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the-monkey-ruler · 5 months

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A Chinese Tall Story (2005) 情癫大圣

Director: Liu Zhenwei Screenwriter: Liu Zhenwei Starring: Nicholas Tse / Charlene Choi / Fan Bingbing / Chen Bolin / Liang Luoshi / Kwan Chi-bin / Cheung Chi-heng / Chung Chun-tao / Tam Yiu-man / Yuen Wah / Wai Ying-hong / Lai Yiu-hsiang Genre: Drama / Comedy / Action / Romance / Fantasy Country/Region of Production: Mainland China / Hong Kong, China Language: Cantonese / Mandarin Chinese Date: 2005-12-22 (Mainland China/Hong Kong, China) Duration: 103 minutes Also known as: A Chinese Tall Story / 情魔大圣 IMDb: tt0469050 Type: Retelling

Summary:

Tang Sanzang (Nicholas Tse) and his three disciples Sun Wukong (Bolin Chen), Zhu Wuneng (Kenny Kwan), and Sha Wujing (Steven Cheung) arrive triumphantly to a hero's welcome in Shache city. Tripitaka's most arduous challenge to achieve deification is to come, only he can perform.

During their stay in the city, the three disciples are captured by evil Tree Spirits. Tripitaka borrows the Golden Pole and tries to find a way to save them. He meets a young lizard imp Meiyan (Charlene Choi) who is more than a visual match for Quasimodo: matted bushy hair, and teeth of any dentist's nightmare. Meiyan falls in love with Tripitaka at first sight and devotes herself to trailing him. She even sets a love trap to ensnare him. Tripitaka unwittingly falls into the trap and in the process breaks the Heavenly Code.

The region is one full of monsters, strange beings and creatures of unknown origins and among them are the beautiful Princess XiaoShan (Fan Bing-bing) and her army. On a passing journey to Earth her path crosses Tripitaka's and she vows her aid. Tripitaka decides to leave with the Princess.

Meiyan is heartbroken. She picks a fight with Princess XiaoShan and, although she loses, she finally discovers her own identity as a galactic warrior. She eventually helps the princess in defeating the enemy and rescues Tripitaka and his disciples.

After the battle, Meiyan surrenders to the Temple of Heaven for judgment. Torn between passion and righteousness, Tripitaka rebels against the heavens to rescue the gallows-bound Meiyan. A benevolent Buddha is moved and pardons the two on condition that they embark on a journey to the West to accomplish the Eight-One Tasks to redeem themselves and save the world.

Source: https://en.wikipedia.org/wiki/A_Chinese_Tall_Story#External_links

Link: https://www1.moviesjoy.sc/film/a-chinese-tall-story-2005/

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rnomics · 7 years

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Long Non-Coding #RNA HOTAIR Regulates the Proliferation, Self-Renewal Capacity, Tumor Formation and Migration of the #cancer Stem-Like Cell (CSC) Subpopulation Enriched from Breast #cancer Cells

by Jia Deng, Mengchang Yang, Rong Jiang, Ning An, Xiaoshan Wang, Bin Liu Purpose Long non-coding #RNAs (l#ncRNAs) play important roles in the malignant behavior of #cancer. HOTAIR, a well-studied l#ncRNA, contributes to breast #cancer development, and overexpression of HOTAIR predicts a poor prognosis. However, the regulatory role of HOTAIR in the #cancer stem-like cell (CSC) subpopulation remains largely unknown. Our goal was to determine the regulatory functions of HOTAIR in the processes of self-renewal capacity, tumor formation and proliferation of CSCs derived from breast #cancer. Methods We first enriched and incubated the CSC population derived from breast #cancer cell line MCF7 (CSC-MCF7) or MDA-MB-231 (MB231, CSC-MB231). Self-renewal capacity and tumor formation were assessed in vitro and in vivo to determine the stemness of CSCs. We assessed the impact on ectopically upregulated or downregulated expression of HOTAIR in CSCs by soft agar, self-renewal capacity and CCK-8 assays. The functional domain of HOTAIR was determined by truncation. RT-qPCR and semiquantitative Western blotting were performed to detect the expression levels of genes of interest. Chromatin IP (ChIP) was employed to detect the transcriptional regulatory activity of p53 on its target gene. Results After the identification of CSC properties, RT-qPCR analysis revealed that HOTAIR, but not other #cancer-associated l#ncRNAs, is highly upregulated in both CSC-MCF7 and CSC-MB231 populations compared with MCF7 and MB231 populations. By modulating the level of HOTAIR expression, we showed that HOTAIR tightly regulates the proliferation, colony formation, migration and self-renewal capacity of CSCs. Moreover, full-length HOTAIR transcriptionally inhibits miR-34a specifically, leading to upregulation of Sox2, which is targeted by miR-34a. Ectopic introduction of miR-34a mimics reverses the effects of HOTAIR on the physiological processes of CSCs, indicating that HOTAIR affects these processes, including self-renewal capacity; these effects are dependent on the regulation of Sox2 via miR-34a. Interestingly, tight transcriptional regulation of p53 by HOTAIR was found; accordingly, p21 is indirectly regulated by HOTAIR, resulting in cell cycle entry. Conclusion These results suggest that HOTAIR is a key regulator of proliferation, colony formation, invasion and self-renewal capacity in breast CSCs, which occurs in part through regulation of Sox2 and p53. http://bit.ly/2k4r9nz #PLoS

