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darth-spectrumite-blog · 7 years

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This is to Rory: when I was talking to you, it was clear. Most of my posts are talking about you too because you treat me the same way as everyone else, you just mobilized a huge squad of Tumblr followers to do so. I got on here to be your friend again, it looked like a good way to reach you, that stopped eventually and it became a place to go to

You. Are. Abusive. As are Alli and Troy probably, but like they stopped, troy even led me through the steps of “if someone treated me like how I supposedly treated you, I would not be there friend anymore”.

You are going to virtue signal your way out of this by saying I am lying. You have mobilized a mass of followers, and people in real life to perpetually obsess, analyze and basically stalk my behavior. My number one most clear boundary was stop testing me.

You make me afraid. You psychoanalyze me so much. Go die in a tire fire you piece of shit. In what world was doing this alright? Forming a giant web of a puzzle to see if I could figure it out? Do you think I couldn’t? Was that the test? If I could I’m not Autistic cause I could figure it out? Shiiit that’s dumber than I am.

Do you remember the night I learned “sniff” can be used to communicate?I started smiling because I thought I had picked up on a code that few new. It quickly turned to terror. You perpetuate that terror regularly. I fucking hate you. Why would you do this? What was possibly so bad that you and your friends all have to constantly talk about me and my behavior? You orchestrated a test in the house that was everyone doing shit to fuck with me. It was so crazy making because WHY WOULD PEOPLE BE SO OBSESSED WITH ME

This was not okay. Now go virtue signal to say why it was all justified in the end.

Edit: you offering me rides when I reimbursed you for gas money is not exploitation. Posting stuff in hopes you might like it is not exploitation. If empathy is an exploitable commodity, then the world, and you, exploit me, or attempts to, constantly through lies “oblivious humor triggers me”

i reimbursed you for taco Bell. I gave you gas money. I stopped asking you for rides to shit and walked 2-3 miles home regularly. Tell me how I abused you plz or you’re talking our your ass. Not every person you are friends or acquittances with then turns sour is exploiting you. Espescially when you keep offering, although make sure it’s known, i very quickly stopped asking. Any time we did stuff in the end, it was because you offered a ride, like to the homeless events. Hope you enjoyed all the free pot you exploiter /s.

Double edit: “I like hearing you talk”- words from when we still hung out after I asked about my rambles. Don’t try to act like that was some aggregious use of mental labor, although it was labor, but that’s what people who like each other do. But then you stopped liking me so it stopped. This is the same pattern as with Maria, but you made it sound like she got sooooooo many rides from you. Times you picked me up when we didn’t go out together: maybe like 5 but definitely under 8. I also gave you many tanks of gas for more than the 2-3 miles it would take to pick me up. But hey, who’s counting? You were. But it sounds like you counted awfully. You are a piece of shit who has to be better than everyone around you so that you are excused from effed up behavior

following the harassment onto the internet, is fucked up. inviting people into our place to have them mock me from the other room to see how I would I respond was wasso probably fucked up too. Telling so many lies I have to go back through and see how many there were, that’s fucked up. The moment I started figuring it out was when you said “yeah, j often don’t know when to stop talking”. Like you’re good at keeping your mouth shut. That should have been a larger red flag. I still trusted you. I trusted you on the way out I trusted you not to hurt me and to be honest, you did everything but that.

I just in general trusted you to not be such a fucking abusive asshole to get a gang of Internet followers to harass me, or passively post things regarding me (still probs harassment if it’s made to appear on my blog). I shouldn’t have trusted you at all.

Now what did I do? Exploit kindness from a person who was 1000x more kind to you, even in the end, now thaaats exploitation

Tripple edit: all boundaries you established I respected, because it’s easy to never contact you again (until yesterday when you really stated fucking with me). Everyone watches me too much but this takes the cake. I never blocked you because you could always just Google my blog, and after seeing how much people stalked Me, the number of blogs you could ha e follow me to report to you, well I was right in thinking it would be futile

#aurant #massivelimestonecube #abusers #i won't talk about this often in the future because who will ever believe me #maybe if it explains my weird behavior but people will still just say i'm lying

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theweeklyprofit · 5 years

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Buy This Pick-and-Shovel 5G Stock Before It Takes Off

Wireless technology has come a long way.

The first generation of wireless known as 1G was rolled out in the 1980s. The only thing a user could do with 1G was make a phone call.

