#matthew winer | Explore Tumblr Posts and Blogs

inkastream · 3 years

Text

⚡ Ύπνος: Τι αποκαλύπτει για τον κίνδυνο Αλτσχάιμερ

Περίπου 40 εκατομμύρια άνθρωποι στον κόσμο πάσχουν από Αλτσχάιμερ.

Ερευνητές από το Πανεπιστήμιο Μπέρκλεϊ της Καλιφόρνια διαπίστωσαν ότι ο ύπνος μπορεί να προβλέψει την εμφάνιση της νευροεκφυλιστικής νόσου.

Όπως επισημαίνει ο επικεφαλής της έρευνας Matthew Walker, καθηγητής ψυχολογίας και νευροεπιστήμης στο Μπέρκλεϋ, ο ύπνος αποτελεί σημαντικό αμυντικό μηχανισμό έναντι της νόσου Αλτσχάιμερ, μέσω μιας διαδικασίας «αυτοκαθαρισμού» κατά τον βαθύ ύπνο.

Σε συνεργασία με τον νευροεπιστήμονα Joseph Winer και μια ομάδα ερευνητών, μελέτησαν σε 32 υγιείς μεσήλικες από τη βάση δεδομένων της Berkeley Aging Cohort Study, τη σχέση της ποιότητας του νυχτερινού ύπνου με τη συσσώρευση β-αμυλοειδούς στον εγκέφαλο, της κυτταροτοξικής πρωτεΐνης που συγκεντρώνεται σε πλάκες και έχει συσχετιστεί με την εμφάνιση της νόσου Αλτσχάιμερ.

Κάθε συμμετέχων κοιμήθηκε ένα βράδυ επί οκτώ ώρες στο εργαστήριο, ενώ υποβλήθηκε σε μελέτη ύπνου, μια σειρά εξετάσεων που καταγράφουν τα εγκεφαλικά κύματα, τον καρδιακό ρυθμό, τα επίπεδα οξυγόνου στο αίμα και άλλους δείκτες ποιότητας του ύπνου.

Κατά τη διάρκεια της πολυετούς μελέτης, οι ερευνητές παρακολούθησαν τον ρυθμό παραγωγής β-αμυλοειδούς πρωτεΐνης στον εγκέφαλο των συμμετεχόντων χρησιμοποιώντας τομογραφία εκπομπής ποζιτρονίων (PET SCAN), επικεντρωμένοι στο στάδιο μη γρήγορης οφθαλμικής κίνησης (non-REM) -πρόκειται για τη φάση έναρξης του βαθέος ύπνου όπου το σώμα χαλαρώνει, η θερμοκρασία του μειώνεται και περνά στη διαδικασία της ξεκούρασης.

Τα αποτελέσματα έδειξαν ότι οι συμμετέχοντες με διακεκομμένο συνολικά ύπνο και περιορισμένο χρονικά βαθύ ύπνο είχαν περισσότερες πιθανότητες υψηλής συγκέντρωσης β-αμυλοειδούς.

Τα ευρήματα κρίθηκαν σημαντικά για την πρόβλεψη της εμφάνισης της νόσου, παρά τη σταθερή υγεία των συμμετεχόντων καθ’όλη τη διάρκεια της μελέτης.

Παράλληλα, καλύπτουν ένα κενό: μολονότι η διάγνωση και πρόβλεψη καθίστανται δυνατές μέσω του γονιδιακού ελέγχου και σχετικών αιματολογικών εξετάσεων, δεν συμβάλουν με κάποιον τρόπο στη θεραπεία του.

Αντιθέτως, σημειώνουν οι ερευνητές, ο βαθύς ύπνος αποδεικνύεται ανεκτίμητη παρέμβαση για τη θωράκιση της γνωστικής ικανότητας, ενισχύοντας παλαιότερες επιστημονικές αποδείξεις για την εμπλοκή του ύπνου στον καθαρισμό του εγκεφάλου από τις αποθέσεις β-αμυλοειδούς.

Η μελέτη δημοσιεύτηκε στο επιστημονικό έντυπο Current Biology.

#ΙΝΚΑ #NEWSROOM

0 notes

krisroley · 3 years

Text

February 3rd 2021

On Social Media

You may have noticed that some parts of yesterday’s blog post made it to other social networks, primarily LinkedIn. I did post a little to Twitter yesterday, but mostly personal stuff and not business-related. I’m having a bit of a clarifying moment when it comes to social media lately that I want to dig into a bit more. LinkedIn doesn’t suffer from this malady because of its nature, but depending on its members' ability to police themselves, it may only be a matter of time. This malady I refer to is the weaponization of social media and the appropriation of content.

Clearly, the whole point behind social media is engagement, but I don’t think any of us anticipated what has happened in the last 4 to 5 years. In retrospect, we should have. If you lived through the age of shock or conservative talk radio, you might have an inkling of what I mean. Someone says something outrageous, and it’s an almost Pavlovian response. We MUST engage. The part I don’t think we could have predicted was social media promoting the outrageousness to the degree they did. Social media might recognize the part they played in this mess one day, but I have a hard time continuing to participate in something designed to promote Shock's Culture for the sake of likes and dollars.

LinkedIn feels different somehow. Yes, it’s a social network, but it is populated by people who have a vested interest in maintaining a professional appearance. I’ve seen many times when someone tries to lob a metaphorical Molotov Cocktail into the mix, and someone says, “That’s not appropriate for this space.” I hope that means that legitimate content is King there, and the engagement follows as a result of the substance of that content, not on the controversy. For now, I’ll put my focus there and see how it goes.

The other issue I mentioned is the appropriation of content, and that’s discussed on next Wednesday’s show.

Just…stop already

A note totally unrelated to anything: Politicians can stop sending me emails now. You’re approaching “We can help you with your extended auto warranty” territory.

Rebundling The News

The great Dave Winer:

The news industry product needs to be re-bundled. I believe the rewards will be huge for the first publication that bets on this idea. They wouldn't be the first, btw -- My.Yahoo did it in the 00's. Have the guts to point to your competition. And if you have a paywall, send them some money and some readers. Now that Jeff Bezos is retired, and owns such a platform, I would stand up and applaud if they had the guts to try this out. I'd also line up to hook my blog into such a network. Not because my writing depends on making money from it, it doesn't, but to help disrupt the news industry that's daydreaming itself to death over distribution, competition and economics.

What I wouldn’t give to be able to subscribe to one feed with what I’ll call an “a la carte” option of news and editorial options. That was one of the great things about RSS Readers at the outset, but content is increasingly siloed or anything more than an excerpt is behind a paywall. I’ve learned never to click on an LA Times Article Link for example, because I know I will never see the story, I’ll get a splash page instead. Same with WaPo. Would I pay some money for the a la carte option I just mentioned? Possibly. Would you?

Some Links Of Interest…

From the Beeb:

Ms Khing, an aerobics teacher, posted her exercise video to Facebook on Monday morning.

At the time, Myanmar's army was in the process of a military coup, detaining Aung San Suu Kyi and other democratically elected leaders from her party.

I don’t think you could be blamed if you were reminded of Baghdad Bob watching this.

Matthew at SLR Lounge is never buying another Sandisk SD Card:

Unfortunately, I’m done buying Sandisk SD cards. and I think you can see why. They seem to be more flimsy than any other memory card (make or model) I have ever had. Inevitably, they split open and spill their memory chip guts.

After looking at these pictures and my stash of Sandisk Memory Cards, I don’t have what you would call a Peaceful Easy Feeling about this. I have more than a few of these, and while I don’t put them through the paces, a professional photographer does, I would like to know they’re gonna hold up. It doesn’t look good, I’ll tell you that much.

From The Verge, Casey Newton talks about Clubhouse’s ‘South By Moment’:

The only social-networking moment I can compare it to in recent years would be the 2015 South by Southwest festival, when the streets of Austin were briefly overrun by people broadcasting themselves on Meerkat. Then, as now, the once-stable field of social networks hummed with a fresh sense of possibility.

I have an account at Clubhouse, which as of right now, lies dormant. I have a habit of opening accounts at different apps with my preferred handle so that no one else takes it and gets a taste of the app before passing judgment (Yes, including THAT one). Newton calls Clubhouse the ‘Medium of Podcasts’ in that it appears to democratize audio in a way that Anchor didn’t, and the experience is as clean and ‘radiant’ as Medium. I agree. I’ll be interested to see how the app is used as time goes on. The funny thing about democratizing media is that everybody is ‘the media.’ The downside to that is that everyone—including me—is ‘the media.’ Open source guys will love it. Matt Deegan over at Matt on Audio might be a bit skeptical…

At it’s worst, I’d say the content is basically the annoying self-promoters from LinkedIn given a microphone to talk to their echo-chamber. At it’s best you can say it’s a place for like-minded people to get together and have a discussion in a screen’s-off environment.

Matt seems to think this might lend itself to more of a panel or conference vibe, and I can see it. The trouble with that is I also see the self-appointed ‘gurus’ and marketers taking it over much like they’ve tried to do with podcasting the second they see money in it. (Rule One: Marketers. Ruin. Everything)

Shot of The Day

#social media #LinkedIn #engagement #weaponized #Clubhouse #Medium #Matt Deegan #Matthew Saville #Sandisk #Casey Newton

