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#sertraline review
whoredeleau · 11 months
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you are normal i am weaving webs about bordy and alex both in nys
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sert anon! so i will now be able to get accommodations at uni due to presenting autistic (not a diagnosis but still). the support document will take up to a couple of weeks but i’m kinda just relieved 😅
Hi darling. I hope you’re okay. I’m glad everything is sorted and you’re going to get the accommodations that you need ☺️
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elliebore · 2 years
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Unironically just thought ‘I haven’t taken my meds in like a week so now is the best time to try grapefruit’
I’m a mess
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seaweed-is-cool · 6 months
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So I saw Next To Normal and I'm not okay
Who knows if this is going to be a comprehensive review or just ramblings about Jack Wolfe (because let's be real that's the initial reason I wanted to go).
The main set was a good choice. The floating kitchen island was utilised effectively in conjunction with the turntable. The use of levels was phenomenal so that even though I was standing, I could see a lot of the action especially the parts in the band boxes and the stairs. Other people who saw it said that during one part where Jack sings in the box they could only see his knees. There was one bit where they came out of the fridge (which I called before the show started aha) and that was fantastic. I wasn't a fan of how they constantly made the screens go up and down. I think it would have been more effective if certain screens weren't used. Nevertheless, the set and costumes were fab and I enjoyed them immensely.
The portrayal of mental health in this show was the best I have ever seen. I felt incredibly seen throughout and if I had the capability to cry (thank you sertraline) I would have. I still feel kinda numb to it but I know that when I listen to the soundtrack I will feel things ahha.
The performances given by each actor were phenomenal. Every single actor was perfect and they hit each section with the love and care it deserved. I would like to have seen more of the doctor because I think he was underutilised. Still, when he was there, he was extremely enjoyable.
Now, onto Jack Wolfe. When he first appeared I was astounded. He had a fantastic American accent (which is hard for a northerner fr) and the way he carried himself on stage was amazing. Little angsty boy for real. I think he'd make an amazing Puck (or maybe I'm just finding similarities between him and Colin Morgan) cause he has this mischievous nature about him that really came out in Gabe.
I adored the other performances so much so that I cannot pick a favourite from them. This musical was the most well-acted I have seen in a very long time (since I saw Les Mis last year). And I really hope that they bring out that archived performance or at least a cast recording.
Thank you again to @annoying-is-my-middle-name for the tickets. I am ever so grateful.
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transmutationisms · 7 months
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DOI 10.1056/NEJMoa0804633 oft-cited 2008 study where sertraline + CBT works better than placebo + CBT for anxiety. Anecdotally, I'm anxious but not depressed, and it worked well for me - distress felt less immediate and I could think it through. I stopped because I didn't like my dreams, and if I forgot or lost access to the pills I'd get anxious AND depressed from withdrawal. Still, "better than placebo" doesn't equate to "proves chem imbalance".
i'd be very cautious about relying on any single study to make any scientific judgment; i'm especially wary about this in regards to psychiatric pharmaceuticals because so many of these turn out to be non-replicable. there are plenty of one-off SSRI studies for depression that show great results and then when you look at the balance of evidence and take into account methodological flaws and author conflicts of interest and p-hacking and misleading presentations of the data, the picture looks very different to what those single studies suggested. this study is also specifically on children, so make of that what you will. also this is the authors' conflict of interest disclosure paragraph:
