#they are essential for conservation and genetic sequencing

[twiainsurancegroup]

[inscinstech]

Unveiling the Future of Genetic Research and Biotechnology

Genetic engineering has made monumental strides in recent years, primarily through advancements in oligonucleotide synthesis. This process involves the artificial creation of oligonucleotides, which are short DNA or RNA molecules. These are crucial for various applications in molecular biology and biotechnology. Modern methodologies have significantly enhanced the precision and efficiency of this synthesis, facilitating the production of highly accurate sequences. These sequences are essential for gene editing, PCR, and DNA sequencing tasks, playing a vital role in many biotechnological processes.

At the heart of modern biotechnology is the DNA synthesizer, a machine that automates the synthesis of oligonucleotides. DNA synthesizers have revolutionized genetic research and biotechnology by enabling the creation of specific DNA sequences with high precision. They have become indispensable in tasks such as gene synthesis, the development of DNA-based therapies, and personalized medicine. DNA synthesizers provide the tools needed for detailed genetic analysis and manipulation, advancing our understanding of genetics.

Recent advancements in oligonucleotide synthesis techniques have led to longer and more complex oligonucleotides with higher fidelity. Overcoming previous limitations in sequence length and accuracy, this progress opens up new possibilities in genetic research. Longer oligonucleotides with fewer errors allow the creation of more complex genetic constructs and the ability to mimic natural genetic processes more accurately. This advancement has significant implications for fields such as medicine, where it can aid in developing new treatments and therapies.

The growing importance of DNA synthesizers in research cannot be overstated. They have streamlined genetic research by rapidly and accurately creating DNA sequences, opening new avenues in various scientific fields. DNA synthesizers are at the forefront of personalized medicine, enabling tailored treatments based on an individual's genetic makeup. In synthetic biology, they facilitate the creation of entirely new genetic sequences, offering innovative solutions to healthcare, agriculture, and environmental conservation challenges.

In conclusion, oligonucleotide and DNA synthesizers remain at the forefront of genetic research and biotechnology. The advancements in these areas have real-world applications that can revolutionize medicine, agriculture, and environmental science. The potential of these technologies is immense, and ongoing development will undoubtedly lead to significant breakthroughs in the coming years. For more detailed insights and information on these cutting-edge technologies, one can explore resources and developments at inscinstech.com.cn, a domain dedicated to advancing the understanding of these crucial scientific tools.

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#lab equipment #dna synthesizer #liquid chromatography #fast protein liquid chromatography #oligonucleotide synthesis #chromatography

[spacetimewithstuartgary]

New publication describes findings on cat evolution, to aid in future disease studies

Morris Animal Foundation-funded researchers have delved into various cat species' entire DNA sequence (genome), uncovering novel perspectives on domestic and wild cat evolution. This new work highlights distinct genetic changes and will be a critical tool for researchers investigating feline diseases and characteristics.

This study, which led to the findings published in Nature Genetics, used cutting-edge genome sequencing and assembly technologies to generate a more comprehensive and complete cat genome assembly, providing fundamental information on the feline blueprint and aiding in advancements in feline medicine.

"This is an ongoing effort because it's very difficult to fill in the missing gaps in the genome sequence, and those gaps aren't just junk," said Dr. William Murphy, the study's principal investigator and Professor of Veterinary Integrative Biosciences at Texas A&M University.

During the study, Murphy and his team identified fewer segmental duplications – duplicated blocks of genomic DNA – in cats compared to other mammal groups while also learning that numerous variances exist in feline DNA. These insights are crucial for those studying feline diseases, behavior and conservation, Murphy said.

"This initial study was just scratching the surface," Murphy said. "Now we're going to be able to use this to go in and start determining the function of parts of the domestic cat genome that were missing before."

The $202,938 grant from Morris Animal Foundation empowered Murphy and his team to leverage cutting-edge genome sequencing and assembly technologies, Murphy added.

"Without Morris Animal Foundation's funding and support for the feline genome project, we would not even be close to where we are now (to filling in the gaps)," Murphy said. "We wouldn't have had the funding to advance and use the latest technologies to get the cat genome on par with the human genome."

Murphy said that while the feline genome is not yet 100% gapless, ongoing refinements, backed by prior grants from Morris Animal Foundation, aim to achieve a comprehensive, telomere-to-telomere feline genome – essential to uncover crucial genetic information.

IMAGE....A figure representing the feline genome work was analyzed by Dr. William Murphy, the principal investigator of the study, and his team at Texas A&M University. The study was funded by the Morris Animal Foundation. Credit William Murphy

#science

[professionalwritings]

Pay Someone To Do My WGU C785 BIOCHEMISTRY Exam

Introduction:

The field of biochemistry delves into the intricate molecular processes that govern life. Among its fascinating aspects is the study of biochemical evolution, which explores how biological molecules, such as proteins, nucleic acids, and metabolites, have evolved over time. In the context of the WGU C785 Biochemistry exam, Pay Someone To Do My WGU C785 BIOCHEMISTRY Exam understanding the principles of biochemical evolution is not only integral to mastering the subject but also provides insights into the broader narrative of life's development on Earth.

Biochemical evolution is rooted in the concept of evolution itself, as proposed by Charles Darwin. It extends the evolutionary paradigm to the molecular level, investigating how the structure and function of biomolecules have changed through natural selection, genetic drift, and other evolutionary mechanisms. Let's explore key aspects of biochemical evolution that students should grasp to excel in the WGU C785 Biochemistry exam.

