“Most engineers like to proceed from A to B to C in a series of logical steps. I’m the rare engineer who says the answer is obviously Z and we will get on with that while you guys work out how to do all the intermediate steps. It makes me a dangerous person to employ in IT but a useful one.“
Sophie Wilson is a computer scientist who designed the architecture behind the Acorn Micro-Computer — the first computer sold by British technology company, Acorn Computers • She CREATED THE ORIGINAL ARM COMPUTER PROCESSOR, which would later become one of the most successful IP cores • By 2012, her design could be found in most of the world’s mobile computers & smartphones
In 2005, Karikó and Weissman published a study announcing a specifically modified form of mRNA, which replaced Uridine with an analog – a molecule which looked the same, but did not induce an immune response. It was a clever biological trick, and one which worked. When mice were injected with this modified mRNA, they lived. “I just remember Drew saying, ’Oh my god, it’s not immunogenic,’” said Karikó. “We realised at that moment that this would be very important, and it could be used in vaccines and therapies.
In 2013, she accepted an offer to become Senior Vice President at BioNTech after UPenn refused to reinstate her to the faculty position she had been demoted from in 1995. “They told me that they’d had a meeting and concluded that I was not of faculty quality,” she said. ”When I told them I was leaving, they laughed at me and said, ‘BioNTech doesn’t even have a website.’”