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#Nonalcoholic fatty liver disease
Latest Trend and Perspective of Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) as a Novel Nomenclature | Abstract
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funsimplethings · 1 year
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thatwashelpful · 2 years
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Nonalcoholic fatty liver disease.
Basics first. The liver is the largest organ of our body. The liver helps your body to digest food, store energy, and remove harmful substances. So, What is Nonalcoholic Fatty Liver? Fatty liver (Hepatic Steatosis) is a diseased condition in which fat builds up in the liver along with inflammation in it. Fatty Liver disease is divided into 2 types. Read more
  2. Alcoholic Fatty Liver Disease (AFLD).
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innonurse · 2 years
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donelrourke · 2 years
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Fatty Liver Disease- What is It and How do you Fix It
Fatty Liver Disease- What is It and How do you Fix It
What Causes Fatty Liver? Most of us already know that excessive amounts of alcohol can cause Fatty Liver but did you know that insulin resistance will also cause Fatty Liver? Watch Dr. Berg explain Nonalcoholic fatty liver disease (NAFLD). Top Critical Tips for Reversing Fatty Liver First, stop all the toxins that are going into your body. Get rid of toxic cleaning products, do not drink or…
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explainslowly · 2 months
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Nonalcoholic fatty liver disease is definitely one of those things you don't want to Google without adding "haes" to the search...
Truly "you should just lose weight" everywhere... You got any other song and dance? No?
Damn I wonder if weight cycling (you know, the thing that happens to like, almost everyone who persistently tries to lose weight) is like. Bad for the liver...
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melodic-melovin · 5 months
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Mélovin Health Update: What We Know So Far (11/13/2023)
Okay so normally I'd just reblog the last post I made, but after trawling through countless news/tabloids sites, Reddit, and the cesspool that is Twitter and sorting through the various information available, it seemed more important to make a separate post entirely so people could see.
HERE IS WHAT HAS HAPPENED/WHAT WE KNOW:
-Mel has been diagnosed with a serious illness.
-I cannot *personally* confirm for sure what illness, HOWEVER, most sources are reporting that it is steatohepatitis, a liver condition, sometimes also known as "Nonalcoholic Fatty Liver Disease"
-In essence: this is essentially an inflammation of the liver caused by fat cells building up in said liver, not brought on by drinking alcohol.
-It is considered a metabolic disorder. There are several potential causes, most of which are tied to type 2 diabetes and obesity complications, hormone imbalances such as with the thyroid, but it can also just be bad luck of the genetic draw.
-This is NOT the same condition as viral hepatitis (aka Hepatitis C, etc.) I mention this specifically because some sites are incorrectly reporting this claim and people are already using that misinformation as ammo to be homophobic and claim that he got this condition as a result of his "orientation". Do not do this. Do not be these people.
-Is it terminal or is it incurable? Well, that's the muddied part of this. Even Mel used the term 'terminal' in his Instagram post about this, however many sources seem to point to 'incurable' as a more accurate term. It could be that the words are very similar in Ukrainian and thus the confusion there.
-Note that steatohepatitis *is* incurable, however it *may* or *may not* be terminal/fatal. We don't know how long he's had it, if there was liver damage already present before his being officially diagnosed, and to what extent. The main complications that can lead to death if no treatment is administered are cirrhosis and scarring, even liver cancer, which the only treatment at that point would be a full liver transplant. Without treatment, expectancy is anywhere between 3-5 years in severe cases, or 10-15 in lesser ones. Again, this is not proof of anything yet, this is only the general knowledge I have gained from researching this condition.
-This diagnosis came about as a result of bloodwork when he intended to get some kind of cosmetic procedure.
-(Before anyone asks what cosmetic surgery was he getting - that I don't know, and I don't think anyone else does either. He hasn't said, and cosmetic is a very broad term and can range from anything like traditionally thought-of plastic surgeries to something less intensive like a mole removal or getting his teeth worked on. Personally I think he's too young to be getting cosmetic work done, but that's not important right now.)
-He is seeking/undergoing treatment and currently resting and recovering at home with his family.
-His Instagram is currently private to non-followers, probably to prevent harassment. I have downloaded the video regarding this apparent diagnosis announcement and will try to upload it.
