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#thereby protecting cells and delaying the aging process. This agent works on many levels
yg1964-123 · 1 month
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Collagen Select is a food supplement aimed at women who want to maintain beautiful, firm and healthy skin.Collagen Select has the ability to neutralise free radicals, thereby protecting cells and delaying the aging process. This agent works on many levels, improving imperfections and promoting a healthy skin appearance.
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iconhub2023 · 1 year
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Collagen Select is a food supplement aimed at women.
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Collagen Select is a food supplement aimed at women who want to maintain beautiful, firm and healthy skin. The product has a 9-component formula and tropical taste, which will appeal to all women. VERISOL® collagen hydrolysate plays a key role in the Collagen Select food supplement as it contributes to increased skin elasticity and reduction of wrinkles. Try Collagen Select and
enjoy visibly younger skin!
Collagen Select is a complex that supports the production of collagen, improving the health of the skin, hair and nails. In addition, the product helps to keep mucous membranes in excellent condition. Collagen Select has the ability to neutralise free radicals, thereby protecting cells and delaying the aging process. This agent works on many levels, improving imperfections and promoting a healthy skin appearance.
Start earning in a category that offers huge sales potential. By promoting Collagen Select Discover the wonderful effect of Collagen Select
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healthandtech · 1 year
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nutriheathcare · 3 years
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Collagen SelectAnti-Aging
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Collagen SelectAnti-Aging
Visibly reduces wrinkles,
Increases skin elasticity,
Helps in maintaining a youthful appearance,
Firms the skin and improves its natural beauty.
https://nplink.net/85gzp5nd
Collagen Select is a food supplement aimed at women who want to maintain beautiful, firm and healthy skin. The product has a 9-component formula and tropical taste, which will appeal to all women. collagen hydrolysate plays a key role in the Collagen Select food supplement as it contributes to increased skin elasticity and reduction of wrinkles.
Collagen Select is a complex that supports the production of collagen, improving the health of the skin, hair and nails. In addition, the product helps to keep mucous membranes in excellent condition. Collagen Select has the ability to neutralise free radicals, thereby protecting cells and delaying the aging process. This agent works on many levels, improving imperfections and promoting a healthy skin appearance.
This formula is enriched with Moldavian dragonhead extract, vitamin A, vitamin C, riboflavin, niacin, biotin, as well as zinc and copper. All these components, together with hydrolysed collagen - Verisol®, form a unique compound which contributes to the proper production of collagen. Collagen Select improves the health of the skin, hair and nails, supports the maintenance of the proper condition of the mucous membrane, and protects the cells from the adverse effects of oxidative stress. This is undoubtedly a unique product which every person interested in maintaining a youthful appearance should try out.
https://nplink.net/85gzp5nd
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omaimbetty-blog · 3 years
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this product help you to restore the radiance of your face https://nplink.net/3k31t46f Collagen Select is a food supplement aimed at women who want to maintain beautiful, firm and healthy skin. The product has a 9-component formula and tropical taste, which will appeal to all women. VERISOL® collagen hydrolysate plays a key role in the Collagen Select food supplement as it contributes to increased skin elasticity and reduction of wrinkles .Collagen Select is a complex that supports the production of collagen, improving the health of the skin, hair and nails. In addition, the product helps to keep mucous membranes in excellent condition. Collagen Select has the ability to neutralise  free radicals, thereby protecting cells and delaying the aging process. This agent works on many levels, improving imperfections and promoting a healthy skin appearance.
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healthycarestore · 3 years
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Collagen Select
Collagen Select is a food supplement aimed at women who want to maintain beautiful, firm and healthy skin. The product has a 9-component formula and tropical taste, which will appeal to all women. VERISOL® collagen hydrolysate plays a key role in the Collagen Select food supplement as it contributes to increased skin elasticity and reduction of wrinkles.
Collagen Select is a complex that supports the production of collagen, improving the health of the skin, hair and nails. In addition, the product helps to keep mucous membranes in excellent condition. Collagen Select has the ability to neutralise free radicals, thereby protecting cells and delaying the aging process. This agent works on many levels, improving imperfections and promoting a healthy skin appearance... Read More
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tevisa · 3 years
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Collagen Select is a food supplement aimed at women who want to maintain beautiful, firm and healthy skin. The product has a 9-component formula and tropical taste, which will appeal to all women. VERISOL® collagen hydrolysate plays a key role in the Collagen Select food supplement as it contributes to increased skin elasticity and reduction of wrinkles.
Collagen Select is a complex that supports the production of collagen, improving the health of the skin, hair and nails. In addition, the product helps to keep mucous membranes in excellent condition. Collagen Select has the ability to neutralise free radicals, thereby protecting cells and delaying the aging process. This agent works on many levels, improving imperfections and promoting a healthy skin appearance.
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healthcare-31 · 3 years
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Collagen Select is a food supplement aimed at women who want to maintain beautiful, firm and healthy skin. The product has a 9-component formula and tropical taste, which will appeal to all women. VERISOL® collagen hydrolysate plays a key role in the Collagen Select food supplement as it contributes to increased skin elasticity and reduction of wrinkles.
Collagen Select is a complex that supports the production of collagen, improving the health of the skin, hair and nails. In addition, the product helps to keep mucous membranes in excellent condition. Collagen Select has the ability to neutralise free radicals, thereby protecting cells and delaying the aging process. This agent works on many levels, improving imperfections and promoting a healthy skin appearance.
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vdsoza · 3 years
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Collagen Select is a food supplement aimed at women who want to maintain beautiful, firm and healthy skin. The product has a 9-component formula and tropical taste, which will appeal to all women. VERISOL® collagen hydrolysate plays a key role in the Collagen Select food supplement as it contributes to increased skin elasticity and reduction of wrinkles.
Collagen Select is a complex that supports the production of collagen, improving the health of the skin, hair and nails. In addition, the product helps to keep mucous membranes in excellent condition. Collagen Select has the ability to neutralise free radicals, thereby protecting cells and delaying the aging process. This agent works on many levels, improving imperfections and promoting a healthy skin appearance.
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maxeones-blog · 3 years
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Collagen Select is a food supplement aimed at women who want to maintain beautiful, firm and healthy skin. The product has a 9-component formula and tropical taste, which will appeal to all women. VERISOL® collagen hydrolysate plays a key role in the Collagen Select food supplement as it contributes to increased skin elasticity and reduction of wrinkles.