Molecular Diversity and Common Ancestry: Biochemical evolution emphasizes the unity of life by highlighting the molecular similarities among diverse organisms. The presence of conserved molecules across different species points to a common ancestry. Students should understand how phylogenetic analyses using molecular data, such as DNA or protein sequences, contribute to our understanding of evolutionary relationships.

Selection Pressures on Biomolecules: The selective pressures acting on organisms in their environments also influence the evolution of biomolecules. For example, enzymes involved in crucial metabolic pathways may evolve to enhance efficiency or adapt to specific environmental conditions. Students should grasp how natural selection shapes the molecular toolkit of living organisms.

Adaptations and Functional Evolution: Biochemical evolution is driven by the adaptive changes in molecular structures that confer functional advantages. Studying how proteins and other biomolecules evolve to perform new functions or adapt to changing environments is crucial. This includes understanding the concept of gene duplication, divergence, and the evolution of gene families.

Neutral Theory and Molecular Clocks: Biochemists often use neutral theory to explain the molecular evolution of certain non-functional sequences. Pay Someone To Do My WGU C785 BIOCHEMISTRY Exam Additionally, molecular clocks, based on the assumption of a relatively constant rate of molecular change, help estimate the timing of evolutionary events. Students should be familiar with these concepts and their applications in deciphering evolutionary timelines.

Horizontal Gene Transfer: In addition to vertical gene transfer from parent to offspring, horizontal gene transfer plays a significant role in biochemical evolution. This mechanism involves the exchange of genetic material between different species, impacting the evolution of prokaryotes and contributing to genetic diversity. Understanding how horizontal gene transfer influences molecular evolution is essential.

Co-evolution of Biomolecules and Organisms: The evolution of biomolecules is intricately linked with the evolution of organisms. As species interact with each other in ecosystems, biomolecules involved in processes like immune response or symbiosis may co-evolve. Students should appreciate the dynamic interplay between molecular evolution and the ecological context.

In conclusion, a thorough understanding of biochemical evolution is crucial for excelling in the WGU C785 Biochemistry exam. It not only provides a historical perspective on the development of life but also offers insights into the functional adaptations of biomolecules. By grasping the principles of molecular diversity, Pay Someone To Do My WGU C785 BIOCHEMISTRY Exam selection pressures, functional evolution, neutral theory, horizontal gene transfer, and co-evolution, students can navigate the complexities of biochemical evolution and apply this knowledge to real-world scenarios in biology and medicine.

#assignment help

[evoldir]

Fwd: Postdoc: UWashington_Seattle.ChinookSalmonGenomics

Begin forwarded message: > From: [email protected] > Subject: Postdoc: UWashington_Seattle.ChinookSalmonGenomics > Date: 1 December 2023 at 07:41:56 GMT > To: [email protected] > > > Postdoctoral Scholar Position: > > Chinook salmon life-history genomics - University of Washington and > Northwest Fisheries Science Center, Seattle Washington USA > > This is a joint appointment at UW’s Molecular Ecology Research Lab and > NOAA’s Northwest Fisheries Science Center. The successful candidate will > use bioinformatics, statistical genomics, and evolutionary theory to > address a wide range of conservation-related problems, from mapping > quantitative trait loci to historical biogeography and demographics. This > person will have the opportunity to be at the forefront of genomics > research related to fisheries and wildlife conservation. The position is > fully funded for 1 year, with potential for additional years, through > NOAA’s Cooperative Research program, including travel, laboratory supplies, > and commercial sequencing. > > The Genetics and Evolution Program within the Conservation Biology Division > at NWFSC is dedicated to supporting the conservation and management of > marine and anadromous species, from deep-sea corals, to salmon, to whales. > State-of-the-art, genetics and genomics tools provide essential information > for managing sustainable marine resources. > > Qualifications > - Expert in bioinformatics, statistical genomics, population genetics, and > evolutionary biology. > - Capable of analyzing a large, existing multi-tiered, DNA sequence data > sets, including RAD sequence and WGS across lineages, populations, and > families. > - Generate and analyze new sequence data for additional populations. > - Demonstrated creativity in applying advanced mathematical and > computational methods to distinguish among evolutionary models, especially > in the presence of potentially confounding forces of migration, mutation, > and demography. > - PhD confirmed by start date. > > Application > Application via the Interfolio system only: > https://ift.tt/M0bG9YC > See Interfolio for EEO statement, benefits, commitment to diversity, > privacy and disability services. The salary for this position will > be $69,264 per year. Priority consideration begins December 20, 2023. > Anticipated start date is May 1, 2024, but no later than June 30, 2024. > > Address other questions to the PIs: > Paul Moran

#IFTTT #Email

[livelectures2]

33+ Fascinating Advanced Higher Biology Project Ideas for Avid Learners

Are you an Advanced Higher Biology student yearning for a meaningful project that not only deepens your understanding but also sets your passion for biology ablaze? You're in the right place! In this blog, we'll take a deep dive into more than 33+ advanced biology project ideas that will transform your journey into an exciting and intellectually rewarding experience.

Genetic Disorders Exploration:

Uncover the intricacies of a specific genetic disorder, unraveling its origins, symptoms, and prospective treatment avenues.

Cancer Biology Investigation:

Venture into the multifaceted realm of cancer biology, probing into the underlying mechanisms and potential therapeutic approaches.

Comparative Anatomy Adventure:

Embark on a journey of comparative anatomy, scrutinizing the anatomical structures of different animal species to unveil their evolutionary connections.