-He is still apparently on the longlist for competing in Vidbir, as announced by Suspilne.
-It is not known if this will impact the release of his newest song or further music going forward.
= o = o = o = o = o = o =
If more develops, I will try to let you all know. Right now, please just try to be supportive, don't harass him or his friends/family for more info (he will no doubt tell us when he is ready), and don't spread wild misinformation. We can only imagine what he must be going through right now. Even if this ends up not being nearly as bad as it sounds, getting a lifelong illness diagnosis is not easy for anyone to handle.
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vbadabeep · 6 months
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eatclean-bewhole · 7 months
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music-for-them-asses · 7 months
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I suddenly remembered that I also got diagnosed with nonalcoholic fatty liver disease when I had the ultrasound for my gallbladder back in February. And how I've only gained weight since upping the dose of my antidepressant. And how I know I need to be healthier but idk where to start and I'm just so overwhelmed I don't do anything 🙃🙃🙃🙃🙃
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mcatmemoranda · 8 months
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Asymptomatic carotid stenosis of 50%–70% should be treated medically to reduce atherosclerotic cardiovascular disease. Initiating statin therapy and smoking cessation will have the greatest impact on reducing his risk [the pt was a 63 y/o M with normal BP who smokes, whose internal carotid artery was 50% stenosed without symptoms]. Without past neurologic symptoms from carotid artery disease, surgical intervention would not be indicated due to the potential risks of surgery, but repeat ultrasonography is considered reasonable.
Extracranial carotid artery atherosclerosis is a risk factor for stroke and warrants risk factor reduction. Nonsurgical approaches that lower stroke risk include smoking cessation, hypertension management with a goal blood pressure of <130/80 mm Hg, management of diabetes mellitus if present, and initiation of high-intensity statin therapy with a target LDL-cholesterol level of <70 mg/dL. Regular physical activity regardless of BMI is associated with a reduction in stroke risk.
Surgical interventions for carotid disease, such as endarterectomy or stenting, carry a significant risk of mortality and disabling stroke. Because of the risks of intervention, screening of asymptomatic patients is not routinely recommended. Similarly, the benefits of intervention must be weighed against the potential risks. Generally, intervention is recommended if the patient has experienced significant symptoms from carotid artery disease such as stroke or high-risk TIA with stenosis >50%.
For asymptomatic patients, the average annual risk of stroke with stenosis ≥70% is about 1% and evaluation for carotid endarterectomy or stenting is recommended if the patient is considered to be at acceptable surgical risk.
Family physicians often see patients with diarrheal illnesses and most of these are viral. Patients sometimes have misconceptions about preferred fluid and feeding recommendations during these illnesses. The World Health Organization recommends oral rehydration with low osmolarity drinks (oral rehydration solution) and early refeeding. Low osmolarity solutions contain glucose and water, which decrease stool frequency, emesis, and the need for intravenous fluids. Soda and sports drinks contain a higher concentration of glucose, which may worsen diarrhea.
Half-strength apple juice has been shown to be effective, and it approximates an oral rehydration solution. Its use prevents patient measurement errors and the purchase of beverages with an inappropriate osmolarity. It is also more appealing to children than many oral rehydration solutions. Water increases the risk of hyponatremia in children. Refeeding on patient request has been shown to decrease the duration of illness.
This asymptomatic patient with mildly elevated transaminases most likely has nonalcoholic fatty liver disease (NAFLD), which is the most common chronic liver disorder in the United States. It is associated with metabolic syndrome. The initial evaluation should include studies to rule out less common causes of liver disease including viral hepatitis and hemochromatosis. Other laboratory studies that assist in evaluation include albumin and platelet levels. These values allow for the calculation of the Fibrosis-4 score or the NAFLD fibrosis score, which are validated to predict the risk of significant liver fibrosis. Patients with an elevated risk of fibrosis require further evaluation, typically with ultrasound-based elastography before considering liver biopsy. Medications and supplements may cause elevated transaminase levels, and a thorough history to elicit this information is important. Statin-induced liver injury is rare and not consistent with this clinical picture. Discontinuing statin therapy is not necessary with mild transaminase elevations due to NAFLD. Metformin is unlikely to cause elevated transaminases and is safe with this severity of liver disease. Liver fibrosis may be detected with CT but ultrasonography is more sensitive and thus preferred.