At times, the call quality could rival that of two tin cans connected by a string.

But wireless tech has made huge advances since those early days.

About every 10 years we’ve seen a new generation of wireless—1G, 2G, 3G, and today’s 4G. Each was faster and more reliable than the previous generation.

As you may already know, we are about to see the next generation of wireless. It’s the new 5G technology, which is slated to hit the market this year.

And that creates a big opportunity for investors.

Why 5G Is So Important

To understand why 5G is such a big deal, you must understand one thing: latency.

Latency is delays in sending information from one point to the next. This is different than bandwidth, which is the volume of data being transferred, not the speed of the transfer.

The lower the latency, the faster information can race across a network.

And the 5G network has very, very, very low latency. This core attribute of 5G will revolutionize many industries.

Remote medical procedures are just one example. Low latency will enable remotely located robots to instantly mimic human movements.

This will give doctors the real-time response they need to perform surgery on a patient located anywhere in the world.

The next era of self-driving cars will also depend on 5G. The new technology will allow cars to “talk” to each other in real time.

5G will even change farming. Farm equipment company John Deere is developing 5G technology that promises to radically boost crop yields.

5G is a gamechanger. And there’s been a ton of money flowing into 5G-related companies.

Major Investment in 5G Is Already Underway

Companies have already spent over $200 billion on 5G infrastructure.

Most of this money has gone toward building 5G-ready cell towers.

That’s a lot of money, but there is much more to come. Research firm Moor Insights & Strategy expects that 5G-related IT hardware spending will reach $326 billion by 2025.

See, to achieve the speed and reliability of 5G requires lots of cell towers.

Today, the 4G network uses 25,000 cell towers across the US. Each one is 100 feet (or more) tall, and they are spaced several miles apart.

The 5G network will need 200,000 cell towers that are much smaller and spaced in a much tighter web across the US.

So in the near term, almost all 5G spending will go to building out the cell tower grid.

When it’s ready, 5G speeds will be 20 gigabytes per second. That’s 1000x faster than today’s 4G technology.

5G will make wireless bandwidth seem infinite. And the companies building the infrastructure for this new technology will be the first to profit.

Picking the Right Horse in the Race to 5G

There are a few ways to invest in the evolution to 5G.

You could buy the stock of companies that maintain and operate 5G infrastructure. These would be stable dividend companies like AT&T, Verizon, and China Mobil.

These are low-risk, limited-upside investments that will take time to bear fruit.

Things work slowly in the telecom space. We saw this play out when 4G was introduced.

To gain the benefits of the 4G network, users had to replace their 3G phones. Phones aren’t cheap, and 3G phone owners had to first be convinced that the new phones and features were worth the money. That took some time.

Instead, I recommend going the “picks and shovels” route. This means companies who build the infrastructure that supports 5G technology.

These companies are making money from their 5G investments right now.

I like to buy companies that sell the “picks and shovels” that industries need… like investing in farm machinery companies rather than agricultural businesses.

In the 5G space, this would be companies that sell the hardware, software, and services to telecom companies.

And we can leverage our bet by owning a company with exposure to the international adoption of 5G technology.

There’s only one company that fits these criteria.

Nokia Corp. (NOK)

Nokia is a Finnish multinational telecommunications company. It is the world’s third-largest telecom equipment manufacturer after Huawei and Cisco.

The company is split into two segments:

Nokia Networks (90% of sales): provides systems and software to build high capacity network infrastructure.

Nokia Technologies (10% of sales): develops consumer products and licenses technology for the Nokia brand.

Almost all of Nokia’s business comes from selling data networking and telecom equipment. That’s just what we want, because I expect those types of sales will see big growth as 5G investment ramps up.

The build out of the 5G network will be global, and Nokia is a truly international company

Even better, two of Nokia’s biggest rivals—ZTE and Huawei, were blacklisted by the US government. This will shrink NOK’s competition in this US market to pretty much just one company—Ericsson.

The investment flow into 5G from the major telecom companies has already started to climb.

In July, Nokia received a $3.5 billion contract from T-Mobile US, which was reportedly the largest 5G deal ever.

T-Mobile has about a 17% share of the US wireless market, making this a major win for NOK.

This Play Will Take Time… Be Patient

The flow of investment will not, however, hit the 5G market like a giant wave.

It will be more like a steadily rising tide. In fact, NOK management expects 5G investment to be soft in the first half of 2019.

