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New study explains Mycobacterium tuberculosis high resistance to drugs and immunity
New study explains Mycobacterium tuberculosis high resistance to drugs and immunity
A consortium of researchers from Russia, Belarus, Japan, Germany and France led by a Skoltech scientist have uncovered the way in which Mycobacterium tuberculosis survives in iron-deficient conditions by utilizing rubredoxin B, a protein from a rubredoxin family that play an important role in adaptation to changing environmental conditions. The new study is part of an effort to study the role of…
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bpod-mrc · a month ago
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Follow the Drugs
In order for antibiotic drugs to be effective at treating bacterial infections, they need to get to where the bugs are. The lung disease tuberculosis (TB), caused by Mycobacterium tuberculosis bacteria, is particularly stubborn, often taking at least six months of treatment with three different antibiotics to get rid of it. To find out why, researchers have developed a new technique known as CLEIMiT, which uses three different types of microscopy to reveal exactly where drugs have gone inside tissues and even individual cells. These images are different coloured versions of the lungs of a mouse infected with Mycobacterium tuberculosis that has been treated with an antibiotic called bedaquiline. Although the drug appears to successfully get into some infected cells, it doesn’t reach them all. The findings are a vital insight into how antibiotics are working in the body and help to explain why TB is so difficult to treat.
Written by Kat Arney
Image by Antony Fearns and Angela Rodgers, cover PLOS Biology, January 2021
Host–Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, London, UK
Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
Published in PLOS Biology, December 2020
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y0rkminster · 4 months ago
Swim in Peace Aeneas, my little rainbow fish
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He fought a valiant battle with mycobacteriosis. Although I had planned to use experimental treatments for him, he ultimately developed severe complications and I made the difficult decision to let him die with dignity.
Aeneas survived severe neglect and off the charts ammonia at the pet store. By the time I got him, he already had myco. I just didn’t know it yet. He put up a hell of a fight. He was also the sweetest, most peaceful betta. Super friendly too. He will be missed.
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mcatmemoranda · 10 months ago
I was getting confused between mycobacterium and mycoplasma because they both have "myco-" in the name.😑
Mycobacteria include mycobacterium tuberculosis, which obviously causes tuberculosis and then there's also mycobacterium avium complex (MAC), which is mycobacterium intracellulare and mycobacterium avium, which cause mycobacterium avium-intracellulare infection (MAI). MAC is a non-tuberculous mycobacterium (NTB). I remember having a question a long time ago about MAC. But I don't remember what it was.
Mycobacteria are acid-fast (the stain can't be washed off by acid) because of mycolic acid in its cell wall. They are bacilli.
Wikipedia says:
MAC bacteria enter most people's body when inhaled into the lungs or swallowed, but only cause infection in those who are immunocompromised or who have severe lung disease such as those with cystic fibrosis or chronic obstructive lung disease (COPD). MAC infection can cause COPD and lymphadenitis, and can cause disseminated disease, especially in people with immunodeficiency.
Mycoplasma is a gram negative bacteria that has no cell wall.
Wikipedia says:
Mycoplasma (plural mycoplasmas or mycoplasmata) is a genus of bacteria that lack a cell wall around their cell membranes. This characteristic makes them naturally resistant to antibiotics that target cell wall synthesis (like the beta-lactam antibiotics). They can be parasitic or saprotrophic (feed on decaying material). Several species are pathogenic in humans, including M. pneumoniae, which is an important cause of "walking" pneumonia and other respiratory disorders, and M. genitalium, which is believed to be involved in pelvic inflammatory diseases. Mycoplasma species are the smallest bacterial cells yet discovered, can survive without oxygen, and come in various shapes. For example, M. genitalium is flask-shaped (about 300 x 600 nm), while M. pneumoniae is more elongated (about 100 x 1000 nm). Hundreds of mycoplasma species infect animals.
The notation also confuses me, which is why I think it's better to write out "mycobacterium tuberculosis" and "mycoplasma pneumoniae" rather than "M. tuberculosis" and "M. pneumoniae."
From Wikipedia:
Important characteristics of mycoplasmal bacteria:
Cell wall is absent and plasma membrane forms the outer boundary of the cell.
Due to the absence of cell wall, these organisms can change their shape and are pleomorphic.
Lack of nucleus and other membrane-bound organelles.
Genetic material is a single DNA duplex and is naked.
Ribosomes are 70S type.
Possess a replicating disc at one end which assist replication process and also the separation of the genetic materials.
Heterotrophic nutrition. Some live as saprophytes but the majority are parasites of plants and animals. The parasitic nature is due to the inability of mycoplasmal bacteria to synthesise the required growth factor.
Cell morphology
Due to the lack of a rigid cell wall, Mycoplasmataceae can contort into a broad range of shapes, from round to oblong. They therefore cannot be classified as rods, cocci, or spirochetes.
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lunamoonbeamz · a year ago
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I go through this so often that it's not even funny. I've had doctors assume that I'm only there for pain killers and completely disregard my pain. They'll have physical evidence of what's causing me to be in this much pain and will still act this way. I've avoided telling by doctors how much pain I'm still in and asking to adjust my meds until today. And for the first time the doctor instantly said we could increase my meds and make sure I'm comfortable. I just want to say that Doctor Ottersbach at Grossmont hospital is a wonderful doctor. As is Doctor Haile.
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the-art-of-medicine · 2 years ago
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Mycobacterium tuberculosis (TB):
Often resistant to multiple drugs
TB symptoms: fever, night sweats, weight loss, cough (nonproductive or productive), hemoptysis (coughing up blood)
Mycobacterium avium-intracelluare:
Causes disseminated, non-TB disease in AIDS
Often resistant to multiple drugs
Prophylaxis with azithromycin when CD4+ count < 50 cells/mm3
Mycobacterium scrofulaceum:
Cervical lymphadenitis in children
Mycobacterium marinum:
Hand infection in aquarium handlers
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