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targcryns · 1 year
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well... you certainly are not supposed to be here.
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deckerferrell55 · 1 year
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Development the β-Arrestin Trafficking Circumstances regarding Ghrelin Receptor GHCaramboxina: C-Tail-Independent Molecular Determining factors in GPCRs
Heat surprise proteins (Hsps) are typically related to anxiety reply and patience. The actual Native indian catfish, Clarias batrachus, is often a river air-breathing hypoxia understanding teleost and is possibly critical catfish kinds regarding aquaculture and then for their financial benefit as meals. The existing research aimed at deciding your transcriptional reply regarding three Hsps, CbHsc71, CbHsp90 leader and CbHsp10 in hypoxia understanding Indian native catfish, D. batrachus, below trial and error and also normal hypoxia. The term report regarding above 3 genes have been analyzed under different periods regarding hypoxia, by means of qRT-PCR. Primers specified via ESTs attained through SSH collections constructed from hypoxia dealt with within a. The Hsp10 ESTs and deduced necessary protein was in silico indicated due to the ORF and then for the physical as well as compound qualities, correspondingly, using GeneScan, blastp, scanprosite, superfamily along with other programs. The phylogenetic sapling ended up being created depending on deduced protein series regarding Hsc71, Hsp90 leader https://www.selleckchem.com/products/Methazolastone.html , Hsp90 experiment with regarding Homo sapiens and also other fish together with CbHsp10 necessary protein throughout MEGA4. The actual deduced proteins patterns associated with CbHsp10 is discovered to have characteristic Hsp10 family signatures, which is proposed regarding inclusion associated with methionine from the general opinion sequences of Hsp10 household signature, as soon as the "proline" deposit. In transcribing amount, these kinds of genes were found to get differentially governed beneath hypoxia strain, in different cells regarding D. batrachus. Your CbHsc71 and also CbHsp90 alpha have been up-regulated following small and long-term hypoxia, whereas CbHsp10 has been considerably down-regulated after short-term hypoxia. The particular differential appearance of such Hsps may play a role throughout safety along with success under hypoxia caused oxidative anxiety in H. batrachus.Self-assembled peptide dependent nanostructures gained ample recognition because of their effortless biocompatibility and numerous prospective apps. An outstanding model of self-assembly associated with hydroxyethylamine based peptide nanostructures ended up being produced and also seen as DIS and also TEM. Spherical ipod nano houses involving I along with III ended up seen using chemical size comparable to Fifty and similar for you to Eighty nm, correspondingly. Additional, My spouse and i selleck chemicals llc as well as III were screened-in against anti-malarial goal, falcipain-3 (FP3), a vital cysteine protease concerned as being a key hemoglobinase regarding Plasmodium falciparum. Curiously, ingredient Hi there completely inhibited the activity regarding FP3. Your efficient attention (1.5 mu Mirielle) of 3 seen to be Wiki wealthier than My spouse and i. This kind of biochemical outcome was substantiated through molecular-docking scientific studies implying Three to be greatest chemical associated with FP3. This is the initial statement displaying that his / her hydroxethylamine dependent peptide nanostructures is quite efficient inhibitor. involving malarial cysteine proteases. (H) 2013 Elsevier Ltd. Almost all rights set aside.Qualifications. Many of us examined the protection and efficiency of growing dosages associated with autologous body patch pleurodesis for treating prolonged atmosphere water leaks in sufferers with innovative continual obstructive lung disease (Chronic obstructive pulmonary disease). Methods. Forty-four individuals using COPD as well as impulsive pneumothorax (SP) about the In 7th place next day of intercostal tube water flow were at random assigned to Some groupings, with 12 patients in each team.
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thereddeadredeemed · 3 years
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An Ironwood meta that just randomly popped into my head.
So I’ve been skimming over a lot of the observations on RWBY from @bionic-jedi and aside from the glurge of absolutely adorable Nuts ‘n Dolts stuff (Which I appreciate, I ship it now), the part that really got my attention was all the shit going down around Ironwood. I don’t watch the show anymore, not that I hated it or anything I just sorta lost interest in the show itself, decided it ultimately wasn’t really for me and mainly just enjoy it through fanart and shipping now, but from what I gathered from bionic-jedi’s Let’s Watch Ironwood sounds absolutely fascinating in all the ways that I don’t think was intentional by the CRWBY but is still pretty awesome that it’s there.