0 notes

spoilersgr · 4 years

Link

Ύπνος και Αλτσχάιμερ: Ερευνητές του Πανεπιστημίου Μπέρκλεϊ της Καλιφόρνια βρήκαν πως ο ύπνος είναι σημαντικός. Κάθε νόσος είναι σημαντικό να προβλέπεται και αυτό κάνει ο ύπνος όσον αφορά τη νεροεκφυλιστική νόσο του Αλτσχάιμερ. Επιπλέον, αποτελεί πολύ καλό μηχανισμό, ο οποίος αμύνεται μέσω της διαδικασίας «αυτοκαθαρισμού» κατά τον βαθύ ύπνο. Τουλάχιστον, αυτά αναφέρει ο επικεφαλής της έρευνας Matthew Walker, καθηγητής ψυχολογίας και νευροεπιστήμης στο Μπέρκλεϊ. Ύπνος και Αλτσχάιμερ: Η μελέτη που πραγματοποιήθηκε σε 32 υγιείς μεσήλικες Σε συνεργασία με τον νευροεπιστήμονα Joseph Winer και μια ομάδα ερευνητών, μελέτησαν σε 32 υγιείς μεσήλικες από τη βάση δεδομένων της Berkeley Aging Cohort Study, τη σχέση της ποιότητας του νυχτερινού ύπνου με τη συσσώρευση β-αμυλοειδούς στον εγκέφαλο, της κυτταροτοξικής πρωτεΐνης που συγκεντρώνεται σε πλάκες και έχει συσχετιστεί με την εμφάνιση της νόσου Αλτσχάιμερ. Κάθε συμμετέχων κοιμήθηκε ένα βράδυ επί οκτώ ώρες στο εργαστήριο. Υποβλήθηκε σε μελέτη ύπνου. Δηλαδή, σε μια σειρά εξετάσεων που καταγράφουν τα εγκεφαλικά κύματα. Επιπλέον, καταγράφουν τον καρδιακό ρυθμό, τα επίπεδα οξυγόνου στο αίμα και άλλους δείκτες ποιότητας του ύπνου. Κατά τη διάρκεια της πολυετούς μελέτης, οι ερευνητές παρακολούθησαν τον ρυθμό παραγωγής β-αμυλοειδούς πρωτεΐνης στον εγκέφαλο των συμμετεχόντων. Αυτό έγινε με τη χρήση τομογραφίας εκπομπής ποζιτρονίων (PET SCAN). Ιδιαίτερη προσοχή δόθηκε στο στάδιο μη γρήγορης οφθαλμικής κίνησης (non-REM). Πρόκειται για τη φάση έναρξης του βαθέος ύπνου όπου το σώμα χαλαρώνει. Η θερμοκρασία του μειώνεται και περνά στη διαδικασία της ξεκούρασης. Τα αποτελέσματα έδειξαν ότι οι συμμετέχοντες με διακεκομμένο συνολικά ύπνο και περιορισμένο χρονικά βαθύ ύπνο είχαν περισσότερες πιθανότητες υψηλής συγκέντρωσης β-αμυλοειδούς. Τα ευρήματα κρίθηκαν σημαντικά για την πρόβλεψη της εμφάνισης της νόσου, παρά τη σταθερή υγεία των συμμετεχόντων καθ’όλη τη διάρκεια της μελέτης. Παράλληλα, καλύπτουν ένα κενό: μολονότι η διάγνωση και πρόβλεψη καθίστανται δυνατές μέσω του γονιδιακού ελέγχου και σχετικών αιματολογικών εξετάσεων, δεν συμβάλουν με κάποιον τρόπο στη θεραπεία του. Αντιθέτως, σημειώνουν οι ερευνητές, ο βαθύς ύπνος αποδεικνύεται ανεκτίμητη παρέμβαση για τη θωράκιση της γνωστικής ικανότητας, ενισχύοντας παλαιότερες επιστημονικές αποδείξεις για την εμπλοκή του ύπνου στον καθαρισμό του εγκεφάλου από τις αποθέσεις β-αμυλοειδούς. Πηγή άρθρου: enimerotiko.gr

0 notes

vidpoker11 · 4 years

Text

How well we sleep may forecast when Alzheimer's begins

How well we sleep may forecast when Alzheimer’s begins

What would you do if you knew how long you had until Alzheimer’s disease set in? Don’t despair. New research from the University of California, Berkeley, suggests one defense against this virulent form of dementia — for which no treatment currently exists — is deep, restorative sleep, and plenty of it.

UC Berkeley neuroscientists Matthew Walker and Joseph Winer have found a way to estimate,…

View On WordPress

#a good night’s sleep #Alzheimer&039;s Disease #demen

0 notes

winbratech · 4 years

Photo

New Post has been published on https://winningbrain.com.ng/your-sleeping-pattern-can-put-you-at-the-risk-of-alzheimers-disease-says-study/

Your sleeping pattern can put you at the risk of Alzheimer’s disease, says study

If forgetting things has become a normal thing for you then it can be a sign of the onset of Alzheimer’s disease. And who’s to blame? Poor sleep. In today’s world of hustle and meeting deadlines, our sleep pattern is really messed up and this lockdown has been the cherry in the top.

A recent research published in the journal Current Biology found that based on your sleep patterns neuroscientists can now estimate a time frame for when Alzheimer’s is most likely to strike in a person’s lifetime. Their findings suggest that one defence against this virulent form of dementia (for which no treatment currently exists) is deep, restorative sleep, and plenty of it.

University of California Berkeley professor of psychology and neuroscience and senior author of the paper, Matthew Walker says: “The sleep you’re having right now is almost like a crystal ball telling you when and how fast Alzheimer’s pathology will develop in your brain. The silver lining here is that there’s something we can do about it. The brainwashes itself during deep sleep, and so there may be a chance to turn back the clock by getting more sleep earlier in life.”

Also, read: Dementia and Alzheimer’s could begin in your 20s. Do these things to reduce their risk

The researchers studied the sleep quality of the study participants The researchers matched the overnight sleep quality of 32 healthy older adults against the buildup in their brains of the toxic plaque known as beta-amyloid—a key player in the onset and progression of Alzheimer’s. This afflicts more than 40 million people worldwide by destroying their memory pathways and other brain functions.

For the experiment, each participant spent an eight-hour night of sleep in Walker’s lab while undergoing polysomnography, a battery of tests that record brain waves, heart rate, blood-oxygen levels and other physiological measures of sleep quality.

Over the course of the multi-year study, the researchers periodically tracked the growth rate of the beta-amyloid protein in the participants’ brains using positron emission tomography, or PET scans and compared the individuals’ beta-amyloid levels to their sleep profiles.

Peaceful sleep is all you need to keep Alzheimer’s disease at bay. Image courtesy: Shutterstock

They found that… The study participants who started out experiencing more fragmented sleep and less non-rapid eye movement (non-REM) slow-wave sleep were most likely to show an increase in beta-amyloid over the course of the study.

Although all participants remained healthy throughout the study period, the trajectory of their beta-amyloid growth correlated with baseline sleep quality. The researchers were able to forecast the increase in beta-amyloid plaques, which are thought to mark the beginning of Alzheimer’s.

Joseph Winer the lead author and a PhD student in Walker’s Center for Human Sleep Science at UC Berkeley says:

“Rather than waiting for someone to develop dementia many years down the road, we are able to assess how sleep quality predicts changes in beta-amyloid plaques. In doing so, we can measure how quickly this toxic protein accumulates in the brain over time, which can indicate the beginning of Alzheimer’s disease.”

What is the link between poor sleep and Alzheimer’s disease? While previous studies have found that sleep cleanses the brain of beta-amyloid deposits, the new results reinforce the link between poor sleep and the disease by identifying deep non-REM slow-wave sleep as the target of intervention against cognitive decline.

The researchers pointed out that though genetic testing can predict one’s inherent susceptibility to Alzheimer’s, and blood tests offer a diagnostic tool, neither offers the potential for a lifestyle therapeutic intervention that sleep does.

“If deep, restorative sleep can slow down this disease, we should be making it a major priority. And if physicians know about this connection, they can ask their older patients about their sleep quality and suggest sleep as a prevention strategy,” says Winer.

The researchers focused on brain activity present during deep slow-wave sleep. They also assessed the study participants’ sleep efficiency, which is defined as actual time spent asleep, as opposed to lying sleepless in bed. The results supported their hypothesis that sleep quality is a biomarker and predictor of the disease down the road.

Healthy lifestyle could help offset risk of dementia and Alzheimer’s. Image courtesy: Shutterstock

“We know there’s a connection between people’s sleep quality and what’s going on in the brain, in terms of Alzheimer’s disease. But what hasn’t been tested before is whether your sleep right now predicts what’s going to happen to you years later,” Winer said. “And that’s the question we had.”

And they got their answer: “Measuring sleep effectively helps us travel into the future and estimate where your amyloid buildup will be,” Walker added

Also, read: From Alzheimer’s to bipolar disorder, obesity can give you all this and more

“Our hope is that if we intervene, then in three or four years the buildup is no longer where we thought it would be because we improved their sleep. Indeed, if we can bend the arrow of Alzheimer’s risk downward by improving sleep, it would be a significant and hopeful advance,” he concluded.

The post Your sleeping pattern can put you at the risk of Alzheimer’s disease, says study appeared first on Healthshots.

#Health

0 notes

madewithonerib · 4 years

Photo

Charles John Ellicott, Christian Theologian [1819–1905] | | Luke 17:2

[2] It were batter for him . . —See Note on Matthew 18:6, where the order of the two sayings is inverted.

Assuming the words to have been repeated where we find them here, the “little ones” must mean the disciples of CHRIST who are, in both senses of the word “offended” by the worldliness of those who profess to be religious.

They are made to stumble by the temptation to follow the bad example, or their faith in the reality of godliness is shaken by seeing that the form exists without the power.

Matthew Henry, Nonconformist Minister [1662-1714] | | Luke 17:1-10

17:1-10 It is no abatement of their guilt by whom an offence comes, nor will it lessen their punishment that offences will come. Faith in GOD's pardoning mercy, will enable us to get over the greatest difficulties in the way of forgiving our brethren.

As with GOD nothing is impossible, so all things are possible to those that can believe.

Our LORD showed HIS disciples their need of deep humility.

The LORD has such a property in every creature, as no man can have in another; HE cannot be in debt to them for their services, nor do they deserve any return from HIM.

Albert Barnes, American Theologian [1798-1870] | | Luke 17:2

It is impossible - It cannot but happen. Such is the state of things that "it will be.

See these verses explained in the notes at Matthew 18:6-7.

Cambridge Bible, Anglican Editor John Perowne [1882] | | Luke 17:2

It were better for him—The literal rendering of the verse is “It is for his advantage if a millstone is hanging round his neck, & he has been flung into the sea, rather than that

In other words, the fate of a person who is lying drowned at the bottom of the sea is better than if his continuance in life would have led to causing “one of these little ones” to stumble.

The general thought is like that of Queen Blanche, who used

to say of her son St Louis when he was a boy, that she would rather see him dead at her feet than know that he had fallen into a deadly sin.

a millstone—The true reading here is lithos mulikos, not mulos onikos, a millstone so large as to require an ass to work it. This is introduced from Matthew 18:6.

one of these little ones—Mark adds “that believe in ME” [Luke 9:42].

The reference is not to children, or the young, though of course the warning applies no less to their case; but primarily to publicans & weak believers.

CHRIST calls even the Apostles ‘children, [John 13:33; 1 John 2:12-13].

Expositor's Greek Testament, William R. Nicoll [1897-1910] | | Luke 17:2

λυσιτελεῖ [λύω, τέλος], it profits or pays; here only in N.T. = συμφέρει in Matthew 18:6—λίθος μυλικός, a millstone, not a great millstone, one driven by an ass [μύλος ὀνικὸς, T.R]., as in Mt.: the vehement emphasis of CHRIST’s words is toned down in Luke. Here as often elsewhere.

The realistic expression of Matthew is doubtless truer to the actual utterance of JESUS, who would speak of the offences created by ambition with passionate abhorrence—περίκειται = perf.pass.of περιτίθημι in sense = has been placed; with ἔρριπται, another perfect, suggesting the idea of an action already complete—the miscreant with a stone round his neck thrown into the sea—εἰς τὴν θάλασσαν: here again a subdued expression compared with Mt—ἢ ἵνα σκανδαλίσῃ, than to scandalise; the subject with ἵνα = the infinitive. Vide Winer, § 44, 8.

Matthew 18:6 | But if anyone causes one of these little ones who believe in ME to stumble, it would be better for him to have a large millstone hung around his neck & to be drowned in the depths of the sea.