Collagen Select is a complex that supports the production of collagen, improving the health of the skin, hair and nails. In addition, the product helps to keep mucous membranes in excellent condition. Collagen Select has the ability to neutralise free radicals, thereby protecting cells and delaying the aging process. This agent works on many levels, improving imperfections and promoting a healthy skin appearance.
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knockdiabetes · 5 years
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At What Blood Sugar Level Should One Start Medication?
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They say, what you eat is what you are! Your health is mostly dependent upon how you manage your diet along with the lifestyle you lead. However, given the busy lifestyle led by today’s generation, it could actually be hard to keep up with a good lifestyle. This is why diseases such as High Blood Pressure, Diabetes, Heart Attack, etc have been taking a toll over the youth with numbers rising every passing day. People develop diabetes occurs when the Blood Sugar Levels or the Blood Glucose Levels or the Blood Sugar Concentration increases more than normal.
What is Glucose?
Glucose is actually a simple form of sugar. Approximately, humans have around 4 grams of the glucose present in the blood for an average weight of 70 kilogram. With the help of metabolic homeostasis, our body regulates the blood sugar levels at regular intervals. Glucose is actually stored in the liver cells and skeletal muscles as glycogen. The fasting blood sugar level, i.e. blood sugar levels without eating for hours is actually maintained constantly at a certain number by the body by use of the glycogen stores present in the skeletal muscles or liver.
How Important Is Glucose for Humans?
Among humans, the amount of glucose present in the blood plays a major role. It is a primary energy source which is critical to normal functioning of the body and brain. Blood sugar levels or glucose levels generally show up lowest as you wake up early in the morning. It rises up slowly as you take your meal for the day by few millimoles. Now, any of the diabetes educators will tell you that blood sugar levels that go way beyond the normal usually point towards conditions such as diabetes. While some opt for allopathic medications for controlling these heightened blood sugar levels, some opt for Ayurvedic medicine for sugar level fluctuations.
Blood Sugar Chart
Type
Fasting Blood Glucose Level
2 Hours After Meals
HbA1c
Normal for Person without diabetes70-99mg/dl (3.9-5.5 mmol/L)Below 140 mg/dl (7.8 mmol/L)Below 5.7 percent
Official ADA Recommendation for Patient with Diabetes80-130 mg/dl (4.4-7.2 mmol/L)Below 180 mg/dl (10.0 mmol/L)Below 7.0 percent
Types of Diabetes
1-Diabetes Mellitus (Hyperglycemia):
Blood sugar levels with diabetes mellitus remain on the higher side which is way above the normal level stated above. In this condition, when unchecked, people with diabetes might experience the blood sugar levels rising above 300 mg/dl. This leads to fatal reactions and medical complications.
2-Diabetes Insipidus (Hypoglycemia):
Diabetes Insipidus also affects your blood sugar levels but, in a manner that is opposite to Diabetes Mellitus. Here, the blood glucose levels go way below the normal leading to seizures, dizziness, unsteadiness, etc.
When should you start taking medications?
Any level of glucose that is way above or below normal can affect the way your body operates leading to major deterioration. Make sure you get a blood test to ensure that you aren’t diabetic. Even if you are pre-diabetic, it is suggested that you should opt for medical advice and start taking medications to ensure that your blood sugar levels are under control.
Try to monitor information such as:
Medication can affect your blood glucose level, so make sure you monitor the dosage and type of medication you take.
What you eat, when you eat, or if you had been fasting.
The amount of physical exercise you opt in to ensure that your high blood sugar remains normal
Now, there are many holistic ways to control your blood sugar levels. Ayurvedic medicine for sugar can help you aid with blood sugar control. Let’s take a look at some of the best Ayurvedic medicine for sugar that can help anyone suffering from diabetes mellitus, diabetes insipidus, or even pre diabetes.
Gymnema Sylvestre (Gurmar):
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Known by the common title Gurmar, Gymnena Sylvestre, this herb is aptly described as “Sugar Crusher”. The efficiency of this Ayurvedic treatment for diabetes is best when it comes to reduction of blood sugar levels. This herb can affect your blood sugar level by assisting in the regeneration of residual beta cells in the pancreas. It also reduces one’s dependence on the insulin medications.
Coccinia Indica:
Coccinia Indica is a powerful ayurvedic medicine for sugar that serves as an anti-diabetic agent. This herb for regulation of plasma blood glucose helps in the breakdown of the starch content in the food and thereby prevents any sudden surge in the blood sugar levels. Additionally, in the long term, this Ayurvedic medicine for sugar helps protect vital organs in your body that might be affected due to an increase in the blood sugar levels. Coccinia Indica also protects the diabetic patients from oxidative stress.
Azadirachta Indica (Neem):
The bitter taste of this herb might leave you feeling disgusted but trust us; it is a boon for patients suffering from diabetes and high blood sugar levels. This Ayurvedic medicine for sugar control can either be used in empty stomach or along with food. The flowers, leaves, and soft barks of this plant is beneficial for people suffering from diabetes insipidus and diabetes mellitus.
Morus Indica (Mulberry):
The leaves of Morus Indica are among the most recommended herbs for Ayurvedic medicine for sugar control. Experimental studies on this popular choice among Ayurvedic medicines suggest that the daily intake of this herb especially when soaked in water overnight can aid with a 38 percent reduction of blood sugar levels. The leaves are known to correct the lipid abnormalities among the Type 2 Diabetics. Chewing mulberry leaves with a glass of water daily in the morning can also delay any onset of diabetic cataract.
Momordica Charantia (Bitter Gourd):
Also known as Bitter Gourd, this anti-diabetic food item is a major addition to your diet when it comes to treating diabetes. It is extensively used as an important Ayurvedic medicine for sugar control. It helps with increasing the secretion of insulin in the blood and improves the functionality of beta cells in the pancreas. It also helps correct any pitta dosha or kapha dosha which in turn helps in controlling blood sugar. It also helps in reversing the pancreatic damage with proper insulin secretion while aiding a better management of blood sugar levels.
Eugenia Jambolana:
The seeds and fruit of Eugenia Jambolana can significantly bring down the blood sugar levels with regulation of plasma blood glucose. Further, it could also bring down any potential risk from kidney dysfunction that occurs due to high blood sugar levels. With Eugenia Jambolana, the level of glucose tolerance increases and it also aids in the healing process of wounds among diabetic patients.