But that’s perfect for investors. It gives us an opening to get in before the tide of money starts to rise.

The multibillion-dollar contract from T-Mobile looks like a sign of some early pump priming for more 5G spending.

The other major wireless carriers in the US aren’t going to let themselves lag behind in the race to 5G.

I think we will soon see more big 5G contracts make the headlines. As a major player in a market with limited competition, Nokia will almost certainly win a lot more US sales by the end of 2019.

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#5g #5g technology #smartphone #nokia #nokiatech

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berylburgessus · 5 years

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How Scalable Vector Graphics Files (SVG) Can Prove Useful for Photographers and Artists

On screens, visual illustrations can be presented in two basic formats, Vector Graphics or Raster Graphics (bitmaps). The former allows scalability and the latter, albeit more visually appealing, discourages it. Knowing when to use these two kinds of formats is key as it determines how well a designer can present his or her artwork on screens as well as what he or she can add to a website. SVG is one of the main formats – if not the main one – for representing vector graphics. It has been around since the early 2000s but its use was discouraged since very few browsers supported it and compared to today, it was not that important. Nonetheless, today, with websites being accessed using devices of various screen sizes, SVG has become a format that must be used and is particularly convenient. Mobile first is the philosophy behind web design in this age and that means web pages scale up and down depending on the screen size of the device used to access them. Images are interesting but they are a headache when it comes to scalability. The seamless capacity of SVG to scale up and down without a lot of trouble makes them perfect for this age of responsive design. SVG files can be used either as image files with the .svg extension or inline as SVG code. As code, SVG offers more flexibility for designers to do with the file as desired. The magic of vector graphics is in their ability to scale up or down without losing detail. This feature is what makes SVG ideal for the mobile-ready age. You can scale SVG up to 1000x without losing details and you do the opposite, but you’ll need a “magnifying glass” to see the image, but still, you won’t lose any detail. SVGs take up very little space because vector graphics don’t use up as much space compared to raster files. This ability to take up little space is another aspect of SVGs that makes them ideal for web design and vector design in general. When space is an issue, SVG files won’t fail you. On websites, you need images that are small because image size affects how fast your web pages will load, especially if your website incorporates a lot of graphics. SVG gives you the ability to express your creativity without worrying much about file sizes. The more illustrations, images, icons, and graphics you need for a design, the higher the chances are that you’ll find SVG invaluable. SVG can be edited using popular graphics applications like Adobe Illustrator, CorelDraw, or Sketch. In fact, if you are creating illustrations or graphics for the web or screens, rather than saving your file as .png or .jpg, SVG is a better option. You know that once you save your artwork as .png or .jpg, you will have converted the artwork into bitmaps and bitmaps do not offer as much flexibility in terms of editing like vectors do. But if you save your work as an SVG file, you retain the vector aspect of the artwork. And as a vector graphic, you can use the embedded SVG code to make modifications to the artwork as needed. This is particularly useful when it comes to changing the color of the artwork or if you intend to use the artwork in any form of animation. Speaking of animations, often, icons are created using sprites, which are various identical images with different properties like different colors or additional details here and there. SVG gives you the ability to modify things like colors on the fly using the embedded SVG code. When creating icons, or images that change according to user behavior, rather than creating sprites, you can create one SVG image and then take advantage of the embedded code to change colors. How about that for flexibility? If you are working on screens as a photographer or an artist, learning to use SVG file formats to represent your work will give you flexibility like never before. This file type gained popularity in design since 2014 and the trend is still happening. Their usage will only increase over the coming years due to their convenience and coolness. Join the wagon lest you be deemed backward. Original Content Source: https://www.njartscouncil.org/photography/information/how-scalable-vector-graphics-files-svg-can-prove-useful-for-photographers-and-artists/

source http://designbundles.weebly.com/blog/how-scalable-vector-graphics-files-svg-can-prove-useful-for-photographers-and-artists

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carlanthonyus · 5 years

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How Scalable Vector Graphics Files (SVG) Can Prove Useful for Photographers and Artists

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ynsespoir · 6 years

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13 Futuristic Healthcare Technology Advances of 2018 – ReferralMD

Let’s kick the 2018 New Year off right…

This is the 6th straight year, ReferralMD has written our Healthcare Technology Review and I wanted to say thanks to everyone for your support in making it the #1 most read healthcare technology publication review in the world.

