodegenerative diseases [2-6].

    Discussion

Proved facts on the neuroprotective effects of phenolic compounds

Several studies have contributed to establish a link between phenolic compounds and neuroprotection, revealing their potential against aging and neurodegenerative diseases [4,5]. In this regard, it is required to notice that there are innumerous possible patho physiological mechanisms related with neurodegeneration, even though the major pathways already identified are neuro- inflammation, oxidative stress, mitochondrial dysfunction, and protein misfolding, all of them susceptible to be affected by the presence of polyphenol [4,7,8]. However, despite the plethora of mechanisms responsible for neurodegeneration, oxidative damage to neuron molecules, and decreased cellular antioxidant species, such as glutathione in the brain, are major aspects of most common neurological diseases [4,8,9]. For instance, dopaminergic neurons of the central nervous system are susceptible to oxidative stress, turning oxidative stress into a risk factor for nigral substance degeneration. In this frame, polyphenols are recognized on their antioxidant particularities, while their presence in neurons has been related with lower levels of reactive oxygen species (ROS) [8]. However, radical scavenging is not the only biological activity of phenolics, which besides working as antioxidants, are also competent to increase the activity and expression of enzymes with antioxidant power. Hence, the endogenous glutathione system, one of the most important antioxidant defense of the organism, can also be boosted by polyphenols, according to previous works in vitro and in vivo [8-10]. In addition, polyphenols also contribute to diminish the level of pro-inflammatory cytokines in brain therapeutic models, such as IL-1β, TNF-α, 1L-4, 1L-6, and 1L-10 [10-12]. Resveratrol has been shown capable to decrease the level of nitrite and the expression of myeloperoxidase, an enzyme that, during microglial respiration, produces hypochlorous acid and tyrosyl radical that are cytotoxic to pathogens, but also to cells [13] Some polyphenols have shown the ability to prevent protein fibrillization, by promoting the clearance of aggregates and oligomers, thus stimulating the cell autophagic pathways [8] which proves once more their neuroprotective actions. Regarding this, for instance, phenolic compounds from green tea have been characterized on their fibril-destabilizing properties in neurological diseases. Hence, resorting to several in vitro studies, it has been demonstrated that epigallocatechin gallate and quercetin can prevent growth and aggregation of amyloidogenic a-synuclein and reduce their levels in the hippocampus and the striatum [14-16]. Mitochondrial disturbances can also be responsible for the damage observed in neurological diseases. Indeed, the loss of the mitochondrial transmembrane potential triggers mechanisms of apoptosis in dopaminergic neurons. In this sense, polyphenols have been noticed as competent to enhance mitochondrial function by increasing the ATP production, while lower ROS and lactate production [17,18].

Constraints to the biological action of polyphenols in the nervous tissues

Despite all the studies aimed at characterizing in vitro and in vivo the benefits of phenolic compounds, there are several biological limits that interfere with the beneficial properties of these compounds, preventing the direct extrapolation of the results retrieved, so far, on biological activity to the pathophysiology of the nervous system [19]. One of the main obstacle for the biological action of phenolics in cells is their bioavailability. In this regard, the amount of phenolic compounds that reaches the cells is conditioned by the physiochemical properties of the compounds, their interaction with food matrix, and the response to the gastrointestinal tract conditions, which means that in most cases, the concentration available is significantly lower to that administrated and, even, to that tested upon in vitro characterizations [8,12,20]. Moreover, a high proportion of phenolic compounds are esterified in glycoside or polymeric forms. This entails that they are poorly absorbed in the gastrointestinal tract, rapidly metabolized upon phase I and II metabolism, and excreted by both urine and bile [4,12,21,22]. This implies that, since the phenolic compounds bioactivity is mostly executed by their metabolites, as a result of the modifications triggered upon the gastrointestinal digestion, it could appear metabolites less effective as antioxidants than the original compounds [23,24]. Despite the evident effect of the factors discussed above, the main obstacle to take advantage of the biological potential of polyphenolic compounds in the nervous system is the final concentrations reached in the cells that for most compounds is not sufficient to trigger operative reactions capable to restore physiological condition of the nervous cells [4]. This is mainly due to the barriers existent between the central nervous system and the environments surrounding it [25]. In this concern, the most selective barrier is represented by the blood- brain barrier that constitutes a dynamic interface between the peripheral tissues and the central nervous system. Blood- brain barrier maintains normal brain function, preserving the homeostatic conditions for nervous cells, required to work appropriately and also shield them against invading organisms and damaging elements [26-28]. This barrier is primarily constituted of endothelial cells connected by adherent tight junctions and functions as a physical, metabolic/enzymatic, transport, and immunological barriers [25,27].

The main difficulties that the phenolic compounds find to cross to the blood-brain barrier are the endothelium of brain microvessles and multidrug resistance-associated proteins. Despite this, some phenolic compounds, such as anthocyanins and curcumin, are able to pass through in a lipophilicity- dependent way, while others cross the blood-brain barrier by a mechanism of phosphorylation/dephosphorylation that regulate their passage (quercetin), but the mechanisms of transport into the blood-brain barrier are still relatively unknown [4,29] and the administration of compounds of interest to develop their biological action in these cells deserve to be explored towards the description of new alternatives.

Nanotechnology contribution to bioavailability of phenolic compounds in brain cells

The drawbacks drawn related to polyphenols bioavailability in cells of the central nervous system led to an interesting field of studies to find new ways to overcome those pitfalls and thus, to take advantage of the biological properties of phenolic compounds. Nanotechnology seems to be a valuable contributor to give response to these constraints, and more specifically nanoparticles. These are promising and versatile delivery systems to transport compounds into remote areas of the body, like the brain [25-27]. Usually nanoparticles size range between 1 and 100nm and can have a natural or synthetic origin [25] Synthetic nanoparticles are manufactured using two basic methods: top-down and bottom-up. The first consists in size- reduction by mechanical processes to shrunk big materials to nano-scale, while the second one consists in the aggregation of diverse nanoparticles [18]. Among the different materials used to obtain nanoparticles it can be stressed poly (ethylenimine), poly (alkylcanonaacrylates) poly (amidoamine) dendrimers, poly (s-caprolactone), poly (lactic-co- glycolic acid), polyesters (poly(lactic acid), and inorganic materials like gold and silica [18,25-29].