Microbial Marvels:

Dive into the mysterious microbial world as you explore the diversity of microorganisms inhabiting a chosen environment.

Ecological Surveys and Biodiversity Assessment:

Conduct in-depth field surveys to assess the biodiversity and environmental impact of a specific area, potentially identifying ways to protect it.

DNA Fingerprinting Unveiled:

Master the art of DNA fingerprinting and delve into its applications in forensic science.

Human Physiology Deconstructed:

Take a comprehensive journey through the human body, unraveling the intricacies of its various systems and their functions.

Biodiversity Hotspots Expedition:

Investigate a local biodiversity hotspot, focusing on unique species, and contribute to their preservation.

Insect Behavior Observatory:

Immerse yourself in the fascinating world of insects, scrutinizing their behavior, interactions, and ecological roles.

Phylogenetic Tree Construction:

Construct a visual representation of evolutionary relationships among various species, offering insights into the tree of life.

Plant Genetics and Agriculture:

Delve into the world of plant genetics, exploring gene expression and its applications in agriculture and crop improvement.

Endangered Species Conservation Crusade:

Research and advocate for the conservation efforts directed towards safeguarding endangered species and their habitats.

Marine Biology Odyssey:

Dive into the depths of marine ecosystems, discovering the enchanting world of marine life and the challenges it faces.

Animal Behavior Analysis and Communication:

Delve into the captivating world of animal behavior and communication, deciphering their intricate languages.

Immunology and Vaccination Unraveled:

Explore the complex workings of the immune system and the science behind the development of life-saving vaccines.

Molecular Biology Techniques Mastery:

Hone your skills in pivotal molecular biology techniques like PCR, gel electrophoresis, and DNA sequencing.

Neuroscience Exploration:

Plunge into the intricacies of the human brain, investigating its functions and unraveling the mysteries of the mind.

Climate Change's Impact on Ecosystems:

Analyze the profound impact of climate change on diverse ecosystems and their inhabitants, helping raise awareness and inspire change.

Hormonal Regulation and Physiological Balance:

Investigate the role of hormones in maintaining physiological equilibrium and their significance in health and disease.

Cell Signaling Pathways Demystified:

Untangle the intricate web of cellular signaling pathways, understanding their essential role in coordinating cellular activities.

Zoology and Taxonomy Journey:

Embark on an exciting exploration of zoology and taxonomy, unraveling the classification and characteristics of animal species.

Genetically Modified Organisms (GMOs) Saga:

Dive into the GMO debate, dissecting the science behind genetically modified organisms and their impact on agriculture and society.

Biomedical Ethics Expedition:

Tackle complex ethical dilemmas in biomedical research, offering thoughtful insights into the moral compass guiding scientific progress.

Microbiome Mysteries Unveiled:

Unearth the secrets of the human microbiome, exploring its crucial role in health and disease.

Invasive Species Impact Assessment:

Investigate the disruptive impact of invasive species on native ecosystems, presenting strategies for mitigation.

Bioinformatics and Computational Biology Odyssey:

Bridge the gap between biology and computer science, uncovering the pivotal role of computational tools in advancing biological research.

Stem Cell Revolution:

Explore the potential applications and ethical considerations surrounding stem cell research, an area teeming with promise.

Epigenetics and Generational Inheritance:

Delve into the intriguing world of epigenetics and its role in the transmission of traits across generations.

Human Genetic Diversity Exploration:

Embark on a genetic journey, scrutinizing the diversity of human populations and understanding the factors shaping our genetic landscape.

Bioluminescence: Nature's Light Show:

Illuminate the fascinating world of organisms that emit light, exploring the biological mechanisms behind this captivating phenomenon.

Aquaponics Systems: Sustainable Agriculture in Action:

Design and implement an aquaponics system to gain insights into sustainable agriculture practices and the intricate balance of aquatic and plant life.

Biochemistry of Photosynthesis Unveiled:

Dissect the biochemical intricacies of photosynthesis in plants, unraveling the process that powers the plant world.

Bridging Biology and Art:

Marry art and biology to create visually stunning representations of scientific concepts, captivating both scientists and art enthusiasts.

Pharmacology and Drug Development Odyssey:

Journey through the complex process of drug development, from initial discovery to clinical applications, understanding the vital role of pharmacology in healthcare.

Cellular Respiration and Energy Production Expedition:

Journey into the heart of cellular respiration, exploring the intricate processes that generate energy to power life.

Ecosystem Services Investigation:

Uncover the hidden services ecosystems provide to humanity, underscoring the importance of preserving these vital natural systems.

Biology in the Cosmos:

Ponder the challenges and prospects of conducting biological research in space, shedding light on the exciting future of space exploration and biology.

Ornithology and Avian Migration Expedition:

Delve into the avian realm, exploring the wonders of bird species and their fascinating migratory patterns.

Nutrition and Health Nexus:

Investigate the intricate link between nutrition and human health, uncovering the secrets to a healthy, well-balanced life.

With this treasure trove of project ideas, you're now equipped to embark on an incredible journey through the realm of Advanced Higher Biology. Not only will you bolster your knowledge and analytical skills, but you'll also kindle a fervent passion for the intricate tapestry of life on our planet. So, pick a project that resonates with your curiosity and embark on a biology adventure that will redefine your academic experience. Happy researching!

