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ryfqtzcessta · 1 year

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an-angel-called-cyn · 8 days

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punk system with angel wings gang

sent you my application

jesus christ hello. can i dm u . desperately thinking of something cool to say. uhhhhh,

did u know that pseudomonas aeruginosa strain 14, while being a deadly pathogen that loves to make humans sick, produces a gorgeous blue green pigment called pyocyanin and if you grow it on a media plate the resulting colonies are cyan.

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brook-and-bower · 2 years

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I feel like rambling into the void of the internet about how cool bacteria are, so here we go!

The other day I saw a plate with some blue Pseudomonas aeruginosa on it. I was curious about why it was blue, and looked it up. The pigmentation is due to a molecule called pyocyanin, which the bacteria also use as a weapon against other bacteria (to protect their resources and outcompete neighboring bacteria) and sometimes human lung cells (pneumonia bad).

This got my attention, because Serratia marcescens produces a red pigment called prodigiosin which also has antibiotic effects. I started to wonder how common it was that bacteria would produce a cool pigment that also works as an antibiotic. So I looked it up, and found a chart of bacterial pigments and what colors they are in an article about them.

As it turns out, according to that article, a lot of these pigments also work as antibiotics or have other effects.

It's relatively common that bacteria produce antibiotics that they have some mechanism to resist so that they can outcompete neighboring bacteria, but I think it's very cool how many of those molecules happen to be colorful. I can't really think of any way it would improve their evolutionary fitness, given their competition/peers don't have eyes and organisms large enough to have eyes can't see it unless they're concentrated way more than they are in nature. It could very well be that they just...happen to be those colors.

That is extremely cool to me, and now I am going to go stare at agar art, which, if you haven't heard of it, is definitely worth looking up (essentially it's taking advantage of those pigments and other features of bacteria to paint with them).

#microbiology #bacteria #microbes are cool #they fascinate me and the more i think about them the cooler they are

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carltonwebb · 2 years

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Embolic serratia aortic control device endocarditis.

The mixture associated with berberine and also d-limonene applied synergistic anticancer consequences in MGC803 tissue by simply cell-cycle arrest, ROS creation, and also apoptosis induction from the mitochondria-mediated inbuilt pathway.Protein-bound polysaccharide Nited kingdom (PSK) is often a scientific immunotherapeutic realtor that displays a variety of biological routines, which includes anti-tumor along with anti-microbial results. With the current economic review, many of us directory your anti-prion task of PSK. That inhibited the formation of protease-resistant irregular prion necessary protein in prion-infected cellular material with no evident adjustments to both the standard prion health proteins turnover or the autophagic perform in the tissue. Their anti-prion task has been predominantly made up of the high molecular weight element(azines) from the proteins part of PSK. A single subcutaneous measure regarding PSK somewhat but drastically continuous the particular tactical use of peritoneally prion-infected mice, but PSK-treated mice produced eliminating antibodies from the anti-prion task associated with PSK. These bits of information declare that PSK is often a brand new anti-prion compound which may be attractive elucidating the particular mechanism of prion reproduction, although structure of the anti-prion component(azines) of PSK calls for additional assessment. (D) The new year Elsevier Corporation. All rights reserved.Many of us explain right here the 1st depiction involving CLEC9A, a bunch Sixth is v C-type lectin-like receptor located in the SH-4-54 solubility dmso "Dectin-1 cluster" regarding related receptors, that are secured inside normal fantastic (NK)-gene sophisticated. Term associated with individual CLEC9A is highly confined within peripheral body, getting recognized only about BDCA3(+) dendritic tissue and so on a little subset involving CD14(+) CD16(-) monocytes. CLEC9A will be indicated in the mobile or portable area like a glycosylated dimer and will mediate endocytosis, but not phagocytosis. CLEC9A contains a cytoplasmic immunoreceptor tyrosine-based activation-like design that may sponsor Syk kinase, and we demonstrate, utilizing receptor chimeras, that receptor could induce proinflammatory cytokine manufacturing. These kinds of files show that will CLEC9A characteristics just as one account activation receptor.Pseudomonas aeruginosa can be an opportunistic pathogen that is the significant source of morbidity and mortality inside individuals along with cystic fibrosis (CF). Some CF patients are considered to acquire G. aeruginosa from your surroundings, person-to-person transmissible ranges happen to be discovered inside CF hospitals throughout the world, and the molecular cause for transmissibility remains poorly realized. Many of us undertook the supporting proteomics way of define proteins single profiles from the transmissible, intense isolate with the Australian epidemic pressure One (AES-1R), the virulent bums/wound identify PA14, along with the badly virulent, laboratory-associated strain PAO1 any time expanded in an unnatural method in which imitates the CF bronchi surroundings in comparison to development in normal research laboratory medium. Healthy proteins raised commonplace throughout AES-1R included those linked to methionine and also S-adenosylmethionine biosynthesis plus the actual synthesis regarding phenazines. Proteomic info have been checked through computing way of life supernatant amounts of the virulence factor pyocyanin, which is the last product from the phenazine walkway. AES-1R and also PAO1 launched higher extracellular levels of pyocyanin in comparison with PA14 any time expanded inside issues that mirror the particular CF lungs.

