#KRAS

[concreteburialplot]

christian ‘kras’ anthony | guitarist | chase atlantic

#this is my formal announcement and apology that i am gonna start posting kras on here #so sorry #but #i’m in love with him 😭😭😭 #HES A CUTE BAND BOY OKAY #i have to put my love somewhere #sorry he doesn’t scream #but like he’s sexy and sings sexy things #idk #just appreciate how pretty he is #kras #kras anthony #christian anthony #christian kras anthony #chase atlantic

[cbirt]

Many proteins are regarded as “undruggable” because of their activity through protein-protein interactions, despite the fact that they have been discovered as therapeutic targets in human diseases. A thorough allosteric map for proteins like KRAS, which is mutated in one out of every ten human malignancies, is required to address this. The goal of this map is to illustrate KRAS inhibitory allosteric communication. The researchers from the Centre for Genomic Regulation conducted a study on this. The effects of more than 26,000 mutations on KRAS folding and binding to six interaction partners were examined in this work. From genetic interactions in double mutants, over 22,000 causal free energy changes could be inferred from large-scale biophysical studies. 

These energy landscapes map inhibitory allosteric sites for a therapeutic target and quantify how mutations affect the binding selectivity of a signaling protein. Although allosteric mutations generally prevent binding to all effectors that have been studied, they can also alter the binding specificity, which may have implications for regulation, evolution, and therapy.

Approximately 10% of all malignancies, including pancreatic, colorectal, lung, and multiple myeloma, have somatically altered protein GTPase KRas (KRAS) versions. KRAS cycles between the inactive GDP-bound and the active GTP-bound states, acting as the prototypical molecular switch. Allostery, or the long-range transfer of information in a protein, is exemplified by the changed shape and activity of KRAS upon GTP binding. The KRAS effectors examples are RALGDS, PIK3CG, and RAF1. Mutations in cancer driver proteins disrupt this cycle, leading to an increase in the number of active GTP-bound effector-binding states.

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#cancer #mutation #oncogene #kras #undruggable #drug discovery

[krasatlantic]

#mitchel cave #chase atlantic #kras #manthony #chase #christiananthony

[makrostil]

kras 2019

#kras #2019 #tck #sbahn #s7 #graffiti #berlin #zugzeit

[liln4rwhal]

missing chase atlantic 💔

#chase atlantic #christian anthony #kras #chxse #concert #tour

[hockeystuff111]

this has nothing to do with hockey but CHRISTIAN ANTHONY IS FINE

#chase atlantic #kras

[cicciototano]

La forza e la delicatezza di un fiore supera ogni barriera 🍀🌸🌼❤️☮️💖#pieropelosphoto #canon #fiori #flowers #carso #kras #summer #stones #peace&love https://www.instagram.com/p/CfVy5zxs0RH/?igshid=NGJjMDIxMWI=

#pieropelosphoto #canon #fiori #flowers #carso #kras #summer #stones #peace

[med-skratki]

Dišiš mi po vseh rožah hkrati, vse rože pa le po tebi. - Josip Osti

#pomlad #josip osti #osti #kras #panova piščal

[lovealways-rissa]

I feel stupid crying in the bathroom over you.

I shouldn’t have confessed.

I shouldn’t have told you how I felt.

I thought we could still be friends

I thought we could move past this.

Ever since that July night, it hasn’t been the same.

Who knew people I thought were my friends would break my heart in a million places.

As I said in the beginning people always leave.

Thank you two for helping prove that.

Thank you two for breaking me more and more everyday.

#personal #thoughts #sc #kras

[oormithomimus]

Fan art made for @31_minty/ Kras on twitter.

Their never ending search for a boyfriend

#furry art #furry fandom #furry #fanart #art #renji #lgbt #boyfriend #kras #spongebob #animated gif #elemental #twitter

[concreteburialplot]

happy [late] birthday kras 💘💘

09.03.2023

#i love him so bad your honor #this is me confirming that this is a bad omens / chase atlantic blog #christian kras anthony #kras #kras anthony #christian anthony #sorry but not sorry #chase atlantic #chase atlantic band #mitchel cave #clinton cave

[krasatlantic]

🥺🥺🥺

#christiananthony #kras #chase #chase atlantic

[kdhhealthcomm]

Beating back cancer one small molecule at a time

Many of targeted therapies for cancer are small molecules created by the “drug hunters” of the pharmaceutical industry.

Targeted therapy revolutionizes outcomes for patients with cancer. Many of these targeted therapies are small molecules created by the “drug hunters” of the pharmaceutical industry. (1)  Drug hunters are looking for small molecules targeting cancer pathways. They examine protein-to-protein bonds, searching for and configuring small molecules that can fit into binding sites, like keys into locks.…

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#biotech #cancer #cancer treatment #drug hunters #hit-to-lead #KRAS #small molecules #targeted therapy

[raurquiz]

#otd #startrek #fridayschild #kirk #spock #mccoy #bones #uhura #sulu #chekov #scotty #eleen #kras #maab #startrek56 @startrekonpplus https://www.instagram.com/p/ClobxmkOdlB/?igshid=NGJjMDIxMWI=

#otd #startrek #fridayschild #kirk #spock #mccoy #bones #uhura #sulu #chekov #scotty #eleen #kras #maab #startrek56

[flexscene]

Edy Kras via Instagram

#edy kras #erduan krasnici #muscle #flex #holesrus #*