#biology #project #ideas

[leedsomics]

Chemoproteomics identifies proteoform-selective caspase-2 inhibitors

Caspases are a highly conserved family of cysteine-aspartyl proteases known for their essential roles in regulating apoptosis, inflammation, cell differentiation, and proliferation. Complementary to genetic approaches, small-molecule probes have emerged as useful tools for modulating caspase activity. However, due to the high sequence and structure homology of all twelve human caspases, achieving selectivity remains a central challenge for caspase-directed small-molecule inhibitor development efforts. Here, using mass spectrometry-based chemoproteomics, we first identify a highly reactive non-catalytic cysteine that is unique to caspase-2. By combining both gel-based activity-based protein profiling (ABPP) and a tobacco etch virus (TEV) protease activation assay, we then identify covalent lead compounds that react preferentially with this cysteine and afford a complete blockade of caspase-2 activity. Inhibitory activity is restricted to the zymogen or precursor form of monomeric caspase-2. Focused analogue synthesis combined with chemoproteomic target engagement analysis in cellular lysates and in cells yielded both pan-caspase reactive molecules and caspase-2 selective lead compounds together with a structurally matched inactive control. Application of this focused set of tool compounds to stratify caspase contributions to initiation of intrinsic apoptosis, supports compensatory caspase-9 activity in the context of caspase-2 inactivation. More broadly, our study highlights future opportunities for the development of proteoform-selective caspase inhibitors that target non-conserved and non-catalytic cysteine residues. http://dlvr.it/Sy27YS

[rnomics]

Biochemical and genetic dissection of the #RNA-binding surface of the FinO domain of Escherichia coli ProQ [Article]

RNA-binding proteins play important roles in bacterial gene regulation through interactions with both coding and non-coding RNAs. ProQ is a FinO-domain protein that binds a large set of RNAs in Escherichia coli, though the details of how ProQ binds these RNAs remain unclear. In this study, we used a combination of in vivo and in vitro binding assays to confirm key structural features of E. coli ProQ’s FinO domain and explore its mechanism of RNA interactions. Using a bacterial three-hybrid assay, we performed forward genetic screens to confirm the importance of the concave face of ProQ in RNA binding. Using gelshift assays, we directly probed the contributions of ten amino acids on ProQ binding to seven RNA targets. Certain residues (R58, Y70, and R80) were found to be essential for binding of all seven RNAs, while substitutions of other residues (K54 and R62) caused more moderate binding defects. Interestingly, substitutions of two amino acids (K35, R69), which are #evolutionarily variable but adjacent to conserved residues, showed varied effects on the binding of different RNAs; these may arise from the differing sequence context around each RNA’s terminator hairpin. Together, this work confirms many of the essential RNA-binding residues in ProQ initially identified in vivo and supports a model in which residues on the conserved concave face of the FinO domain such as R58, Y70 and R80 form the main RNA-binding site of E. coli ProQ, while additional contacts contribute to the binding of certain RNAs. http://rnajournal.cshlp.org/cgi/content/short/rna.079697.123v1?rss=1&utm_source=dlvr.it&utm_medium=tumblr

[atlab1]

The Vital Role of Laboratory Testing and Analysis in Modern Science

Introduction

Laboratory testing and analysis are integral components of the scientific method and play a crucial role in advancing our understanding of the natural world. These processes are essential for a wide range of disciplines, including chemistry, biology, physics, medicine, and environmental science. In this article, we will explore the significance of laboratory testing and analysis, their diverse applications, and the methodologies involved.

The Foundation of Scientific Discovery

Laboratory testing and analysis are the foundation upon which scientific discoveries are built. They provide a controlled environment in which researchers can manipulate variables and conduct experiments to test hypotheses and gather empirical data. This empirical data is crucial for validating theories and expanding our knowledge.

Key Applications

Chemistry: In chemistry, laboratory analysis involves the identification and quantification of chemical substances. Techniques such as chromatography, spectroscopy, and mass spectrometry are used to determine the composition of substances, study chemical reactions, and develop new materials.

Biology: In the field of biology, laboratory testing is essential for studying cellular processes, genetics, and microbiology. Techniques like DNA sequencing, microscopy, and cell culture help biologists understand the complexities of life at the molecular and cellular levels.

Medicine: Clinical laboratories are fundamental to medical diagnostics. Blood tests, urine analysis, and molecular biology techniques are routinely used to diagnose diseases, monitor patient health, and develop new treatments.

Physics: Physics experiments often require precise measurements and controlled conditions. Laboratories equipped with specialized instruments like particle accelerators and spectrometers are essential for studying the fundamental laws of the universe.

Environmental Science: Analyzing soil, water, and air samples in the laboratory is critical for monitoring environmental quality, assessing pollution levels, and developing strategies for environmental conservation.

Methodologies Involved

Laboratory testing and analysis involve a systematic approach:

Hypothesis: Researchers start by formulating a hypothesis or research question. What do they want to investigate or discover?

Experimental Design: They design experiments to test the hypothesis, defining variables, controls, and methods. This step ensures the experiments are repeatable and reliable.

Data Collection: Experiments are conducted in a controlled laboratory environment, and data are collected meticulously. Precise instruments and equipment are often used to ensure accuracy.

Analysis: Data analysis involves statistical methods, graphs, and other techniques to identify patterns and draw meaningful conclusions.

Results and Conclusion: Researchers summarize their findings, drawing conclusions based on the data. These conclusions can either support or refute the initial hypothesis.

Peer Review: Scientific research typically undergoes peer review, where experts in the field evaluate the study's methodology and results for validity and significance.