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mcatmemoranda · 5 years

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I remember the pyocyanin for psuedomonas aeruginosa. It also produces a fruity odor if I recall correctly.

Pseudomonas aeruginosa is a gram-negative rod that produce a distinguishing pyocyanin (blue-green) and fluorescein pigment and commonly infects cystic fibrosis patients or patients who have been on a ventilator for an extended period of time.

#Pseudomonas aeruginosa #pyocyanin #microbiology #pseudomonas

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that-one-support · 5 years

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Hello! 14, 28, 92? 😊

14: If you are outside, what are you most likely doing?

Walking to/from Uni, Walking to/from the Shops

28:What’s your biggest “what if”?

What if I chose the other university course :D I like the one I did but Im always uncertain if it was the right choice.

92: You can re-live any point of time in your life. The time-span can only be a half-hour, though. What half-hour of your past would you like to experience again?

Honestly just any conversation with my Dad tbh

#is that last one too morbid? idk its quite depressing atleast #pyocyanin

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jausters · 4 years

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@pyocyanin tagged me in a music thing so here are my picks. Full circle, @pyocyanin I think we started talking over music!

rules: spell out your url with song titles, then tag as many people as there are letters in your url! J - Joanna - JoJo A - The Apple - VV Brown U - Unemployed - Tierra Whack S - Snakeskin - Rina Sawayama T - Two Brothers - Hanni El Khatib E - Everybody Wants You - Red Hearse R - Red Light - Tei Shi S - Story of My Life - Erika de Casier Tag: @light-waves @cornedbeefhashtags @throwdownyourheart @mdfermaint @officialetulan @nixisting @bangooza @alzensunao

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enclure · 4 years

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I got tagged by @pyocyanin so here it Is I guess lmao

my lock screen + last song listened to + last saved photo

I feel like this says a lot about me

Anyways I tag @goncstate93 @reljes and @letshavechildren

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bpod-bpod · 4 years

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Iron-clad Resistance

Drug resistant ‘superbugs’ are a fast-growing threat to global health due to the misuse and overuse of antibiotics, and urgent action is needed to tackle the problem. Discovering new antibiotics is one solution, but bacteria will still develop resistance in a relatively short time. As an alternative strategy, researchers are trying to understand how bacteria become resistant to antibiotics in the first place. These test tubes contain cultures of Pseudomonas aeruginosa – notorious superbugs that infect open wounds and can cause severe lung infections in people with cystic fibrosis – grown in increasing concentrations of the antibiotic kanamycin (left to right). Intriguingly, the bacteria produce increasing amounts of a green iron-rich pigment called pyocyanin as antibiotic levels rise, which seems to help them become resistant to the drug. Developing drugs that interfere with pyocyanin production could therefore be a good way to prevent Pseudomonas from developing resistance to many commonly used antibiotics.

Written by Kat Arney

Image from work by Kui Zhu and colleagues

Department of Biomedical Engineering, Duke University, Durham, NC, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in PLOS Biology, December 2019

You can also follow BPoD on Instagram, Twitter and Facebook

#science #biomedicine #antibiotic resistance #antibiotic-resistance #kanamycin #pseudomonas aeruginosa #drug resistance #cystic fibrosis #superbugs #iron

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temozolomide3-blog · 4 years

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MICAL2 shuttled between the cytoplasm and the nucleus: A Pyocyanin

MICAL2 shuttled between the cytoplasm and the nucleus: A Pyocyanin. MICAL2 accumulated in the nucleus in PC-9 after treatment with LMB. The bottom panelshowsnuclearandcytoplasmicpositiveratesofendogenousMICAL2:thenuclearpositiveratedramaticallyincreasedafterLMBtreatment.B.Bothnuclearand cytoplasmiclocalizationofexogenousMICAL2inA549-MICAL2cellswithoutLMBtreatment,comparedtoastrongnuclearlocalizationwhentreatedwithLMB.The bottom panel shows that the MICAL2 cytoplasmic positive rate was signiﬁcantly decreased after LMB treatment. C. MICAL2 locations in HeLa cells transfected with −ΔC WT and three truncated mutants of MICAL2. The right panel reveals a signiﬁcant decrease in MICAL2 cytoplasmic positive rate in both MICAL2 and −ΔCΔN −ΔN MICAL2 transfected cells but not MICAL2 transfected cells compared with MICAL2-WT transfected cells 3xFLAG storage.

