#li fraumeni syndrome
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Li-Fraumeni Syndrome Cancer Surveillance Strategy Considerations for Glioblastoma Multiforme | Abstract
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Hey, I saw your post about Li-Fraumeni syndrome. I just learned about it today bc my grandmother was diagnosed with it and my mom is absolutely horrified that she might have it and is scheduled to get tested soon. The genealogist isn't actually certain if it's genetic in my grandma's case but doesn't have any other leads, hence my mother getting tested.
If my mother has it, then there's a 50% chance that I could have it. I can't lie, I am devastated and scared shitless. I don't want to die young or continuously battle cancer throughout my life. I'm also scared of the changes I'll have to make to my body in order to survive—like getting a double mastectomy, for instance. (Not that there's anything wrong with people who get or want them btw!! I'm just feminine and genuinely enjoy this part of my body.)
I am so scared and have no idea what to do. I'm sorry for dumping this on you, but do you happen to have any advice for me?
I'm really sorry to hear about that. If I could give you a hug, I would. Cancer is always scary, whether it's a family member or yourself. My mom was already in remission for Lymphoma and Breast Cancer before they discovered the genetic aspect that prompted testing for my siblings and I, and then had a brain tumor removed last year. And even then, my sister was diagnosed with Breast Cancer shortly after coming up negative for Li-Fraumeni, so even that's never a guarantee, I'm afraid.
For my case, I was always afraid regardless that I would get some kind of cancer just because I've had several family members on both sides die from cancer - if I did get it, it'd be caught too late kind of fears. Being diagnosed with Li-Fraumeni just meant that my doctor and I had a genuine reason to get frequent screenings ordered for scheduling. So instead of the every 5 years or as needed that would've been before, I get some form of preventative screening every year (usually an MRI with contrast), along with the surgeries I personally had always wanted regardless without having to argue and find a justification for them. (In that way, I'm in the opposite boat as you; I wanted the surgeries, but am certainly not gonna judge anyone for NOT wanting them.)
And, honestly, that's really the best advice I have for you. If you and your mother do come up positive, though I certainly hope not, then don't treat it as a guarantee that you'll get cancer and die from it, but as a reason for you and your doctor to work together to get those frequent early screenings scheduled to catch anything that does start to grow before it goes out of control. And if your doctor isn't willing to help you with that, then you find a different doctor who will. Even if you come up negative for the genetic test, if you one day feel something is wrong with your body, you fight for yourself to get whatever tests are needed to find the reason why. My mom's Lymphoma almost didn't get caught in time because her old doctor kept saying it was her diabetes or her weight that was keeping her from keeping any food down for weeks, if not months. Getting that second opinion and the tests saved her life. I hate to think of that happening to anyone else, but unfortunately it does happen pretty frequently for some people.
I rambled a bit here, but that's truly the best I can offer. Regardless of whether the tests come up positive or negative, just listen to your body if something starts to feel wrong, and find a doctor who will then listen to you and work with you to keep you healthy, in whatever way that means to you.
My best to you and your family. I really do hope you get good news, and have a wonderful year.
#cancer#li-fraumeni syndrome#li-fraumeni#Nari answers#anon#I really hope you find this response anon
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Holidays 3.20
Holidays
Alien Abduction Day
American Diabetes Association Alert Day
Atheist Pride Day [also 6.20]
Bibliomania Day
Big Bird Day
Chicka Chicka Boom Boom Day
Culture Day and Creative Intelligentsia Day (Tajikistan)
Dibber Day (French Republic)
Dogs in Yellow Day
Durham Day (UK)
Extraterrestrial Abductions Day
Festival of Extraterrestrial Abductions
French Language Day (a.k.a. International Francophonie Day; UN)
Ghode Jatra (Horse Festival; Nepal)
Global Message Makes Me Happy & Healthy Day
Great British Spring Clean Day (UK)
Hufflepuff Pride Day
International Astrology Day
International Day of Happiness (UN)
International Francophonie Day
Kiss Your Fiancé Day
Lajos Kossuth Day (Hungary)
Legba Zaou (Haiti)
Li-Fraumeni Syndrome Awareness Day
Macaron Day NYC
Mesopotamian/Sumerian Grain Festival (Honoring Ashnan)
Minion Day (Japan)
Mister Rogers Day
National Arts Advocacy Day
National Backyard Bird Photography Day
National Cherry Blossom Festival begins (Washington DC)
National Day of Italian Universities Day (Italy)
National Native HIV/AIDS Awareness Day
National Jump Out! Day
National Marketing Day
National Plagiocephaly & Torticollis Awareness Day
National Vanessa Day
National Westie Day
Oil Nationalization Day (Iran)
Pigeons Return to City-County Building (Ft. Wayne, Indiana)
P320 Day
Smile Rejuvenation Day
Very Hungary Caterpillar Day
Won't You Be My Neighbor? Day
Won’t You Wear a Sweater Day
World Behavior Analysis Day
World Day of Theater for Children and Young People
World Frog Day
World Head Injury Awareness Day
World NIDCAP Day
World Oral Health Day
World Rewinding Day
World Rights to Water Day
World Sparrow Day
Zipper Day
Food & Drink Celebrations
Bock Beer Day (New York) [also 2nd Monday]
Crawfish Cravers Awareness Day
Macaron Day
National Ravioli Day
World Flour Day
3rd Wednesday in March
Engineer’s Day (Belgium; Netherlands) [3rd Wednesday]
Kick Butts Day [3rd Wednesday]
National Carry Out Day (a.k.a. Carry Out Wednesday) [3rd Wednesday]
National Dietician’s Day (Canada) [3rd Wednesday]
National SBDC Day [3rd Wednesday]
Small Business Development Day [3rd Wednesday]
Independence & Related Days
Blackland (a.k.a. Kingdom of Blackland; Declared; 2015) [unrecognized]
Conzorica (a.k.a. Federal Republics of Conzorica; Declared; 2014)
Kirkuk Liberation Day (Iraqi Kurdistan)
Otango Province Anniversary (New Zealand)
Qootärlænt (Declared; 2008) [unrecognized]
Rezaxia (Declared; 2020) [unrecognized]
Tunisia (from France, 1956)
New Year’s Days
Baha’i New Year
Nowruz (New Year) [Day 1, Around Spring Equinox] (a.k.a. ...