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Dr. Walkup reports receiving consulting fees from Eli Lilly and Jazz Pharmaceuticals and fees for legal consultation to defense counsel and submission of written reports in litigation involving GlaxoSmithKline, receiving lecture fees from CMP Media, Medical Education Reviews, McMahon Group, and DiMedix, and receiving support in the form of free medication and matching placebo from Eli Lilly and free medication from Abbott for clinical trials funded by the NIMH; Dr. Albano, receiving royalties from Oxford University Press for the Anxiety Disorders Interview Schedule for DSM-IV, Child and Parent Versions, but not for interviews used in this study, and royalties from the Guilford Press; Dr. Piacentini, receiving royalties from Oxford University Press for treatment manuals on childhood obsessive–compulsive disorder and tic disorders and from the Guilford Press and APA Books for other books on child mental health and receiving lecture fees from Janssen-Cilag; Dr. Birmaher, receiving consulting fees from Jazz Pharmaceuticals, Solvay Pharmaceuticals, and Abcomm, lecture fees from Solvay, and royalties from Random House for a book on children with bipolar disorder; Dr. Rynn, receiving grant support from Neuropharm, Boehringer Ingelheim Pharmaceuticals, and Wyeth Pharmaceuticals, consulting fees from Wyeth, and royalties from APPI for a book chapter on pediatric anxiety disorders; Dr. McCracken, receiving consulting fees from Sanofi-Aventis and Wyeth, lecture fees from Shire and UCB, and grant support from Aspect, Johnson & Johnson, Bristol-Myers Squibb, and Eli Lilly; Dr. Waslick, receiving grant support from Baystate Health, Somerset Pharmaceuticals, and GlaxoSmithKline; Dr. Iyengar, receiving consulting fees from Westinghouse for statistical consultation; Dr. March, receiving study medications from Eli Lilly for an NIMH-funded clinical trial and receiving royalties from Pearson for being the author of the Multidimensional Anxiety Scale for Children, receiving consulting fees from Eli Lilly, Pfizer, Wyeth, and GlaxoSmithKline, having an equity interest in MedAvante, and serving on an advisory board for AstraZeneca and Johnson & Johnson; and Dr. Kendall, receiving royalties from Workbook Publishing for anxiety-treatment materials.
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maximilianthegreatest · 3 months
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I've been having the strangest dreams recently that make no sense and i can remember despite never really having that in my life. Googled it and well...
Antidepressants belonging to the SSRI class, such as sertraline, fluoxetine and citalopram - as well as serotonin-norepinephrine reuptake inhibitors (SNRIs) - were found in the review to intensify dreams and increase how often people reported having nightmares.
So just a PSA to anyone who's on happy pills, your dreams can get weird.
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buggingme · 1 month
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Factitious Disorder - An overview
N Percent
Gender  Male 176 34.2  Female 336 65.4 Marital status  Unmarried 62 30.4  Married 97 47.5  Separated/divorced/widowed 45 22.0 Age (years)  Total mean 33.5  Male 35  Female 32.8 Total range 18–73  Male range 19–67  Female range 18–73 Comorbid psychopathology 239 46.5 Occupation  Health care profession 113 22.0  Others 94 18.3
During hospitalization, 65.8% of patients got a psychiatric consultation. The remaining 34.2% of patients refused or did not have the consultation.
Among the factors considered to be relevant to diagnose these disorders, the exclusion of other organic or psychiatric causes is the most represented, observed in 91.1% of cases.
An atypical presentation is another key issue (89.3%), which implies that the patient’s symptoms or the clinical course of the presumed condition is unusual, sometimes associated with incongruous instrumental findings. In some cases, it is also possible to observe an exacerbation of the symptoms in the presence of the medical staff or, on the contrary, in the absence of any witnesses.
Another important parameter is patient’s unusual behavior (86.2%), followed by treatment failure and/or high disease recurrence (83.7%).
The demographic profile of the sample shows a prevalence of female. The data support the hypothesis of several case reports and reviews that FD occur mainly in women.3,9,10 However, other studies published in the literature show a clear prevalence in male gender. This illusory disagreement finds an explanation in Freyberger’s words, who asserts that there is a prevalence of men in clinical trials for Munchausen Syndrome, while the women are most common in the classic form of FD with a ratio of 3:1.11
A disorder in which one pretends to be sick, by self-injury or making themselves sick.
Therapy
Psychotherapy:To help the patient recognise and acknowledge the problem. Also helps them learn coping skills.
Cognitive behaviour therapy:To bring changes in the person’s thinking and behaviour.
Medication
Antidepressants: To treat the associated depression.
Sertraline . Citalopram
Antianxiety drugs: To treat the associated anxiety.