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sciencespies · 3 years

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These Worms Have No Eyes, but They Avoid the Color Blue

https://sciencespies.com/news/these-worms-have-no-eyes-but-they-avoid-the-color-blue/

These Worms Have No Eyes, but They Avoid the Color Blue

Tiny roundworms called Caenorhabditis elegans don’t have eyes, but that won’t stop them from picking a least-favorite color. New research shows that C. elegans can sense and avoid the color blue even though they lack even the most basic light-sensing systems, Veronique Greenwood reports for the New York Times.

When the worms forage for microbes in compost piles, they need to avoid landmines like the deadly, bright blue toxin produced by Pseudomonas aeruginosa bacteria. Biologist Dipon Ghosh, then working at Yale, wanted to figure out whether the worms used the toxin’s color as a clue to avoid it. A series of experiments tested the worms’ ability to avoid P. aeruginosa that made beige toxins or worked under different-colored lights. The results were in the journal Science on Thursday.

“We wanted to understand which component of the blue pigment toxin pyocyanin – its color or its toxicity – was informing the worms’ avoidance,” says Ghosh, now at MIT, to Inverse’s Tara Yarlagadda. “We could reproduce the effects of pyocyanin on bacterial avoidance with both a harmless blue dye and a clear, colorless toxin, but not either separately.”

The researchers compared the C. elegans’ reactions to toxic blue bacteria, toxic beige bacteria and safe blue bacteria, and found that the combination of blue color and toxicity has the greatest impact on the worms’ decision to wiggle away. In another experiment, the scientists put the C. elegans in a dish with toxic blue bacteria and then turned out the lights. Without lights, the worms didn’t escape the bacteria as quickly as they did with the lights on.

“When he showed me the results of the first experiments, I was shocked,” says Yale neuroscientist Michael Nitabach, a co-author of the study, to the New York Times.

In additional tests of the nematodes’ surprising color-sensing abilities, Ghosh created an apparatus that shone blue and amber-colored light on either side of a lab dish holding nematodes and the colorless version of the toxic bacteria. Under amber light, the nematodes struggled to suss out the dangerous microbes; under blue light, they steered clear.

“We were able to definitively show that worms aren’t sensing the world in grayscale and simply evaluating the levels of brightness and darkness,” says Ghosh in a statement. “They’re actually comparing ratios of wavelengths and using that information to make decisions — which was thoroughly unexpected.”

When the researchers expanded their pool of worms to include wild, varying versions, they realized that the standard lab strain of C. elegans actually isn’t very good at sensing blue. DNA sequencing showed that blue-sensitive C. elegans have a couple of genetic mutations that blue-insensitive worms lack. Future work could figure out what exactly those mutations do to help the worms respond to blue light.

The findings build on previous research that C. elegans avoid ultraviolet light, and other results that show they can sense smell, taste, touch and temperature.

The new results are “surprising and fascinating,” says Brown University neuroscientist Anne Hart, who was not involved in the study, to Shawna Williams at the Scientist magazine, but adds that they make sense because pigments play such a role in microbes’ toxicity and ability to infect hosts.

“There’s every reason for other organisms like C. elegans who have to deal with them to cue in on color and pigment as something to be avoided in some scenarios,” says Hart to the Scientist. “I think the biggest implication is probably: don’t underestimate the invertebrates.”