Pulpit Commentary by Donald Spence Jones [1836-1917] | | Matthew 18:6

Verse 6—There is an opposite side to this picture. Shall offend; cause to stumble - give occasion for a fall, ie either in faith or morals.

This is done by evil example, by teaching to sin, by sneers at piety, by giving soft names to gross offences.

One of these little ones.

Whether child or adult, a pure, simple soul, which has a certain faith it be not strong enough to resist all attack.

Even the heathen recognized the respect due to the young: "Maxima debetur puero reverentia" [Juvenal, 'Sat.' 14:47];

& guilelessness & purity, wherever found, win some regard, even from worthless & careless observers.

To willfully lead one such astray is a deadly sin, which the LORD denounces in solemn terms.

CHRIST affectionately calls HIS disciples "little ones" [Matthew 10:42].Believe in [εἰς] ME.

We must always distinguish between "believe in" [πιστεύειν εἰς, or ἐν: credo in] & "believe" with the simple dative; the former is applied to faith in GOD alone.

Augustine, "Credimus Paulo, sed non credimus inPaulum.

In the present passage the phrase implies the Divinity of CHRIST. It were better; literally, it is profitable. The crime specified is so heinous that a man had better incur the most certain death, if by this means he may avoid the sin & save the soul of his possible victim.

A millstone; a great millstone - such a one as required an ass to inure.The upper, or movable, stone is meant, which was usually turned by the hand. Drowned.

We do not know that the Jews punished criminals by drowning [καταποντισμὸς], though it is probable that it was practised in some cases; but by other nations this penalty was commonly exacted.

Among the Romans, Greeks, & Syrians, it was certainly the practice. Commentators quote Suetonius, 'Aug.,' 67; Diod. Sic., 16:35; Livy, 1:51; Aristophanes, 'Schol.ad Equit.' 1360].

The punishment seems to have been reserved for the greatest criminals; & the size of the stone would prevent any chance of the body rising again to the surface & being buried by friends - a consideration which, in the minds of heathens, greatly increased the horror of this kind of death.

Charles John Ellicott, Christian Theologian [1819–1905] | | Matthew 18:6

[6] Whoso shall offend—The words seem to indicate the thoughts which rise unbidden in the minds of men in proportion as they are Christ-like in character.

We gaze on the innocent beauty of childhood with love & admiration. What if that beauty should be marred by the taint of evil?

What if those who do the Tempter’s work should cause the “little one” to stumble & to fall?

That a millstone were hanged about his neck—The word for “millstone” indicates the larger stone-mill, in working which an ass was commonly employed, as distinguished from the smaller handmill of Luke 17:35].

The punishment was not recognised in the Jewish law, but it was in occasional use among the Greeks [Diod.Sic.xvi. 35], & had been inflicted by Augustus [Sueton. Aug.lxvii].

in cases of special infamy. Jerome states [in a note on this passage] that it was practised in Galilee, & it is not improbable that the Romans had inflicted it upon some of the ringleaders of the insurrection headed by Judas of Galilee.

Our LORD’s words, on this assumption, would come home with a special vividness to the minds of those who heard them.

The infamy of offending one of the “little ones” was as great as that of those whoso crimes brought upon them this exceptional punishment.

It was obviously a form of death less cruel in itself than many others, & its chief horror, both for Jews & heathen, was, probably, that it deprived the dead of all rites of burial.

St. Mark & St. Luke, it may be noted, insert here the complaint of St.John, that he had seen one casting out devils in the name of JESUS, & this must be taken into account as an element in the sequence of thought.

He was unconsciously placing himself among those who were hindering the work of CHRIST, & so “offending” those who believed in HIM [See Note on Mark 9:38].

Matthew Henry, Nonconformist Minister [1662-1714] | | Matthew 18:1-6

Matthew 18:1-6 | At that time the disciples came to Jesus & asked, “Who then is the greatest in the kingdom of heaven?” Jesus invited a little child to stand among them. “Truly I tell you,” He said, “unless you change & become like little children, you will never enter the kingdom of heaven. Therefore, whoever humbles himself like this little child is the greatest in the kingdom of heaven. And whoever welcomes a little child like this in MY Name welcomes ME. But if anyone causes one of these little ones who believe in ME to stumble, it would be better for him to have a large millstone hung around his neck & to be drowned in the depths of the sea.

18:1-6 CHRIST spoke many words of His sufferings, but only one of His glory; yet the disciples fasten upon that, & overlook the others. Many love to hear & speak of privileges & glory, who are willing to pass by the thoughts of work & trouble.

Our LORD set a little child before them, solemnly assuring them, that unless they were converted & made like little children, they could not enter HIS Kingdom.

Children, when very young, do not desire authority, do not regard outward distinctions, are free from malice, are teachable, & willingly dependent on their parents.

It is true that they soon begin to show other dispositions, & other ideas are taught them at an early age; but these are marks of childhood, & render them proper emblems of the lowly minds of true Christians.

Surely we need to be daily renewed in the spirit of our minds, that we may become simple & humble, as little children, & willing to be the least of all.

Let us daily study this subject, & examine our own spirits.

Albert Barnes, American Theologian [1798-1870] | | Matthew 18:6

Whoso shall offend - That is, cause to fall, or to sin; or who should place anything in their way to hinder their piety or happiness. See notes at Matthew 5:29.

These little ones - That is, Christians manifesting the spirit of little children, 1 John 2:1, 1 John 2:12, 1 John 2:18, 1 John 2:28.

It were better for them that a millstone .

Mills, anciently, were either turned by hand [see the notes at Matthew 24:41], or by beasts, chiefly by mules.

These last were of the larger kind, & the original words denote that it was this kind that was intended.

This was one mode of capital punishment practiced by the Greeks, Syrians, Romans, & by some other nations.

The meaning is, it would be better for them to have died before s/he had committed the sin.

To injure, or to cause to sin, the feeblest Christian, will be regarded by CHRIST as a most serious offence, & will be punished accordingly.

Expositor's Greek Testament, William R. Nicoll [1897-1910] | | Matthew 18:6

σκανδαλίσῃ: the opposite of receiving; treating harshly & contemptuously, so as to tempt to unbelief & apostasy.

The pride & selfish ambition of those who pass for eminent Christians make many infidels—ἕνα τ.

μ. τ.: one of the large class of little ones; not merely child believers surely, but all of whom a child is the emblem, as regards social or ecclesiastical importance.

Those who are caused to stumble are always little ones: “majores enim scandala non recipiunt,” Jerome.

One of them: “frequens unius in hoc capite mentio,” Bengel.

This is the one text in which JESUS speaks of HIMSELF as the object of faith [vide The Kingdom of GOD, p.

263]—συμφέρει … ἵνα: vide on Matthew 5:29].

Fritzsche finds here an instance of attraction similar to that in Matthew 10:25—καὶ ὁ δοῦλος, ὡς ὁ κ.

0 notes

scifigeneration · 7 years

Text

A planet hotter than most stars

A newly discovered Jupiter-like world is so hot that it's stretching the definition of the word "planet."

With a day-side temperature of 4,600 Kelvin (more than 7,800 degrees Fahrenheit), planet KELT-9b is hotter than most stars, and only 1,200 Kelvin (about 2,000 degrees Fahrenheit) cooler than our own sun.

In this week's issue of the journal Nature and at a presentation at the American Astronomical Society spring meeting, an international research team led by astronomers at The Ohio State University and Vanderbilt University describes a planet with some very unusual features.

For instance, it's a gas giant 2.8 times more massive than Jupiter but only half as dense, because the extreme radiation from its host star has caused its atmosphere to puff up like a balloon. And because it is tidally locked to its star -- as the Moon is to Earth -- the day side of the planet is perpetually bombarded by stellar radiation, and as a result is so hot that molecules such as water, carbon dioxide, and methane can't form there. The properties of the night side are still mysterious -- molecules may be able to form there, but probably only temporarily.

"It's a planet by any of the typical definitions based on mass, but its atmosphere is almost certainly unlike any other planet we've ever seen just because of the temperature of its day side," said Scott Gaudi, professor of astronomy at The Ohio State University and a leader of the study.

KELT-9b orbits a star, dubbed KELT-9, which is more than twice as large and nearly twice as hot as our sun. Keivan Stassun, a professor of physics and astronomy at Vanderbilt who directed the study with Gaudi said, "KELT-9 radiates so much ultraviolet radiation that it may completely evaporate the planet. Or, if gas giant planets like KELT-9b possess solid rocky cores as some theories suggest, the planet may be boiled down to a barren rock, like Mercury."

That is, if the star doesn't grow to engulf it first. "KELT-9 will swell to become a red giant star in about a billion years," said Stassun. "The long-term prospects for life, or real estate for that matter, on KELT-9b are not looking good."

Given that its atmosphere is constantly blasted with high levels of ultraviolet radiation, the planet may even be shedding a tail of evaporated planetary material like a comet, Gaudi added.

While Gaudi and Stassun spend a lot of time developing missions designed to find habitable planets in other solar systems, the scientists said there's a good reason to study worlds that are unlivable in the extreme.

"As has been highlighted by the recent discoveries from the MEarth collaboration, the planet around Proxima Centauri, and the astonishing system discovered around TRAPPIST-1, the astronomical community is clearly focused on finding Earthlike planets around small, cooler stars like our sun. They are easy targets and there's a lot that can be learned about potentially habitable planets orbiting very low-mass stars in general. On the other hand, because KELT-9b's host star is bigger and hotter than the sun, it complements those efforts and provides a kind of touchstone for understanding how planetary systems form around hot, massive stars," Gaudi said.

Stassun added, "As we seek to develop a complete picture of the variety of other worlds out there, it's important to know not only how planets form and evolve, but also when and under what conditions they are destroyed."

How was this new planet found?

In 2014, astronomers using the KELT-North telescope at Winer Observatory in Arizona noticed a tiny drop in the star's brightness -- only about half of one percent -- that indicated that a planet may have passed in front of the star. The brightness dipped once every 1.5 days, which means the planet completes a "yearly" circuit around its star every 1.5 days.

Subsequent observations confirmed the signal to be due to a planet, and revealed it to be what astronomers call a "hot Jupiter" -- the ideal kind of planet for the KELT telescopes to spot.

KELT is short for "Kilodegree Extremely Little Telescope." Astronomers at Ohio State, Vanderbilt University, and Lehigh University jointly operate two KELTs (one each in the Northern and Southern Hemispheres) in order to fill a large gap in the available technologies for finding extrasolar planets.

Other telescopes are designed to look at very faint stars in much small sections of the sky, and at very high resolution. The KELTs, in contrast, look at millions of very bright stars at once, over broad sections of sky, and at low resolution.

It's a low-cost means of planet hunting, using mostly off-the-shelf technology: whereas a traditional astronomical telescope costs millions of dollars to build, the hardware for a KELT telescope runs less than $75,000.

"This discovery is a testament to the discovery power of small telescopes, and the ability of citizen scientists to directly contribute to cutting-edge scientific research," said Joshua Pepper, astronomer and assistant professor of physics at Lehigh University, who built the two KELT telescopes.