Aloe Vera:
Aloe Vera juice or Aloe Vera gel serves a greater good when it comes to management of blood sugar levels with this Ayurvedic medicine for sugar control. This particular Ayurvedic treatment for diabetes helps maintain the blood sugar levels with the help of a chemical present in the same called phytosterols that has been known for its antihyperglycemic properties.
Oregano:
This particular exotic herb is an Ayurvedic medicine for sugar that comes from Mediterranean and Spanish origin. Oregano houses chemicals called the glycosides that help lower excessive blood sugar levels. Additionally, it increases insulin level in the blood in a holistic way. Oregano can easily be consumed from day-to-day basis in dried form with soups, salads, or in the form of tea. Not just that, one can get oregano oil from your local seller and add few drops to a glass of luke warm water and consume every day after waking up in the morning before having your breakfast.
Fenugreek:
Fenugreek is another important mention when it comes to Ayurvedic medicine for sugar. It is known for its hypoglycaemic activities that increase one’s tolerance level to high blood sugar and thus bringing it down to normal. Also, it is high in fibre level and thereby aids in slowing down any absorption of sugar or carbohydrate.
Why Sugar Knocker?
As of now, Sugar Knocker flaunts 87.68 percent satisfaction rate with 14687+ customers satisfied till date. Sugar Knocker has some of the best herbal ingredients that aid your body in restoration of normal blood sugar levels. Sugar Knocker ensures safety and better health in terms of human consumption with no possible ill effects. It houses age-old herbs such as Momordica Charantia, Gymnema Sylvestre, Petrocarpus Marsupium, Salacia Retriculata, Curcuma Longa, Eugenia Jambolana, Emblica Officinalis, Tinospora Cordifolia, Ocimum Sanctum, Cinnamon, Banaba, Chromium, and Zinc Gluconate that are beneficial for bringing down the blood sugar levels.
Treat the Root Cause instead of just Symptoms of Diabetes with Sugar Knocker
We do NOT challenge conventional medicine but provide supplements that help diabetics to manage their condition better with the use of natural and time-tested ingredients. The all natural Sugar Knocker works along with your prescribed drugs without any side effects and will become an excellent addition to your diabetes management regimen.
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ghaw2007 · 6 years
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6 Blackberry Benefits
6 Blackberry Benefits
1. May Prevent and Slow Growth of Cancer
One of the most widely researched health benefits of blackberries is their ability to work as a cancer-fighting food. The reason for this is most likely due to the rich antioxidants found in the blackberry. Blackberries contain polyphenols, a class of antioxidants known for their cancer-fighting abilities. Specifically, anthocyanin (a particular polyphenol) is found in high concentrations in this fruit. Anthocyanins are thought of as the primary weapon blackberries use against the development of cancer. (1)
For example, an extract of fresh blackberry was found to exhibit tumor-preventive effects on a line of human lung cell cancer. (2) The high levels of oxidative stress that cause the proliferation (growth) of cancer cells are blocked by the anthocyanins found in blackberries. In regard to lung cancer, there has been at least one study demonstrating the effectiveness of cyanidin-3-glucoside, a specific anthocyanin found in blackberries, on the growth of cancerous lung tumors. (3)
In general, blackberries are known to help prevent some of the cell mutation that leads to cancer in the first place. While the cause of cancer is complex and different for every person, the mutation of DNA and healthy cells in particular is what seems to lead to the growth of this disease, so eating antioxidant-rich foods, such as blackberries, helps suppress this mutation. (4)
A study from UCLA in 2006 investigated the effects of six different berry varieties, including the blackberry, on the growth of oral, breast, colon and prostate cancers. Each of the six berry extracts prohibited cancer growth to some degree, urging researchers to continue looking into the impact these berries can have in treating cancer. (5)
Vitamin K may also be a factor in the anti-cancer properties of blackberries. One serving of blackberries has over a third of the daily recommended value of vitamin K, which plays a part in helping prevent and fight prostate, colon, stomach, nasal, oral and liver cancers.
2. Improve and Maintain Brain Function
The incredible nutrient load of blackberries makes them a remarkable candidate for peak mental health. Preliminary studies focused on motor skills and short-term memory retention find that blackberries have great potential in increasing brain performance, like many other berries high in antioxidants, which is why berries are among some of the top brain foods. Short-term memory seems most drastically improved by a consistent diet of blackberries, according to certain reports. (6)
Manganese is one nutrient present in high levels in blackberries that’s vital to brain functioning. A notable percentage of manganese in your body is found in the synapses of your brain. Because of the importance of manganese transmission in the brain, a manganese deficiency is linked to brain conditions like epilepsy. (7) It’s crucial to get the proper amount of manganese in your diet in order to keep your synapses firing correctly.
It also seems that blackberries and extracted compounds from them have the ability to protect brain cells from degeneration. Once again, this is attributed to increased polyphenol concentration in the blood. Interestingly, one particular study on this function of blackberries noted that commercial varieties of blackberries had no effect whatsoever, while wild-grown berries showed significant protective ability. (8)
3. Reduce Inflammation, Fight Infection and Boost Immunity
Because of the antioxidants touted as one of the major health benefits of blackberries, this should be one of the main foods you consume regularly to protect your body from oxidative stress and chronic inflammation responsible for a massive number of diseases.
You see, inflammation is at the root of most diseases. The natural process of inflammation is part of the body’s defense against harmful cells, but the Western diet is especially prone to encouraging chronic, disease-causing inflammation. Blackberries naturally cause a reduction in inflammation and allow your body’s processes to happen as they should, rather than on overdrive. (9, 10)
An example of the blackberry’s ability to fight inflammation is in its protection against stomach ulcers. One study found an 88 percent reduction in the stomach ulcers of subjects given extracted ellagitannins (a type of antioxidant) from blackberries, due to the reduced inflammation of the mucosal lining of the stomach, as well as a drop in the oxidative stress that was also partially responsible for the ulcers. (11)
Anti-inflammatory foods often go hand in hand with foods high in antioxidants, and blackberries are no exception. As whole, healthy foods like blackberries fight inflammation, they also help curb the free radical damage caused by oxidative stress within your body. (12) This damage occurs when the uncharged molecules (free radicals) that are responsible for aging and immune system function are overproduced due to exposure to the sun, too many processed foods or medication use. You can fight oxidative stress with antioxidants like those found in blackberries and other berries (and a ton of other amazing foods), slowing the onset or development of disease and premature aging.
Blackberries also show antibacterial activity, another function by which they protect your body from disease. They can reduce the impact of oral infections by targeting infected cells while leaving other cells untouched, making them a potentially powerful agent to treat infection.