Bahá'í Naw-Rúz (Bahá'í)
Naruz (Afghan New Year)
Navruz (Tajikistan, Ukbekistan)
Norooz (Iran)
Novruz Bairam (a.k.a. Persian New Year; Azerbaijan)
Nowrūz (Persian, Gilaki, Kurdish, Zoroastrians; California)
Rosicrucian New Year
Festivals Beginning March 20, 2024
Jazz & Rhythms Festival (San Cristóbal de las Casas, Mexico) [thru 3.24]
Melbourne International Flower & Garden Show (Melbourne, Australia) [thru 3.24]
National Cherry Blossom Festival (Washington, DC) [thru 4.14]
Trans-Siberian Art Festival (Novosibirsk, Russia) [thru 4.7]
Feast Days
Alexandra (Christian; Saint)
Apple Magic Day (For Norse Goddess Idunn; Starza Pagan Book of Days)
Big Bird (Muppetism)
Blessed John of Parma (Christian; Saint)
Clement of Ireland (Christian; Saint)
Cuthbert of Lindisfarne (Christian; Saint) [maltsters]
Day Sacred to the Goddess Fortuna, the Morrigan, the Norns, the Three Fates, and the Three Mothers (Lakshmi, Parvati, and Sarasvati)
Edward Poynter (Artology)
Extraterrestrial Abductions Day (Pastafarian)
Feast of the Supreme Ritual (Thelema)
Festival For Driving Out All Evils (Inca)
Festival of Isis (Ancient Egypt)
George Caleb Bingham (Artology)
Henrik Ibsen (Writerism)
Herbert of Derwentwater (Christian; Saint)
John Lavery (Artology)
John of Nepomuk (Christian; Saint)
Józef Bilczewski (Christian; Saint)
María Josefa Sancho de Guerra (Christian; Saint)
Martin of Braga (Christian; Saint)
The Martyrs of Mar Saba (Christian; Martyrs)
Michele Carcano (Christian; Saint)
Philo of Alexandria (Positivist; Saint)
Photina and Her Companions (Christian; Martyrs)
Quinquatria, Day 2: Wrestling Day (Pagan)
Spring Harvest Festival (Ancient Egypt; Everyday Wicca)
Wulfram (Christian; Saint)
Xena Day (Church of the SubGenius; Saint)
Zagmuk (Festival celebrating the Resurrection of Marduk)
Lucky & Unlucky Days
Prime Number Day: 79 [22 of 72]
Shakku (赤口 Japan) [Bad luck all day, except at noon.]
Very Unlucky Day (Grafton’s Manual of 1565) [17 of 60]
Premieres
After Hours, by The Weekend (Album; 2020)
Armchair Apocrypha, by Andrew Bird (Album; 2007)
Avalanche is Better None or Snows You Old Man (Rocky & Bullwinkle Cartoon, S1, Ep. 33; 1960)
Back Off Boogaloo, recorded by Ringo Starr (Song; 1972)
Basic Instinct (Film; 1992)
Below Zero Heroes or I Only Have Ice for You (Rocky & Bullwinkle Cartoon, S1, Ep. 34; 1960)
The Book of Thoth (Egyptian Tarot), by Aleister Crowley (Tarot Book; 1944)
Bosko’s Easter Eggs (Happy Harmonies Cartoon; 1937)
Both Sides Now, by Joni Mitchell (Album; 2000)
Cannibal Capers (Disney Silly Symphony Cartoon; 1930)
The Cats Bah (WB LT Cartoon; 1954)
Dumb-Hounded (Droopy MGM Cartoon; 1943)
Duplicity (Film; 2009)
Fractured Friendship (Chilly Willy & Woody Woodpecker Cartoon; 1965)
Hollywood Shuffle (Film; 1987)
Hothouse, by Brian W. Aldiss (Novel; 1962)
I Do Not Want What I Haven’t Got, by Sinead O’Connor (Album; 1990)
I Love You, Man (Film; 2009)
The Impossible Possum, featuring Barney Bear (MGM Cartoon; 1954)
Insurgent (Film; 2015)
Knowing (Film; 2009)
Lady Chatterly’s Lover, by D.H. Lawrence (Novel; 1928)
Man of La Mancha (Broadway Musical; 1965)
Meet the Temptations, by The Temptations (Album; 1964)
Neptune Nonsense (Rainbow Parade Cartoon; 1936)
Newman Laugh-O-Grams (Disney Cartoon; 1921)
Noises Off (Film; 1992)
Off to China (Terrytoons Cartoon; 1936)
The Pink Panther (Film; 1964)
The Postman Always Rings Twice (Film; 1981)
The Romance of Betty Boop (Animated TV Film; 1985)
The Scarlet Letter, by Nathaniel Hawthorne (Novel; 1850)
Sham Battle Shenanigans (Terrytoons Cartoon; 1942)
Straight, No Chaser, by Thelonious Monk (Album; 1967)
Symphony Hour (Disney Cartoon; 1942)
Top Cat and the Beverly Hills Cats (Hanna-Barbera Animated TV Film; 1988)
Uncle Tom’s Cabin, by Harriet Beecher Stowe (Novel; 1857)
Wacky Quacky (Phantasies Cartoon; 1947)
What Price Fleadom (MGM Cartoon; 1948)
Wild Things (Film; 1998)
Ye Olde Songs, featuring Farmer Al Falfa (Terrytoons Cartoon; 1932)
Zen in the Art of Archery, by Eugen Herrigel (Philosophy Book; 1948)
Zombeavers (Film; 2015)
Today’s Name Days
Claudia, Wolfram (Austria)
Ivan, Nicet, Pavao (Croatia)
Světlana (Czech Republic)
Gordius (Denmark)
Malve, Malvi, Malviine (Estonia)
Aki, Jaakkima, Joakim, Jooa, Kim, Kimi (Finland)
Herbert, Printemps (France)
Claudia, Wolfram (Germany)
Claudia, Rodi, Rodianos (Greece)
Klaudia (Hungary)
Alessandra,, Claudia (Italy)
Irbe, Made, Magda, Magdalēna (Latvia)
Filomenas, Imgarda, Irma, Tautvilė, Žygimantas (Lithuania)
Joakim, Kim (Norway)
Aleksander, Aleksandra, Ambroży, Anatol, Bogusław, Cyriaka, Eufemia, Klaudia, Patrycjusz, Ruprecht, Wasyl, Wincenty (Poland)
Víťazoslav (Slovakia)
Alejandra, Daniel, Martín (Spain)
Joakim, Kim (Sweden)
Dillan, Dillion, Dillon, Drew, Dru, Dylan, Dylon (USA)
Today is Also…
Day of Year: Day 80 of 2024; 286 days remaining in the year
ISO: Day 3 of week 12 of 2024
Celtic Tree Calendar: Fearn (Alder) [Day 4 of 28]
Chinese: Month 2 (Ding-Mao), Day 11 (Guy-Wei)
Chinese Year of the: Dragon 4722 (until January 29, 2025)
Hebrew: 10 Adair II 5784
Islamic: 10 Ramadan 1445
J Cal: 20 Green; Sixday [20 of 30]
Julian: 7 March 2024
Moon: 82%: Waxing Gibbous
Positivist: 24 Aristotle (3rd Month) [John the Evangelist]
Runic Half Month: Beore (Birch Tree) [Day 11 of 15]
Season: Spring (Day 2 of 92)
Week: 3rd Week of March
Zodiac: Pisces (Day 31 of 31)
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Unraveling the Mysteries of Brain Tumor Causes: Insights from Dr. Himanshu Gupta, Brain Tumor Surgeon in Jaipur
Introduction
Brain tumors are complex and often mysterious conditions that can have significant impacts on individuals' lives. Understanding the causes of brain tumors is essential for effective prevention and treatment strategies. In this comprehensive guide, we will delve into the various factors that contribute to the development of brain tumors, as well as explore insights provided by Dr. Himanshu Gupta, a renowned Brain Tumor Surgeon in Jaipur.
