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#histamine
superflymiceguy · 5 months
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Hughes and Histamine.
Crossover piece of my character, Hughes, and @superflatpsyche's character, Histamine.
Deta's Sagas X The In-Between!
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writer-at-the-table · 3 months
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I strongly suspect that if you made a venn diagram of type 2 diabetes friendly foods, ibs friendly foods, and low histamine/histamine sensitivity safe foods, you would end up with very little in that center overlap
Which is making my life increasingly annoying and difficult right now
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superflatpsyche · 10 months
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Histamine gives Kyvern a pep talk 😊
(I was experimenting a bit, to see if this art style could be sustainable for a future comic)
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jellyfish3s · 9 days
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i hate having mcas.
that's it. i said it.
it's so tiring. i can't run, or go for long walks, or just sweat a little. i don't have enough strength for staying up for more than 20min, i can't eat some spices that i totally adore, and my spoons are usually so low. sometimes i simply don't want to get out of bed because im so tired but i have to do so anyway, and usually it happens when i know i'll have p.e. classes. i don't think i completed the two classes since the start of the academic year (february) without stopping and sitting and breathing heavily and feeling so itchy because i can't exercise too much or my histamine levels go high as the sky and being covered by sweat is like wearing a full costume made out of histamine, that im *specially* allergic to.
i see people running and jumping and simply walking under the sun and i feel like im missing something because im so young yet so limited. i should be able to be just fine if the climate changes, or if there's something spicy in the food, or if i need to walk a little, or if i just need to walk by a slightly inclined street, but im totally not able to be "just fine" and move on. my dad gets worried everytime we come back from school and i almost faint because of the exercise, and even though i try to explain how i feel, i know he still thinks that maybe it'd be better if i just exercised a little more to build up strength — and he's not the devil because he can't understand it as we only discovered my histamine intolerance this year because of some medical exams i made when i was 4 and my pediatrist never properly explained. i was 4 and now im 15 — it's basically 11 years being exposed to something im deeply allergic to and never understanding why i'd never get better from dermatitis and why i was so weak.
i feel fragile. my parents know i hate being seen as fragile and breakable and weak yet i can't take any longer. im constantly itching, my mind is always kinda numb, im always tired, my periods always hurt, i have constant migraines, my mood swings are worsening and on top of everything comes the game changer: im also neurodivergent. there's always going to exist someone that have the energy to do everything, and that's not me. socially im basically incapable of approaching people i find cool, the amount of work i've got to do to simply exist like a normal person is unbearable and yet i have to be responsible, good, well mannered, pretty, smart, cool, cute, role model, the best. i never learned to fail. i was always the smartest, the joyful, the responsible, the "i wish your grades were like her's" — i feel so bad to everyone who felt so little next to me because i never wanted anyone to live under a shadow of a version of me that i can't even recognize or remember anymore.
the little me would've looked at me with fear on her eyes and asked if we are failing for being so weak and so tired we can't even really care about learning something. are we really failing? i'm just so tired. i could do better if i wasn't constantly battling in order to only navigate my days without this haunting exhaustion taking me over, or if my head didn't hurt that bad, or if my emotional regulation was a little bit more effective, or if the sounds weren't so loud and the light so bright and people so confusing. i could do better if i wasn't restraining myself from eating something i love because i don't want an allergic reaction, or if i could just stim around, or if i could run around under the sun and laugh about it after. maybe if i had some adjustments my life would get so better. i don't want to run with anyone to feel like im part of something; i just want to feel okay with every aspect of myself, and maybe feeling okay is sitting down everytime i feel tired and taking medicine everytime there's an allergic reaction going on, not reducing myself to grades and stop wearing a damn mask in order to be liked.
i hate having mcas, i hate how my scoliosis correction surgery is never taken seriously when it comes to "it's painfully tiring to carry titanium inside me everyday", and i hate how misunderstood i am. i get it now: im not lazy, im simply chronically exposing myself to a lot of things and now my body is totally overloaded. i've been deeply sick for the past weeks and it's caused mainly by the overwhelming sensation of getting up, getting tired, being misunderstood and having everything to do when i don't have that energy to expend. i want to sleep, watch things about my favorite anime, write a little about it, allow myself to really rest for the first time in my life, eat healthy things that aren't like an allergy bomb inside my organism and i really, really, really want to get to live again, being understood and taken seriously, not ever being called lazy or nothing else. i just want to control what happens to myself and stop feeling on the verge of tears everytime i have to do something that requires movements and focus.
little me would be so sad we lost control over our own body to an allergy that could've been minimized before it ruined our life.
