Random thoughts while rounding
Always have to swipe ourselves into the internal medicine wards. Swipe access in, swipe access out. It's to prevent patients with dementia from escaping.
One comes up to us, as we're discussing a case in the hallway. Some of them will just randomly join the walking part to rounds. He patiently waits for us to finish then asks if we can open the door for him, he needs to go home. Ask him where his nurse is, best to ask them, he goes, 'bloody useless" and walks off.
It's not entirely uncommon to get a call from families sometimes (usually disgruntled and frustrated) to go, so Mum or Dad's just escaped from hospital or the ED. Shall I ring the ambulance to bring them back? At the extreme, I've had patients barricade themselves in random rooms.
Mr H is still making his laps around the wards with his walker, if he bumps into something, he some how manages to troubleshoot it or wait for a staff member to move it. Usually a Wow (Workstation on wheels).
Another patient confidently walks past us to an alcohol hand wash/purell/hand sani. Picks up and tries to drink it, when her bedside nurse runs up and stops her. She goes, aww I was only going to take a sip.
Reminiscent of the woman who drank the perfume sample on tiktok. Addiction is hard.
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10/27/2022
Tranquil study challenge day 14
13. What was the most productive thing you did today? Why do you consider this action to be productive?
I went for a 5k run and took my time enjoying some self-care home spa activities. Today was day 6 of my 7 day stretch at the hospital and I have been very tired, not sleeping well, and struggling to stay engaged and complete tasks. Taking the time to exercise, be outside, and relax is important to break out of that cycle.
14. What passions do you have that led you to studying what you're studying in school now?
This is the super cheesy answer that I feel like everyone says but it's still true for me: life long learning and getting to help people on a daily basis.
Today, I am grateful for coffee and crisp fall air.
Today, I choose to give myself a chance to relax.
Today, my goals are
40 Uworld questions
200-300 anki cards
watch video on ECG interpretation
write reflection post on professionalism
complete slides for group practice questions session
workout
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GOLD 2023
Previous treatment categories C and D have been combined into a new category, named E (for
exacerbations). GOLD provides new guidance based on blood eosinophil level. Initial therapy for
categories A, B, and E is as follows:
– A: Long-acting β-agonist (LABA) or long-acting muscarinic antagonist (LAMA)
– B: LABA + LAMA (change from monotherapy)
– E: LABA + LAMA; if blood eosinophils are ≥300 cells/μL, consider LABA + LAMA + inhaled corticosteroid (ICS). No recommendation is made (at any eosinophil level) for ICS without
combined LABA + LAMA.
– For patients with persistent exacerbations despite LABA + LAMA + ICS or for those who have
100 eosinophils/μL, roflumilast (for patients with chronic bronchitis and FEV1 <50% of predicted)
or azithromycin (in nonsmokers) can be considered.
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Highlights of the internship - Week 18:
• The last two days of paediatrics — FINALLY. And the start of internal medicine.
• When I said goodbye to the small surgical procedures room’s staff, they were like, “oh nooo. But we were so used to seeing you. We can gather signatures for you to keep you here ahaha.” 🥹🥹
• Going to miss only ob/gyn part of this hospital.
• At general medicine, I started in endocrinology clinic. We were supposed to get there 30 minutes earlier than the doctor and start admitting the patients, taking their history and getting them ready for the doctor. When she comes, we start admitting them together. This will be the sum of my two weeks here.
• I had the night shift of the first day. I don’t like the first day night shifts!! Nothing requiring an intern really happened so it was calm, at least.
• I got a text from my friend about our gynaecologic oncology attending. He told the nurses she and I are his favourites and firsts, the ob/gyn doctors of the future 🥹🥹🥹 stoppp 🥹🥹🥹
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Enterococcus faecalis
As per wiki, "not to be confused with enterococcus faecium."
why in god's name are they so similarly named. I do not know. but it does change management.
Faecalis is more susceptible to penicillin and ampicillin. Faecalis is more virulent and more likely to cause IE than faecium. Faecium is also more likely to be resistant to ampicillin and vancomycin --> in the US: 80% to vanc, and 90% resistant to ampicillin.
It's a nosocomial common bug, so there aren't any cool case reports. If you walk into a ward, odds are you'll find someone with this. Not as common as staph or strep though.
Image source: bacteria under the microscope
E. Faecalis is gram positive cocci, (purple spheres), previously part of the streptococcus umbrella - if it makes it easier to remember - both appear in chains or pairs (rather than clusters like staph). Similar to strep it is catalase negative. Facultative anaerobe, so it will grow in both bottles. Faecalis is far more common than faecium, both live in the gut (think faeces). They grow at high salt concentrations, 6% (normal saline on the wards is 0.9%) and are usually non haemolytic.