Understanding Brain Tumor Causes
Genetic Predisposition: Some individuals may inherit genetic mutations that predispose them to develop brain tumors. Conditions such as neurofibromatosis, Li-Fraumeni syndrome, and tuberous sclerosis are associated with an increased risk of brain tumor development. Dr. Himanshu Gupta emphasizes the importance of genetic counseling and screening for individuals with a family history of these conditions.
Exposure to Radiation: Exposure to ionizing radiation, whether through medical treatments like radiation therapy or environmental factors, can increase the risk of brain tumor formation. Dr. Himanshu Gupta highlights the significance of minimizing unnecessary radiation exposure and following safety protocols during radiation therapy to mitigate this risk.
Age: While brain tumors can occur at any age, certain types are more common in specific age groups. Gliomas, for example, are more prevalent in adults, whereas medulloblastomas are more commonly diagnosed in children. Dr. Himanshu Gupta stresses the importance of age-appropriate screening and early detection strategies.
Environmental Factors: Prolonged exposure to certain environmental toxins and chemicals may contribute to the development of brain tumors. Occupational exposure to substances like vinyl chloride and formaldehyde has been linked to an increased risk. Dr. Himanshu Gupta advises individuals to minimize exposure to such chemicals and follow safety guidelines in the workplace.
Prevention Strategies
Regular Health Screenings: Routine health check-ups and screenings can help detect any underlying health conditions, including brain tumors, at an early stage. Dr. Himanshu Gupta emphasizes the importance of regular screenings, especially for individuals with a family history of brain tumors or other predisposing factors.
Healthy Lifestyle Choices: Adopting a healthy lifestyle, including a balanced diet, regular exercise, and adequate sleep, can help reduce the risk of developing brain tumors. Dr. Himanshu Gupta recommends maintaining a healthy weight, avoiding tobacco and excessive alcohol consumption, and managing stress levels.
Occupational Safety: Individuals working in industries with potential exposure to carcinogenic chemicals should follow safety protocols to minimize the risk of brain tumor development. Dr. Himanshu Gupta emphasizes the importance of workplace safety measures and regular health monitoring for at-risk individuals.
Limiting Radiation Exposure: Minimizing unnecessary exposure to ionizing radiation is crucial for reducing the risk of brain tumors. Dr. Himanshu Gupta advises healthcare providers to use alternative imaging techniques whenever possible and to adhere to established safety guidelines for radiation therapy.
Conclusion
Understanding the causes of brain tumors and implementing effective prevention strategies are essential for reducing the burden of this disease. With insights from Dr. Himanshu Gupta, a leading Brain Tumor Surgeon in Jaipur, individuals can take proactive steps to protect their brain health and overall well-being. By raising awareness, promoting healthy lifestyles, and advocating for early detection, we can work towards a future with fewer cases of brain tumors and improved outcomes for affected individuals.
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Holidays 3.20
Holidays
Alien Abduction Day
American Diabetes Association Alert Day
Atheist Pride Day [also 6.20]
Bibliomania Day
Big Bird Day
Chicka Chicka Boom Boom Day
Culture Day and Creative Intelligentsia Day (Tajikistan)
Dibber Day (French Republic)
Dogs in Yellow Day
Durham Day (UK)
Extraterrestrial Abductions Day
Festival of Extraterrestrial Abductions
French Language Day (a.k.a. International Francophonie Day; UN)
Ghode Jatra (Horse Festival; Nepal)
Global Message Makes Me Happy & Healthy Day
Great British Spring Clean Day (UK)
Hufflepuff Pride Day
International Astrology Day
International Day of Happiness (UN)
International Francophonie Day
Kiss Your Fiancé Day
Lajos Kossuth Day (Hungary)
Legba Zaou (Haiti)
Li-Fraumeni Syndrome Awareness Day
Macaron Day NYC
Mesopotamian/Sumerian Grain Festival (Honoring Ashnan)
Minion Day (Japan)
Mister Rogers Day
National Arts Advocacy Day
National Backyard Bird Photography Day
National Cherry Blossom Festival begins (Washington DC)
National Day of Italian Universities Day (Italy)
National Native HIV/AIDS Awareness Day
National Jump Out! Day
National Marketing Day
National Plagiocephaly & Torticollis Awareness Day
National Vanessa Day
National Westie Day
Oil Nationalization Day (Iran)
Pigeons Return to City-County Building (Ft. Wayne, Indiana)
P320 Day
Smile Rejuvenation Day
Very Hungary Caterpillar Day
Won't You Be My Neighbor? Day
Won’t You Wear a Sweater Day
World Behavior Analysis Day
World Day of Theater for Children and Young People
World Frog Day
World Head Injury Awareness Day
World NIDCAP Day
World Oral Health Day
World Rewinding Day
World Rights to Water Day
World Sparrow Day
Zipper Day
Food & Drink Celebrations
Bock Beer Day (New York) [also 2nd Monday]
Crawfish Cravers Awareness Day
Macaron Day
National Ravioli Day
World Flour Day
3rd Wednesday in March
Engineer’s Day (Belgium; Netherlands) [3rd Wednesday]
Kick Butts Day [3rd Wednesday]
National Carry Out Day (a.k.a. Carry Out Wednesday) [3rd Wednesday]
National Dietician’s Day (Canada) [3rd Wednesday]
National SBDC Day [3rd Wednesday]
Small Business Development Day [3rd Wednesday]
Independence & Related Days
Blackland (a.k.a. Kingdom of Blackland; Declared; 2015) [unrecognized]
Conzorica (a.k.a. Federal Republics of Conzorica; Declared; 2014)
Kirkuk Liberation Day (Iraqi Kurdistan)
Otango Province Anniversary (New Zealand)
Qootärlænt (Declared; 2008) [unrecognized]
Rezaxia (Declared; 2020) [unrecognized]
Tunisia (from France, 1956)
New Year’s Days
Baha’i New Year
Nowruz (New Year) [Day 1, Around Spring Equinox] (a.k.a. ...
