regenhealthsolutions

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Predicting arrhythmia 30 minutes before it happens using Deep-learning Model

Atrial fibrillation is the most common cardiac arrhythmia worldwide with around 59 million people concerned in 2019. This irregular heartbeat is associated with increased risks of heart failure, dementia and stroke. It constitutes a significant burden to healthcare systems, making its early detection and treatment a major goal. Researchers from the Luxembourg Centre for Systems Biomedicine (LCSB)…

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#Cardiac arrhythmia #Deep learning model #Early detection

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Dawn of CAR-T cell therapy in autoimmune diseases: Chinese Medical Journal review article highlights the potential and promise 

Credit: Chinese Medical JournalDaishi Tian from Huazhong University of Science and Technology Autoimmune disease (AID) refers to the condition in which the immune system identifies the body’s own cells and tissues as foreign, resulting in systemic inflammation. The immune system’s self-attack via autoreactive B and T immune cells and autoantibodies—antibodies against body’s own proteins—may…

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#AUTOIMMUNE DISEASES #CAR-T CELLS

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FDA approves immunotherapy drug combo for non-muscle invasive bladder cancer after UCLA-led research shows improved outcomes for patients

Approval is based on findings from the QUILT 3.032 clinical trial, which was led by UCLA’s Dr. Karim Chamie The U.S. Food and Drug Administration (FDA) has approved the immunotherapy-boosting drug N-803, which is marketed under the brand name Anktiva, to be used in combination with the immunotherapy Bacillus Calmette-Guerin (BCG) for the treatment of patients with BCG-unresponsive…

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#Bladder cancer #FDA #Immunotherapy #UCLA Health

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Long-COVID study reveals immunological improvement two years after infection

Immune abnormalities have largely resolved at 24 months in a cohort of patients with long COVID, providing optimism that long COVID can resolve over time. Biomarkers for long COVID that were present in patients at eight months have largely resolved by 24 months among a cohort of people who contracted COVID-19 during Australia’s first wave.  Jointly led by the Kirby Institute at UNSW…

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#Covid-19 #Long Covid Syndrome #SARS-CoV-2

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AI makes retinal imaging 100 times faster, compared to manual method

NIH scientists use artificial intelligence called ‘P-GAN’ to improve next-generation imaging of cells in the back of the eye Researchers at the National Institutes of Health applied artificial intelligence (AI) to a technique that produces high-resolution images of cells in the eye. They report that with AI, imaging is 100 times faster and improves image contrast 3.5-fold. The advance, they say,…

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#artificial intelligence #retinal diseases

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Physical Activity Reduces Stress-Related Brain Activity to Lower Cardiovascular Disease Risk

Key Takeaways Results from a new study indicate that physical activity may help protect against cardiovascular disease in part by reducing stress-related brain activity This effect in the brain may help to explain why study participants with depression (a stress-related condition) experienced the greatest cardiovascular benefits from physical activity New research indicates that physical…

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#cardiovascular disease risk #Physical activity

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New TRIPOD+AI guidelines reflect growing use of AI in healthcare research

The widespread use of artificial intelligence (AI) in medical decision-making tools has led to an update of the TRIPOD guidelines for reporting clinical prediction models. The new TRIPOD+AI guidelines are launched in the BMJ today. TheTRIPOD guidelines (which stands for Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis Or Diagnosis) were developed in 2015 to…

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#artificial intelligence #Healthcare

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Adolescent Idiopathic Scoliosis patients showed pontine hypertrophy and asymmetry of diffusion parameters in the Brain Corticoreticular Pathway

Heavy school bags, poor posture, one-handed sports are often blamed for the development of curved spine in teens. Known as adolescent idiopathic scoliosis (AIS), it affects those aged 10 to 19 but has no known cause. A team from Singapore General Hospital (SGH) and National Neuroscience Institute (NNI) has now discovered that the answer to this condition may lie in the brain. Employing a…

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#adolescent idiopathic scoliosis #Corticoreticular Pathway

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FDA Approves First Gene Therapy for Children with Metachromatic Leukodystrophy