The commodities and the nanoparticles obtained from them must be nontoxic, biodegradable, and biocompatible, be featured by a prolonged blood circulation time, and be stable, avoiding aggregation and dissociation [18]. These carriers can transport compounds by adsorbing, entrapping or bounding covalently to them [30,31]. The properties of nanoparticles make them a promising system to deliver biologically active compounds into brain, due to the possibility of modifying size, shape, hydrophobicity, surface charge, chemistry, and coating. In this connection, addressing appropriately these features, according to the characteristics of the bioactive molecule and the target tissue were their activity is desired can contribute to enhance the transport of phenolic compounds to the brain and thus, to improve their stability, while circulating, controlling the release of the compound through the blood-brain barrier [25,33].

Nanoparticles improve the solubility of phenolics by encapsulating them, and also protect the compounds from degradation in he gastrointestinal tract. Besides that, and maybe the most important feature of including polyphenols in nanoparticles is that they are able to enhance the absorption of the phenolic compound in brain cells either by disrupting the tight junction of the blood-brain barrier or promote the direct intake by endocytosis [18,25]. Regardless of all that some factors still need to be further studied to make nanoparticles even more helpful in the transport of bioactive compounds to brain cells. Factors like pH, ions, and enzymes, among others, can negatively modulate the properties of the nanoparticles and their delivery as well.

    Conclusion

Phenolic compounds from all sorts of plants have been long studied regarding their potential use as bioactive agents. In brain related diseases there are a large amount of evidence that points towards the several potential uses of phenolic compounds as treatments for those diseases. Factors like antioxidant and anti-inflammatory capacities, as well as proteins defibrillation and mitochondrial regulation, have been pointed as the advantages of the use of all kind of phenolics. Otherwise, the transport of those molecules to cells and tissues, where they can be helpful, can be very complicated or even impossible and, in most cases, this situation is responsible for the loss of important properties of metabolites from phenolic compounds. Nano carriers present themselves as an innovating solution that can help to diminish in a great extent the pitfall of phenolic compounds bioavailability, specially concerning the central nervous system. Thus, although nanotechnology seems to contribute to promising solutions, additional studies should be made in order to make nano carriers even more resistant and suitable for the transport of a growing number of phenolic compounds, which might be helpful to combat neurodegenerative disabling illness.

    Acknowledgement

This work was partisally supported by the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) through Research Projects AGL2016-75332-C2-1-R and RTC-201658362. RDP was sponsored by a Postdoctoral Contract (Juan de la Cierva de Incorporation ICJI2015- 25373) from the Ministry of Economy, Industry, and Competitiveness of Spain. The authors declare no competing financial interests.

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[drlaurynlax]

How to Test for Mold Illness in Your Body 

Do you have mold illness?

Check out my top recommended testing methods to find out, including:

  Mold Toxicity Checklist

Mycotoxin Urine Test

Bloodwork

Gut Testing

Liver Function Testing

DUTCH Cortisol Hormone Test

Visual Contrast Sensitivity Testing

Mold Illness Refresher

Let’s briefly review Mold Illness 101 before diving into my top recommended tests to know what we are looking for in the first place.

  Mold illness or “mycotoxin illness” is a serious condition that is commonly referred to as “CIRS”—Chronic Inflammatory Response Syndrome.

  Unlike a disease—which is condition typically with a specific known cause and similar symptoms (such as insulin resistance, frequent urination and weight gain in people with diabetes)— a syndrome, like CIRS, is a much broader “collection of signs and symptoms” that may present differently in different people.

  Signs & Symptoms of CIRS

Common signs and symptoms of mold illness or CIRS include

Respiratory difficulties (difficulty breathing, shortness of breath, asthma)

Neurological symptoms

Sinus congestion and stuffy nose

Hair loss

Anxiety

Brain fog, confusion or memory loss

Difficulty concentrating

Morning stiffness, joint pain

Light sensitivity

Skin rashes

Red eyes, blurred vision, sweats, mood swings, sharp pains

Feeling lightheaded or dizzy

Appetite swings

Poor body temperature regulation,

Gastrointestinal problems (cramps, abdominal pain)

Weight loss or weight gain (unintentional)

Unusual skin sensations, tingling and numbness

  You may have several of these symptoms—or just one or two. The amount of symptoms don’t matter as much as the unrelenting poor health experienced because of them.

  Although these symptoms are also synonymous with other conditions often talked about in functional medicine—from “adrenal fatigue”, thyroid disorders to gut dysbiosis—the key distinguisher in mycotoxin illness or CIRS is often times, these are often the patients who do not “get better” once commencing a protocol.

  Buttttt….how do you know if you really have “mold illness” or CIRS—or you’re just feeling out of sorts? What tests can you do to reveal true illness

  There are a handful…

  Mold Toxicity Checklist

Aside from identifying your symptoms, answer “Yes” or “No” for the following questions (adapted from Environmental Health Center).

  Yes or No?

Do musty odors bother you?

Have you worked or lived in a building where the air vents or ceiling tiles were discolored?

Have you noticed water damage or discoloration elsewhere?

Has your home been flooded?

Have you had leaks in the roof?

Do you experience unusual shortness of breath?

Do you experience recurring sinus infections?

Do you experience recurring respiratory infections and coughing?

Do you have frequent flu-like symptoms?

Do your symptoms worsen on rainy days?

Do you have frequent headaches?

Are you fatigued and have a skin rash?

  If you answer “yes” to 4 or more, your CIRS-like symptoms may have some more merit.

  Mycotoxin Urine Test

Mycotoxin urine testing is a relatively newer form of testing that can reveal the release of toxins in the urine. If you really suspect mycotoxin illness from molds to be at play, this test can yield highly insightful information for putting your puzzle together.