Bahá'í Naw-Rúz (Bahá'í)
Naruz (Afghan New Year)
Navruz (Tajikistan, Ukbekistan)
Norooz (Iran)
Novruz Bairam (a.k.a. Persian New Year; Azerbaijan)
Nowrūz (Persian, Gilaki, Kurdish, Zoroastrians; California)
Rosicrucian New Year
Festivals Beginning March 20, 2024
Jazz & Rhythms Festival (San Cristóbal de las Casas, Mexico) [thru 3.24]
Melbourne International Flower & Garden Show (Melbourne, Australia) [thru 3.24]
National Cherry Blossom Festival (Washington, DC) [thru 4.14]
Trans-Siberian Art Festival (Novosibirsk, Russia) [thru 4.7]
Feast Days
Alexandra (Christian; Saint)
Apple Magic Day (For Norse Goddess Idunn; Starza Pagan Book of Days)
Big Bird (Muppetism)
Blessed John of Parma (Christian; Saint)
Clement of Ireland (Christian; Saint)
Cuthbert of Lindisfarne (Christian; Saint) [maltsters]
Day Sacred to the Goddess Fortuna, the Morrigan, the Norns, the Three Fates, and the Three Mothers (Lakshmi, Parvati, and Sarasvati)
Edward Poynter (Artology)
Extraterrestrial Abductions Day (Pastafarian)
Feast of the Supreme Ritual (Thelema)
Festival For Driving Out All Evils (Inca)
Festival of Isis (Ancient Egypt)
George Caleb Bingham (Artology)
Henrik Ibsen (Writerism)
Herbert of Derwentwater (Christian; Saint)
John Lavery (Artology)
John of Nepomuk (Christian; Saint)
Józef Bilczewski (Christian; Saint)
María Josefa Sancho de Guerra (Christian; Saint)
Martin of Braga (Christian; Saint)
The Martyrs of Mar Saba (Christian; Martyrs)
Michele Carcano (Christian; Saint)
Philo of Alexandria (Positivist; Saint)
Photina and Her Companions (Christian; Martyrs)
Quinquatria, Day 2: Wrestling Day (Pagan)
Spring Harvest Festival (Ancient Egypt; Everyday Wicca)
Wulfram (Christian; Saint)
Xena Day (Church of the SubGenius; Saint)
Zagmuk (Festival celebrating the Resurrection of Marduk)
Lucky & Unlucky Days
Prime Number Day: 79 [22 of 72]
Shakku (赤口 Japan) [Bad luck all day, except at noon.]
Very Unlucky Day (Grafton’s Manual of 1565) [17 of 60]
Premieres
After Hours, by The Weekend (Album; 2020)
Armchair Apocrypha, by Andrew Bird (Album; 2007)
Avalanche is Better None or Snows You Old Man (Rocky & Bullwinkle Cartoon, S1, Ep. 33; 1960)
Back Off Boogaloo, recorded by Ringo Starr (Song; 1972)
Basic Instinct (Film; 1992)
Below Zero Heroes or I Only Have Ice for You (Rocky & Bullwinkle Cartoon, S1, Ep. 34; 1960)
The Book of Thoth (Egyptian Tarot), by Aleister Crowley (Tarot Book; 1944)
Bosko’s Easter Eggs (Happy Harmonies Cartoon; 1937)
Both Sides Now, by Joni Mitchell (Album; 2000)
Cannibal Capers (Disney Silly Symphony Cartoon; 1930)
The Cats Bah (WB LT Cartoon; 1954)
Dumb-Hounded (Droopy MGM Cartoon; 1943)
Duplicity (Film; 2009)
Fractured Friendship (Chilly Willy & Woody Woodpecker Cartoon; 1965)
Hollywood Shuffle (Film; 1987)
Hothouse, by Brian W. Aldiss (Novel; 1962)
I Do Not Want What I Haven’t Got, by Sinead O’Connor (Album; 1990)
I Love You, Man (Film; 2009)
The Impossible Possum, featuring Barney Bear (MGM Cartoon; 1954)
Insurgent (Film; 2015)
Knowing (Film; 2009)
Lady Chatterly’s Lover, by D.H. Lawrence (Novel; 1928)
Man of La Mancha (Broadway Musical; 1965)
Meet the Temptations, by The Temptations (Album; 1964)
Neptune Nonsense (Rainbow Parade Cartoon; 1936)
Newman Laugh-O-Grams (Disney Cartoon; 1921)
Noises Off (Film; 1992)
Off to China (Terrytoons Cartoon; 1936)
The Pink Panther (Film; 1964)
The Postman Always Rings Twice (Film; 1981)
The Romance of Betty Boop (Animated TV Film; 1985)
The Scarlet Letter, by Nathaniel Hawthorne (Novel; 1850)
Sham Battle Shenanigans (Terrytoons Cartoon; 1942)
Straight, No Chaser, by Thelonious Monk (Album; 1967)
Symphony Hour (Disney Cartoon; 1942)
Top Cat and the Beverly Hills Cats (Hanna-Barbera Animated TV Film; 1988)
Uncle Tom’s Cabin, by Harriet Beecher Stowe (Novel; 1857)
Wacky Quacky (Phantasies Cartoon; 1947)
What Price Fleadom (MGM Cartoon; 1948)
Wild Things (Film; 1998)
Ye Olde Songs, featuring Farmer Al Falfa (Terrytoons Cartoon; 1932)
Zen in the Art of Archery, by Eugen Herrigel (Philosophy Book; 1948)
Zombeavers (Film; 2015)
Today’s Name Days
Claudia, Wolfram (Austria)
Ivan, Nicet, Pavao (Croatia)
Světlana (Czech Republic)
Gordius (Denmark)
Malve, Malvi, Malviine (Estonia)
Aki, Jaakkima, Joakim, Jooa, Kim, Kimi (Finland)
Herbert, Printemps (France)
Claudia, Wolfram (Germany)
Claudia, Rodi, Rodianos (Greece)
Klaudia (Hungary)
Alessandra,, Claudia (Italy)
Irbe, Made, Magda, Magdalēna (Latvia)
Filomenas, Imgarda, Irma, Tautvilė, Žygimantas (Lithuania)
Joakim, Kim (Norway)