Lorazepam . Diazepam
Rare (Fewer than 10,000 cases per year in Australia)
Treatments can help manage condition, no known cure
Doesn't require lab test or imaging
Can last several years or be lifelong
Common for ages 20-40
Symptoms of factitious disorder include:
Exaggeration of symptoms
Faking symptoms; inconsistencies in the symptoms reported
Dramatic presentation
Presence of symptoms only while being observed
Willingness and eagerness to have diagnostic tests or other procedures
Long medical records of multiple admissions to different hospitals
Reluctance by the patient to allow interaction of doctors with family members
Having a vast knowledge of the diseases one claims to have
Many surgical scars
Self-harm for example by injecting oneself with bacteria or gasoline
Tampering diagnostic results e.g., by heating a thermometer
Causes
The exact cause is unknown but it is attributed to psychological factors.
Risk factors for developing the disorder include:
Depression
Low self-esteem
Child abuse
History of illnesses that required hospitalisation
Personality disorders
Desire to be a healthcare professional
Loss of a loved one
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In med school and also preparing for my exam. I have to learn a whole course about antidepressants so here it goes I guess !
Hi! I'm sure that the majority of this will be pretty basic review but let's talk about it!
The first generation of antidepressants were monoamine oxidase inhibitors (MAOIs). They were originally invented to treat tuberculosis but in 1953 Iproniazid was developed and patients taking it showed improvements in their depression symptoms. As their name suggests, they function by inhibiting the breakdown of monoamine neurotransmitters (serotonin, dopamine, norepinephrine, ect) by the enzyme monoamine oxidase, and this leaves more neurotransmitters available for synapse. The problem with this method is that there are monoamines in our food. Patients taking MAOIs have to be careful eating foods that contain lots of tyramine because it can't be broken down. High levels of tyramine can cause sudden increases in blood pressure and even cerebral hemorrhage! Understandably, MAOIs aren't prescribed very often anymore.
The next generation of antidepressants, known as tricyclic antidepressants, was developed in the late 50s. These work by inhibiting both serotonin and norepinephrine reuptake. They are also antagonists for postsynaptic adrenergic α1 and α2 receptors, muscarinic receptors, and histamine H1 receptors. Reuptake inhibition is the mechanism found in a lot of our current antidepressants, but they're a little bit more focused.
In the late 80s, Fluoxetine was finally approved by the FDA and SSRIs continue to dominate the antidepressant landscape. SSRI stands for Selective Serotonin Reuptake Inhibitors, and they do what their name suggests, inhibiting the serotonin transporter (SERT) at the presynaptic axon terminal. This leaves more serotonin (5-HT) available for synapse. Additionally, SSRIs target the 5-HT1A autoreceptors. This seems counter productive at first, because the autoreceptor activation slows 5-HT production and release. But over time, this builds autoreceptor tolerance. Generally, autoreceptors can shut off signaling when there's too much and is a main contributor to building drug tolerance. But since the autoreceptor is now being activated, that shut off function loses efficacy and the extra 5-HT in the synapse from SERT inhibition doesn't cause tolerance to be built up (as much). This is why it takes SSRIs weeks to kick in because the two processes do cancel each other out until the autoreceptors have gotten tolerant. There is variety within SSRIs. Fluoxetine (Prozac) has a half life much longer than Sertraline (Zoloft) and takes longer to get peak plasma concentration.
Serotonin-Noradrenaline reuptake inhibitors work very similarly, they just also inhibit norepinephrine reuptake. (Say what you will about anti-depressants, at least they're named straightforwardly lol). Some patients respond better to SSRIs, some respond better to SNRIs. Unfortunately, a lot of patients don't respond well to either and they can come with difficult side effects.
Moving on from depression, let's talk a little about anxiety and anxiolytics. One of the key brain changes in general anxiety is reduced PFC inhibitory control, associated with reduced GABA(A) receptors. This is coupled with amygdala overactivity. Benzodiazepines help regulate anxiety by increasing GABA control. They do so without nearly as many side effects as the previous barbiturates, and took off in the 1960s. But because they act on GABA, mixing benzodiazepines with alchohol (also acts on GABA) creates lots of abuse potential (think of the Valium + martini housewife). The positive side to this is that benzodiazepines can be used to help someone with alcohol withdrawal, which is otherwise very dangerous. Second generation anxiolytics are partial agonists for 5-HT1A receptors. Moving away from GABA reduces the abuse potential, but also makea the drugs less effective. Generally, SSRIs are prescribed for anxiety before other classes of drugs.