Forgive me if I get the details wrong since I haven’t kept up with the show and all my info is coming second hand from @bionic-jedi​, but from I could gather Ironwood comes across as a man who:
- Is an experienced veteran fighter who individually is very badass with a proven tactical record on the battlefield
- Has the natural charisma to instill genuine loyalty and belief in his cause into his subordinates (To paraphrase Mass Effect 3 for a bit, you can pay a man to fight, you can pay him to charge up a hill, but no amount of money in the world will ever convince a man to believe in you), and does possess a genuine care for the troops under his command
- Will nonetheless still engage in abusive behavior if a subordinate is not performing in a way he believes is proper for their duty (Yeah I would consider forcibly hacking a sapient being to count as that)
- Carries around a very cool badass revolver as a signature weapon 
- While brilliant tactically, possess horrible long term strategic assessment skills that if allowed to be acted upon could have/did end in disaster
You know what that sounds like? Ironwood is almost a perfect RWBY equivalent for George R. Patton (with maybe a bit of Bernard Montgomery thrown in).
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Like, I think that the CRWBY may have accidentally written a scenario that asks “What if Patton was the Supreme Commander of the Western Front instead of Eisenhower?” And the results are an absolute clusterfuck unfolding in real time, but I feel I gotta clarify this.
Patton is one of America’s most celebrated and respected generals, and for good reason. Dude was a badass with a keen sense of armor tactics and mobile warfare that proved repeatedly that he could beat the Germans at their own game. His personal bravery could also never be called into question, having proven his mettle in direct combat during both the Hunt for Pancho Villa and WW1, as well as putting his own life in danger being very close to the front lines numerous times during WW2, one time even riding a tank into a German-occupied village to inspire his men. He also did genuinely care for the lives of his men, only ever seen openly weeping when mourning for the lives of his fallen soldiers, treating his wounded troops with the highest respect, and properly giving praise when they did a good job.
For all of Ironwood’s faults, his own mettle is certainly not into question given he suffered such grievous injuries that half his body is now cybernetics, and the man for sure knows how to fight and fight well, so that’s one similarity with Patton. He has also inspired real loyalty in Winter and the Ace Operatives, and in turn he does seem to actually care for them, and he had no real reason to give Yang a new prosthetic arm (and rather quickly fast tracking her an incredibly advanced one at that), so he’s not completely heartless or devoid of empathy. 
However, Patton was a man focused on the tactical short term in lieu of long term strategic planning, and possessed with some horrendous character flaws that bit him in the ass on several occasions. One of them being the, even by the standards of the 40′s, deplorable manner in which he treated soldiers wracked with what we in the modern day would diagnose as PTSD. The man flat out did not believe PTSD was a real thing, thinking of it as cowardice and...you know what? I’m just gonna let the Wikipedia quotes say it all, I bolded some choice quotes for convenience:
Private Charles H. Kuhl, of L Company, U.S. 26th Infantry Regiment, reported to an aid station of C Company, 1st Medical Battalion, on 2 August 1943. Kuhl, who had been in the U.S. Army for eight months, had been attached to the 1st Infantry Division since 2 June 1943. He was diagnosed with "exhaustion," a diagnosis he had been given three times since the start of the campaign. From the aid station, he was evacuated to a medical company and given sodium amytal. Notes in his medical chart indicated "psychoneurosis anxiety state, moderately severe (soldier has been twice before in hospital within ten days. He can't take it at the front, evidently. He is repeatedly returned.)" Kuhl was transferred from the aid station to the 15th Evacuation Hospital near Nicosia for further evaluation.