Aleksander, Aleksandra, Ambroży, Anatol, Bogusław, Cyriaka, Eufemia, Klaudia, Patrycjusz, Ruprecht, Wasyl, Wincenty (Poland)
Víťazoslav (Slovakia)
Alejandra, Daniel, Martín (Spain)
Joakim, Kim (Sweden)
Dillan, Dillion, Dillon, Drew, Dru, Dylan, Dylon (USA)
Today is Also…
Day of Year: Day 80 of 2024; 286 days remaining in the year
ISO: Day 3 of week 12 of 2024
Celtic Tree Calendar: Fearn (Alder) [Day 4 of 28]
Chinese: Month 2 (Ding-Mao), Day 11 (Guy-Wei)
Chinese Year of the: Dragon 4722 (until January 29, 2025)
Hebrew: 10 Adair II 5784
Islamic: 10 Ramadan 1445
J Cal: 20 Green; Sixday [20 of 30]
Julian: 7 March 2024
Moon: 82%: Waxing Gibbous
Positivist: 24 Aristotle (3rd Month) [John the Evangelist]
Runic Half Month: Beore (Birch Tree) [Day 11 of 15]
Season: Spring (Day 2 of 92)
Week: 3rd Week of March
Zodiac: Pisces (Day 31 of 31)
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Victor McKusick, “Mendelian Inheritance in Man”, 1966, Chromosome #17.
Here I present: Victor McKusick, “Mendelian Inheritance in Man”, 1966, Chromosome #17. Selected traits of chromosome #17 are listed BELOW.
Canavan disease.
Ovarian cancer.
Miller-Dieker syndrome.
Retinitis pigmentosa.
Tumor protein.
Colorectal cancer.
Li-Fraumeni syndrome.
Cystinosis, nephropathic.
Diabetes mellitus, noninsulin-dependent.
Cone dystrophy.
Myasthenic syndrome.
Deafness,…
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The common types of hereditary cancer syndromes include:
1. Inherited Breast and Ovarian Cancer Syndrome (HBOC): HBOC primarily stems from mutations within the BRCA1 and BRCA2 genes. Females carrying these genetic alterations face notably heightened risks of breast and ovarian malignancies. Furthermore, BRCA mutations correlate with elevated susceptibilities to other cancers, such as prostate, pancreatic, and male breast cancer.
2. Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer, HNPCC): Lynch syndrome arises from mutations affecting genes responsible for DNA mismatch repair, notably MLH1, MSH2, MSH6, and PMS2. Those with Lynch syndrome exhibit increased predispositions to colorectal cancer, alongside risks of endometrial, ovarian, gastric, and urinary tract cancers.
3. Familial Adenomatous Polyposis (FAP): FAP manifests with the proliferation of numerous polyps within the colon and rectum, which pose a cancer risk if untreated. Primarily linked to mutations in the APC gene, FAP substantially heightens the likelihood of early-onset colorectal cancer.
4. Li-Fraumeni Syndrome (LFS): LFS, a rare hereditary cancer syndrome, arises from mutations in the TP53 tumor suppressor gene. Individuals with LFS confront elevated lifetime risks of various cancers, including breast cancer, sarcomas, brain tumors, and adrenal gland tumors, often occurring at a young age.
5. Hereditary Diffuse Gastric Cancer (HDGC): HDGC entails an escalated susceptibility to diffuse gastric cancer, characterized by infiltration of the stomach wall. This predisposition predominantly results from mutations in the CDH1 gene, which encodes a protein crucial for cell adhesion.
6. Cowden Syndrome (CS): CS stems from mutations in the PTEN gene and is typified by multiple noncancerous hamartomas, alongside heightened risks of developing diverse cancers, such as breast, thyroid, and endometrial cancers.
7. Hereditary Retinoblastoma (RB1): Hereditary retinoblastoma arises from mutations in the RB1 gene, leading to the formation of cancerous tumors in the retina, typically emerging in early childhood.
8. Von Hippel-Lindau Syndrome (VHL): VHL arises from mutations in the VHL gene and is characterized by the development of tumors and cysts in various organs, including the kidneys, adrenal glands, pancreas, and central nervous system.
If you have a family history of cancer, you should undergo regular cancer screenings for the early detection and management of cancer. You can undergo a regular full body health checkup at Jaslok Hospital Mumbai, which is one of the best hospitals in Mumbai for cancer screening and treatment.
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CJ, throwing you the biggest distraction I can think of. Please explain to me p53 role in cancer 😭 I watch signaling pathway everything!!! Go!!
The TP53 gene is a tumour suppressor gene so it stops the development of tumours. If a person only inherits one functional copy of the gene, their risk of developing multiple cancers in their lifetime is higher (Li-Fraumeni syndrome, it’s rare). More commonly, mutations in the gene are what lead to the development of cancers.