Healthcare Acquisitions on the Rise

2018 is going to be a exciting year for healthcare technology as mergers and acquisitions are heating up. In 2017 alone, there were 43 acquisitions with Internet Brands acquiring WebMD leading the way at $2.8B.

So what does this mean for the future of insurance companies, health systems, startups, and patients?

It means we finally may see some significant changes in how healthcare is administered, improvements in patient access, lower wait times, improved revenues for health systems, lower costs, and much more…

(Huge Game of Thrones Fan, Can’t wait till 2019)

But hopefully the healthcare industry will not remain frozen in time for much longer.

Let’s Get Started (Read on…)

We have personally researched the web for a year to find the best companies that are making a difference and have compiled an amazing list below. Here’s to change!

1. Payer – Provider Analytics/Data

Blurring Lines between Insurance Companies and Physician Practices

Several carriers are already are giving health care organizations claims data, analytics and tools to help make better decisions on which providers are “more appropriate” based on quantitative data, not “Yelp reviews.”

It all boils down to high quality data, and who has it.

Screenshot of ReferralMD

An example of how this is used in a care coordinator’s workflow is when a patient is about to be transferred to a specialist after an initial screening at a PCP or insurance company. The coordinator at the point of care has full visibility to their referral network, provider affiliations (in-network status), accepted insurances, proximity to patient, experience of doctor, and even ranks the specialist on a quantitative score from 1 to 100.

Tools like ReferralMD’s referral management and econsult software can optimize decision support, improve workflow and reduce leakage.

Competitor Analysis

Referral data can also be used by physician liaisons to look up which competitors receive the most referrals in a certain geography based on specialty, location, and more to learn which companies would make the best partners based on referral volume. Another option is to look up your own doctors to see if they are steering patients to competitors.

How much are you losing to out-of-network referrals (Leakage)?

Apply to Receive your Free Competitor Analysis Report

2. Artificial Intelligence

AI-Powered Medical Assistants

Most of us are used to chatting with our phones using Siri about the latest sport scores, or Alexa to turn on music, but how comfortable are we discussing private medical issues with chat-bots that may not all the information in their database.

While promising, AI is still in its infancy, but holds promise for patients today that wish to schedule doctor appointments based on the severity of the symptoms, monitor the health status and notifying a human nurse immediately if the parameters are out of control, help homecare assistants stay informed about patients’ evolution.

Here are a few applications that come to mind, although there are thousands, time will tell which will become successful.

The company, Kore.ai offers smart bots for healthcare facilities. The digital assistant can connect patients to the right contacts directly, give appointment details or make any changes. It lets the patients easily refill prescriptions or pay bills. It delivers lab, test or procedure outcomes or recommended next steps.

Safedrugbot embodies a chat messaging service that offers assistant-like support to health professionals, doctors who need appropriate information about the use of drugs during breastfeeding.

Izzy helps women track their period and serves as a birth control pill reminder.

Bots like Your.Md aim to help patients find a solution to the most common symptoms through AI. However, a chatbot never replaces an experienced doctor. The bot itself exhorts the user to book an appointment with a doctor for a diagnosis, and eventually for the prescription of a therapy.

Florence might be a very useful chatbot for older patients. It is basically a “personal nurse,” and “she” can remind patients to take their pills. You just write the name of the medicine in chat, the number of times a day you must take it and at what time. Then, Florence sends you a message in chat every time you must take the pill.

3. Blockchain for Healthcare

You have probably heard about Bitcoin and its explosive growth from $.08 cents in 2009 to almost $20,000 dollars in 2017. It uses the blockchain technology to exchange information with others.

So what is blockchain you may ask?

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Effectively a blockchain is a kind of independent, transparent, and permanent database coexisting in multiple locations and shared by a community. This is why it’s sometimes referred to as a mutual distributed ledger (MDL) versus a single client-server database like your standard website where one owner controls the access credentials.

So how does blockchain apply to healthcare?

The end goal would be a decentralized record system using blockchain independent of EMR’s controlling the data. But as we know this will not happen until a government mandate or EMRs opening up their data silos.

How bad is communication in healthcare?

There are 26 different electronic medical records systems used in the city of Boston, each with its own language for representing and sharing data. Critical information is often scattered across multiple facilities, and sometimes it isn’t accessible when it is needed most—a situation that plays out every day around the U.S., costing money and sometimes even lives. But it’s also a problem that looks tailor-made for a blockchain to solve, says John Halamka, chief information officer at Beth Israel Deaconess Medical Center in Boston.

