#Angelika Wachowska

[kirstydreaming]

Angelika Wachowska; 📷

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[worldofbeauties]

Angelika Wachowska

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[ultibeauty]

Angelika Wachowska

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[mikhailop-blog]

Angelika Wachowska, Natali Czar

[eiseneisen]

Angelika Wachowska

[kirstydreaming]

Angelika Wachowska & Magdalena Perlinska; 📷

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[llucas-andrade]

Ralph Wietek

Model: Angelika Wachowska

[ubu507]

Angelika Wachowska

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[emzeciorrr]

Orange Foundation - Stranger from Konrad Kidawa on Vimeo.

Wyróżniony spot ramach Papaya Young Directors 2018 dla Fundacji Orange.

Reżyser – Konrad Kidawa Reżyser castingu – Magdalena Ziółkowska Producent – Konrad Kidawa Kierownik produkcji – Natalia Łodygowska, Angelika Biegarczyk Autor zdjęć – Maciej Kwaśniewski Scenograf – Magda Kostyra II Scenograf – Dominik Dardziński Kostiumy – Lena Firak, Gosia Walendzik Charakteryzator – Paulina Nowakowska Operator kamery – Maciej Kwaśniewski Asystent kamery – Andrzej Sepioł Operator stedycam – Mateusz Wasążnik Mistrz oświetlenia – Paweł Chiczewski Oświetlecze – Artur Nowak, Patryk Tync Kierownik planu – Jakub Wypler Dyżurni – Tomasz Konieczny, Jan Kwaśniewski, Maciej Latawiec Postprodukcja – Coloroffon Montażysta – Irek Grzyb Kolorysta – Kasia Żebrowska On line – Coloroffon Supervisor vfx – Filip Czernow Realizator dźwięku – Irena Jakuszewska Opieka postprodukcyjna – Łukasz Matkowski Muzyka / Kompozytor – Ewa Sadowska

Wystąpili – Oskar Olszewski, Weronika Wachowska, Srehal Patel

Podziękowania – Agnieszka Pasternak, Katarzyna Kiliś, Piotr Wachowski, Michał Stępień, restauracja Skubana Gęś, Maciek Marszalek All For Movies, Paweł Kwaśniewski, ATM Grupa, Marcin Mikołajczyk, Film Factory, GripKolektyw

[cancersfakianakis1]

Inhibition of lymphangiogenesis impairs antitumour effects of photodynamic therapy and checkpoint inhibitors in mice

Publication date: September 2017 Source:European Journal of Cancer, Volume 83 Author(s): Angelika Muchowicz, Malgorzata Wachowska, Joanna Stachura, Katarzyna Tonecka, Magdalena Gabrysiak, Dominika Wołosz, Zofia Pilch, Witold W. Kilarski, Louis Boon, Tomasz J. Klaus, Jakub Golab Photodynamic therapy (PDT) has been shown to destroy tumour-associated lymphatic vessels. Therefore, we sought to investigate the functional outcomes of PDT-mediated damage to the lymphatic vessels. We observed that PDT with verteporfin, completely but transiently, blocks the functional lymphatic drainage in the orthotopic mammary tumour models. Sustained inhibition of lymphatic vessels regeneration induced by lenalidomide or the soluble form of vascular endothelial growth factor receptor 3 (sVEGFR3) that neutralises lymphangiogenic vascular endothelial growth factor C (VEGF-C), significantly impaired antitumour efficacy of PDT. Antilymphangiogenic compounds also significantly inhibited the ability of intratumourally inoculated dendritic cells (DCs) to translocate to local lymph nodes and diminished the number of tumour-infiltrating interferon-γ-secreting or tumour antigen-specific CD8+ T cells. Lenalidomide also abrogated antitumour effects of the combination immunotherapy with PDT and anti-programmed death-ligand 1 (PD-L1) antibodies. Altogether, these findings indicate that PDT-mediated damage to the lymphatic vessels negatively affects development of antitumour immunity, and that drugs that impair lymphatic vessel regeneration might not be suitable for the use in combination with PDT. http://ift.tt/2sP1FeT

#Oncology-Sfakianakis