  Some key detected mycotoxins include:

Ochratoxins

Aflatoxins

Trichothecenes

Glicotoxins

  Recommendation:

Great Plains Urine Testing (Order Here on behalf of Dr. Lauryn Lax, OTD).

  *Note: Sometimes false “negatives” can occur with urine testing since some patients are unable to detoxify in the first place. In order to get the most accurate results, I recommend using high dose glutathione + NAC for 5 to 7 days prior to conducting your urine test in order to encourage elimination and detoxification.

  My preferred formula is Trizomal Glutathione by Apex Energetics, which includes both NAC and glutathione. Take 1 tsp 3 times per day for 5 to 7 days.  It is tough to find online, but if you call the company directly at 949-251-0152, request a bottle be sent to you on behalf of Dr. Lauryn Lax.

  Bloodwork

Bloodwork doesn’t always tell the whole story of CIRS or mycotoxin illness, but certainly can point to markers of inflammation and immune dysregulation.

  Unfortunately, many patients consult with their conventional medical practitioners and are told, “Your lab tests are normal”, but have not ordered more specialized tests that help look deeper into mycotoxicity and inflammation.  Helpful markers and their normal ranges for assessing mycotoxin illness include:

  Specialty Mycotoxin Blood Tests

Elevations in the following markers point to mold toxicity

VIP (normal range: 23-63, only available by ARUP Labs)

MSH (normal: 35-81)

MMP-9 (normal: 85-332)

C4a (normal: 0-2380)

TGF-beta-1 (normal: <2380)

Leptin (Male: 0.5-13.8; Female: 1.1-27.5)

HLA-DR (the gene that 25% of the population has, making them more susceptible to mycotoxicity; can only be run by LabCorp)

    OTHER LABS

Other labs that may be “off” on general lab work include:

  Complete Blood Count

Red Blood Count low (normal: 4.40–4.90 x 106/µL)

White Blood Count low or high (normal: 5.0–0 x 103/µL)

  Methylation Markers

MMA high (ideal < 300 nmol/L)

Folate low (ideal > 8 μg/L)

  Bloodsugar Markers

Glucose low or high (normal fasting: 75-85, normal 1-2 hours post-meal: 110-140)

HgbA1C high (normal 4.6–5.3%)

  Liver Enzymes

AST high (normal: Male: 0–25 IU/L; Female: 0–23 IU/L)

ALT high (normal: Male: 0–26 IU/L; Female: 0–20 IU/L)

  Nutrient Markers*

Zinc (often low)* (normal: 81–157 µg/dL)

Copper* often high (excess copper can lead to low zinc) (normal: 81–157 µg/dL)

Iron high or low (ideal: 40–135 µg/dL)

Ferritin high (Male: 30–200 ng/mL; Female: 30–100 ng/mL)

Vitamin D low (normal: 35–60 ng/mL)

  *Urine testing via NutraEval (Order Here and search for “NutraEval FMV by Genova)

  Inflammatory Markers

Total Cholesterol high (normal: 150–220 mg/dL for males; 150–230 mg/dL for females)

LDL Cholesterol high (normal: 0–140 mg/dL)

C Reactive Protein (CRP) high (normal: 0–1 mg/L)

BUN high or low (normal: 13–18 mg/dL)

Creatine low (normal: Male: 0.85–1.1 mg/dL; Female: 0.7 – 1.0 mg/dL)

  Hormone Markers*

*Hormone markers can be a sign that something more is going on “under the hood.” Inflammation from mold toxicity and CIRS can drive hormone imbalance. Since hormones are the “key messengers” made by our glands to regulate body functions, if our hormones are “off”, they may perpetuate the symptoms of CIRS.

  PTH elevation (normal: 10-35 pg/mL

T3 (Thyroid Hormone) deficiency (normal: 2.5–4.0 pg/mL)

Testosterone deficiency

Progesterone deficiency

Estrogen dominance or deficiency

  Bloodwork out of the norm in several of these areas may indicate imbalance.

    Gut Testing

A bi-directional relationship exists between mycotoxins and gut microbiome—mycotoxicity can impact and worsen our gut health, just like poor gut health can make one more susceptible to mycotoxicosis (1)—creating the “perfect” storm.

  On this note, it’s critical to realize, “mold illness” does not just happen from mold alone. Other pathogens that cause the same symptoms as mold illness include:

  Bacteria & bacterial infections (like Babesia and Borrelia)

Fungi

Mycobacteria

Mold

Mold spores

Endotoxins (aka lipopolysaccharides, or LPS; cell wall components of gram-negative bacteria)

Inflammagens (irritants that cause inflammation and edema)

Beta-glucans (sugars that are found in the cell walls of bacteria, fungi, yeasts, algae, lichens, and plants)

Hemolysins (toxins produced by bacteria that can destroy cells)

Volatile organic compounds

  The key theme behind all of these? They affect your gut!

  Your gut microbiome is home to 100 trillion microorganisms (gut bacteria). The healthier your gut bacteria, the healthier you are! The sicker or more pathogenic your gut bacteria, the sicker you are!

  It’s no wonder that candida (fungal overgrowth) and sinus congestion (from fungi and mold growth in the nose—part of the nasal microbiome) are common in those with suspected mold toxicity or CIRS (2).

Given that approximately 80% of your immune system is produced and housed in your gut, a “strong” gut filled with diverse, healthy gut bacteria helps boost your immune fighting defenses to weather the storm of mold and mycotoxin exposure. However, if your gut is infiltrated by pathogens—and not enough “man power” to weather the storm, eventually your gut microbiome profile can shift, resulting in an unhealthier gut…and an unhealthier you.

  Recommendation:

Comprehensive Stool Analysis + Parasitology x 3 (Doctor’s Data) (Order Here)

  Liver Testing & Symptom Checklist

In addition to your gut, your liver—your body’s “chemical processing factory” and recycling system—also plays an important role in guarding against mycotoxin and mold illness. Consider your liver your “defense” for mycotoxin and mold exposure. A sluggish or overworked liver can equally wreak havoc on your health and make you susceptible to mycotoxin illness

  Liver Checklist

The best way to assess for liver dysfunction is a combination of blood markers and symptoms. Common liver malfunction indicators include:

  Nausea

Sensitive to chemicals (perfuma, cleaning agents, etc.)