The astronomers hope to take a closer look at KELT-9b with other telescopes -- including Spitzer, the Hubble Space Telescope (HST), and eventually the James Webb Space Telescope. Observations with HST would enable them to see if the planet really does have a cometary tail, and allow them to determine how much longer that planet will survive its current hellish condition.

Study co-authors from Ohio State include Daniel J. Stevens, Marshall C. Johnson, Matthew Penney, Andrew Gould and Richard Pogge, all of the Department of Astronomy.

American partner institutions include Vanderbilt University, Fisk University, Pennsylvania State University, the Harvard-Smithsonian Center for Astrophysics, Las Cumbres Observatory Global Telescope Network, University of Notre Dame, Lehigh University, NASA Ames Research Center, Bay Area Environmental Research Institute, Swarthmore College, IPAC, Brigham Young University, University of California-Santa Cruz, University of Wyoming, Louisiana State University, University of Louisville, Spot Observatory in Nashville, Westminster College, Kutztown University, University of Hawaii, University of Washington, Texas A&M University, Wellesley College, and Winer Observatory in Sonoita, AZ. International team members are from Denmark, Italy, Japan, Portugal, Switzerland, Australia, Germany and South Africa.

The study was largely funded by the National Science Foundation (NSF) through an NSF CAREER Grant, NSF PAARE Grant and an NSF Graduate Research Fellowship. Additional support came from NASA via the Jet Propulsion Laboratory and the Exoplanet Exploration Program; the Harvard Future Faculty Leaders Postdoctoral Fellowship; Theodore Dunham, Jr., Grant from the Fund for Astronomical Research; and the Japan Society for the Promotion of Science.

#science #space #extrasolar planets #astrophysics

82 notes · View notes

kathleenseiber · 4 years

Text

Sleep is like a ‘crystal ball’ to predict Alzheimer’s

Getting plenty of deep, restorative sleep may offer a defense against Alzheimer’s disease, according to a new study.

Researchers have found a way to estimate, with some degree of accuracy, a time frame for when Alzheimer’s is most likely to strike in a person’s lifetime.

“If deep, restorative sleep can slow down this disease, we should be making it a major priority.”

“We have found that the sleep you’re having right now is almost like a crystal ball telling you when and how fast Alzheimer’s pathology will develop in your brain,” says Matthew Walker, a professor of psychology and neuroscience at the University of California, Berkeley and senior author of the paper in Current Biology.

“The silver lining here is that there’s something we can do about it,” he says. “The brain washes itself during deep sleep, and so there may be the chance to turn back the clock by getting more sleep earlier in life.”

Sleep quality affects plaque

For the new study, Walker and fellow researchers matched the overnight sleep quality of 32 healthy older adults against the buildup in their brains of the toxic plaque known as beta-amyloid. Beta-amyloida is key player in the onset and progression of Alzheimer’s, which destroys memory pathways and other brain functions and afflicts more than 40 million people worldwide.

Their findings show that participants who started out experiencing more fragmented sleep and less non-rapid eye movement (non-REM) slow-wave sleep were most likely to show an increase in beta-amyloid over the course of the study.

“Rather than waiting for someone to develop dementia many years down the road, we are able to assess how sleep quality predicts changes in beta-amyloid plaques across multiple timepoints,” says lead author Joseph Winer, a PhD student in Walker’s Center for Human Sleep Science. “In doing so, we can measure how quickly this toxic protein accumulates in the brain over time, which can indicate the beginning of Alzheimer’s disease.”

Prioritize deep restorative sleep

In addition to predicting the time it is likely to take for the onset of Alzheimer’s, the results reinforce the link between poor sleep and the disease, particularly critical in the face of a tsunami of aging baby boomers on the horizon.

While previous studies have found that sleep cleanses the brain of beta-amyloid deposits, the new findings identify deep non-REM slow-wave sleep as the target of intervention against cognitive decline.

And though genetic testing can predict one’s inherent susceptibility to Alzheimer’s, and blood tests offer a diagnostic tool, neither offers the potential for a lifestyle therapeutic intervention that sleep does, the researchers point out.

“If deep, restorative sleep can slow down this disease, we should be making it a major priority,” Winer says. “And if physicians know about this connection, they can ask their older patients about their sleep quality and suggest sleep as a prevention strategy.”

Sleep efficiency

The 32 healthy participants in their 60s, 70s, and 80s enrolled in the sleep study are part of the Berkeley Aging Cohort Study headed by UC Berkeley public health professor William Jagust, also a coauthor of the new study.

For the experiment, each participant spent an eight-hour night of sleep in Walker’s lab while undergoing polysomnography, a battery of tests that record brain waves, heart rate, blood-oxygen levels, and other physiological measures of sleep quality.

Over the course of the multi-year study, the researchers periodically tracked the growth rate of the beta-amyloid protein in the participants’ brains using positron emission tomography, or PET scans, and compared the individuals’ beta-amyloid levels to their sleep profiles.

Researchers focused on the brain activity present during deep slow-wave sleep. They also assessed the study participants’ sleep efficiency, defined as actual time spent asleep, as opposed to lying sleepless in bed.

The results supported their hypothesis that sleep quality works as a biomarker and predictor of disease down the road.

And they got their answer: “Measuring sleep effectively helps us travel into the future and estimate where your amyloid buildup will be,” Walker says.

As for next steps, Walker and Winer are looking at how they can take the study participants who are at high risk of contracting Alzheimer’s and implement methods that might boost the quality of their sleep.

“Our hope is that if we intervene, then in three or four years the buildup is no longer where we thought it would be because we improved their sleep,” Winer says.

“Indeed, if we can bend the arrow of Alzheimer’s risk downward by improving sleep, it would be a significant and hopeful advance,” Walker says.

Meanwhile, the team offers these tips to improve sleep quality:

Maintain a regular sleep routine, going to bed and waking up at the same time each day.

As part of a nightly wind-down routine, avoid viewing computer, smartphone, and TV screens in the last hour before bedtime, and keep phones and other digital devices out of the bedroom.

Engage in some form of physical exercise during the day.

Get exposure to natural daylight, especially in the first half of the day.

Avoid stimulants, like caffeine, and sedatives, like alcohol, later in the day.

If you can’t sleep, get out of bed and do a relaxing activity away from the bedroom, such as reading in dim light. Only return to bed when you’re sleepy.

Get screened for sleep apnea if you are known to be a heavy snorer and/or feel excessively tired during the day.

Consult your doctor if you are experiencing insomnia, and inquire about cognitive behavioral therapy for insomnia (CBTI).

Additional coauthors are from UC Irvine, the Lawrence Berkeley National Laboratory, and UC Berkeley.

Source: UC Berkeley

The post Sleep is like a ‘crystal ball’ to predict Alzheimer’s appeared first on Futurity.

Sleep is like a ‘crystal ball’ to predict Alzheimer’s published first on https://triviaqaweb.weebly.com/

0 notes

scienceblogtumbler · 4 years

Text

How we sleep today may forecast when Alzheimer’s disease begins

What would you do if you knew how long you had until Alzheimer’s disease set in? Don’t despair. New UC Berkeley research suggests one defense against this virulent form of dementia — for which no treatment currently exists — is deep, restorative sleep, and plenty of it.

Neuroscientists Matthew Walker and Joseph Winer have found a way to estimate, with some degree of accuracy, a time frame for when Alzheimer’s is most likely to strike in a person’s lifetime.

“We have found that the sleep you’re having right now is almost like a crystal ball telling you when and how fast Alzheimer’s pathology will develop in your brain,” said Walker, a UC Berkeley professor of psychology and neuroscience and senior author of the paper published today, Sept. 3, in the journal Current Biology.

“The silver lining here is that there’s something we can do about it,” he added. “The brain washes itself during deep sleep, and so there may be the chance to turn back the clock by getting more sleep earlier in life.”

Walker and fellow researchers matched the overnight sleep quality of 32 healthy older adults against the buildup in their brains of the toxic plaque known as beta-amyloid, a key player in the onset and progression of Alzheimer’s, which destroys memory pathways and other brain functions and afflicts more than 40 million people worldwide.

Their findings show that the study participants who started out experiencing more fragmented sleep and less non-rapid eye movement (non-REM) slow-wave sleep were most likely to show an increase in beta-amyloid over the course of the study.

A wake-up call

“Rather than waiting for someone to develop dementia many years down the road, we are able to assess how sleep quality predicts changes in beta-amyloid plaques across multiple timepoints. In doing so, we can measure how quickly this toxic protein accumulates in the brain over time, which can indicate the beginning of Alzheimer’s disease,” said Winer, the study’s lead author and a Ph.D. student in Walker’s Center for Human Sleep Science at UC Berkeley.

In addition to predicting the time it is likely to take for the onset of Alzheimer’s, the results reinforce the link between poor sleep and the disease, which is particularly critical in the face of a tsunami of aging baby boomers on the horizon.

While previous studies have found that sleep cleanses the brain of beta-amyloid deposits, these new findings identify deep non-REM slow-wave sleep as the target of intervention against cognitive decline.

“If deep, restorative sleep can slow down this disease, we should be making it a major priority,” Winer said. “And if physicians know about this connection, they can ask their older patients about their sleep quality and suggest sleep as a prevention strategy.”

How they conducted the study

The 32 healthy participants in their 60s, 70s and 80s who are enrolled in the sleep study are part of the Berkeley Aging Cohort Study headed by UC Berkeley public health professor William Jagust, also a co-author on this latest study. The study of healthy aging was launched in 2005 with a grant from the National Institutes of Health.

Over the course of the multi-year study, the researchers periodically tracked the growth rate of the beta-amyloid protein in the participants’ brains using positron emission tomography, or PET scans, and compared the individuals’ beta-amyloid levels to their sleep profiles.

Researchers focused on the brain activity present during deep slow-wave sleep. They also assessed the study participants’ sleep efficiency, which is defined as actual time spent asleep, as opposed to lying sleepless in bed.

The results supported their hypothesis that sleep quality is a biomarker and predictor of disease down the road.

Traveling into the future

And they got their answer: “Measuring sleep effectively helps us travel into the future and estimate where your amyloid buildup will be,” Walker said.

“Our hope is that if we intervene, then in three or four years the buildup is no longer where we thought it would be because we improved their sleep,” Winer said.

“Indeed, if we can bend the arrow of Alzheimer’s risk downward by improving sleep, it would be a significant and hopeful advance,” Walker concluded.

In addition to Walker, Winer and Jagust, co-authors of the study are Bryce Mander at UC Irvine, Samika Kumar and Mark Reed at UC Berkeley, and Suzanne Baker at the Lawrence Berkeley National Laboratory.

Tips to improve sleep quality

Maintain a regular sleep routine, going to bed and waking up at the same time each day.

As part of a nightly wind-down routine, avoid viewing computer, smartphone and TV screens in the last hour before bedtime, and keep phones and other digital devices out of the bedroom.