While it would be massively beneficial to patients and providers alike, it looks like the fax machine is hear to stay for another 10 years.

4. 5G Mobile Technology

Fast communication and healthcare are are not usually mentioned in the same sentence, but as wireless technology gets better we are starting to see how the Internet of Medical Things (IoMT) will greatly improve patient lives.

Qualcomm worked with Dr. David Teece, Professor at Haas School of Business, U.C. Berkeley and Chairman and Principal Executive Officer of Berkeley Research Group, on a paper, “5G Mobile: Impact on the Health Care Sector”. Qualcomm Technologies Inc. (QTI) commissioned this report to assess 5G’s potential impact on the evolving health care sector as it begins a shift in focus from volume-based health care to value-based (outcome-based) health care which could generate upwards of $650 billion in savings by 2025, according to Goldman Sachs.

5G enhanced Mobile BroadBand (eMBB) could save you a trip to the doctor.

If you don’t like visiting your doctor, that’s fine, because soon your doctor may visit you. Well, virtually that is. 5G is expected to usher in a new age of greatly enhanced eMBB data rates and hyper connectivity, which will allow doctors to study and analyze numerous patient medical data feeds simultaneously and provide personalized treatment for patients.

5. Internet of Medical Things (IoMT)

Internet of Medical Things, or Healthcare IoT, refers to a connected infrastructure of medical devices and software applications that can communicate with various healthcare IT systems.

As an example, this can be thought of as simply as someone who wears a FitBit to track his or her steps; that step count is tabulated on an iPhone via Bluetooth technology; and then that data can be shared with a physician to provide feedback via Wi-Fi connection and automated reporting data, and it can also send that data to your closest friends and family.

What are the dangers of IoMT?

The greatest danger related IoMT is the high barrier of entry to truly disrupt the healthcare industry and to change the way disease is treated. There is a threshold for the speed at which anyone can execute on delivering these innovative solutions to a population and industry that so desperately need change.

Regulatory hurdles

With each change inherent in the introduction of these systems, there are massive regulatory hurdles that require significant amounts of resources, even more so than a typical medical device pathway to commercialisation.

And beyond the historically proven 10 years and $30M to take a medtech product to the US market, there is the added burden of competing in a commercial space against pharma and other medtech conglomerates that have 1000x more resources and power to squash any new competition, even if the solution is what’s best for the patient.

One of the latest announcements from The Centers for Medicare & Medicaid Services (CMS) confirms that the largest payer in the U.S. sees remote patient monitoring (RPM) as part of the future of care delivery. Why? Because next year, they will begin incentivizing use of connected technology to capture patient-generated health data.

Beginning January 1, 2018, clinicians can use the newly unbundled reimbursement code CPT 99091 to bill for the time they spend reviewing and interpreting data collected or transferred by a remote monitoring tool. The changes to this code will have significant implications for accelerating the adoption of remote monitoring tools into clinical practice.

How can clinicians position themselves to take full advantage of this new incentive, understand the changed guidelines, and determine how RPM could be incorporated into their practices? Read on.

What are the benefits of IoMT?

The benefits to introducing IoMT are vast, and certainly there are even more benefits to be discovered as we continue to grow our expertise in this space as an industry. But to name a few:

Objective reporting: Because the devices can record and report on actual activity at the level of the nervous system, we no longer have to rely solely on subjective patient reports of “how they are feeling”; instead, we have an objective evaluation of the disease progression andpatient therapy efficacy as reported by the devices,

Remote monitoring: Increased patient accountability as the healthcare provider will have a “report card” so to speak of actual patient therapy compliance instead of relying on accuracy of patient summary,

Local activity recording: Device recording capabilities allow for the collection data that we’ve never previously been able to access. This data will vastly improve our understanding of the mechanism of action of these chronic diseases. And if we understand the disease better, we will undoubtedly enhance our approach on disease prevention and therapy,

Automation: The automation of device and therapy records decreases human error or fraudulent reporting within hospitals and sub-acute care facilities,

Precision medicine: the delivery of targeted stimulation that is optimized for that individual facilitates improved therapy with decreased undesired side effects. When you take a pill, for the most part, that pill is metabolised in some fashion and then distributed systemically throughout your body regardless of its intended target. While much there are many advances to decrease these drug-related side effects, the level of precision we can achieve with devices that can steer stimulation to a specific target is of a much higher degree,

Adaptability: Because our systems are built on a feedback loop, the system iterates on that feedback and adjusts for improved patient outcomes.

