The Department of Energy, Environmental & Chemical Engineering provides integrated and multi-disciplinary programs of scientific education in cutting-edge areas organized through four clusters: Aerosol Science & Engineering, Engineered Aquatics Processes, Metabolic Engineering and Systems Biology, and Mulltiscale Engineering.http://ow.ly/Gcji308P7WD
Fuzhong Zhang, Assistant Professor, Department of Energy, Environmental & Chemical Engineering
Non-genetic, cell-to-cell variations in protein and metabolite concentrations cause large heterogeneity in single-cell biosynthetic performance, which dramatically affects ensembles yield and efficiency of bioproduction. Using a product-responsive sensor-selector, the Zhang Lab developed a generalizable technique termed Population Quality Control (PopQC) to enrich high-performing variants. The image shows the spontaneous selection of non-genetic, high-performing variants from an isogenic population.
Illustration by Steve Edwards
zhang.eece.wustl.edu
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Srikanth Singamaneni, Associate Professor, Department of Mechanical Engineering & Materials Science
Zeolitic imidazolate framework-8 (ZIF-8) grown around antibodies anchored to plasmonic nanostructures serves as a protective layer to preserve the biorecognition ability of the antibodies stored at room and elevated temperatures for several days. The biofunctionality of the ZIF-8 protected biochip can be restored by a simple water-rinsing step, making it highly convenient for use in point-of-care and resource-limited settings.
softnano.wustl.edu
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