4. Regulate Menstrual Health
If you struggle with painful symptoms of PMS, one solution might be to introduce more blackberries into your diet. The presence of vitamin K helps regulate hormone function and thereby potentially reduces cramping pains. As a blood-clotting vitamin, it can also help with excessive bleeding and give some pain relief during heavy menstrual cycles.
Another way to alleviate mental and physical PMS symptoms is by consuming foods high in manganese and calcium, both of which are contained in blackberries. (14)
5. Good for the Cardiovascular System
The vitamin K in blackberries is important for the health of your entire cardiovascular system. Vitamin K serves to stop the hardening of arteries by carrying calcium out of them and preventing buildup that can lead to serious diseases.
Healthy consumption of vitamin K is also linked to healthy blood pressure levels, reduced inflammation in cells that line blood vessels (both veins and arteries) as well as a lower chance of heart attack.
In addition, another function of the anthocyanins (remember the polyphenol antioxidant that is so effective against cancer?) in blackberries is their protective effects against endothelial dysfunction and heart failure. Endothelial dysfunction is a mouthful that describes a condition of the blood vessels around the heart where they’re constantly restricting and then dilating. It’s related to various forms of heart disease and associated with a high risk of heart failure or attack.
However, one special anthocyanin, cyanidin-3-O-glucoside, found in blackberries, seems to do a great deal in protecting these blood vessels and may be able to significantly reduce the occurrence of this dysfunction — and, hopefully, delay or stop the onset of the related cardiovascular diseases. (15)
6. Promote Healthy Skin
Sometimes, the health benefits of blackberries reach skin-deep, and that’s no joke. An extract of the blackberry fruit generally protects the skin from UVB damage through antioxidant activity. (16) It also protects the keratinocytes in your skin from UV damage, which are the cells that form a protective layer on your epidermis and then reproduce below the outer layer of skin to continually replenish the epidermis. Once again, the heroes of this story are the anthocyanins in blackberries. (17)
The vitamin C found in blackberry nutrition also helps keep skin healthy and strong. It promotes collagen production, decreases the instance of dry skin and may even prevent premature aging of the skin.
Skin health isn’t all about preventing wrinkles, though. The nutrients in blackberries also have an antiviral effect on infections affecting the skin, specifically the herpes virus responsible for cold sores.
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Early Microbial Exposure Prevents Leukemia
https://healthandfitnessrecipes.com/?p=5687
By Dr. Mercola
Exposure to microbes, or lack thereof, has long been named as a factor in developing diseases ranging from allergies to asthma. Acute lymphoblastic leukemia (ALL), the most common type of childhood cancer, may also have a microbial link, according to Melvyn Greaves of the Institute of Cancer Research in London, U.K.
In a landmark study, Greaves suggests that, among children born with a genetic mutation that can cause ALL, lack of exposure to common infections in the first 12 months of life may increase their risk of later developing a virus or bacteria that triggers ALL.
This "delayed infection" theory thus posits that "priming" the immune system via exposure to a variety of germs, dirt and microbes in early life is essential for its optimal function later. Missing out on this key process, which is becoming increasingly common in developed countries that value regular disinfection and antibacterial cleaning products, could set the stage for the development of ALL.
Is Missing Out on Microbes in Childhood Setting Up the 'Perfect Storm' for ALL?
Greaves' delayed infection theory is based on an extensive analysis of research, culminating in what he calls "two discrete steps" that cause ALL. First, before birth a genetic mutation occurs that's actually quite common; prior research by Greaves and colleagues suggests 1 in 20 children may have it. However, only 1 percent of those with the mutation will go on to develop ALL, such that children aged 15 and under have a 1 in 2,000 cumulative risk of developing the disease.1
The trigger for the disease occurs later in childhood, when an infection prompts another genetic mutation that activates the disease process, leading to ALL. This second trigger, Greaves believes, occurs when the immune system hasn't been adequately primed via exposure to microbes in early life. "Childhood ALL can be viewed as a paradoxical consequence of progress in modern societies, where behavioral changes have restrained early microbial exposure.
This engenders an evolutionary mismatch between historical adaptations of the immune system and contemporary lifestyles. Childhood ALL may be a preventable cancer," he says.2 Among Greaves' supporting research is a 2006 study that suggested influenza may trigger leukemia in some children.3 The study followed trends from 1974 to 2000; peaks in ALL diagnoses occurred in 1976 and 1999, both years that had flu epidemics just a few months prior to the ALL peaks.
Further, in mice with the ALL gene mutation, those kept in a sterile environment did not develop the disease but, once moved to an environment rich with microbes, the cancer developed.4 Greaves is now exploring whether exposure to microbes can prevent leukemia in mice, with the hope that the findings can then be investigated in humans. For now, however, Greaves' study suggests exposure to microbes in early life may be the ticket to preventing ALL, which can be done through:
Vaginal delivery (versus caesarean)
Breastfeeding
Going to day care as a baby
Exposure to older siblings
Past research supports these suggestions, including a 2002 study that found children who spent more time in day care had a significantly reduced risk of ALL.5 Breastfeeding was also associated with a reduced risk of ALL whereas introduction of formula within 14 days of birth was positively associated with ALL, as was exclusive formula feeding to 6 months.6
The Microbial Link to Cancer Keeps Growing
Researchers are only beginning to tap the surface when it comes to unveiling the complex relationship microbes have with human health and disease. Whereas persistent infections, and their related inflammation, have been shown to promote cancer, other pathogens may ignite an antitumor immune response that can even lead to cancer regression.
Writing in the journal Clinical Cancer Research, researchers explained, "Infectious agents and their products can orchestrate a wide range of host immune responses, through which they may positively or negatively modulate cancer development and/or progression."7
Whereas certain viruses, for instance, are known to directly promote cancer, it's likely that other viruses and other microbes act indirectly by way of modulating the immune response, although how this occurs remains a mystery. It seems, however, that infections during early life can be especially impacting.
You've probably heard of the hygiene hypothesis, which is the notion that a child raised in an environment devoid of dirt and germs, and who is given antibiotics that kill off all of the bacteria in his gut, is not able to build up natural resistance to disease and becomes vulnerable to illnesses later in life.
Your immune system is composed of two main groups that work together to protect you. One part of your immune system deploys specialized white blood cells, called Th1 lymphocytes, that direct an assault on infected cells throughout your body. The other major part of your immune system attacks intruders even earlier.