Patton arrived at the hospital the same day, accompanied by a number of medical officers, as part of his tour of the U.S. II Corps troops. He spoke to some patients in the hospital, commending the physically wounded. He then approached Kuhl, who did not appear to be physically injured. Kuhl was sitting slouched on a stool midway through a tent ward filled with injured soldiers. When Patton asked Kuhl where he was hurt, Kuhl reportedly shrugged and replied that he was "nervous" rather than wounded, adding, "I guess I can't take it." Patton "immediately flared up,” slapped Kuhl across the chin with his gloves, then grabbed him by the collar and dragged him to the tent entrance. He shoved him out of the tent with a kick to his backside. Yelling "Don't admit this son of a bitch," Patton demanded that Kuhl be sent back to the front, adding, "You hear me, you gutless bastard? You're going back to the front."
Corpsmen picked up Kuhl and brought him to a ward tent, where it was discovered he had a temperature of 102.2 °F (39.0 °C); and was later diagnosed with malarial parasites. Speaking later of the incident, Kuhl noted "at the time it happened, [Patton] was pretty well worn out  ... I think he was suffering a little battle fatigue himself." Kuhl wrote to his parents about the incident, but asked them to "just forget about it." That night, Patton recorded the incident in his diary: "[I met] the only errant coward I have ever seen in this Army. Companies should deal with such men, and if they shirk their duty, they should be tried for cowardice and shot."
Private Paul G. Bennett, 21, of C Battery, U.S. 17th Field Artillery Regiment, was a four-year veteran of the U.S. Army, and had served in the division since March 1943. Records show he had no medical history until 6 August 1943, when a friend was wounded in combat. According to a report, he "could not sleep and was nervous." Bennett was brought to the 93rd Evacuation Hospital. In addition to having a fever, he exhibited symptoms of dehydration, including fatigue, confusion, and listlessness. His request to return to his unit was turned down by medical officers. A medical officer describing Bennett's condition
And yet another incident like this:
Private Paul G. Bennett, 21, of C Battery, U.S. 17th Field Artillery Regiment, was a four-year veteran of the U.S. Army, and had served in the division since March 1943. Records show he had no medical history until 6 August 1943, when a friend was wounded in combat. According to a report, he "could not sleep and was nervous." Bennett was brought to the 93rd Evacuation Hospital. In addition to having a fever, he exhibited symptoms of dehydration, including fatigue, confusion, and listlessness. His request to return to his unit was turned down by medical officers. A medical officer describing Bennett's condition
The shells going over him bothered him. The next day he was worried about his buddy and became more nervous. He was sent down to the rear echelon by a battery aid man and there the medical aid man gave him some tranquilizers that made him sleep, but still he was nervous and disturbed. On the next day the medical officer ordered him to be evacuated, although the boy begged not to be evacuated because he did not want to leave his unit.
On 10 August, Patton entered the receiving tent of the hospital, speaking to the injured there. Patton approached Bennett, who was huddled and shivering, and asked what the trouble was. "It's my nerves," Bennett responded. "I can't stand the shelling anymore." Patton reportedly became enraged at him, slapping him across the face. He began yelling: "Your nerves, hell, you are just a goddamned coward. Shut up that goddamned crying. I won't have these brave men who have been shot at seeing this yellow bastard sitting here crying." Patton then reportedly slapped Bennett again, knocking his helmet liner off, and ordered the receiving officer, Major Charles B. Etter, not to admit him. Patton then threatened Bennett, "You're going back to the front lines and you may get shot and killed, but you're going to fight. If you don't, I'll stand you up against a wall and have a firing squad kill you on purpose. In fact, I ought to shoot you myself, you goddamned whimpering coward." Upon saying this, Patton pulled out his pistol threateningly, prompting the hospital's commander, Colonel Donald E. Currier, to physically separate the two. Patton left the tent, yelling to medical officers to send Bennett back to the front lines.
As he toured the remainder of the hospital, Patton continued discussing Bennett's condition with Currier. Patton stated, "I can't help it, it makes my blood boil to think of a yellow bastard being babied," and "I won't have those cowardly bastards hanging around our hospitals. We'll probably have to shoot them some time anyway, or we'll raise a breed of morons."