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when your fingers are delightfully stained from weekly food prep
you pray it’s going to be a good week
you never know though
wishes upon prayers
that things function as they should
but you know your only hope is to make it through the week
to the weekend
things are calm and your body can catch up
you feel fresh and want of none
but you still know
those days
or nights
or weeks
will get you
you just want it to be right. function right. why can’t it not hurt. why does one thing have to flare up so many others!!!!
we scream into the void but nothings heard
our faces are flush and we don’t know why
we cannot cry
not for ourselves, only for others
this - where the problems started
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thenarrativefoil · 1 month
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got the meat nightmares again... experienced the full horror of joining what I thought was a community of like minded people that devolved into a cult complete with a demon entity made of dead human body parts and also had lunch in a cafeteria with friends while hannibal lector was hunting some poor son of a bitch down
neither of which were very upsetting it's just an "oh I guess I can't have pork belly even though bacon is okay" 🥲
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er-cryptid · 3 months
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Steps of the Inflammatory Response
Damaged tissues release histamine
Histamine increases blood flow
Histamine causes capillaries to leak
More phagocytes and clotting factors are released
Phagocytes engulf bacteria, dead cells, and cellular debris
Platelets seal the wound
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Patreon
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kingdrawcse · 1 year
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Chemistry behind Hay Fever 🌼🤧
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Springtime means flowers, sunshine, and unfortunately, allergies for some of us. But did you know that 'hay fever' used to be blamed on the smell of hay? In 1859, pollen was identified as the real culprit. Learn how histamine affects our bodies during an allergic reaction.
During an allergic reaction, the body releases histamine, a neurotransmitter that can cause itching, sneezing, and a runny nose. Histamine can also cause capillary vein walls to become more permeable, resulting in localized tissue edema and rash. Additionally, histamine can cause the smooth muscles of the trachea to contract, leading to respiratory tract narrowing and asthma.
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If you suffer from spring allergies, there are tips you can take to alleviate your symptoms. These include:
avoiding exposure to allergens
using over-the-counter or prescription medications
considering allergy shots or immunotherapy
staying informed about the latest research and treatments
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gothamslostboy · 1 year
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smokeorbake · 2 years
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Smoke or Bake says, "You just won't believe how many High Histamine Foods & Drinks (not cannabis) you've been consuming causing a rash for your body can't tolerate it anymore. Try spreading Benadryl ointment on the rash & talk to your natural path about histamines. Then sit back light a joint and get truly active researching & learning about low histamine foods to make your life better. You'll be glad you did. Sometimes we are own worse enemy & our own very best friend."
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eternalgaylord · 2 years
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it does seem that histamine blockers (h1 & h2 specifically) reduce* perception* of post-exercise soreness and pain (ie DOMS), but also the benefits of exercise themselves. the studies i've found are all pretty small, but the findings make sense with what we know of histamine's role in inflammatory response + inflammation's role in muscle repair/growth. enough so that i feel confident in my decision to reserve h2 blockers for very intermittent nocturnal use, in favour of PPIs and antacids (and hopefully other things that actually address the root of the problem, rather than gastric acid production)
a few excerpts under the cut for my own reference
In one study, in spite of the other findings the histamine blockaded group lost less muscle strength than the control:
We believe there are two potential explanations for these results. First, although not evident in circulating biomarkers, histamine-receptor blockade may have reduced inflammation, preserving muscle function or reducing discomfort associated with maximal voluntary contractions. Second, histamine-receptor blockade may have reduced the sensitivity of group III/IV afferent neurons. These possibilities are not mutually exclusive explanations.
The III/IV neurons (which send info to, rather than from, the brain, hence 'afferent') mentioned are implicated in the perception of skeletal muscle pain, like in DOMS. The idea is the activation of h1/h2 receptors in these nerve fibers -> lower threshold for stimulation of nerve fibers -> increased pain, temporary loss of muscle strength, recruitment to protect from muscle damage. Following that, h1/h2 blockade -> higher threshold for stimulation -> less pain to limit activity and muscle damage.
