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jcmarchi · 2 months

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Innovative Chemotherapy Approach Shows Promise Against Lung Cancer - Technology Org

New Post has been published on https://thedigitalinsider.com/innovative-chemotherapy-approach-shows-promise-against-lung-cancer-technology-org/

Innovative Chemotherapy Approach Shows Promise Against Lung Cancer - Technology Org

Lung cancer is not the most common form of cancer, but it is by far the deadliest.

Kytai T. Nguyen, the Alfred R. and Janet H. Potvin Distinguished Professor in Bioengineering at UTA. Image credit: UTA

Despite treatments such as surgery, radiation therapy and chemotherapy, only about a quarter of all people with the disease will live more than five years after diagnosis, and lung cancer kills more than 1.8 million people worldwide each year, according to the World Health Organization.

To improve the odds for patients with lung cancer, researchers from The University of Texas at Arlington and UT Southwestern Medical Center have pioneered a novel approach to deliver cancer-killing drugs directly into cancer cells.

“Our method uses the patient’s own cellular material as a trojan horse to transport a targeted drug payload directly to the lung cancer cells,” said Kytai T. Nguyen, lead author of a new study on the technique in the peer-reviewed Bioactive Materials and the Alfred R. and Janet H. Potvin Distinguished Professor in Bioengineering at UTA. “The process involves isolating T-cells (a type of immune cell) from the cancer patient and modifying them to express a specific receptor that targets the cancer cells.”

The crucial step in this new technique involves isolating the cell membrane from these modified T-cells, loading the membranes with chemotherapy medications, and then coating them onto tiny drug-delivery granules. These nanoparticles are roughly 1/100 the size of a strand of hair.

Jon Weidanz, associate vice president for research and innovation and professor of kinesiology and bioengineering. Image credit: UTA

When these membrane-coated nanoparticles are injected back into the patient, the cell membrane acts as a guide, directing the nanoparticles to the tumor cells with precision. This approach is designed to deceive the patient’s immune system, as the coated nanoparticles mimic the properties of immune cells, avoiding detection and clearance by the body.

“The key advantage of this method lies in its highly targeted nature, which allows it to overcome the limitations of conventional chemotherapy that often lead to detrimental side effects and reduced quality of life for patients,” said co-author Jon Weidanz, associate vice president for research and innovation and a researcher in kinesiology and bioengineering.

“By delivering chemotherapy directly to the tumor cells, the system aims to minimize collateral damage to healthy tissues,” continued Weidanz, who also is a member of UTA’s Multi-Interprofessional Center for Health Informatics.

In the study, researchers loaded the nanoparticles with the anti-cancer drug Cisplatin. The membrane-coated nanoparticles accumulated in parts of the body with the tumors rather than in other parts of the body. As a result, this targeted delivery system reduced the size of the tumors in the control group, demonstrating its efficacy.

“This personalized approach could pave the way for a new era of medicine tailored to each patient’s unique characteristics and the specific nature of their tumor,” Nguyen said. “The potential for reduced side effects and improved effectiveness makes our technique a noteworthy advancement in the field of cancer treatment.”

Source: University of Texas at Arlington

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cbirt · 1 year

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3D Bioprinting Takes Eye Tissue Engineering to New Heights at NIH

Scientists at the National Eye Institute (NEI), part of the National Institutes of Health, have made a significant advancement in the field of 3D bioprinting by successfully creating functional eye tissue using this innovative technique. The potential for this development to revolutionize the treatment of eye conditions and diseases is vast, and further research will undoubtedly continue to build upon these groundbreaking findings.

The research team used 3D bioprinting and patient stem cells to create eye tissue that will help researchers better understand blinding diseases. The team printed a combination of cells that make up the outer blood-retina barrier, a type of eye tissue that supports the retina’s photoreceptors. This technique could potentially provide an unlimited supply of patient-derived tissue for studying degenerative retinal diseases like age-related macular degeneration (AMD).

