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Depending on the type of cancer being treated, patients may need to undergo up to 10 PRRT sessions. Usually, there would be around four-six sessions and these sessions are spaced two-three months apart. In most cases, this procedure is done as an outpatient procedure  
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Prostate cancer is known to be one of the most commonly occurring condition. It’s formation is attributed towards certain aspects. The 3 of them ae mainly associated with it are Age, Ethnicity and Dietary habits. For more info Read our Blog
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In the 1990s PRRT was administered using the radiopeptide 111In-DTPA-octreotide (Octreoscan®), the responses were reasonable but the effects were not long-lived and there were long term adverse sequelae.Next PRRT agent to be developed was the more effective beta-emitting radionuclide Y90, sustained symptomatic and objective responses with 90Y-PRRT were frequently observed, but it also led to significant renal damage.
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For prostate cancer patients who have become refractory to conventional therapy, the department of Nuclear Medicine & Molecular Imaging at the Fortis Memorial Research Institute (FMRI) in India’s Gurugram is not only one of the World’s most advanced Nuclear Medicine Centre but is also the centre that offers the lowest cost for Lu177 PSMA Therapy.
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A peptide i.e. a group of amino acids is created that can bind to the receptors on the tumor cell’s surface.This peptide is then paired with a radioactive atom using a chelator (a bonding agent).This combination of the peptide and the radioactive material creates a radiopeptide.This radiopeptide is injected into a Neurodendocrine Tumor (NET) patient’s bloodstream.
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Many prostate cancers, in particular those that have spread or become resistant to hormonal therapies, express a unique receptor on their cell surface called Prostate Specific Membrane Antigen (PSMA). When Prostate Cancer metastasizes i.e. spreads to other parts of the body, the PSMA receptor is expressed over the sites of metastases as well
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Alpha PRRT is based on the use of specific peptides and monoclonal antibodies, labelled with alpha-emitting radionuclides like Actinium (Ac225) or Bismuth (Bi213) or Lead (Pb212).Once attached, these alpha-emitting radiomolecules destroy the cells by delivering radiation which kills the cells.
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TARE as a much wider range of applications, including use in patients with more advanced liver disease, multi-focal disease, vascular invasion and portal vein thrombosis. Actually, TARE is more suitable for patients of HCC with portal vein thrombosis because of the small size of TARE particles when compared with TACE, which tends to induce more ischemia and necrosis.
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PRRT and other such molecular therapies offer a more personalised cancer treatment as the radiopharmaceuticals can be tailored to the unique biological characteristics of the patient and the molecular properties of the tumour.
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TARE improves disease control & quality of life, has a better tolerability profile, a higher response rate and longer progression-free survival
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