Engage in some form of physical exercise during the day.

Get exposure to natural daylight, especially in the first half of the day.

Avoid stimulants, like caffeine, and sedatives, like alcohol, later in the day.

If you can’t sleep, get out of bed and do a relaxing activity away from the bedroom, such as reading in dim light. Only return to bed when you’re sleepy.

Get screened for sleep apnea if you are known to be a heavy snorer and/or feel excessively tired during the day.

Consult your doctor if you are experiencing insomnia, and inquire about cognitive behavioral therapy for insomnia (CBTI).

source https://scienceblog.com/518371/how-we-sleep-today-may-forecast-when-alzheimers-disease-begins/

0 notes

hizpeace-blog · 4 years

Text

Peace in the Greek

Thayer's Greek LexiconSTRONGS NT 1515: εἰρήνη

εἰρήνη, εἰρήνης, ἡ (apparently from εἴρω, to join; (others from εἴρω equivalent to λέγω; Etym. Magn. 803, 41; Vanicek, p. 892; Lob. Path. Proleg., p. 194; Benfey, Wurzellex. ii., p. 7)), the Sept. chiefly for שָׁלום; (from Homer down); peace, i. e.

1. a state of national tranquility; exemption from the rage and havoc of war: Revelation 6:4; πολλή εἰρήνη, Acts 24:2 (3); τά (WH text omits τά) πρός εἰρήνην, things that look toward peace, as an armistice, conditions for the restoration of peace Luke 14:32; αἰτεῖσθαι εἰρήνην, Acts 12:20; ἔχειν εἰρήνην, of the church free from persecutions, Acts 9:31.

2. peace between individuals, i. e. harmony, concord: Matthew 10:34; Luke 12:51; Acts 7:26; Romans 14:17; 1 Corinthians 7:15; Galatians 5:22; Ephesians 2:17; Ephesians 4:3; equivalent to the anthor of peace, Ephesians 2:14 (cf. Buttmann, 125 (109)); ἐν εἰρήνη, where harmony prevails, in a peaceful mind, James 3:18; ὁδός εἰρήνης, way leading to peace, a course of life promoting harmony, Romans 3:17 (from Isaiah 59:8); μετ' εἰρήνης, in a mild and friendly spirit, Hebrews 11:31; ποιεῖν εἰρήνην, to promote concord, James 3:18; to effect it, Ephesians 2:15; ζητεῖν, 1 Peter 3:11; διώκειν, 2 Timothy 2:22; with μετά πάντων added, Hebrews 12:14; τά τῆς εἰρήνης διώκειν, Romans 14:19 (cf. Buttmann, 95 (83); Winers Grammar, 109 (103f)). Specifically, good order, opposed to ἀκαταστασία, 1 Corinthians 14:33.

3. after the Hebrew שָׁלום, security, safety, prosperity, felicity, (because peace and harmony make and keep things safe and prosperous): Luke 19:42; Hebrews 7:2; εἰρήνη καί ἀσφάλεια, opposed to ὄλεθρος, 1 Thessalonians 5:3; ἐν εἰρήνη ἐστι τά ὑπάρχοντα, αὐτοῦ, his goods are secure from hostile attack, Luke 11:21; ὕπαγε εἰς εἰρήνην, Mark 5:34, and πορεύου εἰς εἰρήνην Luke 7:50; Luke 8:48, a formula of wishing well, blessing, addressed by the Hebrews to departing friends (לְשָׁלום לֵך 1 Samuel 1:17; 1 Samuel 20:42, etc.; properly, depart into a place or state of peace; (cf. Buttmann, 184 (160))); πορεύεσθαι ἐν εἰρήνη, Acts 16:36, and ὑπάγετε ἐν εἰρήνη, James 2:16, go in peace, i. e. may happiness attend you; ἀπολύειν τινα μετ' εἰρήνης, to dismiss one with good wishes, Acts 15:33; ἐν εἰρήνη, with my wish fulfilled, and therefore happy, Luke 2:29 (see ἀπολύω, 2 a.); προπέμπειν τινα ἐν εἰρήνη free from danger, safe, 1 Corinthians 16:11 (others take it of inward peace or of harmony; cf. Meyer at the passage). The Hebrews in invoking blessings on a man called out לְך שָׁלום (Judges 6:23; Daniel 10:19); from this is to be derived the explanation of those expressions which refer apparently to the Messianic blessings (see 4 below): εἰρήνη τῷ οἴκῳ τούτῳ, let peace, blessedness, come to this household, Luke 10:5; υἱός εἰρήνης, worthy of peace (cf. Winers Grammar, § 34, 3 N. 2; Buttmann, 161f (141)), Luke 10:6; ἐλθέτω ἡ εἰρήνη ἐπ' αὐτόν, let the peace which ye wish it come upon it, i. e. be its lot, Matthew 10:13; to the same purport ἐπαναπαήσεται ἡ εἰρήνη ὑμῶν ἐπ' αὐτόν, Luke 10:6; ἡ εἰρήνη ὑμῶν πρός ὑμᾶς ἐπιστραφήτω, let your peace return to you, because it could not rest upon it, i. e. let it be just as if ye had not uttered the wish, Matthew 10:13.

4. Specifically, the Messiah's peace: Luke 2:14; ὁδός εἰρήνης, the way that leads to peace (salvation), Luke 1:79; εἰρήνης ἐν οὐρανῷ, peace, salvation, is prepared for us in heaven, Luke 19:38; εὐαγγελίζεσθαι εἰρήνην, Acts 10:36.

5. according to a conception distinctly peculiar to Christianity, "the tranquil state of a soul assured of its salvation through Christ, and so fearing nothing from God and content with its earthly lot, of whatsoerer sort that is": Romans 8:6; ἐν εἰρήνη namely, ὄντες; is used of those who, assured of salvation, tranquilly await the return of Christ and the transformation of all things which will accompany that event, 2 Peter 3:14; (πληροῦν πάσης ... εἰρήνης ἐν τῷ πιστεύειν, Romans 15:13 (where L marginal reading ἐν πιστεύειν εἰρήνη)); ἔχειν ἐν Χριστῷ εἰρήνην (opposed to ἐν τῷ κόσμῳ θλῖψιν ἔχειν), John 16:33; ἔχειν εἰρήνην πρός τόν Θεόν, with God, Romans 5:1, (εἰρήνη πρός τινα, Plato, rep. 5, p. 465 b.; cf. Diodorus 21, 12; cf. Meyer on Romans, the passage cited; Winer's Grammar, 186 (175); 406 (379))); εὐαγγελίζεσθαι εἰρήνην, Romans 10:15 (R G Tr marginal reading in brackets); τό εὐαγγέλιον τῆς εἰρήνης, Ephesians 6:15; in the expression εἰρήνην ἀφίημι κτλ., John 14:27, in which Christ, with allusion to the usual Jewish formula at leave-taking (see 3 above), says that he not merely wishes, but gives peace; ἡ εἰρήνη τοῦ Χριστοῦ, which comes, from Christ, Colossians 3:15 (Rec. θεοῦ; τοῦ Θεοῦ, Philippians 4:7 (cf. Winers Grammar, 186 (175)). Comprehensively, of every kind of peace (blessing), yet with a predominance apparently of the notion of peace with God, εἰρήνη is used — in the salutations of Christ after his resurrection, εἰρήνη ὑμῖν (לָכֶם שָׁלום, Luke 24:36 (T omits; WH reject the clause); John 20:19, 21, 26; in the phrases ὁ κύριος τῆς εἰρήνης, the Lord who is the author and promoter of peace, 2 Thessalonians 3:16; ὁ Θεός τῆς εἰρήνης Romans 15:33; Romans 16:20; 2 Corinthians 13:1; Philippians 4:9; 1 Thessalonians 5:23; Hebrews 13:20; in the salutations at the beginning and the close of the apostolic Epistles: Romans 1:7; 1 Corinthians 1:3; 2 Corinthians 1:2; Galatians 1:3; Galatians 6:16; Ephesians 1:2; Ephesians 6:23; Philippians 1:2; Colossians 1:2; 1 Thessalonians 1:1; 2 Thessalonians 1:2; 2 Thessalonians 3:16; 1 Timothy 1:2; 2 Timothy 1:2; Titus 1:4; (Philemon 1:3); 1 Peter 1:2; 1 Peter 5:14; 2 Peter 1:2; 2 John 1:3; 3 John 1:15 (14); (Jude 1:2); Revelation 1:4. Cf. Kling in Herzog iv., p. 596f under the words Friede mit Gott; Weiss, Biblical Theol. d. N. T. § 83 b.; (Otto in the Jahrbb. fur deutsch. Theol. for 1867, p. 678ff; cf. Winer's Grammar, 549 (511)).

6. of the blessed state of devout and upright men after death (Wis. 3:3): Romans 2:10.

0 notes

foryourart · 6 years

Photo

New MountainImage courtesy of Sade Gallery.

PLAN ForYourArt: April 12–18

Thursday, April 12

Westwood Openings and Events

CONVERSATIONS Part of the series Future L.A.: Engineering a Sustainable Supercity: Urban Revitalization and the Los Angeles River, Hammer Museum (Westwood), 7:30pm.

Culver City Openings and Events

Die Legende von Paul und Paula (The Legend of Paul and Paula), Wende Museum (Culver City), 6pm.

Miracle Mile and Hollywood Openings and Events

Open Clay Studio with Eunice Lee, Craft and Folk Art Museum (Miracle Mile), 11am–1pm. $30–40.

Talk: Gallery Talk: The Art of Looking—Helen Frankenthaler, LACMA (Miracle Mile), 12:30pm.

New Mountain, SHOW Gallery (Hollywood), 6-9pm.

Atwater Village Openings and Events

Spencer Moody: My Laurels, Cash Machine (Atwater Village), 7–9pm.

Downtown and Chinatown Openings and Events

Tattoo Closing Party, Natural History Museum (Downtown), 5–10pm. $10–12.

Unfolding Language: Hanif Abdurraqib + Brendan Constantine + Amy Gerstler, The Broad (Downtown), 7:30pm.

Benjamin Reiss, Package Factory (Natural Marriage of Natural Resources), Bel Ami (Chinatown), 7–10pm.

Performing Radical Fictions, California African American Museum (Downtown), 7–10pm. $15.

Elsa Trash, Igor Amokian, Zzyzxzyzz, and O.C.D., Human Resources (Chinatown), 8pm.

Eastside Openings and Events

Garden Talk - Out of Africa: Pelargoniums for California Landscapes, The Huntington (San Marino), 2:30pm.

Leila Rahimi: The Myth of Paradise and Other Lies They Told Us, Sade (Lincoln Heights), 7–10pm.

Distinguished Fellow Lecture - Commemorating Charles Darwin, The Huntington (San Marino), 7:30pm.

Chanel Von-Habsburg-Lothringen: BYSTANDER, AWHRHWAR (Highland Park), 8–10pm.