#3d printing #biotechnology #amd #health #technology #stem cells #biomedical engineering #scicomm #medcomm #science news

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macleod · 1 year

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New CRISPR cancer treatment tested in humans for first time

Researchers have made an important step forward toward a long-desired goal: using the gene-editing technology CRISPR to treat cancer. [Source: Time]

Now, PACT Pharma and UCLA have used CRISPR to remove and add genes to these cells to help them recognize a patient’s specific tumor cells. [...]

By genetically engineering T cells to be better at spotting proteins commonly found on the surfaces of blood cancer cells, researchers have been able to develop treatments — called “CAR-T cell therapies” — for people with those cancers. [..]

Using CRISPR, they knocked out a gene for an existing receptor and inserted a gene for a cancer-targeting receptor into T cells that lacked it. Once they had engineered what they thought would be enough T cells, the researchers infused them back into the patient.

The results: Later biopsies found that up to 20% of the immune cells in the patients’ tumors were the engineered T cells, suggesting that those cells were in fact very adept at homing in on the cancer.

Only two of the 16 participants experienced minor side effects — fever, chills, confusion — attributable to the T cells, but they quickly resolved. [..]

A month after treatment, five of the patients’ tumors were the same size as before, suggesting that the engineered cells may have had a stabilizing effect on their condition.

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My thoughts: While the results weren't absolutely mind-staggering, 100% fantastic, the amount that they were able to keep the cancer cells at bay, and normalize the growth is tremendously great.

The researchers went on to say that this may be due to their purposeful limited attack methods, and that this is something they can build on and truly develop a personalized life-saving or extending treatment for cancer.

“We are reprogramming a patient’s immune system to target their own cancer, [..] It’s a living drug, so you can give one dose and ideally have life-long protection [from the cancer].”

Source: Freethink, November 21st, 2022.

#crispr #genetic engineering #biology #cancer #the future is now #mine #news #articles #biotechnology #technology

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theleadersglobe · 10 days

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NATO Adopts Groundbreaking Biotechnology Strategy

In a significant move, NATO has formally adopted its first-ever international strategy to oversee the ethical development and application of biotechnologies and human enhancement technologies. This pioneering strategy, unveiled in a public version on April 12, 2024, after its initial adoption at the Allied Defence Ministers’ meeting in February, marks a major step in addressing the burgeoning role of these technologies in defense and security sectors.

The strategy arises amid the rapid acceleration of biotechnological advancements which pose both opportunities and challenges in the realms of national and international security. By embracing a framework that is informed, value-based, and gender-aware, NATO aims to position itself as a leader in setting ethical standards for the use of such technologies.

Read More:(https://theleadersglobe.com/science-technology/nato-adopts-groundbreaking-biotechnology-strategy/)

#global leader magazine #the leaders globe magazine #leadership magazine #world's leader magazine #article #best publication in the world #news #magazine #business #biotechnology #implicate non-pathogenic research

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kratomkittycat · 2 years

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Today is day 7 without kratom extract

If I make it through today, I will be able to say that I made it a week without kratom extract.

I realized that every week I don’t take any kratom extract, I am saving approximately $165. So every 2 weeks, it’s $330.

I decided that if I make it 2 weeks without kratom extract, then I will buy myself a reward. And I decided that it will be getting my nails and toenails done.

Then, if I make it another 2 weeks, I will get eyelash extensions. I have never gotten them before because I thought that they wouldn’t look pretty on a girl with severe acne, but my skin has become a lot less bad since then (thanks to acne medication).

I already have an appointment for September 24th to get my hair extensions put back in. I made the appointment a while ago when I was still using and had no plans to take any time off from using.

My start date for the new job is just days after that, and it will be a good feeling to be so beautiful when I start my first official lab technician job. I will feel beautiful AND smart!!