Hope that was a good basic review!
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parislohan · 8 months
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i wish i could put some LOCK on sertraline reviews like a child lock computer safety thing that doesn’t allow me to view those pages.. because im just making myself insane…. hearing people talk about the side effects is nottt helping mama because like im already taking the meds now it like it’s happening i have them i started taking them last night so like. i need to just stop reading horror stories and start feeling how i feel and letting things be…
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sekritjay · 2 years
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I'm uh.... back. I didn't really leave I guess... at any point between before and after my last post if I'm being honest, which you may have seen if I popped up in your notifications liking a random post out of the blue because I fat-fingered and then hastily unliked a post on my mobile. So what happened?
Well nothing, frankly. After my dog copped it I didn't expect things to get any worse but they did anyway, and they did in ways I could never have imagined - Covid did a number on the business but in a way that to my egocentric ways seemed at times to specifically target me
Literally from the moment de Pfeffel declared a lockdown I was run ragged every single fucking day. Coupled with the fact that I had to put my entire staff on furlough meant that for the next two years I was doing double the work for two-thirds of the money, with a 20% premium added to everything I had to buy on top. Before the pandemic I had a migraine maybe every other month. During the pandemic it was every other day and even today I get migraines on the regular
And of course people died. Three family friends passed away and none of them from covid - sepsis, cancer and car accident. And I never saw them the entire time, not even at a funeral. All I could do is... get back to work, because I was facing yet another night of doing more work for less money
Shamefully my default response during that time wasn't despondency - it was in fact through extreme temper flare ups, shifting from apathy to explosive anger from even innocuous questions
And now business is on a downturn. Right when my energy bills are skyrocketing. Two months ago I was paying £1,500 a month for electricity, my next bill? £3,500
And I don't derive any pleasure from doing what I loved. If anything, I do those things just to distract myself from what I should be doing but can't seem to face. Even a post like this, which had been sitting uncompleted in my drafts for two months. Because I couldn't bare to face it. Because I honestly felt shame from even voicing it on the internet, in a public sphere. Because it felt like I had lost the ability to meaningfulyl socialise. I haven't even spoken to my real life friends in three years, let alone people on tumblr
I finally managed to get a mental health review a couple of months ago, thinking that it was ADD. Couldn't even get that right - I've been diagnosed with persistent depressive disorder and prescribed sertraline
I'm still not sure if it's *improving* my situation on a personal level as I don't feel any different. Outwardly maybe - anger flare ups stopped happening even when under pressure but no-one seemed to notice. I haven't told my family I'm on antidepressants but they haven't said anything. And I guess it's nice that I don't have intrusive thoughts any more, something which my doctor said that despite everyone getting them, the frequency I was having them was a cause for concern
The fact is though is that the circumstances that lead to depression haven't gone away - I would say that have in fact gotten worse but I don't see any way I can change it in the short term. I'm still doing 60 hours, 7 days a week. I still can't pay myself. I still can't get the fresh start I desperately want
And I still can't sleep properly at night. Plus ca change
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blueonwrestling · 2 years
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anyone got a review of Sertraline for depression, anxiety and all that?
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sayrvne · 1 year
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im writing this now because otherwise i will forget. i have a terrible tendancy for needing serious help with my mental health, then getting doctor’s appointments or meetings with my manager at work set up to start it off, then the second it comes to actually Doing the meeting my mind just goes blank of everything that ails me. i need to record how i’m feeling while it’s actually happening so i can relay it to my doctors or boss or whatever bc otherwise i’m like actually i’m normal :)
i really, really need help. i have been spiralling for hours now. on and off, up and down, it gets better then it gets worse again. i need a lot of help in a lot of different places and it will take a long time but i can’t keep going on like this.
first of all i need to talk to the gp, get a doctors appointment and maybe review the meds i’m on. 50mg of sertraline has kept me stable for a while but also life didn’t really throw much shit at me through the middle of 2022, not until winter came about. now that all that has been dumped on me, sertraline is like inflatable armbands while everything else is bricks tied to my legs.