Openings and Events Beyond Los Angeles

Sandwich Songs: A Noon Concert with Lainey, CalArts (Valencia), 12-1pm.

Desert Chic, Palm Springs Art Museum (Palm Springs), 6–8pm.

Meet the Galen, Palm Springs Art Museum (Palm Springs), 6–8pm. $40–95.

Graphic Design Lecture Series: Design, Bitches, CalArts (Valencia), 4:30pm.

Writing Now Reading Series: Mady Schutzman, CalArts (Valencia), 7–10pm.

Live! at the Museum: Los Angeles Ensemble, Laguna Art Museum (Laguna Beach), 7pm.

Sky Piece by Dawn Givens, CalArts (Valencia), 8pm. Through April 14.

Paul Brach Lecture Series: Elliot Reed, CalArts (Valencia), 9pm.

Micronutrient//Sai//QTQR8R//Dolly Dirtbag//Xoco//Dark Pulse, CalArts (Valencia), 11pm–1am.

Friday, April 13

Openings and Events in Westwood

Metaphors On Vision: Early Films by Stan Brakhage, UCLA (Westwood), 7:30pm. Also April 14.

Openings and Events in Hollywood

Francesca Gabbiani: Vague Terrains/Urban Fuckups, Gavlak (Hollywood), 6–8pm.

Surface Magazine presents: Design Dialogues: Kenya Hara, Japan House LA (Hollywood), 7–8:30pm.

Openings and Events in Chinatown

Pauline Gloss: Lullabies for the Psychotic and Other Work, Human Resources (Chinatown), 7:30pm.

ACCORDANT COMMONS: You are measuring…, Automata (Chinatown), 8pm.

Openings and Events in Glassell Park

Anthony Bodlović: Soma / Sema, elephant (Glassell Park), 7–10pm.

Openings and Events Beyond Los Angeles

Film Screening: Western by Valeska Grisebach, CalArts (Valencia), 4pm.

IncorpoReality, CalArts (Valencia), 4pm–12am.

Night at the Bijou: Tony Conrad: Completely in the Present, CalArts (Valencia), 7:30pm.

CalArts School of Theater Presents: Appropriate, CalArts (Valencia), 8pm.

Saturday, April 14

Westside Openings and Events

Roman Gems and Jewelry: The Art of Adornment, Getty Villa (Pacific Palisades), 1–4pm.

Kelly Berg: Unknown Horizon and Ned Evans: Paintings and Keyholes, Craig Krull Gallery (Santa Monica), 5–7pm.

Alon Aboutboul: LADIES & GENTLEMEN, ARCANE Space (Venice), 6–9pm.

Rob Sato - 442: Original Art From The Graphic Novel, GR2 (Sawtelle), 6:30–10pm.

Openings and Events in Culver City

Legacy, FP Contemporary (Culver City), 3–5pm.

Cig Harvey You an Orchestra You a Bomb and Joanne Dugan: Multiples, Kopeikin Gallery (Culver City), 6–8pm.

Openings and Events in West Hollywood and Hollywood

Reena Spaulings: The Male Gates, Matthew Marks Gallery (West Hollywood), 6–8pm.

DAVIA KING: REBORN, Ewkuks Gallery (West Hollywood), 8pm.

Sue Williams, Regen Projects (Hollywood), 6–8pm.

Miracle Mile Openings and Events

Wheel Throwing Workshop with Wayne Perry, Craft and Folk Art Museum (Miracle Mile), 1–4pm. $45–55.

Film: Documentary Film: Hockney, LACMA (Miracle Mile), 1pm.

Downtown and Chinatown Openings and Events

Symposium: SENGA NENGUDI: IMPROVISATIONS AND CONVERSATIONS, USC Fisher Museum of Art (Downtown), 9am–4pm.

Screening & Panel Discussion: Take None, Give None, Central Library (Downtown), 2pm.

Christoph Weber: Contact, Flora Hauser: Telescope at the Sun, and Wayne Magrin: The Far Away and the Familiar (Narrative Paintings of Surfers, Sailors and Bushrangers), Ibid (Downtown), 3–6pm.

A Retrospective of Dance Duets by Sophia Wang/Brontez Purnell, 356 Mission (Downtown), 3–6pm.

Tomorrowland and Junghwa Hong: Veiled, CB1 Gallery (Downtown), 4–7pm.

CalArts Dance School Performs HUMAN, Hauser & Wirth (Downtown), 4:30–5:30pm.

Folkert de Jong: Cathedra and Nathan Redwood: After Tin Man, DENK Gallery (Downtown), 6–8pm.

Co_Works, Tieken Studio & Gallery (Chinatown), 6–10pm.

HAND AND MIND: Illustration Beats Explanation, FOLD Gallery (Downtown), 6–9pm.

Saved by Grace Gospel Choir 20th Anniversary Concert, California African American Museum (Downtown), 7–9pm. $15.

Nicholas Deyoe and Matt Barbier, Human Resources (Chinatown), 8 and 9:30pm.

MacArthur Park Openings and Events

Brian Zamora: New Lighting Devices, haphazard/ as-is.la (MacArthur Park), 6–8pm.

Eastside Openings and Events

Children's Culinary Workshop: The Artichoke: A Flower Bud You Can Eat, The Huntington (San Marino), 9:30am. Sold out.

Fiber Arts Day, The Huntington (San Marino), 10am–5pm.

Family Day, Pasadena Museum of California Art (Pasadena), 12–5pm.

K. Bradford Workshop: Adventures in Upcycling; Tracee Johnson Workshop: Building Gathering Spaces, Side Street Projects (Pasadena), 1–4pm.

Ankita Mukherji: Places of being, gallery 1993 (Cypress Park), 4–6pm.

Ciara Moore: JET, Keystone Art Space (Lincoln Heights), 6–10pm.

An Evening of performance organized by artist Brian Randolph, ODD ARK•LA (Highland Park), 6–10pm.

Armory Annual Benefit Honoring Scott Ward, Armory Center for the Arts (Pasadena), 6:30–9:30pm. $150.

Corynne Pless and Mercy Weiss: Clear Abstractions, Namaste (Highland Park), 7–9pm.

Be Here Now: Esther Baker-Taparga, Kirsten Davis, Bianca Medina, Odeya Nini, Wilfried Souly and Allison Wyper, Pieter (Lincoln Heights), 8:30–10pm.

Openings and Events Beyond Los Angeles

CREATE - Awkward Family Comedy Show, ESMoA (El Segundo), 1–4pm.

Families: On-Site: North Hollywood—Art in the Ancient Americas, Valley Plaza Branch Library (North Hollywood), 2pm.

The Insanity Principle Workshops Taught by Linda Carmella Sibio, Copper Mountain Mesa Community Center (Joshua Tree), 2–4pm.

Raymond Loewy House [Salon], Palm Springs Art Museum (Palm Springs), 4–6pm.

A Fundraiser and Art Auction by Matthew Monahan and Lara Schnitger, RSVP for address (private studio), 6pm. $75.

Sunday, April 15

Westside Openings and Events

HAMMER FORUM: Ted Lieu: The Trump-Russia Investigation, Hammer Museum (Westwood), 2pm.

Drawing from the Masters: Paper Dimensions, Getty Center (Brentwood), 3:30–5:30pm.

Finding Michelangelo, and Other Tales, Getty Center (Brentwood), 4pm.

Openings and Events in Culver City

Book Signing with Melba Levick and Ruben G. Mendoza for The California Missions, Arcana: Books on the Arts (Culver City), 4–6pm.

West Hollywood Openings and Events

Marathon screening of In the Name of the Place by Mel Chin and the GALA Committee, West Hollywood Public Library (West Hollywood).

Miracle Mile Openings and Events

David Hockney: 82 Portraits and 1 Still-life, LACMA (Miracle Mile), 10am–7pm.

Echo Park and Chinatown Openings and Events

Los Angeles Filmforum and Acropolis Cinema present Stan Brakhage: Life, Death, And The Elements, Echo Park Film Center (Echo Park), 7:30pm. $6–10.

Morgan Evans-Weiler: General Motions in Relation, Automata (Chinatown), 8pm.

Lincoln Heights and Downtown Openings and Events

Workshop: Radical Choreography: Cultivating Listening and Action with Esther Baker-Taparga, Pieter (Lincoln Heights), 11am–2pm.

Sewing Rebellion, California African American Museum (Downtown), 12–4pm.

Cariño: Autocuidado y Curación en Tiempos Difíciles, Main Museum (Downtown), 1–3pm.

Orgasmic Yoga Dr. Victoria Reuveni, Pieter (Lincoln Heights), 7–10pm. $20.

Openings and Events Beyond Los Angeles

Poetry as Portraiture: Adam Zagajewski and Andrew Winer, Santa Barbara Museum of Art (Santa Barbara), 2:30pm.

Mary Kelly and Nizan Shaked in Conversation - The Synthetic Proposition Book Launch, University Art Museum, CSU Long Beach (Long Beach), 3pm.

Orca, CalArts (Valencia), 8–9pm.

Monday, April 16

Culver City Openings and Events

Alternative Realities: Utopian Thought in Times of Political Rupture, Wende Museum (Culver City). Continues April 17.

Frogtown Openings and Events

How Feminism Failed Reproductive Freedom, Women’s Center for Creative Work (Frogtown), 7:30–9:30pm. $8–10.

Openings and Events Beyond Los Angeles

High Desert Test Kitchen april ingredient: yucca, Copper Mountain Mesa Community Center (Joshua Tree), 7pm.

Tuesday, April 17

Westside Openings and Events

SCREENINGS: Grace Jones: Bloodlight and Bami, Hammer Museum (Westwood), 7:30pm.

Miracle Mile Openings and Events

Film: House of Wax, LACMA (Miracle Mile), 1pm.

Hollywood Openings and Events

Nancy Baker Cahill: Hollow Point/Strange Laugh, Los Angeles Contemporary Exhibitions (LACE) (Hollywood), 7–10pm.

Downtown Openings and Events

Youth Now, California African American Museum (Downtown), 12–3pm.

Openings and Events Beyond Los Angeles

Aggregate as Self, Claremont Graduate University (Claremont), 6–9pm.

ArtCenter Spring 2018 Graduate Seminar Lecture: Anne Imhof, ArtCenter College of Design (Pasadena), 7:30pm.

East Asian Garden Lecture Series - Representations of the Garden of Solitary Delight (Dule yuan), The Huntington (San Marino), 7:30pm.

Daedalus Quartet, Santa Barbara Museum of Art (Santa Barbara), 7:30pm.

Wednesday, April 18

Westside Openings and Events

Plato in L.A.: Contemporary Artists' Visions and Palmyra: Loss and Remembrance,, Getty Center (Brentwood), 10am–5pm.

MUSIC & PERFORMANCE: From the Highlands to the Concert Hall: Classical Music of Armenia, 2018, Hammer Museum (Westwood), 7:30pm.

Downtown and Frogtown Openings and Events

“Walkout” Movie Screening & Conversation, Self Help Graphics (Downtown), 6:30pm.