This gene is found on chromosome 17 and provides instructions to make the protein P53. This protein remains in the nucleus of cells and it binds directly to DNA. When DNA becomes damaged, P53 plays a role in determining whether the damaged DNA can be repaired. If it can be repaired, the proper genes will be activated to fix it. If it can’t, P53 will prevent the DNA from undergoing replication and trigger apoptosis (programmed cell death). This stops the damaged DNA from mutating and dividing further.
If P53 is damaged, missing, or suppressed, there is a chance this tumour checkpoint can be missed. In that case, it is much more likely that damaged DNA can “get through” and pass through replication and transcription into RNA and further mutate into cancer.
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TP53 Mutation in Breast Cancer
The TP53 gene:
Is a key tumor-suppressor gene that acts as a checkpoint control for DNA damage
Due to its critical role in controlling cellular damage:
A TP53 germline mutation predisposes patients to multiple malignancies, including breast cancer and soft tissue sarcomas:
The associated familial syndrome was first observed in 1969 and is known as the Li-Fraumeni syndrome
The penetrance of…
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Leukemia in Children
Introduction
Leukemia in children presents a formidable challenge, demanding meticulous management and treatment. This detailed discussion aims to devolve into various facets of childhood leukemia, encompassing its definition, types, causes, risk factors, symptoms, diagnosis, treatment modalities, potential complications, preventive measures, and strategies for supporting a child living with leukemia.
Understanding Leukemia in Children
1. Definition
Leukemia is a hematological malignancy affecting the blood and bone marrow. Its prominence in childhood stems from the rapid proliferation of abnormal blood cells, disrupting the delicate balance within the body.
2. Types of Blood Cells
Understanding the roles of
Red blood cells (erythrocytes),
2.platelets (thrombocytes), and
3.white blood cells (leukocytes)
Is fundamental. An imbalance in these cells results in a spectrum of symptoms, from anemia to increased infection susceptibility.
3. Types of Leukemia
. Acute Lymphocytic Leukemia (ALL): Predominant in children.
Acute Myelogenous Leukemia (AML): The second most common type.
Hybrid or Mixed Lineage Leukemia: A rare amalgamation of ALL and AML.
Chronic Myelogenous Leukemia (CML): Uncommon in children.
Chronic Lymphocytic Leukemia (CLL): Extremely rare in pediatric cases.
Juvenile Myelomonocytic Leukemia (JMML): A rare type with unique growth characteristics.
Causes and Risk Factors
1. Causes
The exact etiology of childhood leukemia remains elusive. Genetic mutations in bone marrow cell genes may occur sporadically or, in some instances, be inherited.
2. Risk Factors
Exposure to Radiation.
Particularly high levels.
Inherited Syndromes.
Down syndrome.
Li-Fraumeni syndrome.
Immune System Conditions.
Inherited disorders affecting immune function.
Family History.
Having a sibling with leukemia elevates the risk.
Symptoms of Leukemia in Children
A diverse array of symptoms underscores leukemia’s impact on children, including;
.Pale skin
. Fatigue
.Dizziness
.Headaches
.Shortness of breath
.Frequent infections
.Fever
. Easy bruising
.Bleeding
.Bone or Joint pain, and
.Abdominal swelling.
Diagnosis:
1. Procedures:
.Blood Tests (Complete Blood Count — CBC): Essential for initial assessment.
Bone Marrow Aspiration or Biopsy: Crucial in detecting leukemia cells.
Lab Tests: Precisely determine leukemia type.
Diagnostic Imaging: X-rays, ultrasound,
lymph node biopsy, and
Lumbar puncture offer a comprehensive diagnostic perspective.
2. Classification
Unlike other cancers, leukemia is not staged but rather classified into groups, subtypes, or both based on type and specific characteristics, aiding in targeted treatment approaches.
Treatment Options:
1. Primary Treatments:
Blood Transfusions: Address low blood counts, bleeding, or infections.
Chemotherapy: The mainstay, killing or inhibiting cancer cells.
Radiation Therapy: High-energy X-rays to target and eradicate cancer cells.
Stem Cell Transplant: Involves high-dose chemotherapy followed by stem cell replacement.
Targeted Therapy: Specific medications tailored to combat certain types of leukemia.
Immunotherapy: Enhances the body’s immune system to combat cancer cells.
Complications:
1. Short-term:
Serious Infections: Resulting from compromised immune function.
Severe Bleeding: A consequence of low platelet levels.
Thickened Blood: Accumulation of leukemia cells in the bloodstream.
2. Long-term:
Leukemia Recurrence: A persistent concern.
Development of Other Cancers: A potential consequence of treatment.
Heart and Lung Problems: Arising from the impact of leukemia or its treatment.
Learning Issues and Growth Delays: Impacts on cognitive development and physical growth.
Fertility Problems and Bone Issues: Osteoporosis as a potential long-term complication.
Prevention:
Preventing childhood leukemia remains challenging, with a focus on caution regarding unnecessary exposure to radiation, especially in diagnostic procedures involving pregnant women and children.
Supporting a Child with Leukemia:
1. Ongoing Care:
Regular visits to oncologists and healthcare providers are crucial for monitoring and addressing emerging issues.
2. Balanced Lifestyle:
Managing eating difficulties and encouraging appropriate exercise play a vital role in supporting overall health.
3. Emotional Support:
Seeking counseling or participating in support groups helps both the child and their family navigate the emotional challenges associated with leukemia.
4. Follow-up Appointments:
Attending all scheduled appointments ensures continuous monitoring and timely intervention if complications arise.
When to Contact Healthcare Provider:
Prompt communication with healthcare providers is essential if the child experiences fever, worsening symptoms, new symptoms, or side effects from treatment.
Key Points Summary:
Leukemia necessitates a comprehensive approach, involving diagnosis, tailored treatment, and ongoing monitoring.
Varied symptoms demand timely medical attention for an optimal prognosis.
Treatment modalities, including chemotherapy and stem cell transplant, are tailored to the specific leukemia type.
Complications, both short-term and long-term, underscore the importance of ongoing follow-up care.
Prevention is limited, with a focus on minimizing unnecessary radiation exposure.
Comprehensive support, encompassing medical, emotional, and lifestyle aspects, is essential for the child’s well-being.
Next Steps:
1. Follow-up Care:
Continued regular check-ups and imaging tests remain integral to post-treatment monitoring.
2. Communication:
Maintaining open and transparent communication with healthcare providers ensures timely intervention if issues arise.