It produces antibodies that try to block dangerous microbes from invading your body's cells in the first place. This latter strategy uses a different variety of white blood cells, called Th2 lymphocytes. The Th2 system also happens to drive allergic responses to foreign organisms.
At birth, an infant's immune system appears to rely primarily on the Th2 system, while waiting for the Th1 system to grow stronger. But the hygiene hypothesis suggests that the Th1 system can grow stronger only if it gets "exercise," either through fighting infections or through encounters with certain harmless microbes. Without such stimulation, the Th2 system flourishes and the immune system tends to react with allergic responses more easily.
The Cancer Hygiene Hypothesis
The hygiene hypothesis posits that children and adults not being exposed to viruses and other environmental factors like dirt, germs and parasites results in their not being able to build up resistance, which makes them more vulnerable to illnesses. The so-called cancer hygiene hypothesis suggests that cancer is one of these illnesses. Even mumps, once a common childhood illness, may play a role in later cancer prevention, according to a study published in BMC Cancer:8
"Infections occur as early as the first year of life and may impact the immune system and cancer risk. The increase in antigenic exposure, after birth through viral/bacterial infections, may be essential for newborns to switch from a Th2 biased to a balanced Th1/Th2 immunity as well as to develop immunological memory.
Also, childhood diseases may activate specific antitumoral responses. For instance, mumps may lead to immune recognition of TAA present on ovarian cancer cells, resulting in an effective immunosurveillance."
It seems that not only the type of infection you're exposed to but also the timing shape how your immune system functions as well as your susceptibility to diseases like cancer.
"Some experimental evidence may also support the cancer hygiene hypothesis, that is, the antitumorigenic role of several inflammatory components, the ability of some commensals and benign gastrointestinal parasites like helminths to downregulate inflammation, as well as the ability of pathogens and their products to stimulate anticancer immunity," according to researchers writing in Clinical Cancer Research,9 who continued:
"Both protective and detrimental effects of microorganisms have been observed, many of them linked to various immune components. Overall, their effect may depend on the fine orchestration between induction and suppression of cancer-promoting or antitumorigenic immunity as well as on the level of pathogen load and the timing between infection and cancer initiation.
In this regard, cancer may be associated with the increased hygiene/decreased exposure to specific microorganisms, similar to what is known for autoimmune diseases and allergies."
Gut Microbes Also Linked to Cancer
Aside from the way microbial exposures affect your immune system, microbes may also play a role in cancer via those that exist in (and on) your body. For instance, beneficial bacteria known as probiotics can help boost activity of immune cells that fight off cancer cells. Certain gut bacteria also have shown potential for treating colon cancer,10 as well as boosting immune system health and reducing inflammation.
Research by Johanna Lampe, Ph.D., at Fred Hutchinson Cancer Research Center suggests microbial metabolism may affect your cancer risk for better or worse in many different ways, by influencing:11,12
DNA repair
Carcinogen metabolism / detoxification
Hormone regulation
Inflammation
Immune function
Apoptosis (programmed cell death)
Microbial proliferation
Microbial differentiation
In fact, fermented foods, prized for their role in supporting gut health, may be a key part of an anticancer diet. For example, butyrate, a short-chain fatty acid created when microbes ferment dietary fiber in your gut, has been shown to induce programmed cell death of colon cancer cells,13 and cultured milk products may reduce your risk of bladder cancer by about 29 percent.14
So eating fermented foods, including lassi, grass fed kefir, natto (fermented soy) and fermented vegetables, preferably homemade, is one of the best ways to nourish your gut health and reduce your cancer risk.
Getting your hands dirty in the garden can also help reacquaint your immune system with beneficial microorganisms on the plants and in the soil. Even washing your dishes by hand, instead of in the dishwasher, may actually leave more "dirt" on the plates and thereby decrease your risk of allergies by stimulating your immune system. It's possible this immune stimulation could play a role in cancer risk as well.
Embracing Microbes for Your Health
Although the mechanisms are still not well understood, the accumulation of research showing health benefits from early, and continued, exposure to microbes in your environment suggests it's a key health strategy to take to heart. If you're healthy, exposure to bacteria and viruses may serve to strengthen your immune system and provide long-lasting defense against disease.
If you don't get this healthy exposure to germs in your environment, it may end up making you sick. Health problems already associated with the hygiene hypothesis include:
Allergies
Asthma
Eczema
Autoimmune diseases
Heart disease, with one study finding that early exposure to viral infections during childhood could reduce the risk of heart disease later in life by up to 90 percent15
Even depression has been connected to early exposure to pathogens, via an inflammatory connection,16 so there are many reasons to avoid an overly sterile environment in the early years of life, even aside from potential cancer prevention.
As mentioned, giving birth vaginally, breastfeeding and allowing your children to be exposed to other children (either siblings or at day care) are prime ways to increase their microbial exposure in the first few months of life. You can also avoid being overly "sterile," and thereby bolster your body's healthy immune function, by:
• Letting your child get dirty. Allow your kids to play outside and get dirty (and realize that if your kid eats boogers, it isn't the end of the world).
• Not using antibacterial soaps and other antibacterial household products, which wipe out the microorganisms that your body needs to be exposed to for developing and maintaining proper immune function. Simple soap and water are all you need when washing your hands. The antibacterial chemicals are quite toxic and have even been found to promote the growth of resistant bacteria.
• Avoiding unnecessary antibiotics. Remember that viral infections are impervious to antibiotics, as antibiotics only work on bacterial infections.
• Serving organic grass fed meat and dairy products that do not contain antibiotics.
Credits: Original Content Source
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jakehglover · 6 years
Text
Early Microbial Exposure Prevents Leukemia
By Dr. Mercola
Exposure to microbes, or lack thereof, has long been named as a factor in developing diseases ranging from allergies to asthma. Acute lymphoblastic leukemia (ALL), the most common type of childhood cancer, may also have a microbial link, according to Melvyn Greaves of the Institute of Cancer Research in London, U.K.
In a landmark study, Greaves suggests that, among children born with a genetic mutation that can cause ALL, lack of exposure to common infections in the first 12 months of life may increase their risk of later developing a virus or bacteria that triggers ALL.
This "delayed infection" theory thus posits that "priming" the immune system via exposure to a variety of germs, dirt and microbes in early life is essential for its optimal function later. Missing out on this key process, which is becoming increasingly common in developed countries that value regular disinfection and antibacterial cleaning products, could set the stage for the development of ALL.