Sick Circle, Women’s Center for Creative Work (Frogtown), 7–9pm.

Cross-Hatched | Impresarios, Inc., The Broad (Downtown), 8pm. $25.

1 note · View note

londontheatre · 7 years

Link

HerStory at Theatre N16 is a festival which celebrates women working in the theatre industry, as writers, directors and performers. The second night of this year’s festival saw six new short pieces, each varying in style, theme and content, including stories about a woman working in a top secret organisation, another suffering from insomnia and one working as a prostitute. These were followed by scene sharings from a workshop with Barbara Houseman, which took four Shakespeare scenes with women taking on some of the male roles.

Particular highlights from the evening include: Shelley Davenport’s incredibly witty Witness A, performed equally as well with a balance of humour and tears; Josephine Starte and Matthew Couton’s fierce performances in the somewhat cryptic The Mutant Man, and the emotional intensity of Dorcas Stevens nd Kudzyani Chiwawa who ever-so-simply brought anger and sympathy to those watching the act of straightforward storytelling. Despite a few moments of comedy, it would have been nice to have seen a little bit more variation across the six performances; by the fourth piece it did all feel a little repetitive, but the quality of performances was just enough to keep it engaging.

Despite a few moments of comedy, it would have been nice to have seen a little bit more variation across the six performances; by the fourth piece it did all feel a little repetitive, but the quality of performances was just enough to keep it engaging.

Perhaps the most interesting portion of the evening was Houseman’s workshop performances. Four female actors spent the day with Houseman working on famous scenes from Shakespeare plays, in which at least one of the characters is a male. We saw women take on such roles as Othello, Hamlet, Angelo and Lord Capulet, amongst others. The gender reversal does two key things: Firstly, it brings new light to old scenes and makes revelations about character, feeling and motive; secondly, it gives women the chance to play roles that they wouldn’t traditionally be able to play. Michelle Barwood’s Hamlet was intellectual and fierce and Maggie Robson’s Lord Capulet was powerful and somewhat wicked.

However, the Q&A which followed these sharings raised some interesting points, particularly regarding the way Houseman and her actors’ perceived gender. Monty Leigh, for example, made a point that to play Iago she went for stereotypically masculine traits (**opening her legs and hunching forward**), however surely this contradicts the point of having women playing these parts. Surely female actors should not have to justify playing male roles by submitting to male stereotypes; not only does this oppose their own performance instincts, but it also represents a “general man” (if such a thing exists) and in attempt to change the way a theatre audience perceives gender, actually conforms to social gender stereotypes.

With this in mind, it was perhaps The Mutant Man which was the most successful of the six pieces, for gender was sort of one and the same; presenting what seemed to be a male and female version of the same character, with virtually no differences in performance style from its male and female performers. HerStory aims to push the boundaries of women’s representation in theatre, and whilst in some ways it managed this, there are still plenty of further opportunities for women that this evening perhaps overlooked.

Review by Joseph Winer

HERSTORY 2016. Over 50 years ago Gloria Steinem began to change the world by speaking about women’s rights, fighting for equality and speaking her mind. But despite Steinem impacting the feminist movement and accomplishing so much the fight is still present. What are the issues that women of the XXI century face on a day to day basis? Why is abortion still a taboo subject? Why are we taken aback when we hear a woman say“I don’t want to have children”? Why are women constantly objectified? And finally have things really changed since Miss Steinem led the women’s liberation movement back in the 60’s and 70s? Those are just few of the hundreds of questions that come to mind when one talks about equality and contemporary feminism. HERSTORY a festival of new writing aims to bring those questions to the stage by creating a platform for political discussion and giving a voice to women. The aim of HerStory Festival is to bring diverse, bold and unapologetic stories to theatre. We believe that women are not only misrepresented in theatre but that there is also a problem with the way we talk about women. HerStory is here to change it. WHAT WE ARE LOOKING FOR: Any pieces of new writing which deal with the issues of womanhood, sex, equality, feminism or tolerance. Political, thought-provoking theatre that can highlight the battle of modern feminism is what we are after! If you are sending a play longer than 30min please bear in mind that we will choose a snippet of it to perform during the festival.

If you would like to enter your piece of writing into the festival please email our Literary Manager Nastazja Domaradzka – [email protected] using HERSTORY as a subject line. Please note that we are currently not taking submissions. Please keep checking in on our website and twitter for announcements. HOW WILL IT WORK: The festival will take place over the space of two days at Theatre N16 in Balham. Prior to which the actors, writers and directors will collaborate together during the rehearsals. There will also be a panel discussion and guest speakers from different organisations and fields.

http://ift.tt/2lJ5PVn LondonTheatre1.com

#IFTTT #LondonTheatre1.com

0 notes

madewithonerib · 4 years

Text

John 15:6 | If anyone does not remain in ME, he is like a branch that is thrown away & withers. Such branches are gathered up, thrown into the fire, & burned.

Matthew 7:19 | Every tree that does not bear good fruit is cut down & thrown into the fire.

John 15:2 | HE cuts off every branch in ME that bears no fruit, & every branch that does bear fruit, HE prunes to make it even more fruitful.

Job 15:30 He shall not depart out of darkness; the flame shall dry up his branches, & by the breath of his mouth shall he go away.

Isaiah 14:19 | But you are cast out of your grave like a rejected branch, covered by those slain with the sword, & dumped into a rocky pit like a carcass trampled underfoot.

remain, μένῃ (menē) Strong's Greek 3306: To remain, abide, stay, wait; with acc: I wait for, await. A primary verb; to stay.

Pulpit Commentary by Donald Spence Jones [1836-1917] | | John 15:6

Verse 6—If any one abide not in ME, he is cast forth as the branch - perhaps away from the vineyard, as well as from proximity to the vine - & is withered.

The two aorists, ἐβλήθη & ἐξηράνθη, are simply cases of a common daily experience.

These are the inevitable consequences of not abiding in the vine.

We may imagine two ways in which this non-abiding in CHRIST, this severance from HIM, may be effected:

[1] the pruning-knife may have lopped them off because of their lack of fruitfulness; or, [2] they may have withered on the stem, &, by their deficiency of strength & life, have suffered from some external assault which they have not had energy to resist.

Lucke, Winer, Tholuck, & Hengstenberg regard the aorists as indicative of what will happen should branches in CHRIST cease to derive life from HIM.

Calvin is satisfied that the expression cannot refer to the elect, but to the hypocrite, while Alford is as confident of its repudiation of unconditional election.

In my opinion it keeps clear of both suggestions.

And they gather them, & cast them into the fire, & they are burned. The vine is one of the noblest of all trees, & produces the most abundant fruit; ****

but it is one of its peculiarities that all its strength is spent on the fruit, & that its branches are utterly valueless for all other purposes.

Heaps of burning vine-prunings may have suggested the awful image which the embodied Love of GOD here adopts.

Some have supposed [Meyer & Alford] that the fire is here the last judgment, which our LORD looks upon as come.

But the present tense, following the two aorists, suggests the immediate consequence of such severance from CHRIST- the fiery trials, fierce temptations, terrible judgments, always overtaking the unfruitful & unfaithful servants, & preluding the awful consummation of Divine judgment,

of which our LORD had often spoken [Matthew 13:42, 50; Matthew 25:41; Luke 16:24], & which the apostle of love described in Revelation 20:15; Revelation 21:8.

Charles John Ellicott, Christian Theologian [1819–1905] | | John 15:6

[6] The thought passes from the fruitful to the sterile branch, from the man who abides to the man who will not abide in CHRIST.

In the natural vineyard such a branch was cast forth, then withered, & gathered with others into bundles, & burned.

The vivid picture illustrates the fearful history of a man who wills not to abide in CHRIST.

[6a] And they are burned—Better, & they burn.*****

The tenses of this verse should be carefully observed.

The burning of withered branches of the natural vine suggests the final judgment, & the whole is thought of from that time.

Hence the earlier verbs are in the past, & the later in the present tense.

Matthew Henry, Nonconformist Minister [1662-1714] | | John 15:1-8

John 15:1-8 | “I am the true vine, & MY Father is the keeper of the vineyard. HE cuts off every branch in ME that bears no fruit, & every branch that does bear fruit, HE prunes to make it even more fruitful. You are already clean because of the WORD I have spoken to you.

Remain in ME, & I will remain in you.

Just as no branch can bear fruit by itself unless it remains in the vine, neither can you bear fruit unless you remain in ME.

I am the vine & you are the branches.

The one who remains in ME, & I in him, will bear much fruit. For apart from ME you can do nothing.

If anyone does not remain in ME, he is like a branch that is thrown away & withers. Such branches are gathered up, thrown into the fire, & burned.

If you remain in ME & MY words remain in you, ask whatever you wish, & it will be done for you. This is to MY Father’s glory, that you bear much fruit, proving yourselves to be MY disciples.

15:1-8 JESUS CHRIST is the Vine, the true Vine. The union of the human & Divine natures, & the fullness of the SPIRIT that is in him, resemble the root of the vine made fruitful by the moisture from a rich soil.

Believers are branches of this Vine.

The root is unseen, & our life is hid with CHRIST; the root bears the tree, diffuses sap to it, & in CHRIST are all supports & supplies.

The branches of the vine are many, yet, meeting in the root, are all but one vine; thus all true Christians, though in place & opinion distant from each other, meet in CHRIST.

Believers, like the branches of the vine, are weak, & unable to stand but as they are borne up.

The FATHER is the Husbandman.

Never was any husbandman so wise, so watchful, about HIS vineyard, as GOD is about HIS Church, which therefore must prosper.

We must be fruitful.

From a vine we look for grapes, & from a Christian we look for a Christian temper, disposition, &life. We must honour GOD, & do good; this is bearing fruit. ****

The unfruitful are taken away.

And even fruitful branches need pruning; for the best have notions, passions, & humours, that require to be taken.

Albert Barnes, American Theologian [1798-1870] | | John 15:6

If a man, abide not in ME [See John 15:4].

If a person is not truly united to GOD by faith, & does not live with a continual sense of their dependence on HIM.

This doubtless refers to those who are professors of religion, but who have never known anything of true & real connection with HIM. ****

Is cast forth - [See the notes at John 15:2]. Also Matthew 8:12; Matthew 22:13.

Matthew 8:12 | But the children of the kingdom will be cast into the outer darkness, where there will be weeping & gnashing of teeth.”

Matthew 22:13 | Then the king told the servants, ‘Tie him hand & foot & throw him outside into the outer darkness, where there will be weeping & gnashing of teeth.’

Is withered - Is dried up.

A branch cut off withers. So of a soul unconnected with CHRIST, however fair it may have appeared.& however flourishing when a profession of religion was first made, yet when it is tried, & it is seen that there was no true grace, everything withers & dies.****

The zeal languishes,

the professed love is gone,

prayer is neglected,

the sanctuary is forsaken, &

the soul becomes like a withered branch reserved for the fire of the last great day.

See a beautiful illustration of this in Ezekiel 15:1-8.