Conclusion

Laboratory testing and analysis are at the heart of scientific exploration and discovery. They enable researchers to delve into the mysteries of the natural world, develop new technologies, and improve our understanding of various phenomena. From chemistry and biology to physics and environmental science, these processes are essential for advancing human knowledge and addressing complex challenges. As technology continues to advance, the capabilities of laboratory testing and analysis will only expand, further enriching our understanding of the world around us.

For More Info :- 

accelerated technology

[fivehundredwords]

who lives rent-free in the brain? Jacob.

*cringe*

Jacob is a messenger protein found in neurons. Specifically, it is a "synapto-nuclear" messenger. This protein is involved in letting the nucleus of the neuron know that certain changes have happened in its synapse.

Jacob is located at the axons or dendrites of the neuron which is at the synapse. This is measured using an estimate called post-synaptic density (PSD).

Jacob also lives in the nuclei of pyramidal neurons. Mostly studied in pyramidal cells and hippocampal neurons, yet lurks in many other brain regions.

Jacob is thought to have no definite structure.

Jacob promotes synaptic plasticity through CREB. When we talk about synaptic plasticity, changes in genetic expression of the neuron are involved. For the expression of a gene to change, the gene structure or arrangement does not necessarily have to change. A big difference shows even when certain parts of the gene are not allowed to express or are allowed to be expressed too much.

Essentially, Jacob and CREB are friends who stroll around on gene sequences and leave a trail of mRNA behind. This exact process is called transcription. Transcription makes mRNA. Therefore, Jacob is associated with CREB-dependent transcription.

In newborn humans, at 2-3 weeks after birth, the expression of Jacob is thought to be increased as their brains make new synapses.

Jacob lives in cats, dogs, their humans, and fellow mammals. This means it is well conserved (i.e. it proved useful enough to be maintained through evolutionary stages) in this kingdom (taxonomical) of animals. Research is yet to confirm the whereabouts of Jacob in other, weirder animals.

#neuroscience #altered my brain chemistry #protein #biochemistry #jacob anderson #jacob black #science side of tumblr #science side help me #science side explain

[hacktechmedia]

agriculture

Importance of Soil Health: The soil is the foundation of agriculture. It's essential to maintain soil health by using sustainable farming practices, including crop rotation, cover cropping, and reducing tillage. Healthy soil promotes healthy crops, helps retain water, and reduces the need for synthetic fertilizers and pesticides.

Sustainable Agriculture: Sustainable agriculture is a farming practice that emphasizes ecological balance, biodiversity, and the conservation of natural resources. It aims to produce food in a way that does not harm the environment and supports the livelihood of farmers.

Crop Rotation: Crop rotation is a farming practice that involves growing different crops in the same field in a planned sequence. This practice helps to prevent soil erosion, improve soil fertility, and reduce the spread of pests and diseases.

Irrigation Management: Irrigation is essential for crop production, but it must be managed carefully to avoid wasting water and to ensure that crops receive the right amount of water at the right time. Water management practices such as drip irrigation, rainwater harvesting, and soil moisture sensors can help farmers use water more efficiently.

Integrated Pest Management (IPM): IPM is a farming practice that combines biological, cultural, and chemical methods to control pests and diseases in crops. It aims to minimize the use of synthetic pesticides while still achieving effective pest control.

Precision Agriculture: Precision agriculture is a farming practice that uses technology to optimize crop production. It involves using sensors, drones, and other tools to collect data on soil conditions, weather patterns, and crop growth, which farmers can use to make more informed decisions about when to plant, fertilize, and harvest their crops.

Agricultural Policy: Government policies can have a significant impact on the agriculture industry. Policies related to subsidies, trade, and environmental regulations can influence the profitability of farmers and the sustainability of the agriculture sector as a whole.

Food Security: Agriculture is critical for ensuring food security, which means that people have access to sufficient, safe, and nutritious food. This topic involves discussions about improving agricultural productivity, reducing food waste, and addressing food inequality and access issues.

Sustainable Livestock Production: Livestock farming is an essential component of agriculture, but it can have negative environmental impacts, such as water pollution and greenhouse gas emissions. Sustainable livestock production practices, such as rotational grazing and manure management, can help reduce these impacts while still supporting the livelihoods of farmers.

Agricultural Innovation: Innovation is essential for the continued growth and sustainability of the agriculture industry. Research and development in areas such as genetics, biotechnology, and precision agriculture can lead to new technologies and practices that improve crop yields, reduce environmental impacts, and increase food security.

[myfeeds]

Evolution of two contagious cancers affecting Tasmanian devils underlines unpredictability of disease threat

