#i84

[gungieblog]

Monument to fallen Pennsylvania State Police.

Monument put up to honor fallen PA. State Troopers who have died in the line of duty erected at rest area entering PA. on I84

[cloudstrife-bbs]

Pupdates, or Unofficial Lack Thereof

Cloud is now 4½-weeks-old.

I still don't know which one has been assigned to me. The puppies are all still too young but, according to the breeder, beginning to show temperament. She says she's still a few weeks out from testing them, which to me, translates to 7-weeks-old before proper testing can be performed and assignments can be made. Plus, her constant repetition of "end of April"--- they'll be 8-weeks on April 16th, which is mid-April. Which also implies that she's keeping them until 9-weeks, which means he won't come home until April 20th or 21st.

Which, truthfully, feels like absolute torture for me.

I trust in my breeder to accurately place my puppy, and that's having a tremendous deal of faith in her. This is a decision for the life of whichever one Cloud ends up being, but she has to do this eleven times. Because the litter is so large, I have to share time and attention with at least ten other families. It would be nice to have a more personal relationship, but I sadly feel like this is gonna be another Sevit's Corgi situation: Money changes Hands, and the relationship is over, for the most part. Business only. Especially because Cloud is only a pet and not a show dog or a sport dog. I don't want to feel robbed of a potential friend and a potential network, especially because the breeder and I are both New Englanders, but I do feel robbed.

The breeder told me that she was going to have an Open House-type of Puppy Party on March 30th, for all the new puppy parents. (I don't know if I mentioned this in my last blog entry.) We are planning to bring up Cloud's very expensive, brand new Impact brand crate with puppy divider. (I hope it lasts as long as it says it does because I want it to be a dog heirloom for future Berger Blanc Suisses for the moolah we coughed up for it.) She also said to bring a towel/blanket that smells like us, and a toy, just for him. We bought him a squeaky plush Mr. Carrot, just like Bolt. We actually got multiples in case the toy doesn't come back with us. We've been sleeping with the towel to make sure it REALLY has our scent on it, but I also have another old bed sheet that I'm bringing to make his crate a bit cozier. I still don't know what time we're going to have to be there by (I asked once already, but received silence), but I'm going to shoot her a text on Monday asking again, trying to be as non-intrusive and friendly as I can in spite of my rampant anxiety. It's a 3.5 hour drive from here to there, and I would very much like to know how early in the morning we have to start out, especially if we want to avoid traffic on I84 through Hartford. I like to plan my life out accordingly and not wait until the last second.

The house is getting cleaner and cleaner and more puppy-proofed. Everyone is excited, waiting for more news about Cloud, but I only have very little to share. It's frustrating, and to be honest, it's contributing a lot to my stress and anxiety. I have all this love in my heart I am just waiting to pour into a puppy, and I feel fit to burst without anything to direct it into. I know that a new dog will be a challenge, but it's a good, healthy challenge that I'm deeply passionate about. I don't have any delusions that this is going to be a cakewalk. It's going to be sleepless nights at first, and lots of puppy biting and him not wanting to listen. Hundreds of repetitions of words as I teach him human language and proper manners. Definitely a lot of pee and poop on my kitchen floor as his body grows.

A lot of "Let me see what you have!" "A knife!" "No!" Hahaha!

But lots of playing, and new experiences every day as I socialize him to things like construction noises, grooming, and our every day life. He has to get used to loud sounds like nail guns, air compressors, miter saws, hammering, all manner of power tools, and I've already educated myself on how gundogs are trained to get an idea of how to desensitize him. He's going to go to puppy class for extra exposure to things, and I want him to learn to be calm and cool, nigh unflappable if I can shape him to be that way. But it's going to take tremendous hard work, discipline, consistency, and at least two years of puppy/teenage bullshit to get him where I want him to be. I'm no stranger to the process; it's just been a decade since I had a puppy. Dogs are to be my life's work, and I may be pushing 40 (I'm turning 38 this September), but this is only the beginning of my purpose. If the Spirits help me through their wisdom and kindness, my legacy will be my Dogs. They are my children.

Cloud: which ever puppy you end up being, I know you'll be brilliant and extraordinary. You are already my hero. You have no idea the darkness you're saving me from. You're going to have an incredible life with us, and you are worth this excruciating wait. I love you, so much. Mommy and Daddy are waiting as patiently as we can until we bring you home.