Ezekiel 15:1-8 | Then the WORD of the LORD came to me, saying, “SON of man, how does the wood of the vine surpass any other branch among the trees in the forest?

Can wood be taken from it to make something useful? Or can one make from it a peg on which to hang utensils?

No, it is cast into the fire for fuel. The fire devours both ends, & the middle is charred.

Can it be useful for anything? Even when it was whole, it could not be made useful.

How much less can it ever be useful when the fire has consumed it & charred it!

Therefore this is what the LORD GOD says: ‘Like wood of the vine among the trees of the forest, which I have given to the fire for fuel, so I will give up the people of Jerusalem.

And I will set MY face against them.

Though they may have escaped the fire, yet another fire will consume them.

And when I set MY face against them, you will know that I am the LORD.

Thus I will make the land desolate, because they have acted unfaithfully, declares the LORD GOD.’”

Men gather them - Word "men" is not in the original, & should not have been in the translation.

The Greek is "they gather them," a form of expression denoting simply they are gathered, without specifying by whom it is done.

From Matthew 13:40-42, it seems that it will be done by the angels.

The expression means, as withered & useless branches of trees are gathered for fuel, so shall it be with all hypocrites & false professors of religion.

Are burned - See Matthew 13:42.

Cambridge Bible, Anglican Editor John Perowne [1882] | | John 15:6

s/he is cast forth—Verb is in a past tense; s/he is already cast forth by the very fact of not abiding in CHRIST.

This consequence follows so inevitably that to state the one is to state the other.

The same remark applies to ‘is withered.

But the cast-out branch may be grafted in again [Romans 11:23]—& the dead branch may be raised to life again [John 5:21; John 5:25].

The rest of the picture looks forward to the day of judgment. ‘Men gather’ should be quite indefinitely, they gather [see on Luke 12:20].

Expositor's Greek Testament, William Nicoll [1897-1910] | | John 15:6

ἐὰν μή τις μείνῃ, “if any one shall not have abided in ME”.

ἐβλήθη … ἐξηράνθη, the gnomic aorist, 1 Peter 1:24; & see Burton, M.& T., 43, & Grotius:

“Hi aoristi sine designatione temporis significant quid fieri soleat, pro quo et praesens saepeusurpatur”.

The whole process undergone by the fruitless branch is described in these six verbs, αἴρει John 15:2, ἐβλήθη, ἐξηράνθη, συνάγουσιν, βάλλουσι, καίεται, & each detail is thus given for the sake of emphasising the inevitableness & the completeness of the destruction.

ἐβλήθη ἔξω ὡς τὸ κλῆμα, “is cast out,” ie, from the vineyard, as the next words show; here this means hopeless rejection.

The result is the natural capacity for fruit-bearing is destroyed. ****

The figure derived from the treatment of the fruitless branch is continued in συνάγουσιν … καίεται, [Matthew 13:49-50; & Matthew 13:41-42].

On καίεται, Euthymius remarks οὐ μὴν κατακαίονται “but are not consumed”.

And in Exodus 3:2, the bush καίεται, but οὐ κατεκαίετο “burns, but was not consumed”.

But this only shows that without the miraculous interposition it would have been consumed. ****

#John 15:6 #connected to CHRIST #true reliance #vine #productive #fruitful #cut-off #depends on GOD #snatching them from the fire #snatched from the fire

0 notes

kathleenseiber · 5 years

Text

Does poor sleep in your 50s warn of Alzheimer’s?

People who report worsening sleep quality as they age from their 50s to their 60s have more protein tangles in their brain, putting them at higher risk of developing Alzheimer’s disease later in life, according to a new study.

The new finding highlights the importance of sleep at every age to maintain a healthy brain into later life.

“Insufficient sleep across the lifespan is significantly predictive of your development of Alzheimer’s disease pathology in the brain,” says the study’s senior author, Matthew Walker, a sleep researcher and professor of psychology at the University of California, Berkeley. “Unfortunately, there is no decade of life that we were able to measure during which you can get away with less sleep. There is no Goldilocks decade during which you can say, ‘This is when I get my chance to short sleep.'”

Walker and his colleagues found that adults reporting a decline in sleep quality in their 40s and 50s had more beta-amyloid protein in their brains later in life, as measured by positron emission tomography, or PET. Those reporting a sleep decline in their 50s and 60s had more tau protein tangles. Both beta-amyloid and tau clusters are associated with a higher risk of developing dementia, though not everyone with protein tangles goes on to develop symptoms of dementia.

Based on the findings, the authors recommend that doctors ask older patients about changes in sleep patterns and intervene when necessary to improve sleep to help delay symptoms of dementia. This could include treatment for apnea, which leads to snoring and frequent halts in breathing that interrupt sleep, and cognitive behavioral therapy for insomnia (CBT-I), a highly effective way to develop healthy sleep habits. It may even include simple sleep counseling to convince patients to set aside time for a full eight hours of sleep and simple sleep hygiene tricks to accomplish that.

Watch Matthew Walker’s 2019 TED talk about the power of sleep:

“The idea that there are distinct sleep windows across the lifespan is really exciting. It means that there might be high-opportunity periods when we could intervene with a treatment to improve people’s sleep, such as using a cognitive behavioral therapy for insomnia,” says first author Joseph Winer, a graduate student. “Beyond the scientific advance, our hope is that this study draws attention to the importance of getting more sleep and points us to the decades in life when intervention might be most effective.”

The 95 subjects in the study were part of the Berkeley Aging Cohort Study (BACS), a group of healthy older adults—some as old as 100—who have had their brains scanned with PET, the only technique capable of detecting both beta-amyloid tangles and, very recently, tau tangles, in the brain.

Memory storage during sleep

The team also made a second discovery. They found that people with high levels of tau protein in the brain were more likely to lack the synchronized brain waves that are associated with a good night’s sleep. The synchronization of slow brain waves throughout the cortex of the sleeping brain, in lockstep with bursts of fast brain waves called sleep spindles, takes place during deep or non-rapid eye movement (NREM) sleep.

The team reports that the more tau protein older adults had, the less synchronized these brain waves were. This impaired electrical sleep signature may therefore act as a novel biomarker of tau protein in the human brain.

“There is something special about that synchrony,” given the consequences of this tau protein disruption of sleep, Walker says. “We believe that the synchronization of these NREM brain waves provides a file-transfer mechanism that shifts memories from a short-term vulnerable reservoir to a more permanent long-term storage site within the brain, protecting those memories and making them safe. But when you lose that synchrony, that file-transfer mechanism becomes corrupt. Those memory packets don’t get transferred as well, so you wake up the next morning with forgetting rather than remembering.”

Greater levels of pathological tau protein, primarily in the brain’s medial temporal lobe (orange and yellow at bottom in cross section of the brain), were associated with weaker synchrony of slow waves (red) and sleep spindles (orange), two brain waves important for storing memories while we sleep. (Credit: Matthew Walker, Joseph Winer/UC Berkeley)

Indeed, last year, Walker and his team demonstrated that synchronization of these brain oscillations helps consolidate memory, that is, hits the “save” button on new memories.

Several years ago, Walker and his colleagues initially showed that a dip in the amplitude of slow wave activity during deep NREM sleep was associated with higher amounts of beta-amyloid in the brain and memory impairment. Combined with these new findings, the results help identify possible biomarkers for later risk of dementia.

“It is increasingly clear that sleep disruption is an underappreciated factor contributing to Alzheimer’s disease risk and the decline in memory associated with Alzheimer’s,” Walker says. “Certainly, there are other contributing factors: genetics, inflammation, blood pressure. All of these appear to increase your risk for Alzheimer’s disease. But we are now starting to see a new player in this space, and that new player is called insufficient sleep.”

The researchers recorded brain rhythms over a single eight-hour night in Walker’s sleep lab, during which most of the 31 subjects wore a cap studded with 19 electrodes that recorded a continual electroencephalogram (EEG). All had previously had brain scans to assess their burdens of tau and beta-amyloid that researchers performed using a PET scanner at the Lawrence Berkeley National Laboratory and study coauthor William Jagust, professor of public health and a member of the Helen Wills Neuroscience Institute, operated.

William Jagust shows how PET scans can help track the progression of Alzheimer’s disease:

youtube

(Credit: Roxanne Makasdjian and Stephen McNally/UC Berkeley)

A biomarker for Alzheimer’s disease?

Doctors have been searching for early markers of dementia for years, in hopes of intervening to stop the deterioration of the brain. Beta-amyloid and tau proteins are predictive markers, but only recently have they become detectable with expensive PET scans that are not widely accessible.

Yet, while both proteins escalate in the brain in old age and perhaps to a greater extent in those with dementia, it is still unknown why some people with large burdens of amyloid and tau do not develop symptoms of dementia.

“The leading hypothesis, the amyloid cascade hypothesis, is that amyloid is what happens first on the path to Alzheimer’s disease. Then, in the presence of amyloid, tau begins to spread throughout the cortex, and if you have too much of that spread of tau, that can lead to impairment and dementia,” Winer says.

Walker adds that, “A lack of sleep across the lifespan may be one of the first fingers that flicks the domino cascade and contributes to the acceleration of amyloid and tau protein in the brain.”

The hypothesis is supported, in part, by Jagust’s PET studies, which have shown that higher levels of beta-amyloid and tau protein tangles in the brain are correlated with memory decline, tau more so than amyloid. Tau occurs naturally inside the brain’s neurons, helping to stabilize their internal skeleton. With age, tau proteins seem to accumulate inside cells of the medial temporal lobe, including the hippocampus, the seat of short-term memory. Only later do they spread more widely throughout the cortex.

While Jagust has run PET scans on the brains of many healthy people, as well as those with dementia, many more subjects are needed to confirm the relationship between protein tangles and dementias like Alzheimer’s disease. Because PET scanners are currently expensive and rare, and because they require injection of radioactive tracers, other biomarkers are necessary, Walker says.

The new study suggests that sleep changes detectable in a simple overnight sleep study may be less intrusive biomarkers than a PET scan.

“As wearable technology improves, this need not be something you have to come to a sleep laboratory for,” says Walker. “Our hope is that, in the future, a small head device could be worn by people at home and provide all the necessary sleep information we’d need to assess these Alzheimer’s disease proteins. We may even be able to track the effectiveness of new drugs aimed at combating these brain proteins by assessing sleep.”

“I think the message is very clear,” Walker adds. “If you are starting to struggle with sleep, then you should go and see your doctor and find ways, such as CBT-I, that can help you improve your sleep. The goal here is to decrease your chances of Alzheimer’s disease.”

The research appears in the Journal of Neuroscience. Additional coauthors are from UC Berkeley, UC Irvine, and the German Center for Neurodegenerative Diseases. Support for the work came from the National Institutes of Health.

Source: UC Berkeley

The post Does poor sleep in your 50s warn of Alzheimer’s? appeared first on Futurity.

Does poor sleep in your 50s warn of Alzheimer’s? published first on https://triviaqaweb.weebly.com/

0 notes