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focusonthegoodnews · 2 years

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Meat Alternatives Made From Fungi Could Cut Deforestation by 50%

Good News Notes: “Researchers from the Potsdam Institute for Climate Impact Research (PIK) have found that substituting just 20% of beef with a fungi-based meat alternative could decrease deforestation by 50% by 2050. According to the researchers, microbial protein, as the fungi-based “meat” is called, can replicate the taste and texture of real beef. But microbial proteins require far less land…

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scanthedata · 3 months

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#business #breaking news #market report #market research #technology #tech #news #health & fitness #healthcare #biology #biotechnology

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manifestomode · 4 months

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youtube

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rodjanikov · 5 months

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I want to be part of the elite so baaad

#let me in the pantheon of stem #I haven't sacrificed years of my life studying for mundane lab analysis #I want to do research o(-(#I don't know if I'd be capable but I want to anyways #stem #rodja.txt #college #I was sixteen when I started to study medical cases and applied biotechnology by myself #at seventeen I was able to come up with screening algorithms for my entire lab group #I think I still have it in me #at eighteen I participated in a medical research that was developing new imaging for cancer diagnosis #and I helped with distinguishing a particular molecule that made the project step forward #I can do this #dark academia #light academia

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jcmarchi · 3 months

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Shuffling Robot Uses Biological Muscle to Move and Spin - Technology Org

New Post has been published on https://thedigitalinsider.com/shuffling-robot-uses-biological-muscle-to-move-and-spin-technology-org/

Shuffling Robot Uses Biological Muscle to Move and Spin - Technology Org

Researchers at the University of Tokyo have created a two-legged biohybrid robot, combining an artificial skeleton with biological muscle, which is capable of walking and pivoting underwater.

Typical biohybrid robots can move in straight lines or perform large turns but struggle to carry out finer movements in smaller spaces. This makes them unsuitable for use in areas with many obstacles, such as in search and rescue operations.

The new robot can pivot on one foot, enabling it to turn within a small circle. At present, it can only work underwater as the lab-grown muscle dries out quickly when exposed to air, losing effectiveness. However, the researchers foresee that it would be possible to create future iterations which can walk on land, by using thicker muscles with their own nutrient supplies and possibly covering them in artificial skin.

Labeled illustration and image of robot. These labeled pictures show the flexible body of the robot, made from skeletal muscle tissue and a clear flexible silicone substrate, attached to the weighted 3D printed legs and feet. Image credit: Kinjo et al/ Matter

If I ask you to imagine a robot made of living muscle on an artificial skeleton, the striding form of a part human, part machine cyborg may come to mind. But the truth is that we are still just taking baby steps when it comes to creating biohybrid, natural-artificial robots.

Building real-life biohybrid robots which can walk like a human, let alone stride or run like one, is a big challenge. Professor Shoji Takeuchi and his team from the Graduate School of Information Science and Technology at the University of Tokyo have taken on this challenge in their latest research.

“By incorporating living tissues as part of a robot, we can make use of the superior functions of living organisms. In our latest research, we combined lab-grown skeletal muscle tissue with flexible artificial legs and 3D-printed feet. Using the muscle tissue to move the legs allowed us to create a small robot with efficient, silent movements and a soft touch,” explained Takeuchi.

This sped-up GIF of the robot underwater shows the legs walking forward, with the muscle contractions being stimulated by electricity. Image credit: Kinjo et al/ Matter/University of Tokyo

The researchers began by growing skeletal muscle in molds to create strips. The muscle tissue loses its ability to move when it becomes too dry, so the robot was designed to be suspended in water. The team made a lightweight skeleton from a floating styrene board, a flexible silicone-based body, acrylic resin legs with brass wire weights, and 3D-printed feet. Two strips of muscle tissue were attached from the body to the feet of the robot, completing the legs.

Each leg was stimulated using hand-held gold electrodes to deliver a charge, similar to your brain sending electrical signals to your body to move. This caused the muscle tissue to contract and the robot to “walk” when the legs were stimulated one after the other.

By stimulating each leg at five-second intervals, they were able to move the robot at a speed of 5.4 millimeters per minute. Although it might not seem particularly fast, the speed of its leg movements was comparable to that of other biohybrid robots.

“Initially, we weren’t at all sure that achieving bipedal walking was possible, so it was truly surprising when we succeeded,” said Takeuchi.