Is Missing Out on Microbes in Childhood Setting Up the 'Perfect Storm' for ALL?
Greaves' delayed infection theory is based on an extensive analysis of research, culminating in what he calls "two discrete steps" that cause ALL. First, before birth a genetic mutation occurs that's actually quite common; prior research by Greaves and colleagues suggests 1 in 20 children may have it. However, only 1 percent of those with the mutation will go on to develop ALL, such that children aged 15 and under have a 1 in 2,000 cumulative risk of developing the disease.1
The trigger for the disease occurs later in childhood, when an infection prompts another genetic mutation that activates the disease process, leading to ALL. This second trigger, Greaves believes, occurs when the immune system hasn't been adequately primed via exposure to microbes in early life. "Childhood ALL can be viewed as a paradoxical consequence of progress in modern societies, where behavioral changes have restrained early microbial exposure.
This engenders an evolutionary mismatch between historical adaptations of the immune system and contemporary lifestyles. Childhood ALL may be a preventable cancer," he says.2 Among Greaves' supporting research is a 2006 study that suggested influenza may trigger leukemia in some children.3 The study followed trends from 1974 to 2000; peaks in ALL diagnoses occurred in 1976 and 1999, both years that had flu epidemics just a few months prior to the ALL peaks.
Further, in mice with the ALL gene mutation, those kept in a sterile environment did not develop the disease but, once moved to an environment rich with microbes, the cancer developed.4 Greaves is now exploring whether exposure to microbes can prevent leukemia in mice, with the hope that the findings can then be investigated in humans. For now, however, Greaves' study suggests exposure to microbes in early life may be the ticket to preventing ALL, which can be done through:
Vaginal delivery (versus caesarean)
Breastfeeding
Going to day care as a baby
Exposure to older siblings
Past research supports these suggestions, including a 2002 study that found children who spent more time in day care had a significantly reduced risk of ALL.5 Breastfeeding was also associated with a reduced risk of ALL whereas introduction of formula within 14 days of birth was positively associated with ALL, as was exclusive formula feeding to 6 months.6
The Microbial Link to Cancer Keeps Growing
Researchers are only beginning to tap the surface when it comes to unveiling the complex relationship microbes have with human health and disease. Whereas persistent infections, and their related inflammation, have been shown to promote cancer, other pathogens may ignite an antitumor immune response that can even lead to cancer regression.
Writing in the journal Clinical Cancer Research, researchers explained, "Infectious agents and their products can orchestrate a wide range of host immune responses, through which they may positively or negatively modulate cancer development and/or progression."7
Whereas certain viruses, for instance, are known to directly promote cancer, it's likely that other viruses and other microbes act indirectly by way of modulating the immune response, although how this occurs remains a mystery. It seems, however, that infections during early life can be especially impacting.
You've probably heard of the hygiene hypothesis, which is the notion that a child raised in an environment devoid of dirt and germs, and who is given antibiotics that kill off all of the bacteria in his gut, is not able to build up natural resistance to disease and becomes vulnerable to illnesses later in life.
Your immune system is composed of two main groups that work together to protect you. One part of your immune system deploys specialized white blood cells, called Th1 lymphocytes, that direct an assault on infected cells throughout your body. The other major part of your immune system attacks intruders even earlier.
It produces antibodies that try to block dangerous microbes from invading your body's cells in the first place. This latter strategy uses a different variety of white blood cells, called Th2 lymphocytes. The Th2 system also happens to drive allergic responses to foreign organisms.
At birth, an infant's immune system appears to rely primarily on the Th2 system, while waiting for the Th1 system to grow stronger. But the hygiene hypothesis suggests that the Th1 system can grow stronger only if it gets "exercise," either through fighting infections or through encounters with certain harmless microbes. Without such stimulation, the Th2 system flourishes and the immune system tends to react with allergic responses more easily.
The Cancer Hygiene Hypothesis
The hygiene hypothesis posits that children and adults not being exposed to viruses and other environmental factors like dirt, germs and parasites results in their not being able to build up resistance, which makes them more vulnerable to illnesses. The so-called cancer hygiene hypothesis suggests that cancer is one of these illnesses. Even mumps, once a common childhood illness, may play a role in later cancer prevention, according to a study published in BMC Cancer:8
"Infections occur as early as the first year of life and may impact the immune system and cancer risk. The increase in antigenic exposure, after birth through viral/bacterial infections, may be essential for newborns to switch from a Th2 biased to a balanced Th1/Th2 immunity as well as to develop immunological memory.
Also, childhood diseases may activate specific antitumoral responses. For instance, mumps may lead to immune recognition of TAA present on ovarian cancer cells, resulting in an effective immunosurveillance."
It seems that not only the type of infection you're exposed to but also the timing shape how your immune system functions as well as your susceptibility to diseases like cancer.
"Some experimental evidence may also support the cancer hygiene hypothesis, that is, the antitumorigenic role of several inflammatory components, the ability of some commensals and benign gastrointestinal parasites like helminths to downregulate inflammation, as well as the ability of pathogens and their products to stimulate anticancer immunity," according to researchers writing in Clinical Cancer Research,9 who continued:
"Both protective and detrimental effects of microorganisms have been observed, many of them linked to various immune components. Overall, their effect may depend on the fine orchestration between induction and suppression of cancer-promoting or antitumorigenic immunity as well as on the level of pathogen load and the timing between infection and cancer initiation.
In this regard, cancer may be associated with the increased hygiene/decreased exposure to specific microorganisms, similar to what is known for autoimmune diseases and allergies."
Gut Microbes Also Linked to Cancer
Aside from the way microbial exposures affect your immune system, microbes may also play a role in cancer via those that exist in (and on) your body. For instance, beneficial bacteria known as probiotics can help boost activity of immune cells that fight off cancer cells. Certain gut bacteria also have shown potential for treating colon cancer,10 as well as boosting immune system health and reducing inflammation.
Research by Johanna Lampe, Ph.D., at Fred Hutchinson Cancer Research Center suggests microbial metabolism may affect your cancer risk for better or worse in many different ways, by influencing:11,12
DNA repair
Carcinogen metabolism / detoxification
Hormone regulation
Inflammation
Immune function
Apoptosis (programmed cell death)
Microbial proliferation
Microbial differentiation
In fact, fermented foods, prized for their role in supporting gut health, may be a key part of an anticancer diet. For example, butyrate, a short-chain fatty acid created when microbes ferment dietary fiber in your gut, has been shown to induce programmed cell death of colon cancer cells,13 and cultured milk products may reduce your risk of bladder cancer by about 29 percent.14
So eating fermented foods, including lassi, grass fed kefir, natto (fermented soy) and fermented vegetables, preferably homemade, is one of the best ways to nourish your gut health and reduce your cancer risk.