Bitter/metallic taste in mouth

Headache over the eyes

Easily motion sick

Itchy skin

Jaundice colored skin/eyes

Swelling (abdomen, legs, ankles)

Light or clay colored stools

Greasy or shiny stools

Constipation

Easily intoxicated

Hormone imbalances (PMS, PMDD, irregular menses)

Glucose/blood sugar imbalances (hypoglycemia in particular)

Brain fog

Nutrasweet/artificial sweetener consumption

History of antibiotics, birth control or long term medications

  Liver Function Blood Markers

ALT: High

AST: High

GGT: High

LDH: High

Alkaline Phosphatase: High

    Cortisol Hormone Testing

Your CNS (central nervous system) is your “stress response system.” When functioning properly, your body is able to overcome stress. If malfunctioning, chronic illness and uncontrolled inflammation happens. Swelling of the brain and “stress response” system can lead to changes in nerve endings and interfere with the electrical signaling to all functions of the body. Enter: The unrelenting CIRS symptoms that persist for those who suffer from mycotoxin illness.

  Cortisol hormone testing can give you a clearer picture of where your “stress hormones” are at, along with neurotransmitter function that play a role in controlling inflammation and stress in the body as well—such as dopamine and serotonin.

  Note: NOT all hormone testing is created equal. While bloodwork is great for assessing sex hormones (estrogen, progesterone, testosterone), it is not great at cortisol testing.

  Cortisol is a constantly changing hormone throughout the day. Therefore you need to collect multiple samples in a given day via urine and saliva in order to see an accurate pattern for your body. In addition, not all urine and saliva tests are created equal! Most tests measure either one or the other—leaving you with only partial results. Most tests also only measure “free cortisol”—NOT metabolized cortisol. However, free cortisol only makes up less than 3% of all cortisol in your body.

  For these reasons, to date, the gold standard for cortisol hormone testing is the DUTCH test—which uses both urine and saliva testing, and measures both free and metabolized cortisol.

  Recommendation:

DUTCH Cortisol Hormone Testing (Order Here)

  Visual Contrast Sensitivity Test

  Dr. Ritchie Shoemaker, creator of SurvivingMold.com and a “father” of mold toxicity recovery invented the “Visual Contrast Sensitivity” test  to measure of one of the neurologic functions of vision called contrast.

  In his years of work with patients recovering from mycotoxin illness, Dr. Shoemaker realized a key theme his patients shared was poor “contrast sensitivity” in their vision.

  His online test can help individuals further identify potential exposure to neurotoxins, biotoxins, and nutritional deficiencies in the body. These compounds have been implicated in diseases such as ADHD, CFIDS, fibromyalgia, mold illness, and Lyme disease.

  It’s not the “end all, be all”, but can be part of a comprehensive work up.

    Beyond Testing

While testing can be a helpful piece of the puzzle to identifying and confirming CIRS and mycotoxin illness, it’s vital to remember, testing is not the “end all, be all.”

  As a functional medicine practitioner, I treat and empower individuals based on the person, not the numbers, and if empirical findings—such as your symptoms or lack of health improvement despite “doing all the things” (i.e. eating clean, working out, sleeping) are still present, then it is safe to assume that something is not right “under the hood.”

  Check out the next post on my top ways to “treat” for mold and get rid of it! (So you can get on with your full, amazing life).

    References

Winnie Pui Pui, Liew & Sabran, Mohd Redzwan. (2018). Mycotoxin: Its Impact on Gut Health and Microbiota. Frontiers in Cellular and Infection Microbiology. 8. 10.3389/fcimb.2018.00060.

Brewer JH, Thrasher JD, Hooper D. Chronic illness associated with mold and mycotoxins: is naso-sinus fungal biofilm the culprit? Toxins (Basel). 2013 Dec 24;6(1):66-80. doi: 10.3390/toxins6010066. PubMed PMID: 24368325; PubMed Central PMCID: PMC3920250.

  The post How to Test for Mold Illness in Your Body  appeared first on Meet Dr. Lauryn.

Source/Repost=> https://drlauryn.com/wellness-knowledge/how-to-test-for-mold-illness/ ** Dr. Lauryn Lax __Nutrition. Therapy. Functional Medicine ** https://drlauryn.com/

#Holistic #Nutrition #Therapy #Recovery #Functional #Medicine #Dr. Lauryn Lax #Dr.Lauryn

[paleorecipecookbook]

How Safe Is Your Over-the-Counter Medicine?

Over-the-counter medicines are a lucrative business for the pharmaceutical industry. Americans make 2.9 billion trips to pharmacies to purchase over-the-counter (OTC) drugs every year, spending a whopping $34.3 billion dollars! (1, 2)

While most OTC drugs have long been considered relatively harmless, recent research suggests otherwise; in many cases, the long-term consequences of taking OTC drugs were inadequately explored before their release on the market, and we are only now beginning to understand their numerous adverse effects. Read on to learn about the health risks of common OTC meds, including ibuprofen, aspirin, acetaminophen, decongestants, antacids, and antihistamines, and discover safe alternatives to these drugs.

Short on time? Use these links to skip ahead!

Why OTC drugs aren’t as safe as you may think

Ibuprofen

Aspirin

Acetaminophen

Decongestants

Proton pump inhibitors (PPIs)

Antihistamines

Alternatives to OTC medications

Ibuprofen and acetaminophen

Aspirin

Decongestants

PPIs

Antihistamines

Why Over-the-Counter Drugs Are Not as Safe as We’ve Been Led to Believe

The public perception of over-the-counter medications is that they must be safe, since they are purchased without a prescription, and frequently without any advice or restrictions. However, a growing body of research shows that OTC drugs are anything but harmless. Ibuprofen, aspirin, acetaminophen, decongestants, and antacids make up most of the OTC drug market and, unfortunately, our overuse of these products is damaging our health.