[nicolesmith137]

i84.net/nicolesmith137

[stelladebraa]

Structural Adaptation of Darunavir Analogs Against Primary Resistance Mutations in HIV-1 Protease

HIV-1 protease is one of the prime targets of agents used in antiretroviral therapy against HIV. However, under selective pressure of protease inhibitors, primary mutations at the active site weaken inhibitor binding to confer resistance. Darunavir (DRV) is the most potent HIV-1 protease inhibitor in clinic; resistance is limited, as DRV fits well within the substrate envelope. Nevertheless, resistance is observed due to hydrophobic changes at residues including I50, V82 and I84 that line the S1/S1’ pocket within the active site. Through enzyme inhibition assays and a series of 12 crystal structures, we interrogated susceptibility of DRV and two potent analogs to primary S1’ mutations. The analogs had modifications at the hydrophobic P1’ moiety to better occupy the unexploited space in the S1’ pocket where the primary mutations were located. Considerable losses of potency were observed against protease variants with I84V and I50V mutations for all three inhibitors.

The crystal structures revealed an unexpected conformational change in the flap region of I50V protease bound to the analog with the largest P1’ moiety, indicating interdependency between the S1’ subsite and the flap region. Collective analysis of protease-inhibitor van der Waals (vdW) interactions in the crystal structures using principle component analysis indicated I84V mutation underlying the largest variation in the vdW contacts. Interestingly, the principle components were able to distinguish inhibitor identity and relative potency solely based on vdW interactions of active site residues in the crystal structures. Our results reveal the interplay between inhibitor P1’ moiety and primary S1’ mutations, as well as suggesting a novel method for distinguishing the interdependence of resistance through principle component analyses.

#Darunavir

[riverrealtyservices]

Call Matthew J. McGroarty | MMcGroarty.riverrealty.com | [phone] ~ Welcome to one of the largest homes in one of the most sought after communities in Fishkill, Green Hills of Glenham. This three bedroom townhouse offers more than most do in this community; private parking with your own garage, 2200+ square footage, amazingly large grand room, and a lovely back balcony right off the primary bedroom for your morning coffee. The design possibilities are endless with the open floor concept. Easy on/off access to I84 and a stones throw to all of Fishkills restaurants and shopping plazas. Don't miss out on this opportunity to own a home in such a prime location. ~ #justlisted #northofnyc #upstateny #upstate #escapenyc #escapemanhattan #escapebrooklyn #hudsonvalley #hudsonvalleyny #hudsonvalleyrealestate #letsgohouseshopping #realestate #catskills #catskillsny #midhudson #midhudsonvalley #saugerties #dutchesscountyny #dutchesscounty #ulstercountyny #ulstercounty #orangecountyny #orangecounty #putnamcountyny #putnamcounty #BTSTeam #sullivancountyny #westchestercounty #westchestercountyny

[cracksz1]

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[gmrstudios]

A Sense of Doubt blog post #2695 - Dad's Last Day: The Columbia River Gorge and Portland - July Fourth, 2022. https://sensedoubt.blogspot.com/2022/07/a-sense-of-doubt-blog-post-2695-dads.html #columbiarivergorge #july4th #FunWithDad #lastday (at I84 Corbett View Point) https://www.instagram.com/p/Cf1ur_yp2veOk6brqxlbJ1nFqOj0uQpLNbrpt40/?igshid=NGJjMDIxMWI=

#2695 #columbiarivergorge #july4th #funwithdad #lastday

[broncop3t3]

I says...

This happened today...200k club! #nissanfrontier @nissan @ I84 https://t.co/LE8n0H6vg4

— BroncoP3t3 (@BroncoP3t3_) Jun 29, 2022

from Twitter https://twitter.com/BroncoP3t3_ June 29, 2022 at 05:43PM via IFTTT

#IFTTT #Twitter

[sheltierv]

On i84 east of ogden

#su22

[johnhopkinsphotography]

Cascade Locks, Oregon

June 11, 2021

#Columbia River Gorge #cascade locks #I84 #oregon #pacific northwest #road tripping #road trip #photography #photographers #digital photography #digital photographers #original photography #original photographers #photographers of the milkyway #photographers on tumblr #photographers of tumblr #hamburgers #snack stand #drive in

[dudlimur]

I. 84

Olyan hirtelen történt mindent. Elhagytál, körülbelül 3 hónapig semmit sem tudtam rólad, majd hirtelen visszatérsz az életembe. Egyszerre ijeszt meg és tesz boldoggá ez az egész.

Úgy érzem mindent átbeszéltünk, és már tisztán látok dolgokat. Ez ugyanúgy az én hibám is volt, mint a tiéd. De te sem tudtál elfelejteni, neked sem ment és te is ugyanúgy szenvedtél, mint én. Jogosan jön a kérdés, hogy akkor ezen az egész szenvedésen miért kellett keresztül mennünk.

 Talán pont emiatt. Hogy megtapasztaljuk ezeket az érzéseket is, amik nem csillapodnak. Rendet kellett tenned magadban, és úgy érzem, készen állsz arra, hogy mellettem maradj.