Biceps tendinitis causes pain with abduction and external rotation of the arm, and tenderness of the bicipital groove with palpation. Resisted supination of the hand with the elbow flexed to 90° is the Yergason test, and anterior shoulder pain with this maneuver is consistent with bicipital tendinitis. Anterior shoulder pain with cross adduction of the arm is more consistent with acromioclavicular arthritis. Axial compression with rotation to the affected side of the slightly extended neck is the Spurling test for cervical radiculopathy. Extension of the elbow would activate the triceps, and internal rotation of the shoulder with the elbow flexed would result in less activation of the biceps than resisted supination.
Doxycycline (100–200 mg daily or 40 mg once daily of a modified-release formulation) and minocycline (100–200 mg daily) are effective options for the treatment of papulopustular rosacea. The modified-release doxycycline, which is a 40-mg capsule, is FDA-approved but is more expensive out of pocket. Oral metronidazole or macrolides such as azithromycin and clarithromycin can also be considered for those who cannot take tetracyclines. Erythromycin would not be a first-line choice. Amoxicillin, cephalexin, and sulfamethoxazole/trimethoprim lack evidence to support their use in the treatment of papulopustular rosacea.
Office spirometry can be very helpful in narrowing the differential diagnosis of dyspnea. Of the options listed, only cystic fibrosis can cause an obstructive pattern. Other causes of an obstructive pattern include asthma, COPD, α1-antitrypsin deficiency, and bronchiectasis, among others. Common diseases or conditions causing restrictive patterns include adverse reactions to nitrofurantoin, methotrexate, and amiodarone. Chest wall conditions such as kyphosis, scoliosis, and morbid obesity can also cause restrictive patterns. Interstitial lung disease, including idiopathic pulmonary fibrosis, sarcoidosis, and asbestosis, also causes a restrictive pattern.
After percutaneous coronary intervention (PCI) for a non–ST-elevation myocardial infarction, the American College of Cardiology (ACC) recommends continuing dual antiplatelet therapy (DAPT) for at least 12 months in patients who do not have a high risk for bleeding. There are few consistent recommendations after 12 months because there is less consistent and high-quality evidence for outcomes beyond this time point.
The net benefit of dual antiplatelet therapy is highest in the first 12 months after PCI. After 12 months of therapy, the risk of bleeding increases. The risk-benefit ratio should be reassessed for all patients after 12 months of therapy. For most patients, discontinuing either the P2Y12 inhibitor or the aspirin is warranted after 12 months. A 2020 meta-analysis found that patients with newer generation drug-eluting stents treated with DAPT for >18 months had a higher all-cause mortality compared with those treated for <6 months.
The ACC indicates that continuing DAPT is reasonable for select patients. Point-of-care tools, such as the PRECISE-DAPT Risk Calculator, use clinical information to calculate the likely cardiac risk reduction and likely risk of bleeding to help inform shared decision-making after 12 months.
Aspirin is the most cost-effective option for long-term antiplatelet therapy. For this patient, who has indicated costs of care are a concern for him, discontinuing clopidogrel is the better choice.
In addition to antiplatelet therapy, control of elevated blood pressure and cholesterol also reduces cardiovascular outcomes in secondary prevention. This patient’s LDL-cholesterol level is at goal and currently <70 mg/dL, so atorvastatin should be continued at the current dosage. He has reached his blood pressure goal of <130/80 mm Hg and has no orthostatic symptoms, so his current blood pressure medication regimen should be continued.
Because patients with an acute ischemic stroke may require the increased perfusion pressure to limit ischemia, antihypertensive therapy should not be given during the first 48–72 hours as long as they are not candidates for, or recipients of, reperfusion therapy with alteplase or thrombectomy; do not have a comorbid condition requiring acute blood pressure lowering; and do not have a blood pressure >220/120 mm Hg. Patients with a history of hypertension can generally resume their home blood pressure medications once they are safely eating and drinking. Basically, you can allow HTN (permissive HTN) within the first 48 hours of having an ischemic stroke that wasn't treated with alteplase or thrombectomy with goal BP <220/120.