but i need more help than just meds. ideally i need some form of regular counselling or therapy. when i had regular counselling sessions with the psychiatric nurse when i was 18/19, that helped me a lot. i’m open to group therapy too, i know there are a lot of local groups that organise recreational stuff like sport or gardening and shit for mentally ill people. maybe i could find a music group?
similar to that, i need to meet some new people. i feel like i would benefit from more local friends, like a dnd group or something. i feel super isolated because the people who care about me the most live at least a city away, sometimes even a country away. it’s incredibly lonely. the difficulty is that i literally don’t know how to make friends! so this will probably be my biggest challenge of them all.
ideally i need some time off work because that on top of trying to keep my sanity together while also making adjustments and improvements to my life is just Too Fucking Much tbh. i need a real break and not a christmas break where you’re obligated to see 23834 family members and do loads of things, i mean like a break where i can just focus on getting my brain factory reset.
in terms of my physical health, i think i’m on the road to recovery, or at least doing a lot better than i was - in the last couple weeks i was diagnosed with pernicious anaemia which is a hereditary condition that results in a b12 deficiency. that ticks all the boxes for the dizziness, lightheadedness, lethargy and fatigue, the latter two i’ve been experiencing for literally years with no progress.
there was more i wanted to say i think but it’s left my head already. maybe next time i’ll be quick enough to note it all down. though maybe it was for the best
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roisingrasby · 1 day
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Today is sponsored by ...
CW: Mental health and suicide. Today's emotions can be summarised as a mix of defeat and rage. To set the tone, this is not share as a "woe is me" post. This is shared as a "This is the stuff I'm dealing with that I wanted to share with you, so you maybe feel less alone too" type of post. At the start of March I went for a Mental Health Assessment of sorts at my local practice, with the Community Mental Health Team. I was with that person for an hour (along with Dan to offer input if needed) and summarised my mental health as best I could. To do that briefly here, current diagnoses are Depression, Generalised Anxiety Disorder, OCD, Complex PTSD and Borderline Personality Disorder. I have had at least 6 different rounds of therapy, with different therapists, psychologists and psychiatrists, using a variety of methods. I am on my 4th different type of meds - Sertraline. I still struggle on a weekly basis with certain levels of passive suicidal ideation (Passive suicidal ideation is having suicidal thoughts come up, but not making plans/actions to die by suicide or hurt myself) and feel like I'll be working part time for the rest of my life as I kept burning myself out working full time. My drive is low unless it's helping others, which is familiar to a lot of us, right.
I am fed up of talking about myself. I am fed up of the guesswork of meds; are my conditions partly due to a lack of serotonin/dopamine/norepinephrine or not having them get sent to the right places at the right times? I wanted to see if I could be considered for Transcranial direct current stimulation (tDCS), which involves electrical stimulation of the brain by applying a weak direct current to the scalp. It is NOT Electroconvulsive therapy. It's taken me quite a while to build up the courage to request it, and I had to be quite firm with my GP to even be put forward to ask for it. I won't go into my reasons for wanting to try it, but it's safe to say after 22 years of being "officially" depressed, the drugs/therapy/myself is not working. Today I received the call from the assessor that "It's bad news" and after the team reviewed my case, I couldn't be considered for tDCS. That in itself was pretty disappointing, but when I asked them why - again, a bold step for me instead of just sadly going "OK" - they didn't know the reasons, which gives me nothing to work with. I asked them to get that information if possible, because otherwise it's not a very helpful "No". We agreed a follow-up phone call next week to see what alternative next steps I could take at this stage. Whew. So that's the rant over and no doubt I'll feel sheepish and like i could have explained myself better, but I think it's important to post whilst things are fresh (and when things have sunk in and been thought about, but now is not the time).
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existentialmagazine · 3 months
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Review: The alt-rock upcomer Molly Meaker just shared her debut ‘Sertraline’, a hard-hitting narrative beneath a bubbly front
Debuting to a sold out upstairs show at Ronnie Scott's in July 2022 and most recently seen opening for Grammy award winning band Chai, the upcoming alt-rock artist Molly Meaker is now ready to share her first ever single 'Sertraline' alongside a 6-date UK tour either side of the release.