 Lehet, hogy pofára fogok esni. Lehet, hogy sokkal jobban fog fájni ez az egész… de ez nem érdekel, mert itt vagy. Itt vagy nekem.

Félek és nyugtalan vagyok, mert nem láthatok bele a fejedbe. Olyan jó lenne a te szemeddel látnom magamat. Vajon mit gondolhatsz rólam.

3 hónap után az első csók… boldogság… vágy… fájdalom… düh… szorongás… elégedettség… siker… megnyugvás volt.

 Annyira szeretnék hinni bennünk. Hogy másként lesz. A lehetőséget megkaptad.

 Az a rossz ebben, hogy én aggódok. Tudom, azt mondod felesleges. De aggódok. Rettegek, hogy ugyanaz lesz. Félek, hogy nem keresel többet. Félek, hogy megint ugyanazt fogod érezni, és mindenen újra keresztül kell, menjek.

 De hiszek bennünk.

 Nézlek, miközben öltözöl, és nem hiszem el. Nem hiszem el, hogy végre itt vagy, megérinthetlek. Hallom a nevetésedet, látom a mosolyodat, és érzem az illatodat. Nagyon rég nem éreztem ezt a boldogságot. Még nem merem teljesen átadni magamat az érzésnek, és óvatos vagyok. De megéri ezen dolgozni, megéri lassan haladni.

 Alig várom, hogy újra láthassalak!

#i84 #levelekneked #szeretlek #szeretem #szeretemot #szerelem #magány #csalódás #csalódottság #fájdalom #párkapcsolat #magyar #magyartumblr #magyar tumblisok #magyartumbli #idézet #idézetek #magyaridézet #szomorú #remény #visszajött #boldogaszívem #félelem #rettegek #szorongás #gondolatokafejemben #gondolatokamikbennemvannak #juttassukelneki

[jasonlocken]

Heading East to the summit of the Blue Mountains over cabbage hill #i84 interstate 84 east : nice easy morning last week… I remember driving over this snow pass during my college years in blizzards. No more ;) . #shotwithmynikon #nikonusa #oregonexplored #exploregon #nikond7100 #nikon #nikonlandscape #embracetheslowpace #lockenlife ✌️ (at Meacham, Oregon) https://www.instagram.com/p/CR3F427BAvB/?utm_medium=tumblr

#i84 #shotwithmynikon #nikonusa #oregonexplored #exploregon #nikond7100 #nikon #nikonlandscape #embracetheslowpace #lockenlife

[sweetnbreezy-blog]

Freedom of the open road.

#open road #road trip #utah #idaho #i84 #i80 #southeast #southbound #moabbound #Moab

[citius-altius-fortivs-blog]

#journeyofapirate #journeyofamoderndaypirate #i84 #oregon

[riverrealtyservices]

Richard Licastri | 845.706.4006 | RLicastri.riverrealty.com ~ Custom Built Log Home on over 2 acres of wooded property. Like a cabin in the woods but in the heart of Fishkill. House is solidly built with top materials including an amazing heating furnace that can burn several fuel types. Mix of forced air and baseboard heat plus central A/C. Gleaming Wide plank floors throughout. Sun lit rooms, flowing floor plan. Large living room with wood burning stove and fieldstone walls. Enter through double French doors to living area with wet bar. Can also be used as a master suite with full bath and washer and dryer. Minutes to Fishkill village, I84, train and shopping along RT 9. Awesome home. Must see to appreciate. ~ #justlisted #northofnyc #upstateny #upstate #escapenyc #escapemanhattan #escapebrooklyn #hudsonvalley #hudsonvalleyny #hudsonvalleyrealestate #letsgohouseshopping #realestate #catskills #catskillsny #midhudson #midhudsonvalley #newlisting #dutchesscountyny #dutchesscounty #ulstercountyny #ulstercounty #orangecountyny #orangecounty #putnamcountyny #putnamcounty #BTSTeam #sullivancountyny #westchestercounty #westchestercountyny #rocklandcounty

[hideouscouch]

Asymmetrical sofa seating - found by @serravision on NE 82nd on the I-84 overpass - #couchesofportland #portlandcouch #curbcouch #streetsofa #portlandtags #portlandgraffiti #abandonedsofa #freecouch #i84 #NE82nd #82ndave #portlandoregon #NEPortland https://www.instagram.com/p/B2XJwodhddg/?igshid=yizahz3i0bx1

#couchesofportland #portlandcouch #curbcouch #streetsofa #portlandtags #portlandgraffiti #abandonedsofa #freecouch #i84 #ne82nd #82ndave #portlandoregon #neportland