#News

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orbemnews · 3 years

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This Creature Is Blind, but Somehow It Knows the Color Blue In the warm, fetid environs of a compost heap, tiny roundworms feast on bacteria. But some of these microbes produce toxins, and the worms avoid them. In the lab, scientists curious about how the roundworms can tell what’s dinner and what’s dangerous often put them on top of mats of various bacteria to see if they wriggle away. One microbe species, Pseudomonas aeruginosa, reliably sends them scurrying. But how do the worms, common lab animals of the species Caenorhabditis elegans, know to do this? Dipon Ghosh, then a graduate student in cellular and molecular physiology at Yale University, wondered if it was because they could sense the toxins produced by the bacteria. Or might it have something to do with the fact that mats of P. aeruginosa are a brilliant shade of blue? Given that roundworms do not have eyes, cells that obviously detect light or even any of the known genes for light-sensitive proteins, this seemed a bit far-fetched. It wasn’t difficult to set up an experiment to test the hypothesis, though: Dr. Ghosh, who is now a postdoctoral researcher at the Massachusetts Institute of Technology, put some worms on patches of P. aeruginosa. Then he turned the lights off. To the surprise of his adviser, Michael Nitabach, the worms’ flight from the bacteria was significantly slower in the dark, as though not being able to see kept the roundworms from realizing they were in danger. “When he showed me the results of the first experiments, I was shocked,” said Dr. Nitabach, who studies the molecular basis of neural circuits that guide behavior at Yale School of Medicine. In a series of follow-up experiments detailed in a paper published Thursday in Science, Dr. Ghosh, Dr. Nitabach and their colleagues establish that some roundworms respond clearly to that distinctive pigment, perceiving it — and fleeing from it — without the benefit of any known visual system. How they accomplish this perceptual feat remains a mystery, but the findings hint that the worms may have hacked other cellular warning systems to gain a kind of color vision. Nematodes like C. elegans do have an aversion to ultraviolet light and certain wavelengths of visible light, past work has shown, and too much light can affect worms’ life spans. Researchers generally thought of this behavior as a way to avoid stressful exposure to sunlight. But using color to steer their foraging behavior — that was a new idea. To see if changing the bacteria’s color would have an effect, Dr. Ghosh next put worms on a mutated strain of P. aeruginosa that was beige rather than blue. This time, the worms didn’t move away any faster whether it was light or dark in the lab. That suggested that they were lacking extra cues from the bacteria’s color. He also put the blue pigment — a toxin called pyocyanin — on E. coli, a common food source for the worms. But rather than feasting on the bacteria, he found that they fled rapidly from the microbes when they were well lighted. Other experiments established that while the worms might sense something unpleasant about the toxin without the presence of the color, they really got moving when blue was visible. The researchers tested dozens of roundworm strains and found that while some did not respond to blue, others were extremely sensitive to it, leaving a mat of harmless E. coli if the right colored light was shining. Trying to understand how the eyeless creatures were sensing this, the researchers compared the genomes of worms that responded strongly to color with those that ignored it. They were able to pinpoint several regions of the genomes that correlated with the behavior. Then they engineered worms with mutations in genes in those regions to see if the creatures’ color detection abilities were affected. Indeed, they uncovered two genes, jkk-1 and lec-3, that seemed to affect the worms’ behavior if mutated. It is still unknown how these two genes, which code for proteins with no obvious connection to vision, connect to the worms’ enigmatic talent. They may be part of a long bucket brigade of proteins, passing on the message from one to the next that something blue is in the area, until it reaches the worm’s neurons and gets the creature moving. The proteins have been flagged in the past, however, in cellular responses to stressors such as ultraviolet light in human and mouse cells, Dr. Ghosh says. If researchers can uncover just how the roundworms are detecting color, they will have new insight into a surprising behavior and a handle on how organisms without a traditional visual system may still be able to perceive visible light. It may also be that an evolutionarily ancient way of avoiding stressors has been tuned to the color blue. Source link Orbem News #blind #Blue #Color #creature

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sangklp · 4 years

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DNA Origami Based Assembly of Au@Ag Nanostar Dimer Nanoantennas for Label-Free Sensing of Pyocyanin. https://t.co/FxadmbrHmG https://www.youtube.com/c/lifesang

#November 20 #2020 at 03:51PM

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pausadamente · 6 years

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I was tagged by @pyocyanin!

My name / Meaning:

Adri.. Wikipedia is telling me it most likely comes “from the Venetic and Illyrian word adur, meaning ‘sea’ or ‘water’ I had no idea! I love that

Western Zodiac: Taurus

Chinese Zodiac: Rabbit

Celtic Zodiac: I’m getting lots of different results for this.. Willow / Bull / Adder / Hare / Sea Serpent ?

Myers-Briggs: INFP-T (The Mediator)

The Four Temperaments: Melancholic

Enneagram: 9w1 (the Peacemaker)

Soul Type: Scholar I think

I’d like to tag @pararayn ily dude

#tag #adri.txt

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mcatmemoranda · 6 years

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biomedscis · 4 years

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Biological Activity And Applications Of Pyocyanin Produced By Pseudomonas Aeruginosa: OAJBS Publishers

Biological Activity And Applications Of Pyocyanin Produced By Pseudomonas Aeruginosa by Diaa A Marrez* in Open Access Journal of Biomedical Science (OAJBS)

There is growing interest in microbial pigments due to their natural character, safe to use, medicinal properties and rich in nutrients like vitamins. Production of these pigments is independent of season and geographical condition. Moreover, microbial pigments can be produced from waste material reducing water and environmental pollutions. Pseudomonas aeruginosa produce a wide variety of pigments as secondary metabolites, which play an important role in interactions between Pseudomonas species and other organisms.

To Know More About Open Access Journal of Biomedical Science Please Visit: Biomedscis Are Click On: https://Biomedscis.Com/

#biomedscis #biomedscis.com #https://biomedscis.com #oajbs #open access journal of biomedical science #biomedical science

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