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#vaccinology
drpedi07 · 1 month
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Japanese Enchephalitis Vaccines
Japanese encephalitis (JE), previously known as Japanese B encephalitis, is caused by the mosquito-borne JE virus; a member of the genus flavivirus (of the Flaviviridae family).
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didanawisgi · 1 year
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sreenivassilicon · 1 year
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Top Three Trends in RNA Therapeutics
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Read more: https://lnkd.in/dAc-cZuh
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astxrwar · 19 days
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i will not correct all the virology/vaccinology misinformation in that post. I will not correct all the virology/vaccinology misinformation in that post. I will go outside and look at the sky and have peaceful thoughts and leave them to be wrong. i am capable of this
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mindshelter · 1 year
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miss writing and also not being tired :[
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medstudentblues · 1 year
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Studying Vaccinology for our Wednesday Pedia shifting exam. I’m proud to say I’m slowly adapting to face to face sessions.
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studentbyday · 3 months
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end-of-semester reset / rejuvenation
🌸 how i want to spend my break so it's productive, restful, and rejuvenating... 🌸
clear and clean all the surfaces and things i use that should be cleaned!! (e.g. desk, piano top, night table, water bottle [try to get into the habit of washing it every day 💧], washroom)
vacuum
get outside as much as possible. the soul needs fresh air 🌬️🥺
all the tasks i planned for the rest of the december study challenge (note to self: see journal index)
back up my files
digital clean-up (e.g. delete unnecessary files from desktop, unsubscribe from things i don't read)
fix the closet mess and organize it for winter ❄️
all. the. laundry.
change bedding
work on figuring out a proper wind down routine that works for me (ideally it should start after dinner and gradually decrease in stimulation level 😅)
fix! my! sleep schedule! (i have 2 weeks to move my wake time from 9am to 8am...or a few minutes before bc i hate the sound of zesty's alarm which nearly always wakes me up with a start 🚨😂 )
journal to answer these questions for 2024: where is my life going? where do i want it to go? what milestones should i be setting for myself? what should i prioritize? (i.e. setting/revising my goals)
set up bujo for next year and figure out how i'm gonna keep track of all the things i wanna do
read a short article on moral philosophy so i have a better idea of what i would be getting into if i take a course on it...
read a vaccinology article
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By Sally Beck March 19, 2024
There is a new threat to food safety in the form of injecting mRNA or modRNA (synthetic or ‘modified’ RNA) vaccines into livestock. Merck have developed the mRNA vaccine Sequivity, which has already been licensed for pigs in the USA, and Australia is currently fast-tracking these jabs to prevent several diseases contracted by cattle. Critics say they could make us more susceptible to the diseases they aim to prevent.
There is also the concern that mRNA vaccines could cause prion diseases. Prions attack nerve cells and cause neurodegenerative brain disorders, the most common of which is Creutzfeldt-Jakob disease (CJD), also known as mad cow disease. It killed nearly 200 people in the UK in the 1980s and 1990s, thanks to corrupted meat and bone meal cattle feed. New cases were still emerging in 2019.
The new vaccines are being developed to immunise cows against foot and mouth disease, lumpy skin disease, which is a viral infection transmitted by blood-feeding insects such as mosquitoes, and other pathogens that can be transferred from animals to people such as avian and swine flu.
Dr Byram Bridle, Associate Professor of Viral Immunology from the Veterinary College at the University of Guelph, Ontario, Canada, a respected agricultural and veterinary public research facility, wrote a damning ten-page analysis of potential harms addressed to Independent MP Andrew Bridgen and the UK Parliament. Dr Bridle has decades of experience in vaccinology and veterinary sciences, and he is just one scientist raising a number of concerns about mRNA vaccines for livestock. 
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swiftyangx12 · 10 months
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Don’t mess with Microbes
[Valorant]
[Gender Neutral!Agent!Reader]
[Synopsis]: What if the new agent is a specialist in Microbiology and also one of the few HQ’s doctors?
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Let’s say [Reader] has a unique career as a microbiologist.
I mean, yes, they have assisted and helped many doctors and scientists of identifying undetected bacteria from patients.
Though, they only joined the Protocol because they were falsely accused of exposing a public area with a human-made pathogen that’s third most lethal than the Bubonic Plague and COVID-19. (It wasn’t them. I swear they did not release a dangerous bio-weapon for malicious purposes.)
They worked as another healer and doctor for the team.
Mostly stayed in their own lab experimenting cultures and observing microorganisms.