Which Companies are Leading the Way?

One company that we feel that is really changing the game is Noteworth, a connected health platform that enables health organizations to prescribe virtual care models to their patients. They help clinicians collect and access contextualized patient-generated health data that improves care coordination and outcomes, reduces costs, and better engages patients.

Noteworth Dashboard

Easily prescribe tailored virtual care models to your patients and assign accompanying care instructions to them.

Receive visualized, usable patient-generated health data in continuous Noteworth Reports you can monitor at any time.

Set customizable alerts, called Focus Notes.

Streamline your documentation and optimize towards reimbursement goals with the Encounters tracker.

6. Update from 2017 – Tricorder XPrize

As you may have read from last years 2017 ReferralMD Healthcare Article , Final Frontier Medical Devices was awarded $2.5M from Qualcomm to continue improving their device and bring it to market.

More about the company:

Final Frontier Medical Devices, a Pennsylvania-based team led by brothers Dr. Basil Harris, an emergency medicine physician, and George Harris, a network engineer, took home the 1st place for their artificial intelligence-based engine, DxtER, that learns to diagnose medical conditions by integrating learnings from clinical emergency medicine with data analysis from actual patients. DxtER includes a group of non-invasive sensors that are designed to collect data about vital signs, body chemistry and biological functions. This information is then synthesized in the device’s diagnostic engine to make a quick and accurate assessment.

7. Breast Cancer Drug – Abemaciclib

One in eight women will be diagnosed with breast cancer in her lifetime. First-line cancer DNA-creating proteins often get dismantled by chemotherapy, but BRCA genes have a backup plan that repairs the DNA and is carried out by poly-ADP-ribose polymerases (PARPs).

Eli Lilly’s breast cancer drug Abemaciclib is all set to hit the market very soon. It belongs to CDK4/6 inhibitors which have been shown to have the most positive effect on metastatic breast cancer, specifically in HER2+ breast cancers. Abemaciclib is armed with certain advantages over its rivals — Pfizer’s Ibrance and Novartis’ Kisqali — as it can be dosed continuously. The clinical studies results have put Abemaciclib roughly on par with its competitors in the first-line setting.

Updated results from MONARCH3 studies have bolstered the potential for this drug to be in the best-in-class category of cancer drugs. In July 2017, the U.S. Food and Drug Administration (FDA) granted Abemaciclib a Priority Review tag, both as a potential monotherapy and combination therapy. Abemaciclib is estimated to enter the market in 2018 and capture a significant market share in this space. Sales are estimated to be USD 1,792 million in 2022.

8. Patient Engagement

The global patient engagement solutions market is expected to grow at a compound annual growth rate of 16.2% over the next five years, reaching $18.7 billion in 2022, according to MarketsandMarkets.

Driving the growth are an aging population, the increasing burden of chronic diseases and a push to get patients to assume more responsibility for managing their care.

Yet while patient engagement tools can enhance communication and help to improve outcomes while reducing costs, barriers such as patient data security and lack of interoperability persist and could prevent the market from reaching its full potential, the report says.

Dive Insight:

Patient engagement is a hot topic these days. During HIMSS17, a number of surveys made the rounds showing patients are using technology to engage with their health, though providers could do more to support the effort.

In the first half of 2017, digital health funding hit a record-breaking $3.5 billion on 188 deals, according to Rock Health. Patient engagement was one of the top categories, along with consumer health information, EHR/clinical workflow and analytics and big data.

As organizations continue the move to value-based care, some hospitals and health systems are adding chief experience officers to the C-suite. In 2016, 44% of healthcare organizations reported having a CXO and 39% of those reported directly to the president or CEO, according to a Vocera Communications survey.

9. Centralized Monitoring of Hospital Patients

Alarm fatigue is a top technology hazard in hospitals nationwide. The sounds that come from monitoring systems in hospitals can desensitize staff in critical situations after long periods of exposure. Nearly 44% of in-patient cardiac arrest cases are not attended to appropriately and 90% of all alarms in hospitals aren’t actionable.