3. Research:
Inquiring about ongoing clinical trials or new treatments enables families to stay informed about emerging possibilities.
Conclusion:
Childhood leukemia mandates a collaborative effort from medical professionals, caregivers, and support networks to optimize outcomes and enhance the quality of life for affected children. As the landscape of pediatric oncology evolves, the commitment to advancing treatment options and minimizing the impact of complications remains paramount, offering hope for a brighter future for children navigating the complexities of leukemia.
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Li-Fraumeni Syndrome Cancer Surveillance Strategy Considerations for Glioblastoma Multiforme
An-Phuc Ta1iD*, Megan Hsu1iD*, Satori Iwamoto1
1California Northstate University College of Medicine, USA
Corresponding Author: An-Phuc Ta ORCID iD and Megan Hsu ORCID iD
Address: College of Medicine, California Northstate University, 9700 West Taron Drive, Elk Grove, California 95757, USA.
Received date: 03 November 2023; Accepted date: 24 November 2023; Published date: 30 November…
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Adrenocortical Carcinoma - An Overview
There are over 200 types of cancer. Breast, prostate, and bowel cancers are the most common, while kidney, skin, and pancreatic cancer are less common. Then there are the rare cancers, like adrenocortical carcinoma (ACC). Also known as cancer of the adrenal cortex, ACC is a tumor that develops on the outer layer of the adrenal gland. Only one in one million people has it, and it’s more prevalent among women than men.
Adrenal glands are the triangle-shaped organs that sit on top of each kidney and produce hormones that give the body feminine or masculine features. They also help balance blood pressure and water and salt in the cells. As such, the growth of a tumor in the adrenal gland impairs the gland’s ability to regulate key bodily functions.
An ACC tumor may be functioning or non-functioning. A functioning ACC tumor causes the overproduction of hormones like testosterone, cortisol, or estrogen. A non-functioning ACC tumor does not impair hormone production.
Due to the nature of the hormones impacted by functioning ACC tumors, ACC affects men and women differently. Overproduction of testosterone in women, for instance, may cause acne, no menstrual periods, balding, and hair growth on the face. Too much estrogen in men may lead to impotence, lower sex drive, and enlarged breasts. Overproduction of cortisol may lead to high blood sugar, weight gain, or high blood pressure.
Half the time, ACC is genetic. People with close relatives who have ACC run the risk of developing it. Hereditary conditions associated with ACC include Li-Fraumeni syndrome, which impairs the TP53 gene responsible for suppressing tumors. Beckwith-Wiedemann syndrome (BWS) is a growth disorder at birth that causes abnormally large body parts.
Because of ACC’s impact on blood sugar levels, urine and blood tests may be used to diagnose it. Imaging studies, such as CT (computed tomography) scan or MRI (magnetic resonance imaging), may also be used. Adrenal angiography or adrenal venography may be conducted to monitor blood flow near the adrenal arteries and veins. A biopsy may also be done, which involves extracting a small tissue and studying it under a microscope.
Certain factors determine treatment options and chances of recovery (prognosis). Factors such as organs affected, whether the cancer has been treated in the past, the patient’s general health, and cancer stage to determine the mode of treatment. Stage I ACC may be treated by removing one or both adrenal glands, while Stage IV may be treated through radiation therapy, chemotherapy, and surgery.
Generally, the earlier a cancer is detected, the better the prognosis. Early diagnosis and treatment prevent the cancer cells from multiplying and spreading to other body parts (metastasis). If ACC spreads to the lung, the resultant cancer would be called metastatic ACC, not lung cancer.
Unlike common cancers, whose causes are often diverse, caused by an array of mutations, and driven by various biological and environmental factors, rare cancers are often more uniform. This makes it relatively easier to identify the most relevant causes and factors that sustain the tumors. Rare cancer research is vital to uncovering the biological, clinical, and molecular features of subsets of common cancers.
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Understanding Sarcoma Cancer: Know the Risk Factors : -In observance of Sarcoma Awareness Month, we aim to educate and empower our community about sarcoma cancer and its risk factors. Being informed about these risk factors can aid in early detection and proactive healthcare management.
Here are the key risk factors associated with sarcoma cancer:
📍 Genetic Predisposition: A family history of sarcoma or certain genetic syndromes like Li-Fraumeni syndrome and neurofibromatosis may elevate the risk.
📍 Previous Radiation Exposure: Individuals who have received radiation therapy for other cancers may have a higher likelihood of developing sarcoma later in life.
📍 Environmental Factors: Exposure to certain chemicals or toxins in the workplace or environment might contribute to sarcoma development.
📍 Age and Gender: Sarcoma can affect people of all ages, but specific types are more common in certain age groups. For instance, osteosarcoma is prevalent in teenagers and young adults, while leiomyosarcoma is more often seen in middle-aged and older adults.
📍 Pre-existing Conditions: Certain non-cancerous conditions, such as Paget's disease and certain benign tumors, can increase the risk of sarcoma.
📍 Certain Genetic Mutations: Specific genetic mutations have been associated with an increased risk of developing certain types of sarcoma.
It is important to note that having one or more of these risk factors does not guarantee the development of sarcoma, and individuals without apparent risk factors may still be affected. Regular health check-ups and timely medical evaluations play a crucial role in detecting sarcoma at an early stage.
More Information About Sarcoma Cancers
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Acute myelogenous leukemia
Overview
Acute myelogenous leukemia (AML), also known as acute myeloid leukemia, is a type of cancer that affects the blood and bone marrow. In AML, abnormal white blood cells (myeloblasts) are produced in the bone marrow, which normally produces healthy blood cells.
AML can develop quickly and aggressively, causing symptoms such as fatigue, shortness of breath, easy bruising or bleeding, and frequent infections. AML can affect people of any age, but it is most common in adults over the age of 60.
The exact cause of AML is not known, but certain risk factors can increase the likelihood of developing the disease, including exposure to certain chemicals or radiation, genetic factors, and certain medical conditions.
Diagnosis of AML typically involves a physical examination, blood tests, and a bone marrow biopsy. Treatment options for AML include chemotherapy, radiation therapy, targeted therapy, and bone marrow transplantation. The specific treatment approach depends on factors such as the patient's age, overall health, and the characteristics of the cancer cells.