There were serious cries for Patton to get sacked after theses incidents, his reputation and job only saved because Eisenhower knew his tactical command abilities were simply too valuable to give up and so was only temporarily relieved of duty instead. Point I’m trying to make here is that while Patton could definitely hold sympathy and understanding for his men, it was contingent on them acting in a way he believed was properly honoring their duty. If they erred from his ideals of a how a proper soldier behaved, he could lapse into some seriously abusive behavior disturbingly quickly.
I can’t be the only one that sees some parallels between this and Ironwood hacking Penny am I? A man who cares for his troops but as soon as Penny acted in a way he deemed to be out of line, immediately sought to violate her autonomy and rights as a sapient being to force her back into line and back into his ideals of how a proper soldier should behave. Perhaps he wasn’t as violently physically aggressive about it as Patton, but arguably what Ironwood did was ethically much worse than slapping the shit out of and threatening people.
Patton also wasn’t the type to worry about the long term consequences of his actions. Before he died in a car accident shortly after WW2 he was unceremoniously sacked from his job after making one too many aggressive comments towards the Soviet Union, potentially nudging towards a potential Operation Unthinkable, and carelessly allowing former Nazis back into political power. Both of these were unthinkably horrible for obvious reasons.
There is one key difference between Patton and Ironwood however. Eisenhower was keenly aware of Patton’s potential shortcomings and he was kept on a leash and out of the highest levers of power, thus preventing him from ever being in a position where his worst traits would allow him to truly fuck up. Ironwood however I feel got Peter Principle’d hardcore and was promoted way above his level of competence (Always a risk for men who gain a reputation as “fightin’ generals”, see: John Bell Hood), where his positive qualities of personal physical bravery, combat skill and tactical leadership is wasted and his worst qualities of hyper-focus on short sighted tactical victories over long term strategic goals, paranoia and distrust leading to an excessive need for control, and moral cowardice are allowed to flourish.
And we see the consequences of it. He may have started with solid pragmatic ideas, but his insanely one-track minded obsession with short term strategic goals like making sure he has control over the Winter Maiden is costing him big long term strategically by burning bridges with potentially valuable allies and isolating himself and his command. Valuable time and resources that could have been spent coordinating forces against Salem wasted on various shenanigans involving Penny, RWBY and JN_R. Especially devastating given that Atlas is the only industrialized military power worth a damn in this world and isn’t reliant on mostly independent and unorganized Hunters and Huntresses (individually skilled but too few in number and takes far too long to train each one to reliably stop a Grimm invasion), and he’s just wasting the resources of the world power best able to hold the line against the Grimm.
Next part is a bit of a non-sequitur and really long so I put it in between the dotted lines if y’all ain’t interested and want to skip on over to the relevant Ironwood parts.
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Getting a feel for the strategic situation in Atlas, I get a strong sense that what Atlas needs more than anything else right now is a Dwight D. Eisenhower. Eisenhower the the exact man needed to lead the Western allies, and I can’t see anyone else doing as realistically as good a job as he did, this is a hill I’ll die on. It wouldn’t look like it at first, the man had never once commanded a unit in battle (a fact that made many of his “actually seen combat” rivals bitter), and his softer, more easy going disposition would seem at odds with the alpha-male take charge image cultivated by men like Patton and Montgomery that would be stereotypically expected of a general, much less a Supreme Commander. 
However, that calm exterior hid a man with a sharp eye on the necessary strategic goals needed for victory, expert resource and personnel management skills, the humility to listen to his subordinates and admit his own mistakes, and most importantly, both the smooth negotiating skills and the iron will necessary to deal with larger than life figures.
The western allies were made up of many different nations and factions and filled to the brim with what I would call (to put it lightly) strong personalities. This was an organization that involved: 
- Franklin D. Roosevelt
- Winston Churchill
- Charles De Gaulle
- Bernard Montgomery
- The aforementioned Patton
- Occasional dealings with Stalin even
All of them larger than life personalities, all of them strong willed and possessed of their own ideas of how to win the war as well as their own political/personal motives, and all of them vying for dominance in the strategic decision making of the Western Allies. It was like herding a clowder of cats, but all the cats had frggin tanks and bombs. Eisenhower actually managed to cut through the bullshit and resist all the arm twisting and actually got all the different countries, armies and leaders together to act upon a united plan. He did this while still being able to control his subordinates worst impulses and (mostly) was able to resist the shitty plans put up and embrace the good ones (for the most part, Montgomery did manage to convince him to approve of Operation Market Garden, and it was the last major German victory of the war mostly due to Monty’s mishandling). Tactical battle ability was largely irrelevant for Eisenhower’s role, and his ability to see the big picture clearly and being able to maneuver through the internal politics meant everything to his success as a Supreme Commander.