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[HQ Laboratory]
Dr. [L/N]: Uh, Dr. Sabine? I think somebody from our team picked up a little nasty bug on their last mission.
Viper: *Looks through the microscope* Oh god.
Dr. [L/N]: It’s okay. I’m working on a vaccine for this one. Thank god I took a course on Vaccinology.
Viper: You studied Vaccinology?
Dr. [L/N]: As a minor in university, yes. Just hope nobody dies on my watch when experimenting.
Viper: *Impressed, yet concerned* Then do what you need to do. You’re responsible if somebody were to become deceased by your hands.
Dr. [L/N]: Understand, Dr. Sabine.
《🦠》
Dr. [L/N]: Jett, you look terrible. *Puts on their medical face mask*
Jett: *Sniffs* I’m fine! Just a little sniffle. ACHOO!
Dr. [L/N]: *Sprays Lysol in the air and area* Girl, go back to your room. I’ll inform Brimstone about your dilemma and in the meantime, no contact with the other agents.
Jett: *Sniffs* Okay…
[An hour later]
[Jett’s Quarters]
Dr. [L/N]: *In a biohazard suit* Jett, I made Kimchi stew.
Jett: *Coughs* You did?
Dr. [L/N]: I heard from Phoenix that you sometimes get homesick and after the Venice incident, it must have been difficult to go through when you were falsely accused for something you’re not responsible for to begin with. Believe me. I know the feeling by experience.
Jett: Oh, doc. *Sniffs*
Dr. [L/N]: Are you crying or is it the sniffles again?
Jett: *Cries out* SNIFFLES!
《🦠》
Dr. [L/N]: Annual vaccines! Line up!
KAY/O: You know I don’t need it.
Dr. [L/N]: I know. That’s why I purchased a sanitary station to disinfect your whole body.
KAY/O: Wow. You really thought of everything.
Dr. [L/N]: I have to keep everyone healthy and safe so we can kick Omega ass.
《🦠》
[Lotus]
Prions (Dr. [L/N]): *Creates a deadly pathogen to infect enemies within a second to drop paralyzed*
Omega!Skye: *Running away from Prions* Shit! Shit! Shit! I didn’t sign up for this shit!
Prions: *Shoots a patho-dart at the enemy*
Omega!Skye: *Drops down and becomes paralyzed*
Prions: Look whose become my next patient~ *Eliminates him with their Sheriff*
[Their team looks at the microbiologist with horror.]
Viper: I like them.
Brimstone: *Looks at her in disbelief*
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[Tagged]: @hhurric4ne @l0serloki @radianights @luckyowl @theluckyr
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applied-soup · 4 months
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hey besties i'm in the process of trying to write an essay and i can't figure out the right string of words to search for what i'm looking for, so i'm turning to you lot
can you think of any examples of people who society thought of and treated as experts, that we now with the benefit of hindsight would think are non-experts?
my current list is rasputin and andrew wakefield, and honestly idk whether to include wakefield because i think he does fit the bill, but would require a lot of caveats and descriptions and i'm on a word limit. like at the end of the day he definitely wasn't an expert on vaccinology or developmental disorders, but he probably should be considered an expert in like childhood gastrointestinal issues? so just calling him entirely a layperson isn't really accurate, but explaining the complexities takes Time and Words which i don't necessarily have
does anyone have any other suggestions to add to the list?
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judasvibe · 7 months
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it is however true a lot of people, all of them terminally scientifically illiterate, have made 'i fucking love science!' an ideological dogma while not understanding anything about what they're parroting
i have graduate education in immunology but i still know if i said on facebook it was predictable mRNA vaccines would be poorly immunogenic and provide low and transient protection.... i'd get called antiscience for it. even though it's not really a secret in the vaccinology scientific community that the most strongly immunogenic vaccines are live attenuated pathogen in design, and not protein subunit (which is essentially what the mRNA is a template for). it's uncontroversial, even. but saying it on mainstream social media is begging to be burned at the altar. the reasons you can't say this publicly aren't because science dont real and you just dont get magic. it's because there is a lot of money to be made in a comparatively cheap to produce vaccine that you can lobby for legislators to make mandatory for normal participation in society.
i understand some people have some psychological need to believe in things that can't be explained by science to spice up their life or something. given that such beliefs are largely unfalsifiable or tautological, the onus should be on them to admit that if it 'defies natural law' so badly, there's a strong chance it simply doesn't exist
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drpedi07 · 1 month
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Influenza Vaccine
Influenza is a contagious illness that causes various respiratory syndromes, including otitis media, croup, bronchiolitis, bronchitis, asthma, and pneumonia.