“Our biohybrid robot managed to perform forward and turning movements with a bipedal walk by effectively balancing four key forces: the muscle contractile force, the restorative force of the flexible body, the gravity acting on the weight, and the buoyancy of the float.”

Explanation of walking movement. The top illustrations show the three phases of the robot’s movement: first, lifting the foot; second, the foot hangs suspended; and third, it lands. The graph below shows the distance traveled and time it took for each phase, the longest being the hanging phase. The combination of the three phases leads to one step. Image credit: Kinjo et al/ Matter/University of Tokyo

The team is now considering how to create a smoother-moving robot that can walk on land by developing methods to stimulate the muscles remotely and creating thicker muscles with a nutrient supply to sustain them.

Takeuchi said: “We’re working on designing robots with joints and additional muscle tissues to enable more sophisticated walking capabilities. Our findings offer valuable insights for the advancement of soft flexible robots powered by muscle tissue and have the potential to contribute to a deeper understanding of biological locomotion mechanisms, further enabling us to mimic the intricacies of human walking in robots.”

Source: University of Tokyo

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affairsmastery · 6 months

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India things!

India aims to increase the Bioeconomy's contribution to GDP (Gross Domestic Product) from 2.6% to 5% by 2030, as outlined in the 'Bioeconomy Report 2022' by the Department of Biotechnology (DBT).

Biotechnology funding in India remains stagnant, with only a 0.0001% allocation of the GDP. Despite a temporary increase during Covid-19, funding levels haven't returned to pre-pandemic standards.

The ‘Guidelines for Genetically Engineered (GE) Insects’, issued by the DBT in April 2023, provide procedural roadmaps for those interested in creating GE insects but have issues.

India's bioeconomy is on a robust growth trajectory, projected to reach USD 150 billion by 2025 and surpass USD 300 billion by 2030.

The sector experienced a remarkable 14.1% increase, reaching USD 80 billion in 2021 compared to USD 70.2 billion in 2020.

In 2021, the sector witnessed the establishment of three biotech startups daily, totaling 1,128 for the year.

With over USD 1 billion invested in research and development, the industry is demonstrating a commitment to innovation and advancement.

Amidst the global pandemic, India administered 4 million Covid-19 vaccine doses and conducted 3 million tests daily, showcasing its resilience and capacity.

Over the past decade, the number of biotech startups has soared from 50 to over 5,300, with expectations of doubling by 2025.

The Biotechnology Industry Research Assistance Council (BIRAC) has played a pivotal role by establishing 74 bio-incubation centers across 21 states/UTs, fostering a supportive environment for bio-entrepreneurs.

Notably, India boasts the second-highest number of USFDA (United States Food and Drug Administration)-approved manufacturing plants outside the US, underscoring its global standing in the biotech industry.

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wintersbiotechnology · 6 months

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#New innovations in biotechnology #Biotechnology research company

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prismmediawire · 7 months

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Sustainable Green Team Secures Groundbreaking $20M Middle East Deal

Agreement showcases company’s ongoing strategic transformation

ORLANDO, FL, October 6, 2023 – Sustainable Green Team (OTCQX: SGTM) ("Company"), a leader in environmentally conscious solutions in the arbor care, disposal, and recycling industry, proudly announces the successful sale of $12 million worth of state-of-the-art equipment as part of a groundbreaking Middle East deal. In addition to the equipment sale, the transaction also includes an allocation of $8 million for transportation and reinstallation, bringing the total deal value to an impressive $20 million.

Earlier this month, Sustainable Green Team invoiced approximately $7.5 million from its innovative new product lines, HumiSoil® and Core Catalyst, to the Middle East. These achievements demonstrate the growing demand for environmentally-friendly and sustainable products in the region.

Tony Raynor, CEO of Sustainable Green Team, said: “We are delighted to be entering into this partnership, which represents a significant milestone for Sustainable Green Team as we continue our strategic transformation.

“Our commitment to sustainability drives us to convert underutilized assets into groundbreaking solutions. With our expertise in recycling, we will provide essential knowledge, cutting-edge equipment, and sustainable fiber solutions to the Middle East, a region with a tremendous need for soil enhancement.”