Over-the-counter medicine can hurt your gut health, your heart, and your immune system. Check out this article for more of the serious, even deadly, side effects of OTC medicine, and get natural alternatives. #healthylifestyle #functionalmedicine #chriskresser

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The Truth about Ibuprofen

Non-steroidal anti-inflammatory drugs, or NSAIDs, are among the most commonly used drugs worldwide, with 70 million prescriptions and 30 billion over-the-counter doses sold annually in the United States. (3)

Ibuprofen’s popularity belies its high potential for adverse effects, including cardiovascular, gastrointestinal, hepatic, kidney, and neonatal health complications.

It Carries Cardiovascular Risks

The cardiovascular risks of NSAIDs, including ibuprofen, were first identified decades ago. (4) Inexplicably, this information has remained mostly undisclosed to the public, causing millions of people to take a drug that could potentially compromise their heart health. In recent years, several studies have finally grabbed the attention of the medical community; in 2017, a study published in the European Heart Journal – Cardiovascular Pharmacotherapy associated ibuprofen consumption with a 31 percent increased risk of cardiac arrest, while several others linked the drug to non-fatal myocardial infarction, congestive heart failure, and high blood pressure. (5, 6, 7)

Ibuprofen and other NSAIDs inhibit cyclooxygenase, an enzyme that produces inflammatory mediators, called prostanoids, from arachidonic acid. While NSAIDs inhibit the production of inflammatory, pain-inducing prostanoids, they also inhibit beneficial prostanoids that promote vasodilation (which helps reduce blood pressure); inhibit platelet aggregation (necessary for the blood to clot); and maintain a healthy vascular system. The reduction of beneficial cardioprotective prostanoids explains the increased risk of cardiovascular complications observed with ibuprofen use.

It May Cause Gastrointestinal Problems

The gastrointestinal complications of NSAIDs are also well recognized. Ibuprofen harms the gastrointestinal (GI) tract by reducing beneficial prostanoids that maintain the integrity of gastric tissue and the intestinal barrier. GI complications are exceedingly common; 60 to 70 percent of individuals who take NSAIDs long term develop intestinal inflammation, increased intestinal permeability, mucosal damage, gastric ulcers, diverticulitis, blood loss and anemia, and nutrient malabsorption. (8) Ibuprofen also alters the gut microbiota. (9, 10, 11) Furthermore, by damaging the intestinal barrier, ibuprofen allows for the transfer of inflammatory bacteria from the intestine to the liver, causing liver inflammation and promoting the development of nonalcoholic fatty liver disease. (12)

Ibuprofen Could Harm the Liver, Kidneys, and Immune Function

Ibuprofen damages the liver and raises levels of the enzymes AST, ALT, ALF, and bilirubin. (These are the primary markers in liver function testing.) Researchers are still trying to understand precisely how ibuprofen causes damage to the liver, but it could be, in part, an immune reaction to the drug or the body’s response to toxic byproducts produced when it attempts to metabolize ibuprofen. (13)

Ibuprofen damages the kidneys and interferes with immune function. The drug reduces glomerular filtration, the process by which the kidneys filter excess fluid and waste products into the urine, thereby straining the kidneys. Ibuprofen also impairs the immune response, suppressing the body’s ability to target and eradicate viral infection. (14)

It Carries Prenatal Risks, Too

In recent years, an alarming body of evidence has accumulated indicating that prenatal use of ibuprofen increases the risk of fetal and infant health problems. Using ibuprofen during pregnancy is associated with decreased birth weight, an increased risk of cerebral palsy, and altered fetal testis development. (15, 16, 17) Ibuprofen may induce these effects in a developing fetus by interacting with maternal hormones, inducing brain oxidative stress, stimulating endocannabinoid receptors in the nervous system, and inhibiting sulfation, a crucial biochemical pathway involved in detoxification.

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Why Aspirin Isn’t as Beneficial as You May Think

Public health authorities have long recommended low-dose aspirin therapy (taking a daily “baby aspirin” dose of 81 mg) for the prevention of cardiovascular disease. (18) However, recent research has cast serious doubt on the validity of this practice. A large NIH-funded study published in 2018 found that aspirin use has no beneficial effects on “healthy lifespan,” classified as life free of dementia or persistent physical disability, in older adults. (19)

In other words, regular aspirin use has no benefits for healthy adults. Aspirin may only exert protective effects in people with pre-existing cardiovascular conditions.

Furthermore, the supposed benefits of aspirin in at-risk individuals must be weighed against the established health risks of the drug, including an increased risk of GI bleeding, hemorrhagic stroke, and brain bleeding. (20, 21)

The problematic effects of aspirin aren’t limited to adults; prenatal aspirin use is associated with an increased risk of fetal testicular dysfunction and cerebral palsy. (22, 23) The mechanisms by which aspirin induces these effects are similar to those noted with ibuprofen; aspirin alters maternal hormone production, causes oxidative stress, and inappropriately stimulates the endocannabinoid system, a biological system that plays a pivotal role in the development and function of the brain.

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Acetaminophen: Dangerous for Children—And Adults

Acetaminophen is an OTC analgesic consumed in the United States in massive quantities. Each week, approximately 23 percent of American adults pop an acetaminophen-containing medicine. (24) Unfortunately, few understand how harmful this common pain-relief drug may be.

If you’re planning on parenthood, take note: The effects of prenatal acetaminophen use by women and men on the health of their children are of special concern.

When women take acetaminophen before becoming pregnant or during pregnancy, they may significantly increase their baby's risk of developing childhood asthma, ADHD, autism, a reduced IQ, behavioral problems, language delay, impaired executive function, and cerebral palsy. (25, 26, 27, 28, 29) (In animal studies, female mice exposed to acetaminophen/paracetamol gave birth to female offspring with dysfunctional reproductive systems.) (30)

Paternal preconception acetaminophen use for eight or more days is also associated with ADHD in children. (31) Acetaminophen increases the risk of these conditions by decreasing glutathione, the body’s master antioxidant, thus leaving the fetal respiratory system and brain vulnerable to oxidative stress.