Prognosis for AML varies depending on several factors, including the patient's age, the stage of the disease, and the specific characteristics of the cancer cells. With treatment, some people with AML can achieve remission or even be cured, while others may experience relapse or have a poorer prognosis.
Symptoms
The symptoms of acute myelogenous leukemia (AML) can vary depending on the stage of the disease and the individual patient. Some common symptoms of AML include:
- Fatigue and weakness
- Shortness of breath
- Easy bruising or bleeding
- Frequent infections
- Fever
- Unexplained weight loss
- Loss of appetite
- Swollen lymph nodes
- Night sweats
- Bone pain or tenderness
These symptoms can also be caused by other medical conditions, so it is important to see a healthcare provider if you are experiencing any of these symptoms or have concerns about your health.
In some cases, AML may not cause any symptoms in the early stages, so routine blood tests may be necessary to detect the disease.
When to see a doctor
It is important to see a doctor if you experience any symptoms that suggest acute myelogenous leukemia (AML) or if you have concerns about your health. In particular, you should see a doctor if you experience any of the following:
- Persistent fatigue, weakness, or shortness of breath
- Easy bruising or bleeding
- Frequent infections or fever
- Unexplained weight loss or loss of appetite
- Swollen lymph nodes
- Bone pain or tenderness
If you have any risk factors for AML, such as a history of exposure to certain chemicals or radiation, or a family history of the disease, you should talk to your doctor about screening tests or other preventive measures.
In addition, if you have been diagnosed with AML, it is important to work closely with your healthcare team to develop a treatment plan and manage your symptoms. Regular follow-up appointments with your doctor are also important to monitor your progress and detect any signs of relapse or complications.
Causes
The exact cause of acute myelogenous leukemia (AML) is not known, but several factors may increase the risk of developing the disease. Some of these risk factors include:
- Exposure to certain chemicals: Exposure to certain chemicals, such as benzene, has been linked to an increased risk of AML.
- Radiation: Exposure to high levels of ionizing radiation, such as in nuclear accidents or cancer treatment, has been linked to an increased risk of AML.
- Genetic factors: Some inherited genetic mutations or syndromes, such as Down syndrome or Li-Fraumeni syndrome, can increase the risk of developing AML.
- Age: AML is more common in adults over the age of 60.
- Smoking: Smoking has been linked to an increased risk of AML.
- Previous chemotherapy or radiation therapy: Treatment for other types of cancer that involve chemotherapy or radiation therapy can increase the risk of developing AML.
- Certain blood disorders: Certain blood disorders, such as myelodysplastic syndrome (MDS), can increase the risk of developing AML.
It is important to note that not everyone who has these risk factors will develop AML, and some people may develop AML without any known risk factors.
Risk factors
There are several risk factors associated with an increased likelihood of developing acute myelogenous leukemia (AML). Some of the most common risk factors include:
- Age: AML is more common in adults over the age of 60.
- Previous chemotherapy or radiation therapy: Treatment for other types of cancer that involve chemotherapy or radiation therapy can increase the risk of developing AML.
- Exposure to certain chemicals: Exposure to certain chemicals, such as benzene, has been linked to an increased risk of AML.
- Genetic factors: Some inherited genetic mutations or syndromes, such as Down syndrome or Li-Fraumeni syndrome, can increase the risk of developing AML.
- Smoking: Smoking has been linked to an increased risk of AML.
- Certain blood disorders: Certain blood disorders, such as myelodysplastic syndrome (MDS), can increase the risk of developing AML.
- Family history of AML: A family history of AML or other blood cancers may increase the risk of developing the disease.
It is important to note that having one or more of these risk factors does not necessarily mean that a person will develop AML, and some people may develop AML without any known risk factors.
Complications
Acute myelogenous leukemia (AML) can lead to a range of complications, both as a result of the disease itself and its treatment. Some of the most common complications of AML include:
- Infections: AML can weaken the immune system, making it more difficult for the body to fight infections. In addition, treatments such as chemotherapy and radiation therapy can further weaken the immune system.
- Bleeding and clotting disorders: AML can interfere with the body's ability to produce enough healthy blood cells, including platelets, which are necessary for proper blood clotting. As a result, people with AML may experience bleeding or clotting disorders.
- Anemia: AML can lead to anemia, which is a condition in which the body does not have enough red blood cells to carry oxygen to the tissues.
- Side effects of treatment: Treatments for AML, such as chemotherapy and radiation therapy, can cause a range of side effects, including nausea, vomiting, hair loss, and fatigue.
- Organ damage: In some cases, AML can cause damage to organs such as the liver, lungs, and kidneys.
- Secondary cancers: Some treatments for AML, such as chemotherapy and radiation therapy, can increase the risk of developing secondary cancers later in life.
It is important for people with AML to work closely with their healthcare team to manage these potential complications and minimize their impact on overall health and well-being.
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Holidays 5.3
Holidays
Birthday of Spam E-mail
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Constitution Day (Poland)
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Invention of the Cross
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Premieres
All Things Considered (Radio Series; 1971)
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Back in My Arms Again, by The Supremes (Song; 1965)
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Beer Barrel Polka, recorded by The Andrews Sisters (Song; 1939)
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Max & Ruby (Animated TV Series; 2002)
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No Deals, Mr. Bond, by John Gardner (Novel; 1987)
Oops!… I Did It Again, by Britney Spears (Album; 2000)
Republic, by New Order (Album; 1993)
Spider-Man (Film; 2002)
Truly Madly Deeply (Film; 1991)
Tweetie Pie (WB MM Cartoon; 1947)
When the Cat’s Away (Disney Cartoon; 1929)
Today’s Name Days
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Alexej (Czech Republic)
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Today is Also…
Day of Year: Day 123 of 2024; 242 days remaining in the year
ISO: Day 3 of week 18 of 2023
Celtic Tree Calendar: Saille (Willow) [Day 18 of 28]
Chinese: Month 3 (Bing-Chen), Day 14 (Xin-You)
Chinese Year of the: Rabbit 4721 (until February 10, 2024)
Hebrew: 12 Iyar 5783
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J Cal: 2 Bīja; Twosday [2 of 30]
Julian: 20 April 2023
Moon: 95%: Waxing Gibbous
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Runic Half Month: Lagu (Flowing Water) [Day 9 of 15]
Season: Spring (Day 45 of 90)
Zodiac: Taurus (Day 14 of 30)
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