From pressing play, the oddly sugary sound of 'Sertraline' dances through your eardrums with an unexpected level of vibrancy for a song on such intimate themes, an anthem-like journey that turns the lows into the highs. Masking meaning behind tumbling drums, groovy guitar strums and bass twangs, 'Sertraline' pounds with an introductory moment of instrumental charisma and charm, bundling you within its glossy covers for quite the tumultuous ride. Simmering for the verse, steady beats and a subtle bassline join together, allowing Molly’s impressive vocals to take the lead through impressive ranges between sombre tones and airy glides. With a short mid-verse intermission, the instruments once again peak into clashing drums, vigorous strums and backing twangs before settling back into the verses’ chant-along infectiousness. The chorus is simple but addictive, flowing through ‘na na na na na’ vocal hooks and dominating instruments at their most brash. The track feels rather untraditional in format though, never leaving you sure whether you’re amidst an ongoing verse, the choruses high or something in-between, capturing more of a living aspect to the way it chooses to evolve and unfold. Delivering an unexpectedly electrifying guitar solo after the more lulled bridge, 'Sertraline' jumps from modern day swagger to more rock and roll roots, ecentrically showing off in a performance made to both uplift and leave you thinking deeper. Molly also seems to become more confident as the track plays out, sharing lines with an attitude and flair that’s utterly mesmerising, reminiscent of some of the most smashing rock headliners.
The lyrics are just as powerful, with the track named after the antidepressant Sertraline and Molly’s own experience through mental health, as well as recovery. From the opening admission that ‘sertraline’s got me feeling sick’, Molly touches on the common themes of antidepressants causing a period of nausea, caught up in a new experience without anyone to share advice on her solitary journey - instead hoping to help other people in the same situation. Continuing ‘I’m finally getting rather good at it, now I feel like I almost exist’ , Molly seems almost torn on her opinions, half-pessimistic as the drugs haven’t quite brought her back to life but perhaps taken her a step closer to where she once was. It’s almost as though her outlook still continues to be rather down though, lingering on lines like ‘this ship is going down’ that don’t seem to wish for anything to go right, finding security and comfort in the unknowns of depression. She does still acknowledge an unhappiness within this rut however, admitting ‘can’t escape, my mind is suffering’ , feeling trapped within an illness that consumes her every moment of existence. There are moments of clarity however, singing ‘a chemical imbalance I suppose, let’s hope these drugs finally hit’ , in some ways maybe relying too heavily on antidepressants to be a quick fix without acknowledging the causes of her emotions. Everything about ‘Sertraline’ is very back and forth, shifting in moods and working through newfound experiences in ways that feels authentic and raw. For those still finding their way along their own mental health journey, ‘Sertraline’ is a single worth checking out for some comfort in an experience that can be isolating.
Check out ‘Sertraline’ for yourself here to enjoy Molly’s vibrant sound and more important lyrical message beneath.
Written by: Tatiana Whybrow
Photo Credits: Unknown
// This coverage was supported and created via Musosoup, #SustainableCurator.
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thewinstersoldier · 11 months
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We out here working through our depression.
I started sertraline October 2021 and I wanna say I stopped taking it January 2023...but I'm going to start taking it again bc I truly cannot raw dog life like this LMAO
Here is my review! When I first started it, the anxiety was RIPPED from my body, anxiety WHO!?
but along with that came emotional numbness and like I was in a constant haze. I wasn't depressed, I was just existing and I felt nothing.
Once I adjusted I was fine and living my life BUT I was regularly using marijuana so that was interacting with my meds and I DO NOT recommend mixing the two AT ALL. I would smoke bc I wanted to feel emotions again but in turn that gave me crippling anxiety suddenly and paranoia so lmao don't do it it's not worth it bc it took hours to come down from really bad thoughts.
And I rarely drink but when I did drink on those meds they made me feel so so so so bad so also don't rec that.
That being said, I'm doing a clean start this time and not mixing SHIT sooooo stay tuned.
It's true though about the NO FEELINGS, I literally couldn't cry and I did not care about anything which can be a pro and a con depending on the situation.
And the low libido...if you like fckin or whatever then say goodbye cos u can't c*m....I'm ace anyways so that doesn't matter to me but I know for a lot of people that is something that is hard to deal with.
Anygays if anyone has questions about Zoloft I don't mind answering!
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