Acetaminophen use during early childhood may also be harmful. The use of acetaminophen in babies between the ages of 12 and 18 months increases the risk of autism spectrum disorder eight-fold. (32) In adults, acetaminophen may blunt emotions and empathy, indicating that it has adverse neurobehavioral effects well beyond pregnancy and childhood. (33, 34)

Acetaminophen is also toxic to the liver and kidneys. Over half of all acute liver failure cases are caused by acetaminophen overdose. (35, 36) Acetaminophen causes liver damage by increasing the permeability of the gut, allowing inflammatory bacteria to move from the gut into the liver. (37) The current recommended maximum dose for acetaminophen of 4,000 mg per day is capable of inducing liver damage, as indicated by elevations in the liver enzyme ALT, after just four days. (38) Last but not least, acetaminophen increases the risk of kidney and blood cancers. (39, 40) While the mechanism is not well understood, a potential explanation is that acetaminophen is a metabolite of phenacetin, a known (and now banned) carcinogen.

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Decongestants Can Have Serious Cardiovascular Side Effects

The active ingredient in most decongestants is pseudoephedrine. Pseudoephedrine stimulates alpha-adrenergic receptors, which activate the sympathetic nervous system, increase heart rate, and raise blood pressure. When taken by individuals with undiagnosed hypertension, decongestants can cause hypertensive emergencies. (41, 42) To put this in perspective, 75 million Americans have hypertension, and over half of those do not have the condition under control or are undiagnosed. While decongestants list potential risks on the label, few people read the label or heed the advice. Decongestants pose a significant threat to these individuals, despite their OTC availability.

Decongestants have also been found to induce urinary problems in males over 50 years of age and can cause insomnia, nervousness, rapid heart rate, heart attack, and heart palpitations. (43) To make matters worse, taking decongestant nasal sprays for longer than just three days can induce a vicious cycle of rebound congestion—essentially, congestion gets worse after you stop taking the decongestant because your nasal passages have become dependent on the drug. This leads many people to continue decongestants indefinitely.

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The Many Dangers of Proton Pump Inhibitors

Proton pump inhibitors (PPIs) are among the most widely used OTC drugs for stomach upset, yet they come with a lengthy list of adverse effects. Proton pumps are well known for their role in the stomach, where they facilitate gastric acid production. The intention of taking a PPI is to reduce the activity of gastric proton pumps, thus lowering gastric acid production and alleviating reflux, peptic ulcers, and indigestion. However, few people realize that proton pumps are present in nearly every cell of the body and are essential for cellular energy production.

This means that PPIs don’t just affect the stomach; they also impair the body’s many other proton pumps and produce a wide range of negative physiological effects.

They Can Hurt Your Gut Health

Gastric acid is a component of chyme, the mixture of gastric juices and partially digested food that passes from the stomach to the small intestine. In a person with normal gastric acid production, chyme regulates the acidity of the upper small intestine, preventing bacteria from overreaching their bounds. By inhibiting gastric acid production, PPIs reduce the acidity of chyme and allow the number of microbes in the small intestine to rise, causing small intestinal bacterial overgrowth (SIBO). (44, 45) PPIs also change the composition of the gut microbiota, increasing levels of opportunistic pathogens and the risk of serious infections including Clostridium difficile, Campylobacter, and pneumonia. (46, 47, 48) Changes to the gut microbiota induced by PPIs may also raise the risk of chronic liver disease by increasing Enterococcus bacteria, which travel from the gut to the liver and exacerbate alcohol-induced liver disease, nonalcoholic fatty liver disease, and nonalcoholic steatohepatitis. (49)

PPIs Can Lead to Nutrient Deficiencies

In addition to controlling bacterial populations in the small intestine, gastric acid is also required for the absorption of nutrients. Low gastric acid impairs digestion. Accordingly, deficiencies of vitamin B12, magnesium, iron, calcium, and vitamin C are common in users of PPIs. (50) In fact, poor magnesium and calcium absorption is one reason why PPIs may increase the risk of osteoporosis. (51)

They Have Neurological Effects

PPIs have been linked to an increased risk of dementia and Alzheimer’s disease. Use of one PPI, omeprazole, is associated with declines in visual memory, episodic memory, motor and mental response speed, new learning, short-term and long-term attention, information retention, and strategy development. (52) Regular users of PPIs have a 44 percent increased risk of dementia compared to those who don’t use the drugs. (53)

There are several ways PPIs may contribute to neurodegeneration:

PPIs increase deposits of amyloid-beta plaques. Accumulations of these malformed proteins have been found in the brains of Alzheimer’s patients. PPIs cause this condition by upregulating enzymes that produce amyloid-beta and reducing the activity of protein-degrading lysosomes.

PPIs interact with tau protein, a component of neurofibrillary tangles. Neurofibrillary tangles accumulate inside neurons and impair neurological function in Alzheimer’s disease.

PPIs decrease magnesium and vitamin B12 levels. B12 deficiency negatively affects cognition and promotes neurological damage by interfering with DNA synthesis and methylation and promoting homocysteine neurotoxicity.  Magnesium deficiency harms cognition by lowering the brain’s defenses against oxidative stress.

PPIs inhibit proton pump function in neurons. Neuronal proton pumps regulate the release of neurotransmitters; impaired proton pump function alters neurotransmitter release and reuptake. (54)

They Can Hurt Your Heart Health

PPIs are harmful to the cardiovascular system. The use of PPIs after a heart attack is associated with a 30 percent increased risk of cardiovascular death, a subsequent heart attack, or stroke. (55) Use of PPIs is also associated with an increased risk of stroke and heart failure. (56, 57) PPIs induce cardiovascular dysfunction by reducing nitric oxide, which promotes the dilation of blood vessels and improves blood flow, and by increasing ADMA, a metabolic byproduct of arginine metabolism that damages the function of endothelial cells, which line the heart and blood vessels. By reducing levels of vitamin B12 and vitamin C, PPIs also weaken the body’s ability to lower homocysteine and oxidative stress, which are underlying causes of cardiovascular disease.

