#whereas like!!! t1n and t2n have the massive difference of cataplexy vs no cataplexy

[fortunatelyfresco]

In the general population as a whole (ie, not just those who are sleepy), the presence or absence of SOREMPs on repeated MSLTs is also quite variable, suggesting that this may not be the best feature to use in discriminating among diseases. Indeed, prominent narcolepsy researchers have concluded that the presence of 2 or more sleep-onset REM periods [eg, on the MSLT] does not appear to have any specific pathognomonic significance.

THATS WHAT IM FUCKING SAYINGGGG, THE MSLT IS A BAD TEST!!!

#tag ramble incoming #so xywav was recently approved as a treatment for idiopathic hypersomnia #and i am hoping that is a step in the direction of like #further differentiating type 1 and 2 narcolepsy #and taking ih more seriously #i don't know enough to actually theorize that t2n and ih are the same disorder but the page this quote is from (the hypersomnia foundation) #lists several areas of overlap in everything from symptoms to brain chemicals #whereas like!!! t1n and t2n have the massive difference of cataplexy vs no cataplexy #and from what i can tell hypocretin deficiency vs no hypocretin deficiency #anyway sorry what i am hoping for is that we're moving towards a point where t1n can be diagnosed #based on cataplexy and/or hypocretin levels (bc cataplexy isnt always severe enough to be observed) #and t2n and ih can be diagnosed based on other symptoms #with effective treatments available for all three diagnoses so getting the wrong one doesnt fuck you over forever #and no one has to take the goddamn mslt