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inkandguns · 10 months
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I want to try this before returning to FedEx in the winter. It’s really difficult to fast while working there.
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citizen-zero · 9 months
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I technically have a liver disease (nonalcoholic fatty liver) and like, it’s something that’s reasonably easy to “treat” in the sense that it calls for lifestyle changes like more exercise and eating more healthily. But holy shit I’m so stressed about it because I didn’t have great lifestyle habits last year and this year has been a struggle and like I’m trying to get on track with that but I’m crazy paranoid that it’s already too late and I’ve already done irreparable damage to my liver and I’m going to have significant health problems imminently. I know it’s probably just my health anxiety being triggered since that’s the one form of anxiety that’s hard for me to manage but I can’t help it.
Logically I know I’m probably not at a severe point yet because sure I’m overweight and I don’t do a lot of exercise but I don’t drink basically ever, and I’m not experiencing noticeable symptoms that I can’t attribute to anything else…like I’m tired because I don’t have a good sleep routine, I have some isolated yellowish spots on my skin that I can’t be confident aren’t bruises or from something else, my eyes look normal….there’s one symptom that’s been concerning but it’s kinda gross so I’m not going there. But basically there’s only one, maybe two signs that I’m getting worse. And I’m already noticing an improvement in the more gross symptom after a only a few days of one specific change, so…
ugh. On the one hand being very aware of my body is good because it means I’ll probably notice if something’s genuinely wrong. But fuck I hate feeling scared all the time. It’s hard to focus on being in the moment and just making changes now. And I’m scared I’m gonna fall off the wagon again like I have in the past even though I’m in a better place than I was back then
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teachingrounds · 2 years
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Q. What is the most common cause of liver cirrhosis in the United States? In the world?
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A. The most common causes of liver cirrhosis in the US are chronic hepatitis C, alcohol, and nonalcoholic fatty liver disease. The most common cause worldwide is hepatitis B, although that is a vaccine-preventable disease if the country has enough resources.
Pro-Tip: With the ability to successfully treat chronic hepatitis C with anti-virals drug, it is being replaced as the most common kind of cirrhosis treated with liver transplant by nonalcoholic fatty liver disease. (Individuals with alcoholic cirrhosis typically have to abstain from drinking for 6 months before they are even considered for transplant, so few are treated this way.)
Image: Thomas Godart, "Cirrhosis, with fatty degeneration of the liver" in an 11 y/o child (19th century)
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topnaturalremedy · 2 years
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What are the health benefits of drinking tea?
Tea is one of the most popular beverages in the world. Tea is rich in micronutrients, including fluoride, magnesium ions, and zinc ions. However, its health benefits are mainly related to three main bioactive compounds. Including catechols, caffeine and L-theanine, tea consumption is often associated with many health benefits, which can help improve mood and cognition, and reduce an individual's risk of cardiovascular disease and diabetes. In this article, the editor took stock of the relationship between drinking tea and the health benefits of the body, and shared it with you! 【1】:Drinking tea can induce epigenetic changes in female body Epigenetic changes are chemical modifications that help turn on/off gene expression. In a recent study published in the international journal Human Molecular Genetics, researchers from Uppsala University in Sweden found that , Tea drinking in women may induce epigenetic changes in specific genes that are thought to interact with cancer and estrogen metabolism. We all know that our living environment and lifestyle, such as food choices, smoking, and exposure to chemicals, can lead to epigenetic changes; in this study, the researchers investigated whether drinking tea and coffee Can trigger epigenetic changes, previous research has shown that coffee and tea play a key role in regulating human disease risk, such as inhibiting tumor progression, reducing inflammation and affecting estrogen metabolism, and the mechanisms may all be through epigenetic mediated by genetic changes. The findings suggest that epigenetic changes occur in tea-drinking women, but not in men. Even more interesting, many epigenetic changes tend to occur in genes involved in cancer and estrogen metabolism. Previous research has shown that drinking tea can reduce estrogen levels in the body, and this clarifies the difference in the biological response of men and women to drinking tea. The researchers pointed out that women tend to drink more than men. Plenty of tea, which also increases our chances of finding a connection between tea drinking and women. Of course, this study did not find any epigenetic changes in coffee-drinking individuals. 