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healthcarebiz · 7 years

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China Jo-Jo Drugstores Adds Three Stores in Lin'an Market and on Track to Achieve Retail Expansion Goal

HANGZHOU, China, Sept. 26, 2017 /PRNewswire/ -- China Jo-Jo Drugstores, Inc. (NASDAQ: CJJD or the "Company") has opened three stores in the newly established Lin'an District of Hangzhou. There are now four China Jo-Jo drugstores in Lin'an District and the Company plans to open two more stores by the end of the year.

"We are pleased to expand our retail pharmacies in the newest district of Hangzhou and provide the community with high quality and convenient pharmacy services," China Jo-Jo's Chairman and CEO, Mr. Liu Lei commented, "We are well on our way to achieve our goal of operating 100 stores in Hangzhou, and remain committed to expanding in new districts such as Lin'an, Xiaoshan, Fuyang and consolidating our retail leadership."

With half a million population and abundant natural resources, Lin'an is one of the most economically developed county-level cities in China. On September 15, 2017, Lin'an was officially included as the tenth district of Hangzhou to promote innovative development and economic transformation.

China Jo-Jo's new stores in Lin'an District feature all of the products and services for which thousands of customers across Hangzhou visit its stores every day, including:

A full service pharmacy staffed by licensed pharmacists and pharmacy staff

Prescription and OTC medicines, TCM, dietary supplements, medical devices

Health and beauty products including many popular brands

General merchandise

The China Jo-Jo Rewards Program, which offers exclusive discounts and enhance customer experience

The three new China Jo-Jo stores in Lin'an District are located at:

No. 639 Jincheng St. & Qianwang St.

No. 616 Jincheng St. & Shijing St.

No. 187 Jincheng St. & Chengzhong St.

About China Jo-Jo Drugstores, Inc.

China Jo-Jo Drugstores, Inc., is a leading China-based pharmacy that engages in retail, wholesale and online distribution and sales of pharmaceutical and health care products, including through its online and retail pharmacies. As of Sep 26, 2017, the Company had 95 retail pharmacies in Zhejiang Province. The Company's wholesale subsidiary supplies its retail stores and distributes drug and healthcare products to other drugstores and drug vendors. For more information, please visit: http://ift.tt/1axPoPP. The Company routinely posts important information on its website.

Forward Looking Statement

Statements in this press release regarding the Company that are not historical facts are forward-looking statements and are subject to risks and uncertainties that could cause actual future events or results to differ materially from such statements. Any such forward-looking statements, including, but not limited to, financial guidance, are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These statements can be identified by the use of forward-looking terminology such as "believe," "expect," "estimate," "may," "will," "should," "project," "plan," "seek," "intend," "anticipate," the negatives thereof, or comparable terminology. Such statements typically involve risks and uncertainties and may include financial projections or information regarding the progress of new product development. It is routine for the Company's internal projections and expectations to change as the quarter and year progresses, and therefore it should be clearly understood that the internal projections and beliefs upon which the Company bases its expectations may change. Although these expectations may change, the Company is under no obligation to inform you if they do. Actual results could differ materially from the expectations reflected in such forward-looking statements as a result of numerous factors, including the risks associated with the effect of changing economic conditions in the People's Republic of China, variations in cash flow, reliance on collaborative retail partners and on new product development, variations in new product development, risks associated with rapid technological change, and the potential of introduced or undetected flaws and defects in products. Readers are referred to the reports and documents filed from time to time by the Company with the Securities and Exchange Commission for a discussion of these and other important risk factors that could cause actual results to differ from those discussed in forward-looking statements. Other than as required under the securities laws, the Company does not assume a duty to update these forward-looking statements.

Investor Relations Contact:

Steve Liu [email protected]

Frank Zhao Chief Financial Officer +86-571-88077108 [email protected]

View original content:http://ift.tt/2y4D6B5

Read this news on PR Newswire Asia website: China Jo-Jo Drugstores Adds Three Stores in Lin'an Market and on Track to Achieve Retail Expansion Goal

#Healthcare

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