Tasmanian devils are susceptible to two fatal transmissible cancers called devil facial tumour 1 (DFT1) and devil facial tumour 2 (DFT2) that have caused rapid population decline in recent decades. The two cancers both manifest with disfiguring facial tumours. In a new study, University of Cambridge researchers mapped the emergence and mutations of DFT1 and DFT2 and characterised these cancers’ ongoing evolution. The findings underline the continued threat that transmissible cancers pose to Tasmanian devils. The results are published today in the journal Science. “The incredible fact that Tasmanian devils have not one, but two, transmissible cancers, makes it possible to compare their evolution, and this gives us new insights into the key mechanisms involved,” said lead author Elizabeth Murchison, Professor of Comparative Oncology and Genetics at the Department of Veterinary Medicine, University of Cambridge. “By looking at the mutations that have accumulated in these cancers’ DNA, we can trace the origins and evolution of these diseases. Our results show that the two cancers arose through similar processes and that both have striking signals of ongoing evolution. It is difficult to predict how this continued cancer evolution will impact devils.” The researchers created an improved ‘reference genome’ – essentially a map of the entire DNA sequence – of the Tasmanian devil and compared this to DNA taken from 119 DFT1 and DFT2 tumours. DFT1 was first observed in 1996 in Tasmania’s northeast and is now widespread throughout Tasmania. DFT2, on the other hand, was first observed in 2014 and remains confined to a small area in Tasmania’s southeast. The scientists identified mutations in the tumours and used these to build ‘family trees’ of how the two cancers had each independently arisen and evolved over time. By tracking mutations the researchers discovered that DFT2 acquired mutations about three times faster than DFT1. As mutations usually occur during cell division, the most likely explanation is that DFT2 is a faster growing cancer than DFT1, say the researchers, underlining the importance of DFT2 as a threat. “DFT2 is still not widespread in the devil population, and very little is known about it. We were really startled to see just how quickly it was mutating, alerting us to what could be a very unpredictable threat to the devils in the long term,” said Maximilian Stammnitz, first author of the study. The team found that DFT1 arose in the 1980s, up to 14 years before it was first observed, whereas DFT2 emerged between 2009 and 2012, only shortly before it was detected. Mapping the mutations revealed that DFT1 underwent an explosive transmission event shortly after it emerged. This involved a single infected devil transmitting its tumour to at least six recipient devils. DFT1 has now spread throughout almost the entire devil population and has recently been reported in the far northwest of Tasmania, one of the few remaining disease-free regions of the state. Researchers also identified for the first time an instance of DFT1 transmission between a mother and the young in her pouch. Additionally, they found that the incubation period – the time between infection and the emergence of symptoms – can in some cases be a year or more. These findings have important implications for conservation scientists working to protect the species. “I come from Tasmania and love Tasmanian devils – they have a special place in my heart,” said Murchison. “Transmissible cancers pose an unprecedented and unpredictable threat to Tasmanian devils. This research highlights the continuing importance of monitoring and conservation programmes. It also gives us new insights into the evolutionary mechanisms operating in cancer more broadly, including in human cancers.” The research was funded by Wellcome, the Gates Cambridge Trust and Eric Guiler Tasmanian Devil Research Grants from the University of Tasmania Foundation.

[oneillhinton17]

Semen good quality being a potential weakness signal in order to SARS-CoV-2 insults within dirty locations.

Granulation muscle created inside the sponges and full-thickness skin color acute wounds revealed short-term upregulation associated with CTGF phrase simply by MSCs and also fibroblasts, hinting a part with this molecule in early cells fix. Even though bovine collagen along with COL1A2 mRNA just weren't increased when recombinant CTGF had been administered to sponges was developed stage (evening 1-6) regarding tissue restoration, extented administration click here (415 times) associated with exogenous CTGF in to PVA sponges led to fibroblast proliferation along with increased deposit regarding collagen inside the new granulation tissue. Meant for their physiological role, CTGF immunoinhibition during earlier restoration (days and nights 0-7) lowered the quantity, business high quality and vascularity associated with experimental granulation muscle from the sponge or cloth product. Nevertheless, CTGF haploinsufficiency had not been sufficient to cut back bovine collagen deposition in excisional pains. Much like intense murine hurt designs, CTGF has been transiently seen in the first period of individual serious melt away injure healing. Together, these types of results further support any biological position for CTGF inside injury restore along with show that whenever CTGF term is actually limited to early tissues fix, the idea will serve any pro-reparative part. These kind of info in addition more show the chance of MSC-derived paracrine modulators to further improve muscle restore. Clinical Investigation (The year 2013) 95, 81-95; doi:10.1038/labinvest.Next year.162; printed on the internet Twenty November 2012Several healthy proteins have been discovered which protect Drosophila telomeres through combination events. They contain UbcD1, HP1, HOAP, the parts with the Mre11-Rad50-Nbs (MRN) complicated, your ATM kinase, as well as the putative transcription factor Woc. Of these healthy proteins, merely HOAP is shown to localize especially from telomeres. Take a look at show that the actual modigliani gene encodes a new health proteins (Moi) that is ripe limited to telomeres, colocalizes as well as physically communicates using HOAP, and is also needed to prevent telomeric fusions. Moi will be encoded with the bicistronic CG31241 locus. This locus generates a individual log made up of 2 ORFs that stipulate distinct important characteristics. One of them ORFs encodes your 20-kDa Moi health proteins. The opposite encodes a 60-kDa health proteins homologous for you to RNA methyltransferases that's not essential for telomere security ( Drosophila Tat-like). Moi and also HOAP talk about many components with the components of shelterin, the proteins intricate that shields man telomeres. HOAP along with Moi are certainly not evolutionarily preserved as opposed to another protein suggested as a factor within Drosophila telomere safety. In the same manner, no shelterin subunits will be conserved throughout Drosophila, many man nonshelterin proteins have got Drosophila homologues. This suggests the HOAP-Moi sophisticated, we all brand "terminin,'' takes on a unique part in the Genetics sequence-independent assemblage associated with Drosophila telomeres. We imagine that sophisticated will be functionally similar to shelterin, that binds chromosome ends in a new sequence-dependent method.In the name compound, C12H11FO4S, your O atom and also the methyl gang of the methylsulfinyl substituent rest upon complete opposite sides with the airplane of the benzofuran fragment [O-S-C-C along with C-S-C-C torsion aspects Is equal to 126.75 (13) along with -123.Fifty five (Thirteen)degrees, respectively]. The particular amazingly construction will be stable simply by weak non-classical intermolecular C-H heart dot middle us dot centre department of transportation A hydrogen-bond connections.