Athletes are apparently more prone to allergies:
Descriptive studies indicate that the incidence of allergies and use of antihistamines in endurance athletes is two times greater than in age-matched controls (1, 17), presumably the result of a switch from nasal to mouth breathing at high ventilation rates (\~30 l/min) and its effects on increasing exposure of deep lung tissue to allergens. [...]the combination of antihistamine medication and muscle-damaging exercise may result in situations where more extensive muscle damage may occur[...] Conversely, athletes competing in multiday events (such as the track and field decathlon, or the multiple qualifying rounds of various athletic competitions) may gain a performance benefit by taking histamine-receptor antagonists. This may allow conservation of strength after strenuous exercise, in conjunction with decreased muscle soreness, across days of competition. Although, if the use of histamine-receptor blockade results in increased muscle damage, the athlete may require an extended period of rest after competition for full muscle recovery.
Similar study on the role of histamine in exercise training:
[...] whole-body insulin sensitivity did not increase in the experimental group treated with H1/H2 antagonists, whereas a substantial improvement was noted in placebo-treated participants. In summary, our data suggest that H1/H2-dependent signaling is involved in the exercise training–induced improvement of whole-body glycemic control. Whether this histaminergic effect is secondary to the observed blunting of angiogenesis and increase in abundance of related proteins or whether there also is a direct role in the up-regulation of the insulin signaling cascade is subject to further research.
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superflymiceguy · 1 year
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The Squad.
@superphatpsyche
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m4ngey · 2 years
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Having out of the blue very sudden allergies that I'd never had before. It's gotten worse since COVID. I've started looking into MCAS and good GOD it sounds EXACTLY like my experience with health and reactions. The brain is fucking wild and C-PTSD fucking blows
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superflatpsyche · 1 year
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A mini-comic about Evera and Histamine’s friendship. They basically just troll each other nonstop.
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mremusings · 1 month
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The Cognitive Commanders - Neurochemicals and Brain Functions
"The Cognitive Commanders - Neurochemicals and Brain Functions" explores the pivotal role of neurochemicals in cognitive processes. It delves into the functions of key neurotransmitters.
 “The Cognitive Commanders – Neurochemicals and Brain Functions” Welcome aboard our intellectual exploration in “The Cognitive Commanders – Neurochemicals and Brain Functions”. This journey delves into the fascinating realm of neurochemicals that serve as the architects and engineers of our cognitive processes. It’s like unlocking the secrets of a high-tech control room where learning, memory,…
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theinflamedqueen · 2 months
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After dealing with a cacophony of symptoms for 4 years. I’m at my lowest today. I’m posting today to start my journey to health and betterment. There were moments today I felt like giving up. I’m going to be as honest and sincere as I possibly can. I hope this reaches people who are silent sufferers like me.
Current physical stats
Height: 5’10
Age: 30
Weight: 200 lbs
Star sign: Virgo
Physical symptoms and background:
Always was hypermobile since I was little. Sister had a heart murmur and was diagnosed with Ehlers Danlos young. The physical symptoms, other than fatigue never really affected me. Now the joint pains and subluxations are a daily pain. I wake up in excruciating pain some days and have to deal with horrible upper back pain. I bruise extremely easily.
I’ve also been diagnosed with ADHD and depression. I deal with brain fog constantly and there are days where I can’t even form sentences properly. I just exist. I also deal with a lot of headaches. I struggle to concentrate on studying and even surviving.
I feel like I’m allergic to being alive at this point.
Many foods cause my airway to close up and my throat to become irritated. Showering makes me itchy. I have dermatographia (I can write on my skin and it raises up) I’ll post a video of this. This points to histamine intolerance or the more insidious Mast cell activation syndrome. If I am stressed or emotional my symptoms worsen for days. I am constantly extremely tired. I have lost half my hair. My vision can become blurrier at times. I struggle with GERD and have to sit up at an angle to sleep. Sinus infections are also a constant in my life. If I have antibiotics my symptoms worsen. I deal with bloating constantly and also with constipation and diarrhea. My skin has also lost all its luster and I deal with breakouts I never have had before. I deal with heart palpitations and extreme anxiety. If my GERD is really bad there are days I feel like I’m going to die.
All of my symptoms have worsened from catching Covid in November 3 years ago. If my symptoms were 1/10 now they are 7/10. I have flares and remittance of symptoms. It’s truly a struggle to live at this point.
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