The U.S. Food and Drug Administration approved Lenmeldy (atidarsagene autotemcel), the first FDA-approved gene therapy indicated for the treatment of children with pre-symptomatic late infantile, pre-symptomatic early juvenile or early symptomatic early juvenile metachromatic leukodystrophy (MLD).  Metachromatic leukodystrophy is a debilitating, rare genetic disease affecting the brain and…

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#FDA #gene therapy #MLD

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Mayo Clinic researchers find promise in new potential treatment for liver failure

A new drug has been shown to increase healing and regeneration of the liver after major surgery, according to a study published in the scientific journal Cell. Researchers hope that this could lead to more surgical options for patients diagnosed with advanced liver tumors and liver failure. “This research is significant because this is the first drug of its kind to show an increase in healing…

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#liver failure #regenerative medicine

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COVID-19 Virus Can Stay in the Body More Than a Year after Infection

COVID RNA (green) present in tissue 6 months after initial infection. Image by Henrich Lab New research provides the strongest evidence yet of long-term viral persistence in otherwise healthy people. The COVID-19 virus can persist in the blood and tissue of patients for more than a year after the acute phase of the illness has ended, according to new research from UC San Francisco that offers…

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#Covid-19 #SARS-CoV-2

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A micro-fragmented collagen gel as a stem cell-assembling platform for critical limb ischemia repair

Critical limb ischemia is a condition in which the main blood vessels supplying blood to the legs are blocked, causing blood flow to gradually decrease as atherosclerosis progresses in the peripheral arteries. It is a severe form of peripheral artery disease that causes progressive closure of arteries in the lower extremity, leading to the necrosis of the leg tissue and eventual…

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#cell therapy #chronic limb ischemia #stem cells

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Preliminary Clinical Trial Results Show ‘Dramatic and Rapid’ Regression of Glioblastoma after Next Generation CAR-T Therapy

MRI results from Participant 3, before infusion (day -7) and after infusion (day 5) Mass General Cancer Center researchers took a new approach to CAR-T, engineering CAR-TEAM cells to treat mixed cell populations within tumors Working in collaboration with Mass General neurosurgeons, the team tested the approach in a phase 1 clinical trial of patients with recurrent glioblastoma First three…

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#CAR-T CELLS #glioblastoma

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Researchers Discover New Cancer-fighting Role for Neutrophils

In a study published in Cell on March 5, Prof. ZHANG Xiaoming at the Shanghai Institute of Immunity and Infection (SIII) of the Chinese Academy of Sciences and Profs. GAO Qiang, FAN Jia and YANG Li at Fudan University have uncovered an unexpected level of complexity hidden within neutrophils, which were previously thought to be a relatively uniform population of short-lived immune cells.  Using…

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#cancer #neutrophils

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Fibrinolytic Biomarkers for Identifying Patients at Risk of Severe COVID-19

Researchers identify associations between proteins involved in fibrinolysis and the development of acute respiratory distress syndrome During the peak of the COVID-19 pandemic, healthcare services experienced an overburdening surge in admissions. Recognizing the complexity of managing COVID-19 cases, researchers have identified proteins related to fibrinolysis as potential biomarkers for…

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#Covid-19 #Fibrinolysis #SARS-CoV-2

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Microplastics and Nanoplastics in Atheromas and Cardiovascular Events

There has been a lot of talk about pollution these days, a phenomenon that is also bad for the heart. But how? An Italian study, the first to have identified the presence of microplastics directly in human arteries, highlights a previously underestimated aspect. After finding them in humans in several organs and tissues, including the placenta, breast milk, liver and lungs, including heart…

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#Atheroma #cardiovascular complications #Microplastics #Nanoplastics

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Zilebesiran RNAi therapeutic lowers blood pressure for months

The results of a phase II study with the RNAi therapeutic zilebesiran have appeared in the specialist journal “JAMA”. Accordingly, injections of the drug every three or every six months lower blood pressure sustainably. Zilebesiran is a substance that exerts its pharmacological effect via RNA interference (RNAi) . The active ingredient is a short RNA section that, as small…

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#Hypertension #RNAinterference #Zilebesiran