#Crizotinib #CM272 #Fluzoparib #Degrasyn #ACSS2 inhibitor #3-TYP #NU7026 #PF-9366 #TPX-0046 #Mobocertinib #Mocetinostat #ULK-101 #MK-8353 #Super-TDU #CD38 inhibitor 1 #Ferrostatin-1 #MDL-28170 #CA-074 methyl ester #Pentosan Polysulfate #Pemetrexed #Tecovirimat #Dubermatinib #PIM447 #AUNP-12 #Ponesimod

[ashbywheeler]

Radiographic Pneumonia throughout Febrile Infants 60 Days and Youthful

We provide an child together with sporadic suprasternal guitar neck mass visible just through greater intrathoracic stress, developed possibly through crying and moping as well as straining. Carried out excellent herniation in the thymus in the guitar neck ended up being confirmed simply by ultrasonography with the attribute sonographic appearances of the normal thymus in addition to its condition, size and placement. Ultrasonography should be the initial image resolution method of preference. Treating superior herniation from the thymus in to the throat ought to be conservative because the thymus obviously involutes along with growing age. Knowing of your differential carried out neck of the guitar puffiness found merely about Vasalva manoeuvre or elevated intrathoracic stress is essential to prevent pointless assessments, prevent radiation, biopsy as well as medical procedures.Marsupials, one of many 3 principal groups of animals, are just within Sydney along with the U . s . continent. Reports done in Foreign marsupials have exhibited the great LEE011 molecular weight possible given by the audience for that understanding of fundamental anatomical mechanisms as well as chromosome progression in animals. Genetic reports throughout United states marsupials tend to be reasonably rare and also cytogenetic info of most species tend to be tied to karyotype explanations, usually with out banding designs. Nonetheless, the first marsupial genome sequenced had been that of Monodelphis domestica, a new Southern American types. The ability about mammalian genome development overall performance in which resulted through research on M. domestica is sharp distinction with the lack of anatomical info on most U . s . marsupial species. The following, all of us produce an introduction to the chromosome studies executed inside marsupials together with emphasis on the particular To the south United states species.The particular appreciation of human immunodeficiency virus (HIV) bag for CD4 and also CCR5 appears to be connected with aspects of R5 malware (malware while using the CCR5 coreceptor) pathogenicity. Even so, admittance productivity comes from complicated interactions relating to the viral cover glycoprotein as well as equally CD4 as well as CCR5, which in turn limits efforts to link virus-like pathogenicity together with surrogate actions involving cover CD4 and CCR5 affinities. Here, we existing a method that delivers any quantitative and comprehensive characterization regarding popular admittance efficiency as being a direct interdependent aim of both CD4 and CCR5 levels. This receptor love profiling program additionally unveiled heretofore not appreciated complexities root CD4/CCR5 use. We first developed a dually inducible cellular range through which CD4 and CCR5 might be at the same time and also individually controlled inside a physiologic range of floor term. Contamination by simply a number of Aids kind 1 (HIV-1) along with simian immunodeficiency virus isolates could possibly be looked at together for up to Forty eight different combinations of CD4/CCR5 appearance quantities, resulting in a unique utilization structure for each virus. Hence, every virus produced an original three-dimensional floor plan where popular contamination diverse as a function of the two CD4 along with CCR5 term.

#FUT-175 #NSC 119875 #IDN-6556 #BMN 673 #NSC 125973 #PUN30119 #RAD001 #R428 #LY2835219 #GSI-IX #Compound 3 #PF-03084014 #GSK2118436 #MLN4924 #PS-341 #CCRG 81045 #BMS-907351 #LY-188011 #LGX818 #MRTX849 #MS-275 #BIBW2992 #GDC-0068 #KD025 #LY2157299 #LEE011 #MK-4827 #KPT-330 #INCB28060 #ZD1839

[shirlleycoyle]

UFO Hunter and Harvard Geneticist Announce $15 Million Effort to Resurrect Woolly Mammoths

A famous Harvard geneticist and a startup founder most famous for planning to launch satellites to search for UFOs in Earth’s atmosphere have announced a new venture to de-extinct woolly mammoths using advanced gene-editing technology.

Investor and co-founder Ben Lamm announced the launch of Colossal, along with a $15 million dollar seed round, Monday morning. It’s not the first science fiction-esque project Lamm has worked on. Lamm is also the founder of Hypergiant Industries, which, among other things, is trying to launch satellites to search for UFOs on earth.

Colossal describes itself as a “breakthrough bioscience and genetic engineering company” that is “accepting humanity’s duty to restore Earth to a healthier state, while also solving for the future economies and biological necessities of the human condition through cutting-edge science and technologies.”

Colossal will essentially sponsor research at a Harvard Medical School lab run by co-founder George Church, an infamous and at times controversial geneticist who has been discussing the possibility of de-extinction for nearly a decade. Church has been an emphatic supporter of de-extinction—the restoration of extinct species to their former habitats—and conducted research into mammoth de-extinction for nearly a decade.

In a Zoom call with Motherboard, Lamm said the company was building off of research from Church, as well as other researchers like David Rice, who have managed to sequence the genome of 23 Asian elephants, the closest living relative to woolly mammoths. Eriona Hysolli, Colossal’s lead biological scientist, also extracted and analyzed DNA from a well-preserved mammoth caracas found in the permafrost of the Siberian taiga.