Centralized monitoring provides an off-site monitoring of patients by technicians to give patients and clinicians a second set of eyes while providing better care from a distance. Technicians communicate directly with the caregivers on-site.

Using sensors and high-definition cameras, clinicians can monitor blood pressure, heart, respiratory rates, pulse oximetry and more easily. An alert is generated that alerts caregivers on-site that help is needed. A recent study that evaluated the system reported a 93% survival rate of cardiopulmonary arrests using the systems.

10. LDL Cholesterol Drugs

There is a new class of LDL cholesterol lowering drugs that are expected to be disruptors in the next year. The new drugs are expected to lower cholesterol to unprecedented levels.

When taken with a Statin cholesterol lowering drug, the new class of drugs is expected to lower cholesterol levels by 75%.

The small interfering RNA therapy to lower LDL was also a new innovation in 2017. They are given twice a year instead of monthly or weekly like other treatments.

Dr. Leslie Cho of the Heart & Vascular Institute at the Cleveland Clinic suggests that we will continue to see a new class of agents to lower LDL levels in 2018.

Statin drugs could one day be an over-the-counter drug, said Cho.

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11. Gene Therapy for Inherited Retinal Diseases

Gene therapy for inherited retinal diseases is expected to receive a number of FDA approvals in 2018, if not late 2017. Currently, there are no known treatments for the rare diseases, but the growing research of specific genetic etiology may soon restore vision loss in patients.

Recombinant AAV2 vector encoding a functional copy of the RPE65 gene is expected to receive FDA approval in the next year to treat retinal diseases that are caused by biallelic RPE65 mutations.

According to Dr. Aleksandra Rachitskaya of the Cleveland Clinic’s Cole Eye Institute, the gene therapy won’t cure blindness completely, but will instead preserve the vision that is already there. However, there are currently retinal implants out there that help cure blindness and researchers are using stem cell therapies to combat retinal diseases. She also said that a new methodology called optogenetics, which involved modifying cells to function as other cells, could bring new hope to treating the diseases.

12. Hybrid Closed-Loop Insulin Delivery System

The most anticipated disruptor of 2018 will be the hybrid closed-loop insulin delivery system, better known as an artificial pancreas. It is the next step in creating a fully-automated delivery system.

In 2016, the FDA approved the first hybrid closed-loop insulin delivery system. The system is designed to help manage Type 1 diabetes. It is a fully automated insulin delivery system that connects a continuous glucose monitor with an insulin pump, eliminating the need for people with diabetes having to test and manage their insulin levels themselves. Studies have shown that the system steadies blood glucose levels and has even dropped A1C levels by a half percent.

Jim Young, chair of the Endocrinology & Metabolism Institute at the Cleveland Clinic, said it’s not quite an “artificial pancreas” because it doesn’t perform all of the same functions of a pancreas, but it does handle the insulin function well.

Young also suggests that it has taken so long to get to market because of a “fear of failure” – too much or too little insulin could be a problem.

An example is Medronic, which has stepped ahead of the pack last September when it won FDA approval for its MiniMed 670G artificial pancreas hybrid closed loop system, making it the 1st system of its kind to win clearance globally. While the system isn’t a stand-alone artificial pancreas, as it requires entry of carbohydrates and a baseline blood sample, it is a significant step toward the development of a fully capable closed-loop solution.

13. Non-Invasive Diabetes Monitoring

Apple is reportedly working on a “super secret” medical project: building sensors to monitor blood sugar levels without piercing the skin and has hired a small team of biomedical engineers to work at a nondescript office in Palo Alto, California, miles from corporate headquarters.

They are part of a super secret initiative, initially envisioned by the late Apple co-founder Steve Jobs, to develop sensors that can noninvasively and continuously monitor blood sugar levels to better treat diabetes, according to three people familiar with the matter.

Such a breakthrough would be a “holy grail” for life sciences. Many life sciences companies have tried and failed, as it’s highly challenging to track glucose levels accurately without piercing the skin.

More than 29 million people in the US suffer from diabetes, and many struggle to keep the condition in balance. “On average a lot of diabetes patients aren’t achieving what they want, and that’s all about their glucose control,” Jake Leach, senior VP of research and development at glucose monitoring system maker Dexcom, told us.

“So if we can provide them with better information to make better decisions on managing their diabetes, I think we can get some of these better outcomes that are going to ultimately reduce the cost of managing diabetes.”

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