【2】Drinking tea reduces mortality, is it true? Professor Nicolas Danchin from France presented a study involving 131,000 people at the annual meeting of the European Heart Association on August 31. The study revealed that tea drinking reduced non-cardiovascular mortality by 24%. Professor Tang Shan said: "If you have to choose between tea and coffee, it's probably better to drink tea. Both coffee and tea are an important part of our lifestyle. Their impact on cardiovascular (CV) health is Studies have been done in the past, sometimes with conflicting results. We looked at the effects of coffee and tea on CV-factor mortality and non-CV-factors in a large cohort of French people with a lower risk of cardiovascular disease. Mortality impact." The study involved 131,401 people, aged 18 to 95, who had undergone medical examinations at the Centre for Preventive Medicine at the Free School of Philosophy and Psychology in Paris between January 2001 and December 2008. Over the next average of 3.5 years, there were 95 deaths from CV causes and 632 deaths from non-CV causes. Coffee or tea consumption was divided into three levels on the self-help questionnaire: none, 1-4 cups per day, and 4 or more cups per day. [3] Take a break, drink a cup of tea, drink a cup of coffee, you can also prevent liver disease Cirrhosis, or chronic liver disease, is a serious condition that has become the leading cause of death across the United States. To prevent liver disease, a new study recommends taking a break and enjoying a good cup of tea. Liver disease-related deaths are often the result of cirrhosis. Although the vast majority of cases of cirrhosis in people are caused by chronic alcohol consumption, nonalcoholic fatty liver disease (NAFLD) can also lead to cirrhosis. The latest study, published in the Journal of Hepatology, adds a new set of preventive factors: tea and coffee. Scientists led by Dr. Sarwa Darwish Murad, a liver specialist at the Erasmus University Medical Center in Rotterdam, the Netherlands, set out to study the effects of drinking tea and coffee on liver health. 【4】IJC: Regular consumption of coffee and tea reduces the risk of endometrial cancer A new study by American scientists shows that women who drink coffee and tea regularly can reduce the risk of endometrial cancer. Scientists at the Roswell Park Cancer Institute reported in the April issue of the International Journal of Cancer that they tracked nearly 1,100 women and found that those who drink coffee and tea regularly People had a lower risk of developing endometrial cancer than non-drinkers, and the more coffee and tea they drank, the lower their risk of developing this cancer. Those who drank more than 4 cups of coffee or tea a day had a roughly 50 percent lower risk of endometrial cancer than those who didn't, the report said. Those who drank an average of 2 cups of tea or coffee a day had a 44% and 29% lower risk of developing this cancer than those who did not drink it. 【5】Which tea is most beneficial to the health of the body? News reading: What science says about getting the most out of your tea Tea is one of the most popular beverages in the world. Of course, tea is also a matter of personal preference; everyone's preference for tea is different, so what does the scientific community say about it? Drinking tea is often associated with a number of health benefits, which can help improve mood and cognition, and reduce an individual's risk of cardiovascular disease and diabetes. Tea is also rich in micronutrients, including fluoride, magnesium ions, and zinc ions, but the health benefits shown are primarily related to three major bioactive compounds, including catechol, caffeine, and L-Theanine, a bioactive compound is a non-essential nutrient that can affect the health of the body. Laboratory and animal studies have shown that these bioactive compounds can have a variety of health effects, but the results of research in humans are unclear; catechol is a polyphenol, and polyphenols It is a class of natural compounds with antioxidant properties. Antioxidants can inhibit cell damage in the body. Caffeine can make the body alert. At the same time, the amino acid L-theanine is believed to relax people. These bioactive compounds will make us experience To the brewed taste and texture. [6] Population study suggests a cup of tea a day may improve heart health Original report: A daily cup of tea may soothe your heart A new study recently found that a cup of tea a day may be good for heart health. The study found that people who drank a cup of tea a day were 35 percent less likely to develop heart failure or other major cardiovascular disease than those who didn't drink tea. The study also found that tea drinkers also had a lower risk of