“They’ve pretty much managed to complete the assembly of the 60 plus genes that would essentially make an elephant genome functionally that of a woolly mammoth,” Lamm said. “That’s the phenotypic attributes: small ears for low temperatures; cold-tolerant hemoglobin; 10 centimeters of brown fat; and of course what people mostly know and love, that furry, shaggy coat.”

The company is currently in the gene-editing phase, where it’s working to leverage genetic tools like CRISPR to splice and edit cells which can then be cloned to create embryos.

If all goes to plan, Lamm said that he is “confident” Colossal will produce its first set of elephant-mammoth hybrid calves in four to six years. Long term, the plan is to have large herds of mammoths reintroduced to the Arctic.

Colossal argues that returning extinct species to their original habitats will “revitalize lost ecosystems for a healthier planet.” Bringing back the Arctic grasslands, the company says, will slow the melting of permafrost storing gases like carbon and methane. A spokesperson also told Motherboard that technology developed by Colossal could be applied to other current species facing extinction. (Notably, the company does explicitly exclude the “use of these Harvard technologies in humans”).

Church’s lab is no stranger to criticism, however. In a round of media interviews in 2017, Church claimed he was two years away from creating a hybrid elephant-mammoth embryo, a feat that one expert claimed Church knew “neither he nor anybody else is going to make” in that time span. Other experts have voiced ethical concerns regarding mammoth de-extinction, especially the potential use of surrogate mothers, and lambasted the potential gamble of placing “your climate-change mitigation hopes on a herd of woolly mammoths.”

There’s also the question of whether potential de-extinction is even worth the hefty price tag and resources, and whether those should instead be spent on species that are still living and breathing. Lamm, for his part, doesn’t see de-extinction and current conservation efforts as an intrinsic zero-sum game.

Colossal acknowledges that there are scientific hurdles ahead. Implementing a woolly mammoth embryo remains one of the challenges, and the company is exploring both surrogacy and artificial wombs as potential options.

Lamm claims it’s different this time, though. Church worked for years on a “shoestring budget”—a $100,000 donation from venture capitalist Peter Thiel. Now, Church and his team have millions of dollars behind them and a team of powerful investors.

“This allows us to give the biologists and scientists the focus they need to be successful,” Lamm said. “I truly believe that if I or others had been focusing the right level of capital and energy into this five years ago, we would have mammoths today.”

UFO Hunter and Harvard Geneticist Announce $15 Million Effort to Resurrect Woolly Mammoths syndicated from https://triviaqaweb.wordpress.com/feed/

[evoldir]

Fwd: Postdoc: UArizona.ComparativePopGenomics

Begin forwarded message: > From: [email protected] > Subject: Postdoc: UArizona.ComparativePopGenomics > Date: 26 May 2023 at 06:25:13 BST > To: [email protected] > > > NSF funded 2-year postdoc in comparative population genomics and > transcriptomics on the diversification of biota from Baja California > Peninsula > > Focus on bioinformatic analyses of population genomic data via > low-coverage whole genome resequencing and RNA Seq across multiple > species of plants, lizards and desert rodents.  University of Arizona, > School of Natural Resources and the Environment > > A funded 2-year postdoc is available in population genomic analyses via > low coverage whole genome resequencing and RNA-Seq. The position is part > of a NSF-funded transdisciplinary GeoGenomics investigation that combines > geologic, climatic, and genomic data to test multiple non-mutually > exclusive hypotheses in Baja California peninsula (Mexico).The genomic > data will be used to test the effects of marine seaways, volcanic > activity, glacial refugia, and rainfall asynchrony on the biological > diversification through signatures in the genomes of desert reptiles, > mammals, and plants. The postdoc will work as part of the larger Baja > GeoGenomics consortium (https://ift.tt/PuzIQsU) composed of a team > of geologists and biologists from University of Arizona, University of > Oregon, Arizona State University, University of Arkansas, and California > State University. Eagerness to work in a multidisciplinary setting > and with a team is essential.  The research project can focus on any, > or multiple, of the following: > >  *   Conducting population genomic analyses to identify genetic >      variants from low-coverage genome sequencing >  *   Parametrize models of neutral divergence for multiple species >      constrained by the geologic evidence >  *   Perform landscape genomic analyzes to test concordance with niche >      modeling hypotheses of expansion-contraction from glacial refugia >  *   Correlate present-day ecological niches with spatial signals of >      natural selection both from genome sequencing and differential RNA- >      Seq expression >  *   Develop novel bioinformatic approaches for simultaneously >      integrating geologic, genomic, and ecological datasets. > > Interested candidates should send their CV, names of 2 > references, and a brief summary of interests, including how > your background would apply to these topics (and be prepared > to have 2 reference letters send on request), by June 7, 2023, > to both Adrian Munguia-Vega ([email protected]) and Melanie > Culver ([email protected]). Selected researcher(s) will work in > collaboration with both Dr. Munguia-Vega and Culver, and will join > Dr. Melanie Culver’s Conservation Genetics Lab at University of > Arizona, Tucson, AZ. Official application needs to be submitted to > postdoc job posting at the University of Arizona Human Resources. > https://ift.tt/viWTQqU > > Starting date: August 2023 > Payrate: $56,484/hour with an ERE of 17.6%  (includes health benefits > but not retirement contributions). > Recent Media coverage: > https://bit.ly/3Z7jaFH > > Project Description: > https://ift.tt/v7ijXLT > > "Culver, Melanie - (mculver)"

#IFTTT #Email