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shadowfreak98 · 6 months

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Ranulf the Armadillo and Deyne the Mouse

These two are a couple important characters for the Future story arc.

Ranulf [left] is their powerhouse/heavy-hitter. He is more of the brawn of the group and will not hesitate to punch robots. Most misconstrue him as a hothead, or even a meathead. He can be a little spacey at times, and perhaps impulsive, but unlike his ancestor, he is incredibly collected and calm. He is a big brother to that of Deyne and Cryptum. They are the only family he has, and he would do anything to protect them.

Deyne [right] is not so chill. She can get pretty fired up at times if her buttons are pushed enough. Her role is the Freedom Fighters’ tactician. She is the one who organizes plans, and strategies. She intelligent beyond her years, and she knows it... which can lead to some butting of heads with other Freedom Fighters... she can be quite arrogant at times but she is always pulled back to Mobius by her beloved best friend and big sis Cryptum.

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tzmbrenda4449671-blog · 7 years

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Ways To Curl Hair With The Instyler

Have you always wanted adorable ringlets, but were convinced your hair wouldn't hold? Program off your best Curly Sue looks with this simple guide on ways to obtain retro 50's rings. Apply mousse to "damp hair" and roll with Velcro rollers. Sit under a hood clothes dryer which is much less destructive than using a electric hair curling tool or hot rollers. Mousse might offers a softer hold, gel a together hold. A short hairstyle that is rather stylish, but oh, so simple to preserve is the brief and sleek pixie cut. It's the type of hairstyle that could literally be done in a matter of minutes. We have actually seen this hairstyle on celebs like Vocalist Rihanna and model Agyness Deyn.

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atintintintin · 7 years

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Behavioural characterization of AnkyrinG deficient mice, a model for ANK3 related disorders.

Behav Brain Res. 2017 Apr 11;:

Authors: van der Werf IM, Van Dam D, Missault S, Yalcin B, De Deyn PP, Vandeweyer G, Kooy RF

Abstract ANK3 encodes AnkyrinG (AnkG), a member of the Ankyrin family that is expressed in several different isoforms in many tissues. A unique serine-rich domain and tail domain in the two largest isoforms of AnkG (270 and 480kDa), restrict AnkG to the axon initial segment and nodes of Ranvier of myelinated neurons. At these sites, AnkG is a master regulator, coordinating the strict clustering of components necessary for proper action potential initiation and propagation along the axon. These components include voltage-gated sodium channels, potassium channels and members of the L1 cell adhesion molecule family. Genetic variation in the ANK3 gene has been linked to a range of neuropsychiatric and neurodevelopmental disorders in human, including schizophrenia, bipolar disorder, intellectual disability and autism spectrum disorders. Here, we study the effect of reduced expression of the large isoforms of Ank3 on cognition and behaviour using a heterozygous knockout mouse model. In three independent behavioural tests, being the open field test, elevated plus maze and social interaction test, we found evidence for increased anxiety in our Ank3 mouse model. Besides, we observed specific neuroanatomical defects in heterozygous knockout mice, including a smaller cingulate cortex, granular retrosplenial cortex, primary motor cortex and fimbria of the hippocampus.

PMID: 28411148 [PubMed - as supplied by publisher]

via pubmed: autism http://ift.tt/2oMFIy6

#IFTTT #pubmed: autism

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