If Eisenhower or an Eisenhower-esque figure was in charge of Atlas during this latest season, you’d probably get a drastically different turn of events. An Eisenhower would not be so quick to drastic action as Ironwood was. An Eisenhower would probably sit down with their subordinates, hear out all their arguments for why or why shouldn’t a specific action be taken, then calmly consider their actions. An Eisenhower would probably then say “Working with an enemy agent to hack into the Winter Maiden is a dumb idea” and proceed to create plans on how to coordinate all available forces in Remnant to best fend off Salem.
Atlas as a whole doesn’t really strike me as the type of organization that would raise an Eisenhower though. Militaries are always offshoots of the cultures that create them, and I don’t believe it to be a coincidence that a Supreme Commander like Eisenhower would be American. The country was literally founded on democratic ideals and it was enshrined very early into its history that the military would always be subordinate to the civilian government. This precedent makes it necessary that anyone that rises high enough in the military must be able to respect a strong civilian presence and be able to work with both internal and external politics. Any general that rises high enough must be half-general half-politician by necessity (there’s a reason why former military often do have successful political careers after retiring from service, including the aforementioned Eisenhower who eventually became the 34th President of the United States).
Atlas just doesn’t strike me as having that same sort of cultural framework. If anything the Atlas military strikes me as having a cultural framework closer to WW2 Germany where tactical efficiency and high tech weaponry/tools is prized above all else, often at the cost of long term strategic goal setting. Nazi Germany and Imperial Japan never set realistic goals for themselves and predictably got steamrolled eventually. Occasionally you’ll get an online thread asking “What if Germany/Japan had smart top leadership during WW2?” But that’s a trick question. A WW2 Germany/Japan with sensible leadership...just isn’t WW2 Germany/Japan at all, it was intrinsic to the identity and character of those nations in that time period. Similarly, I just don’t see an Atlas military that sees a potential Eisenhower in their ranks and thinks to promote them to High Command as opposed to just shuffling them off as an aide to some random officer and never consider them for higher promotion. An organization that prizes short term tactical victory over long term strategic goals just isn’t the type of organization to do that.
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Thing is though, I think just from what I gathered, Ironwood just shot up to be my favorite RWBY character because of how frigging fascinatingly horrible he is. He’s not an entirely awful person (at least not at first), but his own paranoia and fear combined with his habit of confusing short term tactical advantage with long term strategic goals leads him down the path of utterly despicable actions while convincing himself that it’s all for the greater good. All while being an idiot and wasting the legitimate game-changer resources of having an actual army when everyone else is still dicking around with hunters and huntresses as their only defense.
Smart money is he’s gonna die, it seems to be where he’s heading. If CRWBY’s writing staff has some serious cajones however, it’d be really cool if they pulled a Catra on him and see how low they can make him sink before making him hit rock bottom, realize his mistakes and force him to work hard for a redemption arc. I dunno, maybe I’m giving him too much slack but I actually do feel for him a little bit. The dude was clearly an alright guy that had the world fall down on him and just wasn’t suited for the massive responsibility that circumstances forced on his shoulders. He’s still a soldier that genuinely wants to protect Atlas, he’s just too short sighted to see how his actions just aren’t what Atlas is gonna need in the long term. Maybe a harsh talking to by Glinda would do him some good (I still ship IronWitch don’t @ me). I dunno, I just think that a redemption arc would be a lot harder to write than just killing him off, and thus would be that much more satisfying to see it pulled off right like what Noelle Stevenson did with Catra’s character in She-Ra.
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