They Can Lead to an Increased Risk for Serious Illnesses—And Even Death

PPIs increase the risk of chronic kidney disease, gastric cancer, and colon cancer. A shocking 20 to 50 percent increase in risk for chronic kidney disease has been observed with regular use of PPIs. (58) PPIs promote gastric and colon cancer by raising the pH of the stomach, which causes the release of excessive amounts of gastrin, the hormone that causes the stomach to release gastric acid. Hypergastrinemia promotes gastric and colorectal cell hyperplasia, fundic gland polyps, and gastric carcinoids. (59, 60)

Long-term use of PPIs carries an increased risk of death, according to a recent study published in BMJ Open. In the study, the researchers examined the medical records of 275,000 users of PPIs and nearly 75,000 people who took another type of acid-suppressing drug, H2 blockers. They ultimately found that those who took PPIs for one to two years had a 50 percent increased risk of dying over the next five years compared to those on H2 blockers! (61) The increased risk of death is likely due to the neurological, cardiovascular, renal, and carcinogenic effects of prolonged PPI use.

The Issues PPIs Cause Are Long Term

As if the numerous harmful effects of PPIs weren’t enough, these drugs can also cause problems once they’ve been stopped. PPIs elevate the pH of the stomach, stimulating cells (known as parietal cells) to make more of the hormone gastrin. Elevated gastrin causes the stomach to produce more proton pumps and larger amounts of stomach acid. When PPIs are removed, the increased quantity of proton pumps and gastric acid can result in worse reflux than before the PPI, a condition referred to as “rebound reflux.” Rebound reflux promotes a hard-to-break cycle in which removal of the PPI worsens reflux, causing the affected individual to reach for PPIs again and again. However, the good news is that parietal cells are continually undergoing renewal, as healthy cells replace old ones, so former PPI users are not necessarily destined for rebound reflux forever.

Finally, there is evidence that the adverse effects of PPIs can pass from mothers to children. Use of PPIs during pregnancy may increase the risk of asthma in children by interfering with maternal digestion of proteins. Impaired maternal protein digestion may increase the number of allergens to which a fetus is exposed. Ultimately, this can cause changes in a developing baby’s immune system that may bring about an increased risk of allergies after birth. (62)

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Antihistamines May Impact Your Brain

In 2016, total sales of antihistamines in the United States amounted to a staggering $6.89 billion dollars, making them some of the most popular OTC medications. (63) Unfortunately, antihistamines are not exactly harmless. A recent study found that the use of anticholinergic drugs, a class of drugs under which antihistamines are included, is associated with an increased risk of dementia. (64) Benadryl, one of the most popular antihistamines, has been found in animal studies to impair memory consolidation, the process by which memories are stabilized after their initial acquisition. (65)

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Here Are Your Alternatives to OTC Drugs

Clearly, over-the-counter drugs are not as harmless as we’ve been led to believe. Fortunately, there are many safe, natural alternatives to OTC drugs that you can use to relieve pain, protect your heart, reduce congestion and allergies, and alleviate acid reflux and indigestion.

Five Alternatives to Ibuprofen and Acetaminophen

If you’re looking for pain relief, try one of these remedies in place of an OTC pain killer.

1. Boswellia

Boswellia is a resin extracted from the Boswellia serrata tree native to India, the Middle East, and North Africa. In ayurveda, an ancient Indian system of medicine, boswellia is used to treat arthritic pain, reduce inflammation, and quell fevers. Modern science has confirmed the anti-inflammatory, antiarthritic, and analgesic properties of this plant, which mediates these conditions through the inhibition of inflammatory leukotrienes. (66) Boswellia that has been standardized to contain 30 percent AKBA (3-acetyl-11-keto-beta-boswellic acid) is most useful for relieving pain and inflammation and improving joint mobility.

If supplementing with Boswellia serrata resin itself, the therapeutic dosage is typically between 800 and 1,200 mg taken three times per day. Encapsulated boswellia supplements that have been standardized for AKBA content, on the other hand, are taken at much lower doses of around 100 to 250 mg per day. Pregnant women must avoid boswellia because it can promote abortion.

2. Tart Cherry Juice

Tart cherry juice contains high levels of antioxidant and anti-inflammatory compounds that reduce inflammation in the musculoskeletal system. Tart cherry juice has demonstrated benefits in the treatment of arthritis, exercise-induced muscle pain, and fibromyalgia. (67) Seek out a version that doesn’t contain added sugars to reap maximum anti-inflammatory benefits.

Tart cherry juice is most frequently consumed as a juice. In clinical trials, doses of tart cherry juice ranging from two to 12 ounces per day have been used; I recommend starting at the lower end of this range (two ounces) and working your way up from there, if necessary, until you notice a reduction in inflammation and pain. I recommend choosing an organic, no-sugar-added tart cherry juice such as Pomona Organic Tart Cherry Juice. Tart cherry juice can be safely consumed by pregnant women.

3. Turmeric

Turmeric, which contains the compound curcumin, is useful for alleviating arthritis pain. (68) Curcumin by itself has low bioavailability, requiring high doses to achieve therapeutic results. Piperine, a compound in black pepper, enhances curcumin absorption, so look for supplements that contain both compounds. Curcumin/piperine supplements should ideally contain 500 mg curcumin and 20 mg piperine per dose. Up to three doses can be taken per day. (69)

More recently, two more curcumin products with enhanced bioavailability were introduced to the market: BCM-95, a product that combines natural cofactors from turmeric root with curcumin to enhance bioavailability, and Meriva, a patented combination of curcumin and soy lecithin. The recommended dose of BCM-95 is 500 mg twice a day and that for Meriva is 200 to 500 mg twice a day.

While it is safe for pregnant women to consume turmeric in low doses with food, it should not be taken in high doses, such as those found in supplements, during pregnancy.