Getting your hands dirty in the garden can also help reacquaint your immune system with beneficial microorganisms on the plants and in the soil. Even washing your dishes by hand, instead of in the dishwasher, may actually leave more "dirt" on the plates and thereby decrease your risk of allergies by stimulating your immune system. It's possible this immune stimulation could play a role in cancer risk as well.
Embracing Microbes for Your Health
Although the mechanisms are still not well understood, the accumulation of research showing health benefits from early, and continued, exposure to microbes in your environment suggests it's a key health strategy to take to heart. If you're healthy, exposure to bacteria and viruses may serve to strengthen your immune system and provide long-lasting defense against disease.
If you don't get this healthy exposure to germs in your environment, it may end up making you sick. Health problems already associated with the hygiene hypothesis include:
Allergies
Asthma
Eczema
Autoimmune diseases
Heart disease, with one study finding that early exposure to viral infections during childhood could reduce the risk of heart disease later in life by up to 90 percent15
Even depression has been connected to early exposure to pathogens, via an inflammatory connection,16 so there are many reasons to avoid an overly sterile environment in the early years of life, even aside from potential cancer prevention.
As mentioned, giving birth vaginally, breastfeeding and allowing your children to be exposed to other children (either siblings or at day care) are prime ways to increase their microbial exposure in the first few months of life. You can also avoid being overly "sterile," and thereby bolster your body's healthy immune function, by:
• Letting your child get dirty. Allow your kids to play outside and get dirty (and realize that if your kid eats boogers, it isn't the end of the world).
• Not using antibacterial soaps and other antibacterial household products, which wipe out the microorganisms that your body needs to be exposed to for developing and maintaining proper immune function. Simple soap and water are all you need when washing your hands. The antibacterial chemicals are quite toxic and have even been found to promote the growth of resistant bacteria.
• Avoiding unnecessary antibiotics. Remember that viral infections are impervious to antibiotics, as antibiotics only work on bacterial infections.
• Serving organic grass fed meat and dairy products that do not contain antibiotics.
from HealthyLife via Jake Glover on Inoreader https://articles.mercola.com/sites/articles/archive/2018/06/05/early-microbial-exposure-prevents-leukemia.aspx
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heathertruitt · 6 years
Text
Ranking the best beta-alanine supplements of 2017
Beta alanine is an amino acid that you can take in supplement form to improve your workout performance, especially in short, high-intensity anaerobic efforts like HIIT training.
If you want to take your workout intensity and your overall athletic performance, (often mixed with a pre-workout), beta alanine is a good place to start.
Here are the top beta alanine supplements on the market.
1. Transparent Labs Beta Alanine
Click here for the lowest price
Transparent Labs gets the nod here for keeping it simple: pure beta alanine powder without any artificial coloring, no artificial coloring, and no preservatives.
Just mix one scoop (3,000 mg) 15-30 minutes before your workouts for optimal endurance and repetitions in your next workout.
2. BulkSupplements Pure Beta Alanine
Click here for the lowest price on Amazon
When it comes to cheap and pure supplement ingredients, BulkSupplements is the undisputable king. Their half-kilo (500g) beta alanine supplement is about as minimalist as it can get–it’s tested for purity and quality, and comes in a plain white bag.
All the measuring and blending happens on your end, which is great from a customization perspective, but can be a pain if you don’t have a high-quality scale. For DIYers, there is no better choice, but if you want something simple, get a supplement that comes in a pill.
3. NOW Sports Beta Alanine
Click here for the lowest price on Amazon
If all you want is a beta alanine supplement you can take before your workout, without having to hassle with scoops and scales and other ingredients, look no further than NOW Sports.
Each gelatin capsule (sorry, vegans) contains 750 mg of beta alanine and only a minimal amount of binders and stabilizing agents.
4. Optimum Nutrition Beta Alanine
Click here for the lowest price on Amazon
Optimum Nutrition provides a nice middle ground between the ultra-minimal beta alanine supplements that are nothing but pure powder in a bag and a hyper-processed pre-workout supplement.
Optimum Nutrition provides a tub full of beta alanine, mixed with a few micronutrients and L-histidine to help keep your workout performance at its prime.
5. Micro Ingredients Muscle Up Pure Beta Alanine
Click here for the lowest price on Amazon
As another beta alanine supplement that comes in loose powder form, the obvious comparison is to BulkSupplements.
While they are pretty comparable in most respects, the scales tip towards BulkSupplements, simply because that company has a more established record of quality and purity in their supplements. Micro Ingredients is still a fine choice, though.
6. Optimum Nutrition Gold Standard Pre-Workout
Click here for the lowest price on Amazon
Though there are a lot of ingredients in Optimum Nutrition’s pre-workout blend, beta alanine is the cornerstone ingredient.
Each scoop provides a hefty 1.5 grams of beta alanine, alongside B vitamins, caffeine, amino acids, and creatine. These work together to provide a robust performance-enhancing effect in your workout, especially if it involves short bursts of anaerobic activity.
7. Cellucor C4
Click here for the lowest price on Amazon
This pre-workout blend features beta alanine in a central role, but it’s not the only active ingredient. It’s a great choice if you want beta alanine to work synergistically to boost your workout performance, because it contains an array of B vitamins, creatine nitrate, and caffeine.
Just watch when you use it; the caffeine and the other energy-boosting supplements will pump you up for a late night workout, but you might not be able to fall asleep later.
8. BSN N.O.-XPLODE
Click here for the lowest price on Amazon
This one’s another in the category of pre-workout blends that incorporate beta alanine’s performance-enhancing properties as a central part of the supplement’s benefits.
However, N.O.-XPLODE has so many ingredients with so many different effects that it drifts towards “kitchen sink” territory. Plenty of people still swear by its results, but it’s not clear if all of the ingredients serve a cohesive purpose.
9. Primaforce Beta Alanine
Click here for the lowest price on Amazon
Primaforce offers a loose powder form of beta alanine, but it doesn’t rank as highly because you only get 200 grams per container.
The quality is good; beta alanine is literally the only ingredient and it’s manufactured in the United States, but if you are going to get bulk powder, in most cases you’d probably want to opt for a 500 gram option.