calcification in the coronary arteries of the heart, which the researchers said was associated with heart disease, stroke and other serious diseases. Dr. Elliott Miller of Johns Hopkins said: "We found that people who drank tea moderately had slower progression of coronary calcification and a lower risk of cardiovascular events." But Miller also pointed out that they haven't been able to prove whether there is a causal relationship between tea drinking and heart disease risk. "This is just an observational study, and we can't say for sure whether it's the tea itself or the people who drink it that have healthier lifestyle habits that lead to a lower risk of cardiovascular disease." For the study, Miller and his research team analyzed data from a study that began in 2000 and is still ongoing, with more than 6,000 participants, both men and women. When the study started, none of the participants had heart disease. [7]: Green tea is not only healthy, it can also be used to treat cancer in the future Scientists in Singapore have recently discovered that an active ingredient in green tea can serve as a potential nano-drug delivery system for delivering protein drugs to treat cancer. In animal experiments, the researchers used this antioxidant called gallic acid (EGCG) to load Roche and Genentech's breast cancer drug Herceptin. Compared with the control group, the drug-loaded system was more than twice as effective. . At the same time, after being encapsulated by the drug-loading system, the accumulation of the drug in the liver and kidney was reduced by about 70%, and the accumulation in the lung was reduced by 40%. The research has been published in the prestigious journal Nature Nanotechnology. Until recently, EGCG was only considered a beneficial component of green tea, and its drug-carrying system function was only recently discovered. The researchers combined EGCG with polyethylene glycol, allowing EGCG to protect the protein drug from degradation. Jackie Ying, who is in charge of this research, said that it is the first time to apply the active ingredients in green tea to the field of nanomedicine, and the synergistic effect of the drug and the drug delivery system also surprised the researchers. [8]: Researchers think coffee and tea may help liver health A cup of coffee or tea in the morning may be more than a booster before you work. An international team of researchers led by researchers at Duke-NUS Graduate School of Medicine and Duke University School of Medicine has suggested that increasing caffeine intake may reduce fatty liver disease in patients with nonalcoholic fatty liver disease (NAFLD). Worldwide, 70% of people with diabetes and obesity have fatty liver. An estimated 30% of American adults have the disease, and its prevalence is on the rise in Singapore. Apart from diet and exercise, there is no effective treatment to cure NAFLD. Using cell cultures and mouse models, researchers such as Paul Yen observed that caffeine stimulates the metabolism of lipids stored in liver cells and reduces fatty liver in mice fed a high-fat diet. 【9】: Green tea catechins effectively block rheumatoid arthritis ​​ Researchers from Washington State University have identified a new way to fight joint pain, inflammation and tissue damage caused by rheumatoid arthritis. The study was published in the international journal Arthritis and Rheumatology. Rheumatoid arthritis is a serious autoimmune disorder that affects the function of the small joints of the hands and feet, often causing painful bulges in the joints, which then develop into cartilage damage, bone erosion, and joint deformities. Researcher Salah-uddin Ahmed pointed out that the current treatment of rheumatoid arthritis drugs are very expensive, and have a certain degree of immunosuppression, sometimes not suitable for long-term use. The researchers evaluated a phytochemical called catechin (epigallocatechin gallate, EGCG), an anti-inflammatory molecule found in green tea, that There is great potential for the treatment of rheumatoid arthritis because the molecule can effectively block the effects of the disease without blocking the precursors of other cellular functions. [10] Another major effect of green tea: reverse liver damage Original article: Finding liver cancer early and reversing its course Liver cancer is often fatal in humans because it is often diagnosed at an advanced stage. But, in animal models, a new work has uncovered a potential diagnostic biomarker for liver cancer, as well as a potential way to reverse pre-existing liver damage. The research will be reported at the 2015 AACR Annual Meeting in Philadelphia. Dr. Ying Fu, Georgetown Lombardi Comprehensive Cancer Center, explained the new work, "Hepatocellular carcinoma, the most common type of liver cancer, is the world's most The third leading cause of cancer death." "In this work, we found in two animal models that damaged lesions of DNA (guanine) (γ-OH-Acr-dG) are associated with hepatocellular cancer. It has the potential to be an early diagnostic tool for hepatocellular cancer. Biomarkers."
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