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Leveraging its recycling prowess, Sustainable Green Team has developed a comprehensive equipment solution that not only addresses the urgent need for sustainable practices but also tackles the scarcity of high-quality soil. The company’s cutting-edge equipment is set to revolutionize the approach to soil enhancement in the Middle East, paving the way for a more sustainable and fruitful future.

Sustainable Green Team extends a warm invitation to industry stakeholders, partners, and enthusiasts to join in celebrating this momentous achievement. Together, we can make a tangible difference in the world, one step at a time.

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About Sustainable Green Team

Sustainable Green Team (OTCQX: SGTM) is at the forefront of promoting environmental sustainability through innovative recycling solutions. Committed to preserving and protecting our planet, we specialize in transforming underutilized assets into valuable resources that benefit both the environment and society. With our expertise and cutting-edge equipment, we strive to create a greener future for generations to come. For more information, please visit www.sustainablegreenteam.com.

Cautionary Note Regarding Forward-Looking Statements

This news release contains forward-looking statements included within the meaning of Section 27A of the Securities Act of 1933, and Section 21E of the Securities Exchange Act of 1934, as amended. All statements regarding our expected future financial position, results of operations, cash flows, financing plans, business strategy, products, and services, competitive positions, growth opportunities, plans and objectives of Management for future operations, including words such as "anticipate," "if," "believe," "plan," "estimate," "expect," "intend," "may," "could," "should," "will," and other similar expressions are forward-looking statements and involve risks, uncertainties and contingencies, many of which are beyond our control, which may cause actual results, performance, or achievements to differ materially from anticipated results, performance, or achievements. The Company cautions readers not to rely on any such forward-looking statements, which speak only as of the date made. We are under no obligation to (and expressly disclaim any such obligation to) update or alter our forward-looking statements, whether as a result of new information, future events or otherwise.

For more information

Tony Raynor

CEO & Chairman of the Board

[email protected]

407-886-8733

SOURCE: Sustainable Green Team

#press release #prism mediawire #stock market #investing #otc markets #otc #sustainability #Biotech #biotechnology #SGTM #stock maket news #OTCQX #Youtube

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yogasblogyogaanitha · 7 months

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Biotech Breakthroughs - Revolutionizing New Drug Creation and Manufacturing

How do these companies utilize biotechnology to discover and produce new drugs? Biotechnology plays a crucial role in the discovery and production of new drugs for pharmaceutical and biopharmaceutical companies. These companies leverage various biotechnological techniques and tools to identify, develop, and manufacture novel therapeutic agents. Here’s an overview of how they utilize…

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#biopharmaceutical #biotech and drug innovation #business #How do these companies utilize biotechnology to discover and produce new drugs?

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kratomkittycat · 2 years

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The Morning of Day 5

I ended up taking some of my sleep medicine and got some good sleep last night. I woke up a little before 8, and now it’s after 9.

I got a call from the big pharma company. They offered me the job as a lab tech. I said yes. Since finding out, I’ve been having a lot of different overwhelming emotions.

They didn’t say anything about a drug test yet, but I know it’s coming. So now I have to stay super dedicated and not take any kratom extract for the next few weeks.

It’s hard to believe that it’s only day 5.

#special interest #kratom extract #kratom #actually autistic #drug blog #infodump #info dump #autistic adult #lab technician #drug test #biotech #biotechnology #big pharma #girls who like drugs #new job #first job after graduation #surprise

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biglisbonnews · 8 months

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Bactometer: New Intelligent Device Detects Multi-Resistant Bacteria (in Less Than 60 Minutes) Bactometer, developed over 15 years of research, is a rapid biological detector targeting antimicrobial resistance in hospitals. Combining magnetic methods with machine learning, it promises... https://scitechdaily.com/bactometer-new-intelligent-device-detects-multi-resistant-bacteria-in-less-than-60-minutes/

#Technology #Antibiotics #Bacteria #Biotechnology #INESC Brussels Hub #Technology News #Research & Innovations - SciTechDaily

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