4. CBD Oil

CBD comes from the Cannabis sativa plant. It is extracted from the resin of cannabis buds and flowers and does not contain psychoactive THC. CBD exerts pain-relieving effects, alleviating neuropathic, rheumatoid arthritis, and cancer pain by acting on the body’s endocannabinoid system. (70) I recommend thoroughly researching the brand of CBD oil you intend to use because inadequate regulation of the CBD industry has led to a lack of standardization and a high rate of mislabeling. (71)

5. Collagen

Collagen is a protein found in the connective tissue, skin, and bones of both our own bodies and the animals we eat. Supplementation with collagen has been found to significantly improve range of motion and alleviate joint pain in individuals with exercise-induced joint discomfort. (72) You can obtain collagen in your diet by consuming bone broth, chicken skin, or bone-in sardines, or by supplementing with a hydrolyzed collagen powder such as Vital Proteins’ Collagen Peptides.

In addition to these supplements, consuming an anti-inflammatory diet, getting adequate sleep and sun exposure, acupuncture, and keeping stress at a minimum can also alleviate pain with zero side effects.

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Four Options to Try Instead of Aspirin

Instead of aspirin, protect your cardiovascular health with these natural alternatives.

1. An Unprocessed, Nutrient-Dense Diet

A processed diet high in refined carbohydrates and lacking in crucial nutrients increases your risk of heart disease. Conversely, a nutrient-dense diet composed of organic, grass-fed animal products, seafood, plentiful non-starchy vegetables, moderate amounts of starchy plants, fruits, nuts and seeds, and healthy fats creates a foundation for a healthy heart.

2. Sunshine

Our bodies evolved under conditions of plentiful sun exposure. Sun exposure is required for the production of vitamin D and nitric oxide, both of which boost heart health. Aim for approximately 15 minutes of sun exposure per day, with face and limbs exposed as much as possible, during the peak hours of the day.

3. Exercise

This may seem like a no-brainer, but exercise is crucial for your heart health and is a much safer way to protect your heart than taking aspirin! Aim for regular exercise—30 or more minutes per day four days a week. Also, if you work a sedentary job, make sure to take frequent standing and walking breaks throughout the day or invest in a standing desk. Prolonged sitting is a major but modifiable risk factor for cardiovascular disease that we can easily reverse by getting out of our desk chairs! (73)

4. Improve Your Gut Health

A growing body of evidence indicates that the gut microbiota influences the development of cardiovascular disease. (74) Protect your heart by optimizing your gut health with an anti-inflammatory diet rich in fiber, eating fermented foods, and by addressing gut dysbiosis and possible infections. (75)

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Three Natural Decongestants

Instead of decongestants, try these home remedies.

1. A Warm Compress

Try applying a warm pack over your sinuses. Wet a washcloth with warm water and hold it over your sinuses to relieve sinus pressure.

2. A Hot Shower with Essential Oils

The steam from the shower will vaporize the oils, which you can then inhale into your sinuses. Eucalyptus and peppermint are two excellent options for opening the sinuses. (76)

3. Warm Tea and Soup

Drinking warm liquids can help loosen up congestion.

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Instead of Taking PPIs, Follow These Three Steps to Fix the Underlying Problem

Reflux is typically not caused by high stomach acid but rather by increased intra-abdominal pressure resulting from SIBO, which in turn may have been caused by low stomach acid. Instead of PPIs, you can cure reflux without medication by focusing on eradicating SIBO and restoring adequate stomach acid production. Here’s how to correct reflux without PPIs.

1. Eat a Low-Carb Diet

You can address SIBO with a low-carbohydrate diet or a low-FODMAP diet. The low-FODMAP diet should not be followed long term because it may starve beneficial gut bacteria of the fermentable fiber they require for fuel.

2. Improve Your Stomach Acid Production

Boost stomach acid production with hydrochloric acid capsules and supplement with enzymes and nutrients that aid digestion. Note that individuals on aspirin, corticosteroids, ibuprofen, or other NSAIDs should not take hydrochloric acid due to the risk of exacerbating GI bleeding and ulcers. Bitter herbs such as dandelion, gentian, and yellow dock and apple cider vinegar or lemon juice can also promote gastric acid production.

3. Feed Your Good Bacteria

Restore beneficial bacteria and a healthy mucosal lining in the gut with fermented foods, probiotics, bone broth, and gelatin.

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Instead of Antihistamines, Try These Five Options

There are many natural ways to alleviate allergies without resorting to antihistamines.

1. Quercetin

Quercetin, a flavonoid found in kale, onions, apples, and a variety of other fruits and vegetables, is a potent natural antihistamine that is free of side effects. (77)

2. Vitamin C

Vitamin C also lowers histamine by physically breaking apart the structure of the histamine molecule. (78)

3. Raw Honey

Local raw honey can benefit those with seasonal allergies by suppressing IgE-mediated hypersensitivity reactions and histamine release by mast cells. (79)

4. Improving Your Gut Health

Improving the health of your gut may also alleviate allergies. Research indicates that children with allergies tend to have increased levels of opportunistic and pathogenic bacteria, such as Staphylococcus, Clostridium, and Escherichia coli, and reduced levels of healthy bacteria such as Lactobacillus and Bifidobacteria. (80, 81)

5. Alleviating SIBO

SIBO may also contribute to allergies by triggering excess histamine production. Restoring balance to the gut microbiota with probiotics, particularly ones that degrade histamine, such as Bifidobacterium infantis and Lactobacillus plantarum, and treating SIBO may relieve allergic symptoms. Consuming fermentable fiber, which gut bacteria metabolize to produce butyrate, reduces intestinal permeability and increases T regulatory cells, which suppress certain immune responses such as those involved in allergies.

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Now I want to hear from you. Do you regularly take over-the-counter medications? Would you consider trying any of the alternatives I’ve suggested? Let me know in the comments below.

The post How Safe Is Your Over-the-Counter Medicine? appeared first on Chris Kresser.

Source: http://chriskresser.com January 31, 2019 at 12:59AM

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