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didanawisgi · 1 year
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‘There is a theoretical expectation that some types of vaccines could prompt the evolution of more virulent (“hotter”) pathogens. This idea follows from the notion that natural selection removes pathogen strains that are so “hot” that they kill their hosts and, therefore, themselves. Vaccines that let the hosts survive but do not prevent the spread of the pathogen relax this selection, allowing the evolution of hotter pathogens to occur. This type of vaccine is often called a leaky vaccine.’
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deblala · 5 days
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Six Vaccinology-illiterate US Presidents Have Promoted Big Pharma’s Fast-tracked Experimental Vaccines - Global Research
https://www.globalresearch.ca/six-vaccinology-illiterate-us-presidents-promoted-big-pharma-fast-tracked-experimental-vaccines/5852842
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vikiblog77 · 7 days
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Pioneering Vaccine Development: The Critical Role of Medical Microbiologists from Dehradun's Esteemed B.Sc Programs
In the realm of public health and infectious disease control, vaccines stand as one of the most formidable weapons. The journey from conceptualization to the delivery of an effective vaccine is intricate, demanding the collaboration of various scientific disciplines. At the heart of this scientific odyssey are medical microbiologists, whose expertise and insights are indispensable. The B.Sc Medical Microbiology course in Dehradun, offered by some of the best colleges in the region, is shaping the next generation of microbiologists who are poised to contribute significantly to the field of vaccine development.
Deciphering Pathogens: The First Step in Vaccine Development
The initial phase of vaccine development hinges on an in-depth understanding of the pathogen. Students of the B.Sc Medical Microbiology course in Dehradun receive rigorous training in pathogen biology, learning to identify and analyze viruses, bacteria, and other microorganisms. This foundational knowledge is critical, as identifying the antigens that can best stimulate an immune response is a cornerstone of vaccine creation.
Harnessing Biotechnology in Vaccine Formulation
Advances in biotechnology have revolutionized vaccine development, allowing for the creation of safer, more effective vaccines. Dehradun's microbiology programs place a strong emphasis on biotechnological methods, equipping students with the skills to employ genetic engineering, recombinant DNA technology, and other cutting-edge techniques. This expertise is crucial for the design of subunit, mRNA, and vector-based vaccines, which represent the future of immunization strategies.
Overcoming Challenges in Vaccine Development
The path to developing a vaccine is fraught with challenges, from ensuring efficacy and safety to overcoming logistical hurdles in production and distribution. Medical microbiologists from Dehradun's B.Sc programs are trained to navigate these complexities, learning about the rigorous clinical trial phases, regulatory approvals, and ethical considerations involved. Their education prepares them to contribute solutions to these challenges, advancing the field of vaccine development.
Global Impact and the Fight Against Emerging Diseases
The recent global health crises have underscored the importance of rapid vaccine development in the face of emerging and re-emerging diseases. Graduates of the B.Sc Medical Microbiology course in Dehradun are equipped not only with the scientific knowledge but also with a global perspective on public health. They are prepared to join international efforts to combat new health threats, contributing to vaccine development projects that can save millions of lives worldwide.
The Future of Vaccinology
As we look to the future, the role of medical microbiologists in vaccine development will only grow in importance. With their deep understanding of pathogens, expertise in biotechnological methods, and readiness to tackle global health challenges, graduates of Dehradun's B.Sc Medical Microbiology programs are at the forefront of this vital field. The best colleges in Dehradun are not just educating students; they are preparing the vaccine developers of tomorrow, who will continue to push the boundaries of what is possible in public health and immunology.
In conclusion, the B.Sc Medical Microbiology course in Dehradun stands as a testament to the pivotal role of education in advancing healthcare and public safety. Through rigorous training and a commitment to excellence, these programs are nurturing the minds that will lead the next wave of innovations in vaccine development, safeguarding the health of populations around the globe.
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nuadox · 8 days
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Study maps main genes involved in immune response to infection by dengue virus
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- By Maria Fernanda Ziegler , Agência FAPESP -
By comparing data for the immune response to natural infection by dengue virus to data for activation of the immune system by dengue vaccines, researchers at the University of São Paulo (USP) have identified molecular markers that could be used in the development of novel vaccines and treatments for dengue.
They also reiterated the efficacy of two vaccines already available on the market: Q-Denga, manufactured by Takeda Pharma (Japan) and now being distributed by the national health service in Brazil (Sistema Único de Saúde, SUS); and Dengvaxia, produced by Sanofi-Pasteur (France). Both are live attenuated virus vaccines.