Key thing to be aware of is that it can be a healthy part of your gut or genital tract but under the right circumstances for it - it can become pathogenic/disease causing. Further key thing: intrinsically resistant to bactericidal antibiotics hence they require synergism between a combination or prolonged duration in severe cases. like IE.
It's considered an opportunistic infection (for the lay public, it means when you're unwell or immunosuppressed, it becomes a problem). Increasingly it is a nosocomial infection (hospital acquired), 60% of cases in the US were acquired in hospital. They survive very harsh environments, including ethanol and can survive 10 mins at 60 degrees celsius and on surfaces from days to months. They are killed at 80 degrees or with 70% ethanol.
Similar to staph and strep, it can cause a variety of infections, including:
Infective endocarditis --> 3rd most common cause, 90% are faecalis other 5% are faecium (after staph aureus and strep viridans), subacute course, now more associated with TAVIs (elderly/frail/multimorbid patients). high mortality, 10-35%
UTIs - cause up to 20% of UTIs, but usually associated in hospital setting and with catheters/devices etc.
wound infections & OM (rarely)
line associated --> always replace lines if you can in sepsis, one cause of bacteraemia is the line
2nd or 3rd most common cause of nosocomial Utis, sepsis and wound infections (less often: diabetic ulcers, prosthetic joints)
less common: meningitis - and usually associated with shunts and neurosurgical procedures --> anything to do with devices and hospital. Mortality risk of 20%
odd association: strongyloides hyperinfection (remember this increases risk for bacteraemia), as post earlier.
sepsis/bacteraemia mortality risk is 25%
bottom line: high mortality in severe disease
Epidemio:
more likely to be found in the elderly populations who are multi-morbid and less independent in their activities of daily living.
Special powers:
No toxins (like staph or strep), but have inherent antibiotic resistance or are amenable to this and are very durable/hardy. Ability to form biofilms - hence attraction to lines and devices and staying there. This limits abx penetration allows them to persist. They gain resistance by their ability to pick up and transfer mobile gene elements like plasmids via conjugation etc. Abx including: cephalosporin, clinda, TMP-SMX, aminoglycosides like gent.
It is becoming more notorious for resistance particularly vancomycin resistant enterococcus faecalis (also not to be confused with VRE - Patients who were recently hospitalised or institutionalized are often swabbed for this, but this is actually E. faecium they're referring to). increased risk for this include previous antibiotics use (eg cephalosporins, vancomycin), due to disrupted gut biome, and exposure risk - more likely to occur if you've been recently hospitalised, require routine access to the wards (i.e. dialysis) etc. Also increased association with devices (like pacemakers), diabetics and stomach acid suppression from PPIs.
Investigations
Relevant imaging i.e. CT for abdominal collections, and culture/staining. sensitivities are an absolute must including aminoglycoside resistance, pencillin and vanco, which most labs will automatically do anyway when it's identified, teams just gotta remember to chase. other possibilities include PCR or 16s rRNA sequencing
Interesting additional work up: Colonoscopies. Some reports are starting to recommending doing this routinely if no source is found in cases of bacteraemia or IE. As there is an increasing association with neoplasms from the gut. Similar to guidelines for strep bovis.
Management
in general UTIs, wound infections etc, most are susceptible to penicillins and ampicillin, so you can treat with either.
Management of beta lactam resistant enterococcus:
- resistant against beta lactams --> refer to immunology for desensitisation, vanco is not as effective against enterococci, duration is 6 weeks in severe infection
Vanco resistant (your local infectious diseases team will be involved)
daptomycin, linezolid --> equally effective, tigecycline (last resort/salvage)
Treatment in IE --> synergism is key for bacteriocidal effect (durability)
in case of bacteraemia, try the denova calculator to determine risk of IE - Duration of symptoms, Embolizations, Number of positive cultures, Origin, valve disease, and Auscultation murmurs
if susceptible, it's intermittent doses of benzylpenicillin or continuous infusion at 2.4 g IV plus gentamicin (if concerning for kidneys, shorten the duration to 2 weeks) for approx 4-6 weeks
--> unless there's high level resistance to aminoglycosides
or if resistant as above options
issue with aminoglycosides -> ototoxicity and nephrotoxicity, requires frequent monitoring and caution in elderly
Resources:
Pathogen data sheet - Canadian government
StatPearls
Australian therapeutic guidelines - paywall, unless you're at an Australian hospital/medical school
Uptodate - always the gold standard, but is behind a paywall unless you have institutional access
Wikipaedia
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