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theroadtofairyland · 6 months

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Homeschooled

Watercolor On Black Cotton Paper

2023, 41"x 30"

Golden Teacher Mushroom, Psilocybe cubensis

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disease · 5 months

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Psilocybe cubensis

#psilocybe cubensis #mushrooms #fungi #psilocybin #mycology #u

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canisovis · 9 months

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Coyote + Cubesis color sketch comm.

#art #coyote #mushroom #psilocybe #psilocybe cubensis #sketch

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animxpossessed · 2 months

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“Psychedelics are illegal not because a loving government is concerned that you may jump out of a third story window. Psychedelics are illegal because they dissolve opinion structures and culturally laid down models of behaviour and information processing. They open you up to the possibility that everything you know is wrong.” ― Terence McKenna

#psilocybe cubensis #dmt #spirituality #culture

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soulslostinthewind · 6 months

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i watched the marbled floor turn into a field of clovers. i knew then, this is it, this is all there is, all there has ever been, all there will ever be. the man took my hand but it was- it was no longer attached to me. i think that i am not my body. and that i am highly favored by God, and that God is real and so is everything else. every single particle of my being belongs to all of you. kiss me through the electric current flowing through glowing strands, extending from our brains like the strings of eight billion marionette puppets. the man took my hand- i kept mistakenly lying my hand on top of his as if he were courting me. if i listened close enough i could feel the electric current connecting every mind in the room. i smiled at my mother; i kept asking her what she was doing but she could not hear me through the screen of psilocybin—or perhaps i could not hear her. all of my thoughts were in the form of rhythmic poetry. i couldn’t stop smiling at those clovers dancing in the orange glow. oh, how i loved the shade of orange in the lightbulb. only the one that was the correct shade of orange. it made me feel warm. the man was angry, arguing with a woman. i think that they may have been speaking english. i was in another place. i could feel his thoughts. i could feel my soul caressing my tired vessel. i could feel everything that was. and as i fell into the depths of worldly poison, i could feel my limbs reattach themselves; once again caging me beneath their sinister embrace.

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anima-1518 · 3 months

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#mushrooms #hongos #psilocibina #psilocybe cubensis #420girl #girl smoking #420culture #420daily #420life #nature

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fancycheliniarts · 1 year

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Mushies I inked traditionally and colored in PS! Can't get enough of these funky dudes

#mushrooms #amanita muscaria #psilocybe cubensis #fungi art #mushroom art #tattoo flash #illustration #digital art #mycology

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theroadtofairyland · 11 months

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Homeschooled

Watercolor On Black Cotton Paper

2023, 41"x 30"

Golden Teacher Mushroom, Psilocybe cubensis

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thatheathen · 6 months

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the golden teacher

#the golden teacher #thatheathen #missheathen #magic mushrooms #depression killer #psilocybe cubensis #psilocybin #Psilocybin Mushrooms #shrooms

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fivehundredwords · 1 year

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how is psilocybin metabolized?

To metabolize is to breakdown a chemical to its simpler component forms for cells to use. Psilocybin is a psychedelic compound found in fungi of several genera including Psilocybe, Panaeolus, and Copelandia. Inside the body, it influences the functional molecular mechanisms of several organs, mainly the brain, kidneys, and liver. On its own psilocybin is not as effective. To produce its infamous hallucinogenic effect in the brain, it must be converted to psilocin. Psilocin is the main active molecule, which is derived from the prodrug psilocybin.

There are two ways of getting these metabolites inside the body: oral ingestion (for example, eating the "magic mushrooms") and intravenous injection. When orally ingested, the mushrooms are digested in the usual way. Eventually, the psilocybin in the mushrooms reaches the liver where it is converted to psilocin. An enzyme, alkaline phosphatase, acts on psilocybin such that its phosphate group (PO₄³⁻) is replaced with a hydroxyl group (−OH). Psilocin is further acted upon by diverse enzymes to obtain products which are either excreted through urine or contribute to other functions in hepatocytes (liver cells) as psilocin metabolites.

There is a format to convert chemical equations to sentences. Nevertheless, I firmly believe that one must have the convenience of remembering their organic chemistry without having a stroke. Behold,

psilocin + monoamine oxidase = 4-hydroxyindole-3-acetaldehyde

psilocin + glucuronosyltransferase = psilocin glucoronide (PCG)

psilocin + aldehyde reductase = 4-hydroxytryptophol

psilocin + aldehyde dehydrogenase = 4-hydroxyindole-3-acetic acid (4HIAA)

The fates of each of these products are an elaborate article on their own, and I will be happy to write them should you be interested. Let me know!

Now, we remember that the primary effects due to which human beings consume psilocybin-containing mushrooms are caused by psilocin in the brain. The exact step-by-step mechanism has not yet been outlined; however, general molecular interactions have been found in studies. This psychoactive compound shows an interesting resemblance to serotonin the neurotransmitter. The psilocin binds to 5-HT2A (a molecule in a cell membrane which responds specifically to serotonin i.e., a serotonin receptor) with high affinity, which is believed to be essential for hallucinogenic effect. It also binds to other receptors with varying affinities, although their significance is yet to be understood.

Psilocybin and its metabolized products are completely removed from the body after 24 hours of consumption. The kidneys take pride in detoxifying circulating blood by creating the waste product urine; psilocin consumed can be detected in blood plasma 6-8 hours after consumption. Majority of the psilocin excreted through urine is in the form of psilocin-O-glucoronide. Psilocybin that remains psilocybin is also excreted through urine by the kidneys.

Introducing psilocybin in the body through veins produces effects of similar intensity as the former method. Whereas it remains as an active compound in the blood for a shorter duration. Turton et. al. conducted an fMRI (functional magnetic resonance imaging) study to compare the subjective experience of intravenous psilocybin injection interestingly explains how their participants’ descriptions of their experiences were influenced by the MRI scanner environment and the 1960s, when psychedelics were first introduced to western culture.

bibliography:

Passie T, Seifert J, Schneider U, Emrich HM. The pharmacology of psilocybin. Addiction biology. 2002 Oct;7(4):357-64.

Tylš F, Páleníček T, Horáček J. Psilocybin–summary of knowledge and new perspectives. European Neuropsychopharmacology. 2014 Mar 1;24(3):342-56.

Turton S, Nutt DJ, Carhart-Harris RL. A qualitative report on the subjective experience of intravenous psilocybin administered in an FMRI environment. Current Drug Abuse Reviews. 2014 Aug 1;7(2):117-27.

#psilocybe cubensis #psilocybe azurescens dried #psilocybe semilanceata #magic mushies #magic mushrooms #metabolites #mushrooms #altered my brain chemistry #psilocybin research #science side of tumblr #science side explain #science side help me

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vivaciouslyvibing · 1 year

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#I started growing shrooms bc why not #its a steep learning curve but easy once you get it #psa: throw the bin out once your pins stop fruiting #I didnt and I got mad sick from the spores floating around #my eyes were so swollen and I couldnt stop sneezing #vv #shrooms #high #psilocybe cubensis #psilocybin

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