“We analyzed the data systemically and found various similarities between the immune response elicited by vaccines and the immune response to natural infection. Of course, vaccines induce an immune response without the damage done by the virus. We were also able to characterize several pathways [that involve signaling between defense cells]. The interferon pathway [mediated by this antiviral protein produced by leukocytes – white blood cells – and fibroblasts] proved to be crucial, with several important genes that can be considered novel biomarkers of the disease,” Otávio Cabral-Marques, a professor of molecular medicine at the University of São Paulo’s Medical School (FM-USP) and principal investigator for the study, told Agência FAPESP.
The study was supported by FAPESP via two projects (18/18886-9 and 20/01688-0) and reported in an article published in the journal Frontiers in Immunology. It is the first to identify immune signatures of dengue by systems vaccinology, an approach that explores the complex interactions underlying vaccine-induced immunity in humans.
The researchers analyzed 955 transcriptome samples from patients with natural dengue infection and participants in clinical trials of dengue vaccines (the transcriptome is the complete set of RNA molecules in the organism). They obtained the data from a public database.
They found 237 differentially expressed genes common to both the patient samples and trial participant samples. “Based on 20 of these shared genes, we were able to create a panel to distinguish disease severity, especially in the late acute stage. We also used machine learning techniques to classify ten predictors [immune signatures] of disease severity in cases of natural infection. These are crucial to the immune response to the virus,” said Desirée Rodrigues Plaça, first author of the article and a PhD candidate at USP with a scholarship from FAPESP.
Dengue is caused by four viral serotypes (DENV-1 through DENV-4) and, when symptomatic, progresses through three clinical stages: febrile (initial acute), critical (late acute) and recovery.
Interferon pathway
“There are many differences, but we also found many similarities between the immune responses induced by vaccines and natural infection. By funneling the dataset, we identified 20 genes that are common to both processes and similarly expressed. They are responsible for enriching the immune system’s protective pathways, especially the type I and type II interferon pathways,” Plaça said.
Interferons are cytokines whose main role is to inhibit viral replication. They trigger a chain reaction that affects several molecules. According to the article, the interferon antiviral pathways are not only responsible for early (front-line) defense, but their complex biological functions also set the stage for development of robust and lasting adaptive immunity.
“The interferon pathways are very important to activate the adaptive response, which consists of T cells and B cells [types of white blood cells called lymphocytes] and provides permanent protection [as do vaccines]. It’s extremely important therefore to know which genes associated with the interferon pathways are key drivers of the adaptive response that affords the best protection,” Placa said.
Genes
With the information they obtained in the study, the researchers were able to develop therapeutic strategies to inhibit, activate or induce expression of genes involved in the immune response, opening up possibilities for the investigation of targeted therapies for dengue fever.
They identified the main genes (such as OAS2, ISG15, AIM2, OAS1, SIGLEC1, IFI6, IFI44L, IFIH1 and IFI44) involved in orchestrating various aspects of the adaptive immune response. OAS2 and OAS1 have antiviral functions, while ISG15 restricts virus replication, for example. AIM2 activates the inflammasome, a multiprotein complex of the innate immune system that when activated produces molecules that tell the system to send reinforcements to the infection site, initiating pro-inflammatory responses crucial for effective antiviral defense.
SIGLEC1 participates in immune cell interactions, facilitating antigen presentation and adaptive immune recognition. IFI6, IFI44L and IFI44, all of which are interferon-inducible, are implicated in modulation of apoptosis (programmed cell death) and antiviral defense. IFIH1 is a crucial sensor in shaping adaptive responses to RNA viruses such as dengue. IFIT5 and HERC5 “are known for their roles in interferon-mediated inhibition of viral replication”, the authors note.
“The many relevant genes involved in this complex process underscore the intricacy of the link between the initial antiviral pathways and subsequent adaptive immune processes. It’s as if the beginning and end of a story were joined up,” Cabral-Marques said.
The article “Immunological signatures unveiled by integrative systems vaccinology characterization of dengue vaccination trials and natural infection” is at: www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1282754/full.
This text was originally published by FAPESP Agency according to Creative Commons license CC-BY-NC-ND. Read the original here.
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Header image: The study identified similarities between the immune response to natural infection and the immune response elicited by the vaccines Q-Denga and Dengvaxia. Credit: Fabio Rodrigues-Pozzebom/Agência Brasil.
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