10. ProLab Beta Alanine Extreme
Click here for the lowest price on Amazon
ProLab makes a capsule-based beta alanine supplement which looks pretty convenient, but it doesn’t live up to expectations. Each capsule only contains 400 mg of beta alanine, which is barely more than half what you can get from other brands.
It does include L-Histidine, which not all other pill based beta alanine supplements have, but all in all, there are better options out there on every front.
Beta alanine benefits and side effects
Beta-alanine, also known carnosine precursor, is a type of non-essential amino acid that gets converted into a molecule called carnosine. Carnosine then acts as a buffer acid into the muscles that helps increase stamina, muscle development and physical performance in the range of 60 to 240 seconds.
Carnosine is basically stored in the cells and it is released when the PH level drops in the body.  It acts to counter the rising acidity in your muscles during high intensity exercise, and as such you can improve your performance by boosting the concentration of beta alanine inside your muscle fibers.
Beta-alanine is not so easily consumed in the diet that we eat regularly like chicken, whey, fish or beef. Therefore, beta-alanine supplementation is required. As it improves physical performance, this supplement can be quite helpful for those for those who engage in endurance exercise and train for long hours in the gym.
This article will provide a detailed understanding of the many health benefits of aeta-alanine supplementation, the recommended dosage and possible side-effects.
Benefits
The carnosine molecule that beta-alanine converts into buffer H+ ions help slow down the aging process. This effect is backed by various research studies and scientific works. According to studies, carnosine from beta-alanine acts like resveratrol.  This molecule is known to protect the heart and improve blood flow in the body. Also, it has been observed that muscle carnosine concentration drops up to 45 percent during the aging process ‎(1, ‎2) . This suggests that increasing carnosine stores in the body can slow down the aging process.
Other research studies conducted on beta-alanine suggest that carnosine lowers the cellular aging rate in cultured-fibroblasts. Thus, the anti-aging effect can be due to this molecule’s ability to lower telomere shortening in cultured-fibroblasts ‎(3).
Telomeres are strands of DNA that help prevent aging when your cells divide and multiply.  As they get shorter, your biological age increases, and you start to appear and feel older.  Decreasing the rate at which your telomeres shrink could have longevity-boosting effects, though this is yet to be confirmed in humans.
Carnosine made through beta-alanine has been found to have neurological antioxidant effects. Beta-alanine can moderate several neurological actions by taurine’s competitive inhibition. This is because both taurine and beta-alanine compete with each other for the same transporter to enter the brain. Just like taurine, beta-alanine acts via GABA receptors and glycine.
Besides this, when converted to carnosine, beta-alanine has shown to support antioxidant enzyme structures Cu/ZnSOD (Superoxide Dismutase). It reduces the aggregation of oxidized proteins in neural tissues, thereby supporting motor function in people suffering from mental disorders like Parkinson’s and Alzheimer’s diseases (4).
Research studies on beta-alanine have shown that its supplementation can increase muscle carnosine concentrations in the body that ultimately boost the ability to perform high intensity or endurance exercise ‎(5).
Raised muscle carnosine levels help reduce fatigue and build the stamina required to perform activities like jumping, sprinting and weightlifting for long hours. Carnosine facilitates buffering capacity of hydrogen ions which accumulate during rigorous or intense exercise (6).
If you can delay the buildup of hydrogen ions, you delay the onset of acidosis, the “burning” feeling you get after a tough effort.  This means that beta alanine can help you run faster, lift more, and push harder in your next workout.
In addition to this, the improved endurance exercise advantage through beta-alanine supplementation can be attributed to the fact that the muscle carnosine concentration increase also delays the onset of blood-lactate accumulation. A study showed that beta-alanine supplementation over the course of 28 days improved running performance in athletes as it helped in slowing down the negative effects relate to blood-lactate building in the bodies of athletes (7).
Other scientific research studies conducted on beta-alanine have proved that the increase in carnosine concentration due to beta-alanine supplementation can increase muscle mass by 20 to 80 percent as compared to high intensity interval training alone (‎8).
Intake of beta-alanine supplements daily for at least 30 days can significantly increase strength. A study published in the International Journal of Sport Medicine showed that athletes who took beta-alanine supplement for a month completed 22% more squats at 70% of their one rep max primarily because they had greater mean power that resulted from loading up on amino acids.
Side Effects
Large doses of beta-alanine supplements can result in parasthesia. Parasthesia is a condition that is accompanied with uncomfortable tingling or prickling feeling on the skin that commonly people experience on the face, chest, and abdomen. Besides this, over dose of beta-alanine supplement can also lead to itching and burning feeling in the ears or on the scalp. Studies have shown that doses of beta-alanine greater than 800mg pre-workout can cause mild to acute parasthesia that may last for an hour or sometimes even 90 minutes.
To avoid this side effect, use the time release formulation or take smaller doses of beta-alanine around 0.8 to 1g in a day.  This will allow you to reach the optimal dosage levels without getting the negative side effects that can result from taking large doses at once.
Recommended Dosage
As beta-alanine acts as a quick stimulant, consuming it pre-workout is a good idea. The benefits of aeta-alanine related to performance are largely based on the increased concentration of muscle carnosine over time. Hence the time of day doesn’t really matter as long as an athlete consistently consumes beta-alanine daily. The standard every dose of beta-alanine is approximately 3 to 5 g spread over 2 to 3 doses in a day for first 6 days.
However, as you move to the maintenance phase, 3g divided in 3 doses daily is enough. This is primarily because carnosine concentration in the body builds up with regular supplementation. However, it also drops by 2% in every 2 weeks in case the supplementation is stopped.
Recap
Also called b-alanine and carnosine precursor, beta-alanine is a supplement that can be best described as one of the types of non-essential amino acids. When this supplement is consumed, it gets converted into carnosine which is a molecule that quickly buffers acid into the muscles thereby increasing stamina, promoting muscle development, and improving physical performance. Other benefits include anti-aging properties and improved motor function in patients suffering from mental disorders.
The standard dosage of beta-alanine is 3 to 5g spread over two to three doses in a day. Large doses of beta-alanine have shown side effects resulting in an uncomfortable tingling feeling on the skin— a condition that is known as parasthesia.
  https://bodynutrition.org/beta-alanine/
https://bodynutritionorg.wordpress.com/2017/10/22/ranking-the-best-beta-alanine-supplements-of-2017/
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